| Published Application/Species/Sample/Dilution | Reference |
|---|
- immunocytochemistry; human
| Wang K, Xiao J, Peng B, Xing F, So K, Tipoe G, et al. Retinal structure and function preservation by polysaccharides of wolfberry in a mouse model of retinal degeneration. Sci Rep. 2014;4:7601 pubmed publisher |
| Addison J, Koontz C, Fugett J, Creighton C, Chen D, Farrugia M, et al. KAP1 promotes proliferation and metastatic progression of breast cancer cells. Cancer Res. 2015;75:344-55 pubmed publisher |
| Li J, Setiawan M, Wu H, Beuerman R, Zhao P. Regulation of Toll-like receptor expression in human conjunctival epithelial cells. Mediators Inflamm. 2014;2014:493596 pubmed publisher |
| Chatterjee P, Chiasson V, Seerangan G, Tobin R, Kopriva S, Newell Rogers M, et al. Cotreatment with interleukin 4 and interleukin 10 modulates immune cells and prevents hypertension in pregnant mice. Am J Hypertens. 2015;28:135-42 pubmed publisher |
- immunohistochemistry - paraffin section; human
- immunocytochemistry; human
| Tengroth L, Millrud C, Kvarnhammar A, Kumlien Georén S, Latif L, Cardell L. Functional effects of Toll-like receptor (TLR)3, 7, 9, RIG-I and MDA-5 stimulation in nasal epithelial cells. PLoS ONE. 2014;9:e98239 pubmed publisher |
- immunocytochemistry; human
- western blot; human
| Ichikawa T, Sugiura H, Koarai A, Minakata Y, Kikuchi T, Morishita Y, et al. TLR3 activation augments matrix metalloproteinase production through reactive nitrogen species generation in human lung fibroblasts. J Immunol. 2014;192:4977-88 pubmed publisher |
| Pohar J, Pirher N, Bencina M, Mancek Keber M, Jerala R. The ectodomain of TLR3 receptor is required for its plasma membrane translocation. PLoS ONE. 2014;9:e92391 pubmed publisher |
- immunocytochemistry; human
| Hamidi S, Schäfer Korting M, Weindl G. TLR2/1 and sphingosine 1-phosphate modulate inflammation, myofibroblast differentiation and cell migration in fibroblasts. Biochim Biophys Acta. 2014;1841:484-94 pubmed publisher |
- immunohistochemistry - paraffin section; human
| Anagandula M, Richardson S, Oberste M, Sioofy Khojine A, Hyoty H, Morgan N, et al. Infection of human islets of Langerhans with two strains of Coxsackie B virus serotype 1: assessment of virus replication, degree of cell death and induction of genes involved in the innate immunity pathway. J Med Virol. 2014;86:1402-11 pubmed publisher |
- immunocytochemistry; mouse
| Fadnis P, Ravi V, Desai A, Turtle L, Solomon T. Innate immune mechanisms in Japanese encephalitis virus infection: effect on transcription of pattern recognition receptors in mouse neuronal cells and brain tissue. Viral Immunol. 2013;26:366-77 pubmed publisher |
| Menendez D, Shatz M, Azzam K, Garantziotis S, Fessler M, Resnick M. The Toll-like receptor gene family is integrated into human DNA damage and p53 networks. PLoS Genet. 2011;7:e1001360 pubmed publisher |
| Fukuda K, Watanabe T, Tokisue T, Tsujita T, Nishikawa S, Hasegawa T, et al. Modulation of double-stranded RNA recognition by the N-terminal histidine-rich region of the human toll-like receptor 3. J Biol Chem. 2008;283:22787-94 pubmed publisher |
| Ranjith Kumar C, Miller W, Sun J, Xiong J, Santos J, Yarbrough I, et al. Effects of single nucleotide polymorphisms on Toll-like receptor 3 activity and expression in cultured cells. J Biol Chem. 2007;282:17696-705 pubmed |
| Ranjith Kumar C, Miller W, Xiong J, Russell W, Lamb R, Santos J, et al. Biochemical and functional analyses of the human Toll-like receptor 3 ectodomain. J Biol Chem. 2007;282:7668-78 pubmed |
- immunohistochemistry - paraffin section; human
| Furrie E, Macfarlane S, Thomson G, Macfarlane G. Toll-like receptors-2, -3 and -4 expression patterns on human colon and their regulation by mucosal-associated bacteria. Immunology. 2005;115:565-74 pubmed |
