B7-2/CD86 Antibody (BU63) | Novus Biologicals NBP2-25208 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

B7-2/CD86 Antibody (BU63)

catalog :

NBP2-25208

quantity :

0.1 mg (also 0.02 mg)

price :

419 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

BU63

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 36

Reference
Xia Z, Zhou C, Hong Y, Li F, Zhang W, Ji H, et al. TFPI2 hypermethylation promotes diabetic atherosclerosis progression through the Ap2α/PPARγ axis. J Mol Cell Cardiol. 2025;198:45-59 pubmed publisher
Liu J, Shi Y, Zhao Y, Liu Y, Yang X, Li K, et al. A Multifunctional Metal-Phenolic Nanocoating on Bone Implants for Enhanced Osseointegration via Early Immunomodulation. Adv Sci (Weinh). 2024;11:e2307269 pubmed publisher
Prinz L, Riet T, Neureuther D, Lennartz S, Chrobok D, H xfc bbe H, et al. An anti-CD19/CTLA-4 switch improves efficacy and selectivity of CAR T cells targeting CD80/86-upregulated DLBCL. Cell Rep Med. 2024;5:101421 pubmed publisher
Shi C, Zhang Y, Wu G, Zhu Z, Zheng H, Sun X, et al. Hyaluronic Acid-Based Reactive Oxygen Species-Responsive Multifunctional Injectable Hydrogel Platform Accelerating Diabetic Wound Healing. Adv Healthc Mater. 2024;13:e2302626 pubmed publisher
Luo Y, Ali T, Liu Z, Gao R, Li A, Yang C, et al. EPO prevents neuroinflammation and relieves depression via JAK/STAT signaling. Life Sci. 2023;333:122102 pubmed publisher
Jia H, Wei P, Zhou S, Hu Y, Zhang C, Liang L, et al. Attenuated Salmonella carrying siRNA-PD-L1 and radiation combinatorial therapy induces tumor regression on HCC through T cell-mediated immuno-enhancement. Cell Death Discov. 2023;9:318 pubmed publisher
Tan Y, Coyle R, Barrs R, Silver S, Li M, Richards D, et al. Nanowired human cardiac organoid transplantation enables highly efficient and effective recovery of infarcted hearts. Sci Adv. 2023;9:eadf2898 pubmed publisher
Chen S, Xing Z, Geng M, Zhao R, Yang X, Zhu X, et al. Macrophage fusion event as one prerequisite for inorganic nanoparticle-induced antitumor response. Sci Adv. 2023;9:eadd9871 pubmed publisher
Yao S, Zhou Z, Wang L, Lv H, Liu D, Zhu Q, et al. Targeting endometrial inflammation in intrauterine adhesion ameliorates endometrial fibrosis by priming MSCs to secrete C1INH. iScience. 2023;26:107201 pubmed publisher
Chen L, Song X, Yao Z, Zhou C, Yang J, Yang Q, et al. Gelatin nanofiber-reinforced decellularized amniotic membrane promotes axon regeneration and functional recovery in the surgical treatment of peripheral nerve injury. Biomaterials. 2023;300:122207 pubmed publisher
Tan X, Fang P, Li K, You M, Cao Y, Xu H, et al. A HER2-targeted antibody-novel DNA topoisomerase I inhibitor conjugate induces durable adaptive antitumor immunity by activating dendritic cells. MAbs. 2023;15:2220466 pubmed publisher
Ling Q, Fang J, Zhai C, Huang W, Chen Y, Zhou T, et al. Berberine induces SOCS1 pathway to reprogram the M1 polarization of macrophages via miR-155-5p in colitis-associated colorectal cancer. Eur J Pharmacol. 2023;949:175724 pubmed publisher
Jia X, Xie L, Liu Y, Liu T, Yang P, Hu J, et al. Astragalus polysaccharide (APS) exerts protective effect against acute ischemic stroke (AIS) through enhancing M2 micoglia polarization by regulating adenosine triphosphate (ATP)/ purinergic receptor (P2X7R) axis. Bioengineered. 2022;13:4468-4480 pubmed publisher
Luo Z, Xia K, Liu Y, Liu J, Rao S, Hu X, et al. Extracellular Vesicles from Akkermansia muciniphila Elicit Antitumor Immunity Against Prostate Cancer via Modulation of CD8+ T Cells and Macrophages. Int J Nanomedicine. 2021;16:2949-2963 pubmed publisher
Liu P, Peng C, Chen X, Wu L, Yin M, Li J, et al. Acitretin Promotes the Differentiation of Myeloid-Derived Suppressor Cells in the Treatment of Psoriasis. Front Med (Lausanne). 2021;8:625130 pubmed publisher
Yang D, Shen L, Chen R, Fu Y, Xu H, Zhang L, et al. The Effect of Talaromyces marneffei Infection on CD86 Expression in THP-1 Cells. Infect Drug Resist. 2021;14:651-660 pubmed publisher
Klinge U, Dievernich A, Tolba R, Klosterhalfen B, Davies L. CD68+ macrophages as crucial components of the foreign body reaction demonstrate an unconventional pattern of functional markers quantified by analysis with double fluorescence staining. J Biomed Mater Res B Appl Biomater. 2020;: pubmed publisher
