Delta Np73 Antibody (38C674.2) - BSA Free | Novus Biologicals NBP2-24873 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Delta Np73 Antibody (38C674.2) - BSA Free

catalog :

NBP2-24873

quantity :

0.1 mg (also 0.025 mg)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

DyLight 405

clone name :

38C674.2

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 41

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; loading ...; fig 3d	Malik N, Yan H, Yang H, Ayaz G, DuBois W, Tseng Y, et al. CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PLoS Genet. 2021;17:e1009553 pubmed publisher
immunohistochemistry - paraffin section; human	Hassan H, Dave B, Singh R. TP73, an under-appreciated player in non-Hodgkin lymphoma pathogenesis and management. Curr Mol Med. 2014;14:432-9 pubmed
immunohistochemistry - paraffin section; human	Hassan H, Varney M, Jain S, Weisenburger D, Singh R, Dave B. Disruption of chromosomal locus 1p36 differentially modulates TAp73 and ΔNp73 expression in follicular lymphoma. Leuk Lymphoma. 2014;55:2924-31 pubmed publisher
immunocytochemistry; human	Shin A, Joo J, Bak J, Yang H, Kim J, Park S, et al. Site-specific risk factors for colorectal cancer in a Korean population. PLoS ONE. 2011;6:e23196 pubmed publisher
chromatin immunoprecipitation; human	Rastogi S, Rizwani W, Joshi B, Kunigal S, Chellappan S. TNF-? response of vascular endothelial and vascular smooth muscle cells involve differential utilization of ASK1 kinase and p73. Cell Death Differ. 2012;19:274-83 pubmed publisher
western blot; human	Lefkimmiatis K, Caratozzolo M, Merlo P, D Erchia A, Navarro B, Levrero M, et al. p73 and p63 sustain cellular growth by transcriptional activation of cell cycle progression genes. Cancer Res. 2009;69:8563-71 pubmed publisher
western blot; mouse	Tomasini R, Tsuchihara K, Wilhelm M, Fujitani M, Rufini A, Cheung C, et al. TAp73 knockout shows genomic instability with infertility and tumor suppressor functions. Genes Dev. 2008;22:2677-91 pubmed publisher
western blot; human	Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008;112:2450-62 pubmed publisher
western blot; rat	Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa N, et al. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain. 2008;131:2425-42 pubmed publisher
western blot; human	Righetti S, Perego P, Carenini N, Zunino F. Cooperation between p53 and p73 in cisplatin-induced apoptosis in ovarian carcinoma cells. Cancer Lett. 2008;263:140-4 pubmed publisher
immunohistochemistry - frozen section; human	Dominguez G, Garcia J, Peña C, Silva J, Garcia V, Martínez L, et al. DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1. J Clin Oncol. 2006;24:805-15 pubmed
immunohistochemistry - paraffin section; rat western blot; rat	Saifudeen Z, Diavolitsis V, Stefkova J, Dipp S, Fan H, El Dahr S. Spatiotemporal switch from DeltaNp73 to TAp73 isoforms during nephrogenesis: impact on differentiation gene expression. J Biol Chem. 2005;280:23094-102 pubmed
immunocytochemistry; human western blot; human	Sayan A, Paradisi A, Vojtesek B, Knight R, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005;330:186-93 pubmed
western blot; human	Vossio S, Palescandolo E, Pediconi N, Moretti F, Balsano C, Levrero M, et al. DN-p73 is activated after DNA damage in a p53-dependent manner to regulate p53-induced cell cycle arrest. Oncogene. 2002;21:3796-803 pubmed
	Zhao L, Hsiao T, Stonesifer C, Daniels J, Garcia Saleem T, Choi J, et al. The Robust Tumoricidal Effects of Combined BET/HDAC Inhibition in Cutaneous T-Cell Lymphoma Can Be Reproduced by ΔNp73 Depletion. J Invest Dermatol. 2022;142:3253-3261.e4 pubmed publisher
	Pham T, Fan C, Pfeifer D, Zhang H, Sun X. Image-Based Network Analysis of DNp73 Expression by Immunohistochemistry in Rectal Cancer Patients. Front Physiol. 2019;10:1551 pubmed publisher
	Guo J, Jia R. Splicing factor poly(rC)-binding protein 1 is a novel and distinctive tumor suppressor. J Cell Physiol. 2018;234:33-41 pubmed publisher
	Yang L, Yang X, Tang Y, Zhang D, Zhu L, Wang S, et al. Inhibition of DNA‑PK activity sensitizes A549 cells to X‑ray irradiation by inducing the ATM‑dependent DNA damage response. Mol Med Rep. 2018;17:7545-7552 pubmed publisher
	Gonzalez R, De La Rosa A, Rufini A, Rodríguez Hernández M, Navarro Villarán E, Marchal T, et al. Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. PLoS ONE. 2017;12:e0174326 pubmed publisher
	Morandi E, Verstappen R, Zwierzina M, Geley S, Pierer G, Ploner C. ITGAV and ITGA5 diversely regulate proliferation and adipogenic differentiation of human adipose derived stem cells. Sci Rep. 2016;6:28889 pubmed publisher
	Prabhu V, Hong B, Allen J, Zhang S, Lulla A, Dicker D, et al. Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated Î”Np73 Inhibition and p73 Activation. Cancer Res. 2016;76:1989-99 pubmed publisher
	Veselska R, Neradil J, Nekulova M, Dobrucka L, Vojtesek B, Sterba J, et al. Intracellular distribution of the ?Np73 protein isoform in medulloblastoma cells: a study with newly generated rabbit polyclonal antibodies. Histol Histopathol. 2013;28:913-24 pubmed publisher
