product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
CCR2 Antibody (3G7) - BSA Free
catalog :
NBP2-35334
quantity :
0.1 mg (also 0.025 mg)
price :
379 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
3G7
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
citations: 30
Reference
Sung P, Yang S, Peng Y, Sun C, Tao M, Hsieh S. CLEC5A and TLR2 are critical in SARS-CoV-2-induced NET formation and lung inflammation. J Biomed Sci. 2022;29:52 pubmed publisher
Han B, Alonso Valenteen F, Wang Z, Deng N, Lee T, Gao B, et al. A Chemokine Regulatory Loop Induces Cholesterol Synthesis in Lung-Colonizing Triple-Negative Breast Cancer Cells to Fuel Metastatic Growth. Mol Ther. 2021;: pubmed publisher
Virk H, Rekas M, Biddle M, Wright A, Sousa J, Weston C, et al. Validation of antibodies for the specific detection of human TRPA1. Sci Rep. 2019;9:18500 pubmed publisher
Wenstedt E, Verberk S, Kroon J, Neele A, Baardman J, Claessen N, et al. Salt increases monocyte CCR2 expression and inflammatory responses in humans. JCI Insight. 2019;4: pubmed publisher
Sahoo S, Majhi R, Tiwari A, Acharya T, Kumar P, Saha S, et al. Transient receptor potential ankyrin1 channel is endogenously expressed in T cells and is involved in immune functions. Biosci Rep. 2019;39: pubmed publisher
Brandolini L, Castelli V, Aramini A, Giorgio C, Bianchini G, Russo R, et al. DF2726A, a new IL-8 signalling inhibitor, is able to counteract chemotherapy-induced neuropathic pain. Sci Rep. 2019;9:11729 pubmed publisher
Ma S, Zhang Y, He K, Wang P, Wang D. Knockout of TRPA1 exacerbates angiotensin II-induced kidney injury. Am J Physiol Renal Physiol. 2019;317:F623-F631 pubmed publisher
Miao F, Wang R, Cui G, Li X, Wang T, Li X. Engagement of MicroRNA-155 in Exaggerated Oxidative Stress Signal and TRPA1 in the Dorsal Horn of the Spinal Cord and Neuropathic Pain During Chemotherapeutic Oxaliplatin. Neurotox Res. 2019;: pubmed publisher
Kameda T, Zvick J, Vuk M, Sadowska A, Tam W, Leung V, et al. Expression and Activity of TRPA1 and TRPV1 in the Intervertebral Disc: Association with Inflammation and Matrix Remodeling. Int J Mol Sci. 2019;20: pubmed publisher
CONKLIN D, Guo Y, Nystoriak M, Jagatheesan G, Obal D, Kilfoil P, et al. TRPA1 channel contributes to myocardial ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol. 2019;316:H889-H899 pubmed publisher
Ma W, Chen X, Cerne R, Syed S, Ficorilli J, Cabrera O, et al. Catechol estrogens stimulate insulin secretion in pancreatic β-cells via activation of the transient receptor potential A1 (TRPA1) channel. J Biol Chem. 2019;294:2935-2946 pubmed publisher
Peixoto Neves D, Soni H, Adebiyi A. CGRPergic Nerve TRPA1 Channels Contribute to Epigallocatechin Gallate-Induced Neurogenic Vasodilation. ACS Chem Neurosci. 2019;10:216-220 pubmed publisher
Wang Z, Xu Y, Wang M, Ye J, Liu J, Jiang H, et al. TRPA1 inhibition ameliorates pressure overload-induced cardiac hypertrophy and fibrosis in mice. EBioMedicine. 2018;36:54-62 pubmed publisher
Alghamdi T, Batchu S, Hadden M, Yerra V, Liu Y, Bowskill B, et al. Histone H3 Serine 10 Phosphorylation Facilitates Endothelial Activation in Diabetic Kidney Disease. Diabetes. 2018;67:2668-2681 pubmed publisher
Takahashi N, Chen H, Harris I, Stover D, Selfors L, Bronson R, et al. Cancer Cells Co-opt the Neuronal Redox-Sensing Channel TRPA1 to Promote Oxidative-Stress Tolerance. Cancer Cell. 2018;33:985-1003.e7 pubmed publisher
Lowin T, Bleck J, Schneider M, Pongratz G. Selective killing of proinflammatory synovial fibroblasts via activation of transient receptor potential ankyrin (TRPA1). Biochem Pharmacol. 2018;154:293-302 pubmed publisher
De Logu F, Nassini R, Materazzi S, Carvalho Gonçalves M, Nosi D, Rossi Degl Innocenti D, et al. Schwann cell TRPA1 mediates neuroinflammation that sustains macrophage-dependent neuropathic pain in mice. Nat Commun. 2017;8:1887 pubmed publisher