| Francois S, El Benna J, Dang P, Pedruzzi E, Gougerot Pocidalo M, Elbim C. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol. 2005;174:3633-42 pubmed |
| Liu W, Wang Y, Liu S, Zhang X, Cao X, Jiang M. E3 Ubiquitin Ligase RNF13 Suppresses TLR Lysosomal Degradation by Promoting LAMP-1 Proteasomal Degradation. Adv Sci (Weinh). 2024;11:e2309560 pubmed publisher |
| Hiltunen N, Kemi N, V xe4 yrynen J, B xf6 hm J, Kauppila J, Huhta H, et al. Toll-like receptors 1-9 in small bowel neuroendocrine tumors-Clinical significance and prognosis. PLoS ONE. 2024;19:e0302813 pubmed publisher |
| Alaimo A, Genovesi S, Annesi N, De Felice D, Subedi S, Macchia A, et al. Sterile inflammation via TRPM8 RNA-dependent TLR3-NF-kB/IRF3 activation promotes antitumor immunity in prostate cancer. EMBO J. 2024;43:780-805 pubmed publisher |
| Haddaoui H, van Eijck C, Doukas M, van den Bosch T, van Koetsveld P, Hofland L, et al. Rintatolimod: a potential treatment in patients with pancreatic cancer expressing Toll-like receptor 3. Am J Cancer Res. 2023;13:2657-2669 pubmed |
| Xiao J, Huang J, Jian X, Wang H, Lan H, Liao Z, et al. IRE1α arm of unfolded protein response in muscle-specific TGF-β signaling-mediated regulation of muscle cell immunological properties. Cell Mol Biol Lett. 2023;28:15 pubmed publisher |
| Eskuri M, Kemi N, Helminen O, Huhta H, Kauppila J. Toll-like receptors 3, 7, 8, and 9 in gastric cancer. APMIS. 2023;131:92-99 pubmed publisher |
| Lam L, Dobkin J, Eckart K, Gereg I, DiSalvo A, Nolder A, et al. Bat Red Blood Cells Express Nucleic Acid-Sensing Receptors and Bind RNA and DNA. Immunohorizons. 2022;6:299-306 pubmed publisher |
| Stolberg Stolberg J, Boettcher A, Sambale M, Stuecker S, Sherwood J, Raschke M, et al. Toll-like receptor 3 activation promotes joint degeneration in osteoarthritis. Cell Death Dis. 2022;13:224 pubmed publisher |
| Su R, Cai L, Xiong P, Liu Z, Chen S, Liu X, et al. TLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma. J Inflamm Res. 2022;15:1437-1456 pubmed publisher |
| Wolpaw A, Grossmann L, Dessau J, Dong M, Aaron B, Brafford P, et al. Epigenetic state determines inflammatory sensing in neuroblastoma. Proc Natl Acad Sci U S A. 2022;119: pubmed publisher |
| Lincez P, Shanina I, Horwitz M. Changes in MDA5 and TLR3 Sensing of the Same Diabetogenic Virus Result in Different Autoimmune Disease Outcomes. Front Immunol. 2021;12:751341 pubmed publisher |
| Branchi V, Esser L, Boden C, Jafari A, Henn J, Lingohr P, et al. A Combined TLR7/TLR9/GATA3 Score Can Predict Prognosis in Biliary Tract Cancer. Diagnostics (Basel). 2021;11: pubmed publisher |
| Li Y, Chen X, Jin R, Chen L, Dang M, Cao H, et al. Injectable hydrogel with MSNs/microRNA-21-5p delivery enables both immunomodification and enhanced angiogenesis for myocardial infarction therapy in pigs. Sci Adv. 2021;7: pubmed publisher |
| Yoshida T, Miura T, Matsumiya T, Yoshida H, Morohashi H, Sakamoto Y, et al. Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer. Clin Exp Gastroenterol. 2020;13:427-438 pubmed publisher |
| Shang L, Deng D, Roffel S, Gibbs S. Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa. Contact Dermatitis. 2020;83:347-360 pubmed publisher |
| Ginting T, Christian S, Larasati Y, Suryatenggara J, Suriapranata I, Mathew G. Antiviral interferons induced by Newcastle disease virus (NDV) drive a tumor-selective apoptosis. Sci Rep. 2019;9:15160 pubmed publisher |
| Szollosi A, McDonald I, Szabó I, Meng J, van den Bogaard E, Steinhoff M. TLR3 in Chronic Human Itch: A Keratinocyte-Associated Mechanism of Peripheral Itch Sensitization. J Invest Dermatol. 2019;139:2393-2396.e6 pubmed publisher |