	Leonard M, Kommagani R, Payal V, Mayo L, Shamma H, Kadakia M. ?Np63? regulates keratinocyte proliferation by controlling PTEN expression and localization. Cell Death Differ. 2011;18:1924-33 pubmed publisher
	Accardi R, Scalise M, Gheit T, Hussain I, Yue J, Carreira C, et al. IkappaB kinase beta promotes cell survival by antagonizing p53 functions through DeltaNp73alpha phosphorylation and stabilization. Mol Cell Biol. 2011;31:2210-26 pubmed publisher
	Nekulova M, Zitterbart K, Sterba J, Veselska R. Analysis of the intracellular localization of p73 N-terminal protein isoforms TAp73 and ?Np73 in medulloblastoma cell lines. J Mol Histol. 2010;41:267-75 pubmed publisher
	Vilgelm A, Washington M, Wei J, Chen H, Prassolov V, Zaika A. Interactions of the p53 protein family in cellular stress response in gastrointestinal tumors. Mol Cancer Ther. 2010;9:693-705 pubmed publisher
	Wilhelm M, Rufini A, Wetzel M, Tsuchihara K, Inoue S, Tomasini R, et al. Isoform-specific p73 knockout mice reveal a novel role for delta Np73 in the DNA damage response pathway. Genes Dev. 2010;24:549-60 pubmed publisher
	Rosenbluth J, Johnson K, Tang L, Triplett T, Pietenpol J. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009;8:3702-6 pubmed
	Sari Y, Smith K, Ali P, Rebec G. Upregulation of GLT1 attenuates cue-induced reinstatement of cocaine-seeking behavior in rats. J Neurosci. 2009;29:9239-43 pubmed publisher
	Marqués García F, Ferrandiz N, Fernández Alonso R, González Cano L, Herreros Villanueva M, Rosa Garrido M, et al. p73 plays a role in erythroid differentiation through GATA1 induction. J Biol Chem. 2009;284:21139-56 pubmed publisher
	Rosenbluth J, Mays D, Pino M, Tang L, Pietenpol J. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008;28:5951-64 pubmed publisher
	Mor I, Bruck T, Greenberg D, Berson A, Schreiber L, Grisaru D, et al. Alternate AChE-R variants facilitate cellular metabolic activity and resistance to genotoxic stress through enolase and RACK1 interactions. Chem Biol Interact. 2008;175:11-21 pubmed publisher
	Mor I, Sklan E, Podoly E, Pick M, Kirschner M, Yogev L, et al. Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med. 2008;12:479-95 pubmed publisher
	Zitterbart K, Zavrelova I, Kadlecova J, Spesna R, Kratochvilova A, Pavelka Z, et al. p73 expression in medulloblastoma: TAp73/DeltaNp73 transcript detection and possible association of p73alpha/DeltaNp73 immunoreactivity with survival. Acta Neuropathol. 2007;114:641-50 pubmed
	Castellino R, De Bortoli M, Lin L, Skapura D, Rajan J, Adesina A, et al. Overexpressed TP73 induces apoptosis in medulloblastoma. BMC Cancer. 2007;7:127 pubmed
	Toscano F, Parmentier B, Fajoui Z, Estornes Y, Chayvialle J, Saurin J, et al. p53 dependent and independent sensitivity to oxaliplatin of colon cancer cells. Biochem Pharmacol. 2007;74:392-406 pubmed
	Bozzetti C, Nizzoli R, Musolino A, Martella E, Crafa P, Lagrasta C, et al. p73 and p53 pathway in human breast cancers. J Clin Oncol. 2007;25:1451-3; author reply 1453-4 pubmed
	Cabrera Socorro A, Pueyo Morlans M, Suarez Sola M, Gonzalez Delgado F, Castañeyra Perdomo A, Marin M, et al. Multiple isoforms of the tumor protein p73 are expressed in the adult human telencephalon and choroid plexus and present in the cerebrospinal fluid. Eur J Neurosci. 2006;23:2109-18 pubmed
	Papoutsaki M, Lanza M, Marinari B, Nistico S, Moretti F, Levrero M, et al. The p73 gene is an anti-tumoral target of the RARbeta/gamma-selective retinoid tazarotene. J Invest Dermatol. 2004;123:1162-8 pubmed
	Tomkova K, Belkhiri A, El Rifai W, Zaika A. p73 isoforms can induce T-cell factor-dependent transcription in gastrointestinal cells. Cancer Res. 2004;64:6390-3 pubmed
	Lunghi P, Costanzo A, Levrero M, Bonati A. Treatment with arsenic trioxide (ATO) and MEK1 inhibitor activates the p73-p53AIP1 apoptotic pathway in leukemia cells. Blood. 2004;104:519-25 pubmed

product information

master code :

NBP2-24873

SKU :

NBP2-24873

product name :

Delta Np73 Antibody (38C674.2) - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The Delta Np73 Antibody (38C674.2) - BSA Free from Novus is a mouse monoclonal antibody to Delta Np73. This antibody reacts with human,mouse,rat. The Delta Np73 Antibody (38C674.2) - BSA Free has been validated for the following applications: Immunoprecipitation,Chemotaxis,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP).

target :

Delta Np73

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

38C674.2

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

This antibody was developed against a peptide corresponding to a portion of amino acid residues 1-50 of human dNp73. Mouse and human sequences are more than 95 % identical at these amino acid residues. In mouse, alanine at position 8 is replaced by methionine.

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Rat

gene symbol :

TP73

accessionNumbers :

O15350

applications :

Immunoprecipitation,Chemotaxis,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Chromatin Immunoprecipitation (ChIP)

USD :

409 USD

alt names :

p53-related protein, p73, tumor protein p73

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage