TLR8 Antibody (44C143) - BSA Free | Novus Biologicals NBP2-24917 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

TLR8 Antibody (44C143) - BSA Free

catalog :

NBP2-24917

quantity :

0.1 mg (also 0.025 mg)

price :

429 USD

clonality :

monoclonal

host :

mouse

conjugate :

DyLight 350

clone name :

44C143

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, dot blot

more info or order :

Novus Biologicals product webpage

citations: 49

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry; mouse; 1:850; loading ...; fig 3h western blot; mouse; 1:850; loading ...; fig s1 immunohistochemistry; human; 1:850; loading ...; fig 2h western blot; human; 1:850; loading ...; fig s1	Huhta H, Helminen O, Kauppila J, Salo T, Porvari K, Saarnio J, et al. The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer. J Histochem Cytochem. 2016;64:470-82 pubmed publisher
immunohistochemistry - paraffin section; human	Youn J, Shim H, Lee J, Ji A, Oh J, Hong N, et al. Detailed pathologic evaluation on endomyocardial biopsy provides long-term prognostic information in patients with acute myocarditis. Cardiovasc Pathol. 2014;23:139-44 pubmed publisher
flow cytometry; human immunocytochemistry; human	Schwab N, Zozulya A, Kieseier B, Toyka K, Wiendl H. An imbalance of two functionally and phenotypically different subsets of plasmacytoid dendritic cells characterizes the dysfunctional immune regulation in multiple sclerosis. J Immunol. 2010;184:5368-74 pubmed publisher
immunocytochemistry; human	Clark R, Huang S, Murphy G, Mollet I, Hijnen D, Muthukuru M, et al. Human squamous cell carcinomas evade the immune response by down-regulation of vascular E-selectin and recruitment of regulatory T cells. J Exp Med. 2008;205:2221-34 pubmed publisher
western blot; human	Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
western blot; human	Hart O, Athié Morales V, O Connor G, Gardiner C. TLR7/8-mediated activation of human NK cells results in accessory cell-dependent IFN-gamma production. J Immunol. 2005;175:1636-42 pubmed
	Hiltunen N, Kemi N, V xe4 yrynen J, B xf6 hm J, Kauppila J, Huhta H, et al. Toll-like receptors 1-9 in small bowel neuroendocrine tumors-Clinical significance and prognosis. PLoS ONE. 2024;19:e0302813 pubmed publisher
	Campbell G, Rawat P, Teodorof Diedrich C, Spector S. IRAK1 inhibition blocks the HIV-1 RNA mediated pro-inflammatory cytokine response from microglia. J Gen Virol. 2023;104: pubmed publisher
	Campbell G, Rawat P, Spector S. Pacritinib Inhibition of IRAK1 Blocks Aberrant TLR8 Signalling by SARS-CoV-2 and HIV-1-Derived RNA. J Innate Immun. 2022;:1-11 pubmed publisher
	De Luccia T, Ono E, Menon R, Borbely A, Mattar R, RICHARDSON L, et al. The effect of Gestational Diabetes Mellitus on the fetal compartment. J Reprod Immunol. 2021;145:103314 pubmed publisher
	Li Y, Chen X, Jin R, Chen L, Dang M, Cao H, et al. Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021;7: pubmed publisher
	Menendez D, Snipe J, Marzec J, Innes C, Polack F, Caballero M, et al. p53-responsive TLR8 SNP enhances human innate immune response to respiratory syncytial virus. J Clin Invest. 2019;129:4875-4884 pubmed publisher
	Evankovich J, Lear T, Baldwin C, Chen Y, White V, Villandre J, et al. Toll-Like Receptor 8 Stability is Regulated by Ring Finger 216 in response to circulating MicroRNAs. Am J Respir Cell Mol Biol. 2019;: pubmed publisher
	Deng G, Ge J, Liu C, Pang J, Huang Z, Peng J, et al. Impaired expression and function of TLR8 in chronic HBV infection and its association with treatment responses during peg-IFN-?-2a antiviral therapy. Clin Res Hepatol Gastroenterol. 2017;41:386-398 pubmed publisher
	Helminen O, Huhta H, Kauppila J, Lehenkari P, Saarnio J, Karttunen T. Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas. APMIS. 2017;125:85-92 pubmed publisher
	Helminen O, Huhta H, Lehenkari P, Saarnio J, Karttunen T, Kauppila J. Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett's esophagus, dysplasia and adenocarcinoma. Oncoimmunology. 2016;5:e1127495 pubmed publisher
	Jeon Y, Kim C, Koh J, Chung D, Ha G. Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. Oncotarget. 2016;7:41811-41824 pubmed publisher
	Jamin A, Dehoux L, Dossier C, Fila M, Heming N, Monteiro R, et al. Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome. Clin Exp Immunol. 2015;182:332-45 pubmed publisher
	Chatillon J, Hamieh M, Bayeux F, Abasq C, Fauquembergue E, Drouet A, et al. Direct Toll-Like Receptor 8 signaling increases the functional avidity of human CD8+ T lymphocytes generated for adoptive T cell therapy strategies. Immun Inflamm Dis. 2015;3:1-13 pubmed publisher
	Zimmermann M, Aguilera F, Castellucci M, Rossato M, Costa S, Lunardi C, et al. Chromatin remodelling and autocrine TNFÎ± are required for optimal interleukin-6 expression in activated human neutrophils. Nat Commun. 2015;6:6061 pubmed publisher
