p27/Kip1 Antibody (SX53G8) | Novus Biologicals NBP2-32889 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

p27/Kip1 Antibody (SX53G8)

catalog :

NBP2-32889

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

SX53G8

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

citations: 1

Reference
Gao J, Wu L, Wang Y, Cui S, Duan S, Dong Z, et al. Knockdown of Cxcl10 Inhibits Mesangial Cell Proliferation in Murine Habu Nephritis Via ERK Signaling. Cell Physiol Biochem. 2017;42:2118-2129 pubmed publisher

product information

brand :

Novus

master code :

NBP2-32889

SKU :

NBP2-32889-0.02mg

product name :

p27/Kip1 Antibody (SX53G8)

description :

The p27/Kip1 Antibody (SX53G8) from Novus Biologicals is a mouse monoclonal antibody to p27/Kip1. This antibody reacts with human, mouse, rat, primate. The p27/Kip1 Antibody (SX53G8) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

target :

p27/Kip1

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

SX53G8

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Purified GST-p27 fusion protein of human origin

isotype :

IgG1 Kappa

purity :

Protein A purified

species :

Human, Mouse, Rat, Primate

specificity :

This MAb recognizes a 27kDa protein, identified as the p27Kip1, a cell cycle regulatory mitotic inhibitor. It is highly specific and shows no cross-reaction with other related mitotic inhibitors. In Western blotting of cell lysates from 7 human breast cancer cell lines (ZR75-1, ZR75-30, MCF-7, MDAMB453, T47D, CAL51, 734B), the antibody labels a single band corresponding to p27Kip1. It functions as a negative regulator of G1 progression and has been proposed to function as a possible mediator of TGF- induced G1 arrest. p27Kip1 is a candidate tumor suppressor gene. Reportedly, low p27 expression has been associated with unfavorable prognosis in renal cell carcinoma, colon carcinoma, breast carcinomas, non-small-cell lung carcinoma, hepatocellular carcinoma, multiple myeloma, and lymph node metastases in papillary carcinoma of the thyroid, as well as a more aggressive phenotype in carcinoma of the cervix.

gene symbol :

CDKN1B

catalog number base :

NBP2-32889

accessionNumbers :

P46527

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

2020 USD :

129

2021 USD :

149 USD

alt names :

CDKN4, cyclin-dependent kinase inhibitor 1B, cyclin-dependent kinase inhibitor 1B (p27, Kip1), Cyclin-dependent kinase inhibitor p27, KIP1P27KIP1, MEN1B, MEN4, p27Kip1

storage :

Store at 4C.