Li M, Su X, Ren Y, Zhao X, Kong L, Kang J. HDAC8 inhibitor attenuates airway responses to antigen stimulus through synchronously suppressing galectin-3 expression and reducing macrophage-2 polarization. Respir Res. 2020;21:62 pubmed publisher
Shehata M, Saad Eldien H, Meligy F, Bahaidarh S. The Possible Protective Role of Barley Seeds on the Spleen after Administration of Glucocorticoids in Adult Albino Rats: A Histological and Immunohistochemical Study. J Microsc Ultrastruct. 2019;7:171-180 pubmed publisher
Wu J, Huang T, Hsieh Y, Wang Y, Yen C, Lee G, et al. Cancer-Derived Succinate Promotes Macrophage Polarization and Cancer Metastasis via Succinate Receptor. Mol Cell. 2020;77:213-227.e5 pubmed publisher
Joly Amado A, Davtyan H, Serraneau K, Jules P, Zitnyar A, Pressman E, et al. Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and pSer396-tau pathology. Neurobiol Dis. 2020;134:104636 pubmed publisher
Zhu L, Li L, Wang X, Pan L, Mei Y, Fu Y, et al. M1 macrophages regulate TLR4/AP1 via paracrine to promote alveolar bone destruction in periodontitis. Oral Dis. 2019;: pubmed publisher
Wang T, Xu Y, Yuan Y, Xu P, Zhang C, Li F, et al. Succinate induces skeletal muscle fiber remodeling via SUNCR1 signaling. EMBO Rep. 2019;20:e47892 pubmed publisher
Liu D, Guo M, Zhou P, Xiao J, Ji X. TSLP promote M2 macrophages polarization and cardiac healing after myocardial infarction. Biochem Biophys Res Commun. 2019;: pubmed publisher
Kaushik N, Kaushik N, Adhikari M, Ghimire B, Linh N, Mishra Y, et al. Preventing the Solid Cancer Progression via Release of Anticancer-Cytokines in Co-Culture with Cold Plasma-Stimulated Macrophages. Cancers (Basel). 2019;11: pubmed publisher
Zhao J, Zhang Z, Xue Y, Wang G, Cheng Y, Pan Y, et al. Anti-tumor macrophages activated by ferumoxytol combined or surface-functionalized with the TLR3 agonist poly (I : C) promote melanoma regression. Theranostics. 2018;8:6307-6321 pubmed publisher
Caielli S, Veiga D, Balasubramanian P, Athale S, Domic B, Murat E, et al. A CD4+ T cell population expanded in lupus blood provides B cell help through interleukin-10 and succinate. Nat Med. 2019;25:75-81 pubmed publisher
Rivera Del Álamo M, Díaz Lobo M, Busquets S, Rodríguez Gil J, Fernández Novell J. Specific expression pattern of tissue cytokines analyzed through the Surface Acoustic Wave technique is associated with age-related spontaneous benign prostatic hyperplasia in rats. Biochem Biophys Rep. 2018;14:26-34 pubmed publisher
Guo M, Xiao J, Sheng X, Zhang X, Tie Y, Wang L, et al. Ginsenoside Rg3 Mitigates Atherosclerosis Progression in Diabetic apoE-/- Mice by Skewing Macrophages to the M2 Phenotype. Front Pharmacol. 2018;9:464 pubmed publisher
Peruzzotti Jametti L, Bernstock J, Vicario N, Costa A, Kwok C, Leonardi T, et al. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell. 2018;22:355-368.e13 pubmed publisher
Nguyen G, Park S, Le C, Park W, Choi D, Cho E. Metformin ameliorates activation of hepatic stellate cells and hepatic fibrosis by succinate and GPR91 inhibition. Biochem Biophys Res Commun. 2018;495:2649-2656 pubmed publisher
Schliefsteiner C, Peinhaupt M, Kopp S, Lögl J, Lang Olip I, Hiden U, et al. Human Placental Hofbauer Cells Maintain an Anti-inflammatory M2 Phenotype despite the Presence of Gestational Diabetes Mellitus. Front Immunol. 2017;8:888 pubmed publisher
Guo Y, Xie C, Li X, Yang J, Yu T, Zhang R, et al. Succinate and its G-protein-coupled receptor stimulates osteoclastogenesis. Nat Commun. 2017;8:15621 pubmed publisher
Li T, Hu J, Gao F, Du X, Chen Y, Wu Q. Transcription factors regulate GPR91-mediated expression of VEGF in hypoxia-induced retinopathy. Sci Rep. 2017;7:45807 pubmed publisher
Mu X, Zhao T, Xu C, Shi W, Geng B, Shen J, et al. Oncometabolite succinate promotes angiogenesis by upregulating VEGF expression through GPR91-mediated STAT3 and ERK activation. Oncotarget. 2017;8:13174-13185 pubmed publisher
Hu J, Li T, Du S, Chen Y, Wang S, Xiong F, et al. The MAPK signaling pathway mediates the GPR91-dependent release of VEGF from RGC-5 cells. Int J Mol Med. 2015;36:130-8 pubmed publisher