	Tengroth L, Arebro J, Kumlien Geor n S, Winqvist O, Cardell L. Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients. PLoS ONE. 2014;9:e105618 pubmed publisher
	Camacho Sandoval R, Del Río Estrada P, Rivero Arrieta A, Reyes Teran G, Bonifaz L. Differential partial activation phenotype and production of tumour necrosis factor-? by conventional dendritic cells in response to lipopolysaccharide in HIV+ viraemic subjects and HIV+ controllers. Clin Exp Immunol. 2014;178:489-503 pubmed publisher
	Bernard M, Han X, Inderbitzin S, Agbim I, Zhao H, Koziel H, et al. HIV-derived ssRNA binds to TLR8 to induce inflammation-driven macrophage foam cell formation. PLoS ONE. 2014;9:e104039 pubmed publisher
	Green T, Santos M, Ejaeidi A, Craft B, Lewis R, Cruse J. Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells. Exp Mol Pathol. 2014;97:44-8 pubmed publisher
	Wang C, Eng H, Lin K, Liu H, Chang C, Lin T. Functional polymorphisms of TLR8 are associated with hepatitis C virus infection. Immunology. 2014;141:540-8 pubmed publisher
	Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
	Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
	Chamberlain N, Kim S, Vila O, Volin M, Volkov S, Pope R, et al. Ligation of TLR7 by rheumatoid arthritis synovial fluid single strand RNA induces transcription of TNF? in monocytes. Ann Rheum Dis. 2013;72:418-26 pubmed publisher
	Berger M, Hsieh C, Bakele M, Marcos V, Rieber N, Kormann M, et al. Neutrophils express distinct RNA receptors in a non-canonical way. J Biol Chem. 2012;287:19409-17 pubmed publisher
	Pang M, Bala S, Kodys K, Catalano D, Szabo G. Inhibition of TLR8- and TLR4-induced Type I IFN induction by alcohol is different from its effects on inflammatory cytokine production in monocytes. BMC Immunol. 2011;12:55 pubmed publisher
	Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
	Dasari P, Zola H, Nicholson I. Expression of Toll-like receptors by neonatal leukocytes. Pediatr Allergy Immunol. 2011;22:221-8 pubmed publisher
	van den Berk L, Jansen B, Siebers Vermeulen K, Netea M, Latuhihin T, Bergevoet S, et al. Toll-like receptor triggering in cord blood mesenchymal stem cells. J Cell Mol Med. 2009;13:3415-26 pubmed publisher
	Biasin M, Piacentini L, Lo Caputo S, Naddeo V, Pierotti P, Borelli M, et al. TLR activation pathways in HIV-1-exposed seronegative individuals. J Immunol. 2010;184:2710-7 pubmed publisher
	Panda A, Qian F, Mohanty S, van Duin D, Newman F, Zhang L, et al. Age-associated decrease in TLR function in primary human dendritic cells predicts influenza vaccine response. J Immunol. 2010;184:2518-27 pubmed publisher
	Clancy R, Alvarez D, Komissarova E, Barrat F, Swartz J, Buyon J. Ro60-associated single-stranded RNA links inflammation with fetal cardiac fibrosis via ligation of TLRs: a novel pathway to autoimmune-associated heart block. J Immunol. 2010;184:2148-55 pubmed publisher
	Wu J, Meng Z, Jiang M, Zhang E, Trippler M, Broering R, et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010;129:363-74 pubmed publisher
	Pietschmann K, Beetz S, Welte S, Martens I, Gruen J, Oberg H, et al. Toll-like receptor expression and function in subsets of human gammadelta T lymphocytes. Scand J Immunol. 2009;70:245-55 pubmed publisher
	Vatakis D, Nixon C, Bristol G, Zack J. Differentially stimulated CD4+ T cells display altered human immunodeficiency virus infection kinetics: implications for the efficacy of antiviral agents. J Virol. 2009;83:3374-8 pubmed publisher
	Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed
	Cohen P, Koski G, Czerniecki B, Bunting K, Fu X, Wang Z, et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008;112:1832-43 pubmed publisher
	Zuiderwijk Sick E, van der Putten C, Bsibsi M, Deuzing I, de Boer W, Persoon Deen C, et al. Differentiation of primary adult microglia alters their response to TLR8-mediated activation but not their capacity as APC. Glia. 2007;55:1589-600 pubmed
	Kaji M, Tanaka J, Sugita J, Kato N, Ibata M, Shono Y, et al. Ciprofloxacin inhibits lipopolysaccharide-induced toll-like receptor-4 and 8 expression on human monocytes derived from adult and cord blood. Ann Hematol. 2008;87:229-31 pubmed
	Murciano C, Villamon E, Yáñez A, Murciano J, Mir A, O Connor J, et al. In vitro response to Candida albicans in cultures of whole human blood from young and aged donors. FEMS Immunol Med Microbiol. 2007;51:327-35 pubmed
	Zola H, Swart B, Banham A, Barry S, Beare A, Bensussan A, et al. CD molecules 2006--human cell differentiation molecules. J Immunol Methods. 2007;319:1-5 pubmed
	Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed
	Levy O, Suter E, Miller R, Wessels M. Unique efficacy of Toll-like receptor 8 agonists in activating human neonatal antigen-presenting cells. Blood. 2006;108:1284-90 pubmed
	Lee J, Wu C, Lee K, Chuang T, Katakura K, Liu Y, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103:1828-33 pubmed
	Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O. Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-8 pubmed

