PMEL17/SILV Antibody (HMB45) | Novus Biologicals NBP2-44520 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

PMEL17/SILV Antibody (HMB45)

catalog :

NBP2-44520

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

HMB45

reactivity :

human, rat, dogs

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 4

Reference
Phelan M, Kruczek K, Wilson J, Brooks M, Drinnan C, Regent F, et al. Soy Protein Nanofiber Scaffolds for Uniform Maturation of Human Induced Pluripotent Stem Cell-Derived Retinal Pigment Epithelium. Tissue Eng Part C Methods. 2020;26:433-446 pubmed publisher
Helmink B, Reddy S, Gao J, Zhang S, Basar R, Thakur R, et al. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020;577:549-555 pubmed publisher
Navik U, Sheth V, Kabeer S, Tikoo K. Dietary Supplementation of Methyl Donor l-Methionine Alters Epigenetic Modification in Type 2 Diabetes. Mol Nutr Food Res. 2019;63:e1801401 pubmed publisher
Lahola Chomiak A, Footz T, Nguyen Phuoc K, Neil G, Fan B, Allen K, et al. Non-Synonymous variants in premelanosome protein (PMEL) cause ocular pigment dispersion and pigmentary glaucoma. Hum Mol Genet. 2019;28:1298-1311 pubmed publisher

product information

brand :

Novus

master code :

NBP2-44520

SKU :

NBP2-44520-0.02mg

product name :

PMEL17/SILV Antibody (HMB45)

description :

The PMEL17/SILV Antibody (HMB45) from Novus Biologicals is a mouse monoclonal antibody to PMEL17/SILV. This antibody reacts with human, canine (negative), rat (negative). The PMEL17/SILV Antibody (HMB45) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Flow (Intracellular), Immunofluorescence.

target :

PMEL17/SILV

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

HMB45

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Extract of pigmented melanoma metastases from lymph nodes

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Canine (Negative), Rat (Negative)

specificity :

By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. Metastatic amelanotic melanoma can often be confused with a variety of poorly differentiated carcinomas, large cell lymphomas, and sarcomas using H & E stains alone. It is also difficult to differentiate melanoma from spindle cell carcinomas and various types of mesenchymal neoplasms. This MAb stains fetal and neonatal melanocytes, junctional and blue nevus cells, and malignant melanoma. This MAb also stains Angiomyolipoma (PEComa).

theoretical molecular weight :

95 kDa

gene symbol :

PMEL

catalog number base :

NBP2-44520

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunohistochemistry-Paraffin, Flow (Intracellular), Immunofluorescence

2020 USD :

129

2021 USD :

149 USD

alt names :

D12S53EP1, gp100, ME20, ME20-M, melanocyte protein mel 17, Melanocyte protein Pmel 17, Melanocytes lineage-specific antigen GP100, Melanoma-associated ME20 antigen, melanosomal matrix protein17, PMEL17P100, premelanosome proteinME20M, SI, SIL, silver (mouse homolog) like, silver homolog (mouse), Silver locus protein homolog, silver, mouse, homolog of, SILVPmel17

storage :

Store at 4C.