This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal TLR9 Antibody (26C593.2) [PE]
catalog :
NBP2-24907
quantity :
0.1 ml
price :
369 USD
clonality :
monoclonal
host :
mouse
conjugate :
PE
clone name :
26C593.2
reactivity :
human, mouse, rat, dog
application :
immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
citations: 53
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; human
Meng Y, Kujas M, Marie Y, Paris S, Thillet J, Delattre J, et al. Expression of TLR9 within human glioblastoma. J Neurooncol. 2008;88:19-25 pubmed publisher
Lopez M, Palmer B, Lawrence D. Naïve T cells, unconventional NK and NKT cells, and highly responsive monocyte-derived macrophages characterize human cord blood. Immunobiology. 2014;219:756-65 pubmed publisher
Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georén S, Latif L, Cardell L. Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. PLoS ONE. 2014;9:e98239 pubmed publisher
Belmont L, Rabbe N, Antoine M, Cathelin D, Guignabert C, Kurie J, et al. Expression of TLR9 in tumor-infiltrating mononuclear cells enhances angiogenesis and is associated with a worse survival in lung cancer. Int J Cancer. 2014;134:765-77 pubmed publisher
Figueiredo M, Amorim I, Pinto A, Barbosa V, Pinheiro L, Deoti B, et al. Expression of Toll-like receptors 2 and 9 in cells of dog jejunum and colon naturally infected with Leishmania infantum. BMC Immunol. 2013;14:22 pubmed publisher
Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
Chauhan S, Singh V, Rai R, Rai M, Rai G. Distinct autoantibody profiles in systemic lupus erythematosus patients are selectively associated with TLR7 and TLR9 upregulation. J Clin Immunol. 2013;33:954-64 pubmed publisher
Hu F, Zhang L, Zheng J, Zhao L, Huang J, Shao W, et al. Spontaneous production of immunoglobulin M in human epithelial cancer cells. PLoS ONE. 2012;7:e51423 pubmed publisher
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
Siponen M, Kauppila J, Soini Y, Salo T. TLR4 and TLR9 are induced in oral lichen planus. J Oral Pathol Med. 2012;41:741-7 pubmed publisher
Souza Fonseca Guimaraes F, Parlato M, Fitting C, Cavaillon J, Adib Conquy M. NK cell tolerance to TLR agonists mediated by regulatory T cells after polymicrobial sepsis. J Immunol. 2012;188:5850-8 pubmed publisher
Silver A, Arjona A, Walker W, Fikrig E. The circadian clock controls toll-like receptor 9-mediated innate and adaptive immunity. Immunity. 2012;36:251-61 pubmed publisher
Zuo D, Yu X, Guo C, Yi H, Chen X, Conrad D, et al. Molecular chaperoning by glucose-regulated protein 170 in the extracellular milieu promotes macrophage-mediated pathogen sensing and innate immunity. FASEB J. 2012;26:1493-505 pubmed publisher
Karim R, Meyers C, Backendorf C, Ludigs K, Offringa R, van Ommen G, et al. Human papillomavirus deregulates the response of a cellular network comprising of chemotactic and proinflammatory genes. PLoS ONE. 2011;6:e17848 pubmed publisher
Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
van Gent M, Griffin B, Berkhoff E, van Leeuwen D, Boer I, Buisson M, et al. EBV lytic-phase protein BGLF5 contributes to TLR9 downregulation during productive infection. J Immunol. 2011;186:1694-702 pubmed publisher
Myles A, Aggarwal A. Expression of Toll-like receptors 2 and 4 is increased in peripheral blood and synovial fluid monocytes of patients with enthesitis-related arthritis subtype of juvenile idiopathic arthritis. Rheumatology (Oxford). 2011;50:481-8 pubmed publisher
Schneberger D, Lewis D, Caldwell S, Singh B. Expression of toll-like receptor 9 in lungs of pigs, dogs and cattle. Int J Exp Pathol. 2011;92:1-7 pubmed publisher
Sethi R, Brar R, Singh O, Singh B. Immunolocalization of pulmonary intravascular macrophages, TLR4, TLR9 and IL-8 in normal and Pasteurella multocida-infected lungs of water buffalo (Bubalus bubalis). J Comp Pathol. 2011;144:135-44 pubmed publisher
Wang C, Cao S, Yan Y, Ying Q, Jiang T, Xu K, et al. TLR9 expression in glioma tissues correlated to glioma progression and the prognosis of GBM patients. BMC Cancer. 2010;10:415 pubmed publisher