product information

master code :

NBP2-24917

SKU :

NBP2-24917

product name :

TLR8 Antibody (44C143) - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The TLR8 Antibody (44C143) - BSA Free from Novus is a mouse monoclonal antibody to TLR8. This antibody reacts with human,mouse,rabbit. The TLR8 Antibody (44C143) - BSA Free has been validated for the following applications: Flow Cytometry,Cytometric Bead Assay Standard,Flow - IC,Flow Cytometry Control,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Dot Blot,Flow (Intracellular),Simple Western,CyTOF-ready.

target :

TLR8

category :

Primary Antibodies

buffer :

PBS pH 7.4

clonality :

Monoclonal

clone :

44C143

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

This antibody was developed against a KLH-conjugated synthetic peptide of human TLR8, within amino acids 750-850.

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Rabbit

gene symbol :

TLR8

Antibody validation :

Orthogonal Validation

applications :

Flow Cytometry,Cytometric Bead Assay Standard,Flow - IC,Flow Cytometry Control,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Dot Blot,Flow (Intracellular),Simple Western,CyTOF-ready

extended description :

Clone 44C143 was used by HLDA to establish CD designation.

USD :

429 USD

product details :

Clone 44C143 was used by HLDA to establish CD designation.

alt names :

CD288, CD288 antigen, MGC119599, MGC119600, toll-like receptor 8

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage