p21/CIP1/CDKN1A Antibody (WA-1) | Novus Biologicals NBP2-29463 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

p21/CIP1/CDKN1A Antibody (WA-1)

catalog :

NBP2-29463

quantity :

0.1 mg (also 20 ug)

price :

399 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

WA-1

reactivity :

human, mouse, chimpanzee

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 25

Published Application/Species/Sample/Dilution	Reference
western blot; mouse; 1:50; loading ...; fig 7a	Xiang J, Yang S, Xin N, Gaertig M, Reeves R, Li S, et al. DYRK1A regulates Hap1-Dcaf7/WDR68 binding with implication for delayed growth in Down syndrome. Proc Natl Acad Sci U S A. 2017;114:E1224-E1233 pubmed publisher
	Kaur N, Lum M, Lewis R, Black A, Black J. A novel antiproliferative PKCα-Ras-ERK signaling axis in intestinal epithelial cells. J Biol Chem. 2022;298:102121 pubmed publisher
	Saleh T, Alhesa A, Al Balas M, Abuelaish O, Mansour A, Awad H, et al. Expression of therapy-induced senescence markers in breast cancer samples upon incomplete response to neoadjuvant chemotherapy. Biosci Rep. 2021;41: pubmed publisher
	Kaczorowski A, Tolstov Y, Falkenstein M, Vasioukhin V, Prigge E, Geisler C, et al. Rearranged ERG confers robustness to prostate cancer cells by subverting the function of p53. Urol Oncol. 2020;38:736.e1-736.e10 pubmed publisher
	Couture R, Mora N, Al Bittar S, Najih M, Touaibia M, Martin L. Luteolin modulates gene expression related to steroidogenesis, apoptosis, and stress response in rat LC540 tumor Leydig cells. Cell Biol Toxicol. 2019;: pubmed publisher
	Mishra P, Paital B, Jena S, Swain S, Kumar S, Yadav M, et al. Possible activation of NRF2 by Vitamin E/Curcumin against altered thyroid hormone induced oxidative stress via NFĸB/AKT/mTOR/KEAP1 signalling in rat heart. Sci Rep. 2019;9:7408 pubmed publisher
	Zhou X, Liu S, Lin X, Xu L, Mao X, Liu J, et al. Metformin Inhibit Lung Cancer Cell Growth and Invasion in Vitro as Well as Tumor Formation in Vivo Partially by Activating PP2A. Med Sci Monit. 2019;25:836-846 pubmed publisher
	Aratani S, Tagawa M, Nagasaka S, Sakai Y, Shimizu A, Tsuruoka S. Radiation-induced premature cellular senescence involved in glomerular diseases in rats. Sci Rep. 2018;8:16812 pubmed publisher
	Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H. Platinum(IV) complexes conjugated with phenstatin analogue as inhibitors of microtubule polymerization and reverser of multidrug resistance. Bioorg Med Chem. 2017;25:4686-4700 pubmed publisher
	Ge X, Pettan Brewer C, Morton J, Carter K, Fatemi S, Rabinovitch P, et al. Mitochondrial catalase suppresses naturally occurring lung cancer in old mice. Pathobiol Aging Age Relat Dis. 2015;5:28776 pubmed publisher
	Meads M, Fang B, Mathews L, Gemmer J, Nong L, Rosado Lopez I, et al. Targeting PYK2 mediates microenvironment-specific cell death in multiple myeloma. Oncogene. 2016;35:2723-34 pubmed publisher
	Romanov V, Pospelov V, Pospelova T. Cyclin-dependent kinase inhibitor p21(Waf1): contemporary view on its role in senescence and oncogenesis. Biochemistry (Mosc). 2012;77:575-84 pubmed publisher
	Tagoug I, Sauty De Chalon A, Dumontet C. Inhibition of IGF-1 signalling enhances the apoptotic effect of AS602868, an IKK2 inhibitor, in multiple myeloma cell lines. PLoS ONE. 2011;6:e22641 pubmed publisher
	Koike M, Yutoku Y, Koike A. Accumulation of p21 proteins at DNA damage sites independent of p53 and core NHEJ factors following irradiation. Biochem Biophys Res Commun. 2011;412:39-43 pubmed publisher
	Wedel S, Hudak L, Seibel J, Juengel E, Tsaur I, Wiesner C, et al. Inhibitory effects of the HDAC inhibitor valproic acid on prostate cancer growth are enhanced by simultaneous application of the mTOR inhibitor RAD001. Life Sci. 2011;88:418-24 pubmed publisher
	Wedel S, Hudak L, Seibel J, Juengel E, Oppermann E, Haferkamp A, et al. Critical analysis of simultaneous blockage of histone deacetylase and multiple receptor tyrosine kinase in the treatment of prostate cancer. Prostate. 2011;71:722-35 pubmed publisher
	Elamin M, Shinwari Z, Hendrayani S, Al Hindi H, Al Shail E, Khafaga Y, et al. Curcumin inhibits the Sonic Hedgehog signaling pathway and triggers apoptosis in medulloblastoma cells. Mol Carcinog. 2010;49:302-14 pubmed publisher
	Juengel E, Engler J, Natsheh I, Jones J, Mickuckyte A, Hudak L, et al. Combining the receptor tyrosine kinase inhibitor AEE788 and the mammalian target of rapamycin (mTOR) inhibitor RAD001 strongly inhibits adhesion and growth of renal cell carcinoma cells. BMC Cancer. 2009;9:161 pubmed publisher
	Nobre R, Herráez Hernández E, Fei J, Langbein L, Kaden S, Grone H, et al. E7 oncoprotein of novel human papillomavirus type 108 lacking the E6 gene induces dysplasia in organotypic keratinocyte cultures. J Virol. 2009;83:2907-16 pubmed publisher
	Luty W, Rodeberg D, Parness J, Vyas Y. Antiparallel segregation of notch components in the immunological synapse directs reciprocal signaling in allogeneic Th:DC conjugates. J Immunol. 2007;179:819-29 pubmed
	Rossner P, Binkova B, Milcova A, Solansky I, Zidzik J, Lyubomirova K, et al. Air pollution by carcinogenic PAHs and plasma levels of p53 and p21(WAF1) proteins. Mutat Res. 2007;620:34-40 pubmed
	Nair A, Shishodia S, Ahn K, Kunnumakkara A, Sethi G, Aggarwal B. Deguelin, an Akt inhibitor, suppresses IkappaBalpha kinase activation leading to suppression of NF-kappaB-regulated gene expression, potentiation of apoptosis, and inhibition of cellular invasion. J Immunol. 2006;177:5612-22 pubmed
	Scott M, Ingram A, Ball K. PDK1-dependent activation of atypical PKC leads to degradation of the p21 tumour modifier protein. EMBO J. 2002;21:6771-80 pubmed
	Rossner P, Binkova B, Chvatalova I, Sram R. Acrylonitrile exposure: the effect on p53 and p21(WAF1) protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts. Mutat Res. 2002;517:239-50 pubmed
	Blaydes J, Luciani M, Pospisilova S, Ball H, Vojtesek B, Hupp T. Stoichiometric phosphorylation of human p53 at Ser315 stimulates p53-dependent transcription. J Biol Chem. 2001;276:4699-708 pubmed