Booth J, Arsenault R, Napper S, Griebel P, Potter A, Babiuk L, et al. TLR9 signaling failure renders Peyer's patch regulatory B cells unresponsive to stimulation with CpG oligodeoxynucleotides. J Innate Immun. 2010;2:483-94 pubmed publisher
Keestra A, de Zoete M, Bouwman L, van Putten J. Chicken TLR21 is an innate CpG DNA receptor distinct from mammalian TLR9. J Immunol. 2010;185:460-7 pubmed publisher
Jukkola Vuorinen A, Rahko E, Vuopala K, Desmond R, Lehenkari P, Harris K, et al. Toll-like receptor-9 expression is inversely correlated with estrogen receptor status in breast cancer. J Innate Immun. 2009;1:59-68 pubmed publisher
Machida H, Ito S, Hirose T, Takeshita F, Oshiro H, Nakamura T, et al. Expression of Toll-like receptor 9 in renal podocytes in childhood-onset active and inactive lupus nephritis. Nephrol Dial Transplant. 2010;25:2530-537 pubmed publisher
Kim Y, Park J, Brand D, Fitzpatrick E, Yi A. Protein kinase D1 is essential for the proinflammatory response induced by hypersensitivity pneumonitis-causing thermophilic actinomycetes Saccharopolyspora rectivirgula. J Immunol. 2010;184:3145-56 pubmed publisher
Chentoufi A, Dasgupta G, Nesburn A, Bettahi I, Binder N, Choudhury Z, et al. Nasolacrimal duct closure modulates ocular mucosal and systemic CD4(+) T-cell responses induced following topical ocular or intranasal immunization. Clin Vaccine Immunol. 2010;17:342-53 pubmed publisher
Wu J, Meng Z, Jiang M, Zhang E, Trippler M, Broering R, et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010;129:363-74 pubmed publisher
Zhou M, McFarland Mancini M, Funk H, Husseinzadeh N, Mounajjed T, Drew A. Toll-like receptor expression in normal ovary and ovarian tumors. Cancer Immunol Immunother. 2009;58:1375-85 pubmed publisher
Palladino M, Savarese M, Chapman J, Dughi M, Plaska D. Localization of Toll-like receptors on epididymal epithelial cells and spermatozoa. Am J Reprod Immunol. 2008;60:541-55 pubmed publisher
Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed
Meneghin A, Choi E, Evanoff H, Kunkel S, Martinez F, Flaherty K, et al. TLR9 is expressed in idiopathic interstitial pneumonia and its activation promotes in vitro myofibroblast differentiation. Histochem Cell Biol. 2008;130:979-92 pubmed publisher
Selleri S, Palazzo M, Deola S, Wang E, Balsari A, Marincola F, et al. Induction of pro-inflammatory programs in enteroendocrine cells by the Toll-like receptor agonists flagellin and bacterial LPS. Int Immunol. 2008;20:961-70 pubmed publisher
Ju X, Zenke M, Hart D, Clark G. CD300a/c regulate type I interferon and TNF-alpha secretion by human plasmacytoid dendritic cells stimulated with TLR7 and TLR9 ligands. Blood. 2008;112:1184-94 pubmed publisher
Hammadi A, Billard C, Faussat A, Kolb J. Stimulation of iNOS expression and apoptosis resistance in B-cell chronic lymphocytic leukemia (B-CLL) cells through engagement of Toll-like receptor 7 (TLR-7) and NF-kappaB activation. Nitric Oxide. 2008;19:138-45 pubmed publisher
Zhang Y, Davis E, Blecha F, Wilkerson M. Molecular cloning and characterization of equine Toll-like receptor 9. Vet Immunol Immunopathol. 2008;124:209-19 pubmed publisher
Cognasse F, Hamzeh Cognasse H, Lafarge S, Chavarin P, Pozzetto B, Richard Y, et al. Identification of two subpopulations of purified human blood B cells, CD27- CD23+ and CD27high CD80+, that strongly express cell surface Toll-like receptor 9 and secrete high levels of interleukin-6. Immunology. 2008;125:430-7 pubmed publisher
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Nakamura K, Miyazato A, Xiao G, Hatta M, Inden K, Aoyagi T, et al. Deoxynucleic acids from Cryptococcus neoformans activate myeloid dendritic cells via a TLR9-dependent pathway. J Immunol. 2008;180:4067-74 pubmed
Pegu A, Qin S, Fallert Junecko B, Nisato R, Pepper M, Reinhart T. Human lymphatic endothelial cells express multiple functional TLRs. J Immunol. 2008;180:3399-405 pubmed