product information

brand :

Novus

catalog number base :

NBP2-25208

SKU :

NBP2-25208

product name :

B7-2/CD86 Antibody (BU63)

units size :

0.1 mg (also 0.02 mg)

description :

The B7-2/CD86 Antibody (BU63) from Novus is a mouse monoclonal antibody to B7-2/CD86. This antibody reacts with human,mouse,rat. The B7-2/CD86 Antibody (BU63) has been validated for the following applications: IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Immunofluorescence,Knockout Validated,Block/Neutralize,Immunocytochemistry/ Immunofluorescence.

target :

B7-2/CD86

category :

Primary Antibodies

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

BU63

concentration :

0.2 mg/ml

conjugate :

Unconjugated

all_available conjugate :

Unconjugated

host :

Mouse

immunogen :

ARH-77 (B-lymphoblastoid cell line)

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human,Mouse,Rat

specificity :

KLF9 - Kruppel-like factor 9

theoretical molecular weight :

70 kDa

gene symbol :

CD86

Antibody validation :

Knockout/Knockdown

top caption :

Knockout Validated: B7-2/CD86 Antibody (BU63) [NBP2-25208]

accessionNumbers :

NP_001193853, P42081, P42081

applications :

IF/IHC,Flow Cytometry,Immunohistochemistry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Simple Western,Immunofluorescence,Knockout Validated,Block/Neutralize,Immunocytochemistry/ Immunofluorescence

extended description :

Clone BU63 was used by HLDA to establish CD designation.

USD :

419 USD

product details :

Clone BU63 was used by HLDA to establish CD designation.

alt names :

Activation B7-2 antigen, B70, B7-2, B7-2 antigen, B-lymphocyte activation antigen B7-2, BU63, CD28 antigen ligand 2, CD28LG2B7-2 antigen), CD86 antigen, CD86 molecule, CTLA-4 counter-receptor B7.2, FUN-1, LAB72, MGC34413, T-lymphocyte activation antigen CD86

storage :

Store at 4C.

more info or order :

Novus Biologicals product webpage