product information

brand :

Novus

master code :

NBP2-29463

SKU :

NBP2-29463

product name :

p21/CIP1/CDKN1A Antibody (WA-1)

description :

The p21/CIP1/CDKN1A Antibody (WA-1) from Novus Biologicals is a mouse monoclonal antibody to p21/CIP1/CDKN1A. This antibody reacts with human, mouse, chimpanzee, monkey. The p21/CIP1/CDKN1A Antibody (WA-1) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

target :

p21/CIP1/CDKN1A

category :

Primary Antibodies

sizes available :

0.1 mg (also 20 ug)

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

WA-1

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Human recombinant p21/CIP1/CDKN1A protein (Uniprot: P38936 )

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Mouse, Chimpanzee, Monkey

specificity :

This monoclonal antibody recognizes a 21kDa protein, identified as the p21WAF1 tumor suppressor protein

theoretical molecular weight :

21 kDa

gene symbol :

CDKN1A

accessionNumbers :

P38936, P38936

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

USD :

410

USD 2023 :

399 USD

alt names :

CAP20cyclin-dependent kinase inhibitor 1, CDK-interacting protein 1, CDKN1melanoma differentiation associated protein 6, CIP1WAF1CDK-interaction protein 1, cyclin-dependent kinase inhibitor 1A (p21, Cip1), MDA6, MDA-6, Melanoma differentiation-associated protein 6, p21, p21CIP1, p21Cip1/Waf1, PIC1, SDI1DNA synthesis inhibitor, wild-type p53-activated fragment 1

storage :

Store at 4C.

more info or order :

Novus Biologicals product webpage