Nakano S, Morimoto S, Suzuki J, Nozawa K, Amano H, Tokano Y, et al. Role of pathogenic auto-antibody production by Toll-like receptor 9 of B cells in active systemic lupus erythematosus. Rheumatology (Oxford). 2008;47:145-9 pubmed
Tran N, Koch A, Berkels R, Boehm O, Zacharowski P, Baumgarten G, et al. Toll-like receptor 9 expression in murine and human adrenal glands and possible implications during inflammation. J Clin Endocrinol Metab. 2007;92:2773-83 pubmed
Kindrachuk J, Potter J, Brownlie R, Ficzycz A, Griebel P, Mookherjee N, et al. Nucleic acids exert a sequence-independent cooperative effect on sequence-dependent activation of Toll-like receptor 9. J Biol Chem. 2007;282:13944-53 pubmed
Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
Ewaschuk J, Backer J, Churchill T, Obermeier F, Krause D, Madsen K. Surface expression of Toll-like receptor 9 is upregulated on intestinal epithelial cells in response to pathogenic bacterial DNA. Infect Immun. 2007;75:2572-9 pubmed
Palladino M, Johnson T, Gupta R, Chapman J, Ojha P. Members of the Toll-like receptor family of innate immunity pattern-recognition receptors are abundant in the male rat reproductive tract. Biol Reprod. 2007;76:958-64 pubmed
Lee J, Mo J, Katakura K, Alkalay I, Rucker A, Liu Y, et al. Maintenance of colonic homeostasis by distinctive apical TLR9 signalling in intestinal epithelial cells. Nat Cell Biol. 2006;8:1327-36 pubmed
Mansson A, Adner M, Cardell L. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res. 2006;7:36 pubmed
Lee J, Wu C, Lee K, Chuang T, Katakura K, Liu Y, et al. Activation of anti-hepatitis C virus responses via Toll-like receptor 7. Proc Natl Acad Sci U S A. 2006;103:1828-33 pubmed
Miller L, Sørensen O, Liu P, Jalian H, Eshtiaghpour D, Behmanesh B, et al. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005;174:6137-43 pubmed
Abel K, Wang Y, Fritts L, Sanchez E, Chung E, Fitzgerald Bocarsly P, et al. Deoxycytidyl-deoxyguanosine oligonucleotide classes A, B, and C induce distinct cytokine gene expression patterns in rhesus monkey peripheral blood mononuclear cells and distinct alpha interferon responses in TLR9-expressing rhesus monkey plasmacytoi. Clin Diagn Lab Immunol. 2005;12:606-21 pubmed
Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O. Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-8 pubmed
Greene C, Carroll T, Smith S, Taggart C, Devaney J, Griffin S, et al. TLR-induced inflammation in cystic fibrosis and non-cystic fibrosis airway epithelial cells. J Immunol. 2005;174:1638-46 pubmed
Lee H, Dunzendorfer S, Tobias P. Cytoplasmic domain-mediated dimerizations of toll-like receptor 4 observed by beta-lactamase enzyme fragment complementation. J Biol Chem. 2004;279:10564-74 pubmed
product information
Catalog Number :
NBP2-24907
Product Name :
Mouse Monoclonal TLR9 Antibody (26C593.2) [PE]
List Price :
369 USD
product type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
CD289, CD289 antigen, toll-like receptor 9
Buffer :
PBS
Clonality :
Monoclonal
Clone :
26C593.2
Conjugate :
PE
Application Summary :
Flow Cytometry, Immunocytochemistry/Immunofluorescence
Host :
Mouse
Immunogen :
This antibody was developed against KLH-conjugated synthetic peptide corresponding to amino acids 268-300 of human TLR9 isoform A (Genbank accession no. AAF78037).
Isotype :
IgG1 Kappa
Preservative :
0.05% Sodium Azide
Purity :
Protein G purified
CrossReactivity :
Canine, Equine, Human, Mouse, Primate, Rat
Storage :
Store at 4C in the dark.
Swissprot Human :
Q9NR96
Uses :
Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM sodium citrate buffer, pH 6.0 for 10-20 min followed by cooling at RT for 20 min. In human PBMC, a ~120 kDa band is observed. A smaller isoform, TLR9 isoform B (Genbank accession no. AAF72190) containing 975 amino acids may also be observed in some cases.
Research Area :
Cytokine Research, Immunology, Innate Immunity, Toll Like Receptors
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.