| Igase M, Shousu K, Fujiki N, Sakurai M, Bonkobara M, Hwang C, et al. Anti-tumour activity of oncolytic reovirus against canine histiocytic sarcoma cells. Vet Comp Oncol. 2019;17:184-193 pubmed publisher |
| Gao X, Gao S, Guan Y, Huang L, Huang J, Lin L, et al. Toll-like receptor 3 controls QT interval on the electrocardiogram by targeting the degradation of Kv4.2/4.3 channels in the endoplasmic reticulum. FASEB J. 2019;33:6197-6208 pubmed publisher |
| Regel I, Raulefs S, Benitz S, Mihaljevic C, Rieder S, Leinenkugel G, et al. Loss of TLR3 and its downstream signaling accelerates acinar cell damage in the acute phase of pancreatitis. Pancreatology. 2019;19:149-157 pubmed publisher |
| Zhu J, Message S, Mallia P, Kebadze T, Contoli M, Ward C, et al. Bronchial mucosal IFN-α/β and pattern recognition receptor expression in patients with experimental rhinovirus-induced asthma exacerbations. J Allergy Clin Immunol. 2019;143:114-125.e4 pubmed publisher |
| Gu R, Ding M, Shi D, Huang T, Guo M, Yu L, et al. Calcium/Calmodulin-Dependent Protein Kinase IV Mediates IFN-γ-Induced Immune Behaviors in Skeletal Muscle Cells. Cell Physiol Biochem. 2018;46:351-364 pubmed publisher |
| Zou H, Su R, Ruan J, Shao H, Qian K, Ye J, et al. Toll-like receptor 3 pathway restricts Marek's disease virus infection. Oncotarget. 2017;8:70847-70853 pubmed publisher |
| Auger J, Santinón A, Roy D, Mossman K, Xu J, Segura M, et al. Type I Interferon Induced by Streptococcus suis Serotype 2 is Strain-Dependent and May Be Beneficial for Host Survival. Front Immunol. 2017;8:1039 pubmed publisher |
| Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell L. Substance P represents a novel first-line defense mechanism in the nose. J Allergy Clin Immunol. 2018;141:128-136.e3 pubmed publisher |
| Brempelis K, Yuen S, Schwarz N, Mohar I, Crispe I. Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury. Hepatology. 2017;65:1336-1351 pubmed publisher |
| Helminen O, Huhta H, Kauppila J, Lehenkari P, Saarnio J, Karttunen T. Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas. APMIS. 2017;125:85-92 pubmed publisher |
| Helminen O, Huhta H, Lehenkari P, Saarnio J, Karttunen T, Kauppila J. Nucleic acid-sensing toll-like receptors 3, 7 and 8 in esophageal epithelium, barrett's esophagus, dysplasia and adenocarcinoma. Oncoimmunology. 2016;5:e1127495 pubmed publisher |
| Huhta H, Helminen O, Kauppila J, Salo T, Porvari K, Saarnio J, et al. The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer. J Histochem Cytochem. 2016;64:470-82 pubmed publisher |
| Silva Barrios S, Smans M, Duerr C, Qureshi S, Fritz J, Descoteaux A, et al. Innate Immune B Cell Activation by Leishmania donovani Exacerbates Disease and Mediates Hypergammaglobulinemia. Cell Rep. 2016;15:2427-37 pubmed publisher |
| Evangelista M, Castro S, Alves C, Dias A, Souza V, Reis L, et al. Early IFN-? production together with decreased expression of TLR3 and TLR9 characterizes EAE development conditional on the presence of myelin. Autoimmunity. 2016;49:258-67 pubmed publisher |
| Yang Y, Wang S, Huang Z, Zou H, Yan B, Luo W, et al. The RNA-binding protein Mex3B is a coreceptor of Toll-like receptor 3 in innate antiviral response. Cell Res. 2016;26:288-303 pubmed publisher |
| Reins R, Baidouri H, McDermott A. Vitamin D Activation and Function in Human Corneal Epithelial Cells During TLR-Induced Inflammation. Invest Ophthalmol Vis Sci. 2015;56:7715-27 pubmed publisher |
| Jamin A, Dehoux L, Dossier C, Fila M, Heming N, Monteiro R, et al. Toll-like receptor 3 expression and function in childhood idiopathic nephrotic syndrome. Clin Exp Immunol. 2015;182:332-45 pubmed publisher |
| Tengroth L, Arebro J, Kumlien Geor n S, Winqvist O, Cardell L. Deprived TLR9 expression in apparently healthy nasal mucosa might trigger polyp-growth in chronic rhinosinusitis patients. PLoS ONE. 2014;9:e105618 pubmed publisher |
