WT1 Antibody (WT1/857 + 6F-H2) | Novus Biologicals NBP2-44607 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

WT1 Antibody (WT1/857 + 6F-H2)

catalog :

NBP2-44607

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

WT1/857 + 6F-H2

reactivity :

human, mouse, rat

application :

immunohistochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 5

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - frozen section; mouse; 1:200; loading ...; fig 1b	Chen X, Zhao Y, Xu J, Bao J, Zhao J, Chen J, et al. The Nephroprotective Effect of TNF Receptor-Associated Factor 6 (TRAF6) Blockade on LPS-Induced Acute Renal Injury Through the Inhibition if Inflammation and Oxidative Stress. Med Sci Monit. 2020;26:e919698 pubmed publisher
	Luo W, Chen X, Ye L, Chen X, Jia W, Zhao Y, et al. Kaempferol attenuates streptozotocin-induced diabetic nephropathy by downregulating TRAF6 expression: The role of TRAF6 in diabetic nephropathy. J Ethnopharmacol. 2020;:113553 pubmed publisher
	Chen X, Zhang X, Xu J, Zhao Y, Bao J, Zheng Z, et al. AZD4547 Attenuates Lipopolysaccharide-Induced Acute Kidney Injury by Inhibiting Inflammation: The Role of FGFR1 in Renal Tubular Epithelial Cells. Drug Des Devel Ther. 2020;14:833-844 pubmed publisher
	Zheng C, Huang L, Luo W, Yu W, Hu X, Guan X, et al. Inhibition of STAT3 in tubular epithelial cells prevents kidney fibrosis and nephropathy in STZ-induced diabetic mice. Cell Death Dis. 2019;10:848 pubmed publisher
	Liang G, Song L, Chen Z, Qian Y, Xie J, Zhao L, et al. Fibroblast growth factor 1 ameliorates diabetic nephropathy by an anti-inflammatory mechanism. Kidney Int. 2018;93:95-109 pubmed publisher

product information

brand :

Novus

master code :

NBP2-44607

SKU :

NBP2-44607-0.02mg

product name :

WT1 Antibody (WT1/857 + 6F-H2)

description :

The WT1 Antibody (WT1/857 + 6F-H2) from Novus Biologicals is a mouse monoclonal antibody to WT1. This antibody reacts with human, rat. The WT1 Antibody (WT1/857 + 6F-H2) has been validated for the following applications: Immunohistochemistry, Immunohistochemistry-Paraffin.

target :

WT1

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

WT1/857 + 6F-H2

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant full length human WT1 protein (WT1/857); Recombinant fragment aa1-181 of human WT1 (6F-H2)

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Rat

specificity :

Recognizes a 47-55kDa-tumor suppressor protein, identified as Wilm's Tumor (WT1) protein. The antibody reacts with all isoforms of the full-length WT1 and also identifies WT1 lacking exon 2-encoded amino acids, frequently found in subsets of sporadic Wilm s tumors.WT1, a sporadic and familial pediatric kidney tumor, is genetically heterogeneous. Wilm s tumor is associated with mutations of WT1, a zinc-finger transcription factor that is essential for the development of the metanephric kidney and the urogenital system. The WT1 gene is normally expressed in fetal kidney and mesothelium, and its expression has been suggested as a marker for Wilm s tumor and mesothelioma. WT1 protein has been identified in proliferative mesothelial cells, malignant mesothelioma, ovarian carcinoma, gonadoblastoma, nephroblastoma, and desmoplastic small round cell tumor. Lung adenocarcinomas rarely stain positive with this antibody. WT1 protein expression in mesothelial cells has become a reliable marker for the diagnosis of mesotheliomas.

gene symbol :

WT1

catalog number base :

NBP2-44607

accessionNumbers :

P19544

applications :

Immunohistochemistry, Immunohistochemistry-Paraffin

2020 USD :

129

2021 USD :

149 USD

alt names :

AWT1, NPHS4GUD, WAGR, Wilms tumor 1, Wilms tumor protein, WIT-2, WT33

storage :

Store at 4C.