Matsuda K, Okamoto N, Kondo M, Arkwright P, Karasawa K, Ishizaka S, et al. Mast cell hyperactivity underpins the development of oxygen-induced retinopathy. J Clin Invest. 2017;127:3987-4000 pubmed publisher
Nummenmaa E, Hamalainen M, Moilanen L, Moilanen T, Vuolteenaho K, Moilanen E. TRPA1 expression is downregulated by dexamethasone and aurothiomalate in human chondrocytes: TRPA1 as a novel factor and drug target in arthritis. RMD Open. 2017;3:e000556 pubmed publisher
Zhang Y, Liu S, Qu D, Wang K, Zhang L, Jing X, et al. Kif4A mediate the accumulation and reeducation of THP-1 derived macrophages via regulation of CCL2-CCR2 expression in crosstalking with OSCC. Sci Rep. 2017;7:2226 pubmed publisher
Chen J, Ping Y, Tseng M, Chang Y, Lee H, Hsieh R, et al. Notch1-promoted TRPA1 expression in erythroleukemic cells suppresses erythroid but enhances megakaryocyte differentiation. Sci Rep. 2017;7:42883 pubmed publisher
Hidaka T, Ogawa E, Kobayashi E, Suzuki T, Funayama R, Nagashima T, et al. The aryl hydrocarbon receptor AhR links atopic dermatitis and air pollution via induction of the neurotrophic factor artemin. Nat Immunol. 2017;18:64-73 pubmed publisher
Lu Y, Piplani H, McAllister S, Hurt C, Gross E. Transient Receptor Potential Ankyrin 1 Activation within the Cardiac Myocyte Limits Ischemia-reperfusion Injury in Rodents. Anesthesiology. 2016;125:1171-1180 pubmed
Nummenmaa E, Hamalainen M, Moilanen L, Paukkeri E, Nieminen R, Moilanen T, et al. Transient receptor potential ankyrin 1 (TRPA1) is functionally expressed in primary human osteoarthritic chondrocytes. Arthritis Res Ther. 2016;18:185 pubmed publisher
Lee K, Lin H, Lee H, Tsai F, Lee T. Loss of Transient Receptor Potential Ankyrin 1 Channel Deregulates Emotion, Learning and Memory, Cognition, and Social Behavior in Mice. Mol Neurobiol. 2017;54:3606-3617 pubmed publisher
Lee K, Lee H, Lin H, Tsay H, Tsai F, Shyue S, et al. Role of transient receptor potential ankyrin 1 channels in Alzheimer's disease. J Neuroinflammation. 2016;13:92 pubmed publisher
Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015;137:15859-64 pubmed publisher
Billeter A, Galbraith N, Walker S, Lawson C, Gardner S, Sarojini H, et al. TRPA1 mediates the effects of hypothermia on the monocyte inflammatory response. Surgery. 2015;158:646-54 pubmed publisher
Weng H, Patel K, Jeske N, Bierbower S, Zou W, Tiwari V, et al. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 2015;85:833-46 pubmed publisher
Terada Y, Fujimura M, Nishimura S, Tsubota M, Sekiguchi F, Kawabata A. Roles of Cav3.2 and TRPA1 channels targeted by hydrogen sulfide in pancreatic nociceptive processing in mice with or without acute pancreatitis. J Neurosci Res. 2015;93:361-9 pubmed publisher
product information
brand :
Novus
master code :
NBP2-35334
SKU :
NBP2-35334
product name :
CCR2 Antibody (3G7) - BSA Free
description :
The CCR2 Antibody (3G7) - BSA Free from Novus Biologicals is a mouse monoclonal antibody to CCR2. This antibody reacts with human, mouse. The CCR2 Antibody (3G7) - BSA Free has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.
target :
CCR2
category :
Primary Antibodies
sizes available :
0.1 mg (also 0.025 mg)
buffer :
PBS
clonality :
Monoclonal
clone :
3G7
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
A synthetic peptide made to an N-terminal portion of the human CD63 protein (between residues 1-100) [UniProt P41597]
isotype :
IgG2b Lambda
purity :
Protein G purified
species :
Human, Mouse
gene symbol :
CCR2
accessionNumbers :
P41597
applications :
Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin
USD :
356
USD 2023 :
379 USD
alt names :
C-C chemokine receptor type 2, C-C CKR-2, CC-CKR-2CKR2B, CCR-2, CCR2A, CCR2B, CD192, CD192 antigen, chemokine (C-C motif) receptor 2, CKR2, CKR2A, CMKBR2MGC111760, FLJ78302, MCP-1 receptor, MCP-1-RMGC103828, MGC168006, Monocyte chemoattractant protein 1 receptor, monocyte chemotactic protein 1 receptor
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.