| Green T, Santos M, Ejaeidi A, Craft B, Lewis R, Cruse J. Toll-like receptor (TLR) expression of immune system cells from metastatic breast cancer patients with circulating tumor cells. Exp Mol Pathol. 2014;97:44-8 pubmed publisher |
| Østvik A, Granlund A, Torp S, Flatberg A, Beisvag V, Waldum H, et al. Expression of Toll-like receptor-3 is enhanced in active inflammatory bowel disease and mediates the excessive release of lipocalin 2. Clin Exp Immunol. 2013;173:502-11 pubmed publisher |
| Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher |
| Yan K, Zhu W, Yu L, Li N, Zhang X, Liu P, et al. Toll-like receptor 3 and RIG-I-like receptor activation induces innate antiviral responses in mouse ovarian granulosa cells. Mol Cell Endocrinol. 2013;372:73-85 pubmed publisher |
| Pohar J, Pirher N, Bencina M, Mancek Keber M, Jerala R. The role of UNC93B1 protein in surface localization of TLR3 receptor and in cell priming to nucleic acid agonists. J Biol Chem. 2013;288:442-54 pubmed publisher |
| Yamashita M, Chattopadhyay S, Fensterl V, Saikia P, Wetzel J, Sen G. Epidermal growth factor receptor is essential for Toll-like receptor 3 signaling. Sci Signal. 2012;5:ra50 pubmed publisher |
| Kleinman M, Kaneko H, Cho W, Dridi S, Fowler B, Blandford A, et al. Short-interfering RNAs induce retinal degeneration via TLR3 and IRF3. Mol Ther. 2012;20:101-8 pubmed publisher |
| Kuznik A, Bencina M, Svajger U, Jeras M, Rozman B, Jerala R. Mechanism of endosomal TLR inhibition by antimalarial drugs and imidazoquinolines. J Immunol. 2011;186:4794-804 pubmed publisher |
| Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher |
| Peltier D, Simms A, Farmer J, Miller D. Human neuronal cells possess functional cytoplasmic and TLR-mediated innate immune pathways influenced by phosphatidylinositol-3 kinase signaling. J Immunol. 2010;184:7010-21 pubmed publisher |
| Taura M, Fukuda R, Suico M, Eguma A, Koga T, Shuto T, et al. TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. Cancer Sci. 2010;101:1610-7 pubmed publisher |
| Johnston M, Wang A, Catarino M, Ball L, Phan V, MacDonald J, et al. Extracts of the rat tapeworm, Hymenolepis diminuta, suppress macrophage activation in vitro and alleviate chemically induced colitis in mice. Infect Immun. 2010;78:1364-75 pubmed publisher |
| Ménager P, Roux P, Mégret F, Bourgeois J, Le Sourd A, Danckaert A, et al. Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. PLoS Pathog. 2009;5:e1000315 pubmed publisher |
| Sacre S, Lo A, Gregory B, Simmonds R, Williams L, Feldmann M, et al. Inhibitors of TLR8 reduce TNF production from human rheumatoid synovial membrane cultures. J Immunol. 2008;181:8002-9 pubmed |
| Taura M, Eguma A, Suico M, Shuto T, Koga T, Komatsu K, et al. p53 regulates Toll-like receptor 3 expression and function in human epithelial cell lines. Mol Cell Biol. 2008;28:6557-67 pubmed publisher |
| Cohen P, Koski G, Czerniecki B, Bunting K, Fu X, Wang Z, et al. STAT3- and STAT5-dependent pathways competitively regulate the pan-differentiation of CD34pos cells into tumor-competent dendritic cells. Blood. 2008;112:1832-43 pubmed publisher |
| Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher |
| Kleinman M, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452:591-7 pubmed publisher |
| Kim H, Yang E, Lee J, Kim S, Shin J, Park J, et al. Double-stranded RNA mediates interferon regulatory factor 3 activation and interleukin-6 production by engaging Toll-like receptor 3 in human brain astrocytes. Immunology. 2008;124:480-8 pubmed publisher |
| Duffy K, Lamb R, San Mateo L, Jordan J, Canziani G, Brigham Burke M, et al. Down modulation of human TLR3 function by a monoclonal antibody. Cell Immunol. 2007;248:103-14 pubmed |
| Morikawa T, Sugiyama A, Kume H, Ota S, Kashima T, Tomita K, et al. Identification of Toll-like receptor 3 as a potential therapeutic target in clear cell renal cell carcinoma. Clin Cancer Res. 2007;13:5703-9 pubmed |
| Lundberg A, Drexler S, Monaco C, Williams L, Sacre S, Feldmann M, et al. Key differences in TLR3/poly I:C signaling and cytokine induction by human primary cells: a phenomenon absent from murine cell systems. Blood. 2007;110:3245-52 pubmed |
| Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed |
| Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed |
| Johnsen I, Nguyen T, Ringdal M, Tryggestad A, Bakke O, Lien E, et al. Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling. EMBO J. 2006;25:3335-46 pubmed |
| Yang X, Murthy V, Schultz K, Tatro J, Fitzgerald K, Beasley D. Toll-like receptor 3 signaling evokes a proinflammatory and proliferative phenotype in human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;291:H2334-43 pubmed |
| Sun J, Duffy K, Ranjith Kumar C, Xiong J, Lamb R, Santos J, et al. Structural and functional analyses of the human Toll-like receptor 3. Role of glycosylation. J Biol Chem. 2006;281:11144-51 pubmed |
| LeBouder E, Rey Nores J, Raby A, Affolter M, Vidal K, Thornton C, et al. Modulation of neonatal microbial recognition: TLR-mediated innate immune responses are specifically and differentially modulated by human milk. J Immunol. 2006;176:3742-52 pubmed |
| Mansson A, Adner M, Cardell L. Toll-like receptors in cellular subsets of human tonsil T cells: altered expression during recurrent tonsillitis. Respir Res. 2006;7:36 pubmed |
| Groskreutz D, Monick M, Powers L, Yarovinsky T, Look D, Hunninghake G. Respiratory syncytial virus induces TLR3 protein and protein kinase R, leading to increased double-stranded RNA responsiveness in airway epithelial cells. J Immunol. 2006;176:1733-40 pubmed |
| Qi H, Shelhamer J. Toll-like receptor 4 signaling regulates cytosolic phospholipase A2 activation and lipid generation in lipopolysaccharide-stimulated macrophages. J Biol Chem. 2005;280:38969-75 pubmed |
| de Bouteiller O, Merck E, Hasan U, Hubac S, Benguigui B, Trinchieri G, et al. Recognition of double-stranded RNA by human toll-like receptor 3 and downstream receptor signaling requires multimerization and an acidic pH. J Biol Chem. 2005;280:38133-45 pubmed |
| Schneeman T, Bruno M, Schjerven H, Johansen F, Chady L, Kaetzel C. Regulation of the polymeric Ig receptor by signaling through TLRs 3 and 4: linking innate and adaptive immune responses. J Immunol. 2005;175:376-84 pubmed |
| Ueta M, Hamuro J, Kiyono H, Kinoshita S. Triggering of TLR3 by polyI:C in human corneal epithelial cells to induce inflammatory cytokines. Biochem Biophys Res Commun. 2005;331:285-94 pubmed |
| Li K, Chen Z, Kato N, Gale M, Lemon S. Distinct poly(I-C) and virus-activated signaling pathways leading to interferon-beta production in hepatocytes. J Biol Chem. 2005;280:16739-47 pubmed |
| Harii N, Lewis C, Vasko V, McCall K, Benavides Peralta U, Sun X, et al. Thyrocytes express a functional toll-like receptor 3: overexpression can be induced by viral infection and reversed by phenylmethimazole and is associated with Hashimoto's autoimmune thyroiditis. Mol Endocrinol. 2005;19:1231-50 pubmed |
| Funami K, Matsumoto M, Oshiumi H, Akazawa T, Yamamoto A, Seya T. The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int Immunol. 2004;16:1143-54 pubmed |
| Wen L, Peng J, Li Z, Wong F. The effect of innate immunity on autoimmune diabetes and the expression of Toll-like receptors on pancreatic islets. J Immunol. 2004;172:3173-80 pubmed |
| Matsumoto M, Funami K, Tanabe M, Oshiumi H, Shingai M, Seto Y, et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J Immunol. 2003;171:3154-62 pubmed |
