product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TLR5 Antibody (19D759.2) - BSA Free
catalog :
NBP2-24787
quantity :
0.1 mg (also 0.025 mg)
price :
399 USD
clonality :
monoclonal
host :
mouse
conjugate :
DyLight 550
clone name :
19D759.2
reactivity :
human, mouse, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, dot blot
more info or order :
Novus Biologicals product webpage
citations: 40
Published Application/Species/Sample/DilutionReference
  • flow cytometry; human; fig 3c
Carevic M, Oz H, Fuchs K, Laval J, Schroth C, Frey N, et al. CXCR1 Regulates Pulmonary Anti-Pseudomonas Host Defense. J Innate Immun. 2016;8:362-73 pubmed publisher
  • immunohistochemistry - paraffin section; human
Jouhi L, Datta N, Renkonen S, Atula T, Mäkitie A, Haglund C, et al. Expression of toll-like receptors in HPV-positive and HPV-negative oropharyngeal squamous cell carcinoma--an in vivo and in vitro study. Tumour Biol. 2015;36:7755-64 pubmed publisher
  • immunohistochemistry - paraffin section; human
Mäkinen L, Atula T, Häyry V, Jouhi L, Datta N, Lehtonen S, et al. Predictive role of Toll-like receptors 2, 4, and 9 in oral tongue squamous cell carcinoma. Oral Oncol. 2015;51:96-102 pubmed publisher
  • immunohistochemistry - paraffin section; human
Helminen O, Huhta H, Takala H, Lehenkari P, Saarnio J, Kauppila J, et al. Increased Toll-like receptor 5 expression indicates esophageal columnar dysplasia. Virchows Arch. 2014;464:11-8 pubmed publisher
  • immunohistochemistry - paraffin section; human
  • immunocytochemistry; human
  • western blot; human
Grimm M, Munz A, Exarchou A, Polligkeit J, Reinert S. Immunohistochemical detection of Helicobacter pylori without association of TLR5 expression in oral squamous cell carcinoma. J Oral Pathol Med. 2014;43:35-44 pubmed publisher
  • western blot; human
Kato K, Lillehoj E, Park Y, Umehara T, Hoffman N, Madesh M, et al. Membrane-tethered MUC1 mucin is phosphorylated by epidermal growth factor receptor in airway epithelial cells and associates with TLR5 to inhibit recruitment of MyD88. J Immunol. 2012;188:2014-22 pubmed publisher
  • immunohistochemistry - paraffin section; human
Deng J, Ma Krupa W, Gewirtz A, Younge B, Goronzy J, Weyand C. Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res. 2009;104:488-95 pubmed publisher
  • western blot; mouse
Ha H, Lee J, Kim H, Kwak H, Kim H, Lee S, et al. Stimulation by TLR5 modulates osteoclast differentiation through STAT1/IFN-beta. J Immunol. 2008;180:1382-9 pubmed
Hiltunen N, Kemi N, V xe4 yrynen J, B xf6 hm J, Kauppila J, Huhta H, et al. Toll-like receptors 1-9 in small bowel neuroendocrine tumors-Clinical significance and prognosis. PLoS ONE. 2024;19:e0302813 pubmed publisher
Eskuri M, Kemi N, Helminen O, Huhta H, Kauppila J. Toll-like receptors 1, 2, 4, 5, and 6 in gastric cancer. Virchows Arch. 2023;: pubmed publisher
Qiu C, Wang J, Zhu L, Cheng X, Xia B, Jin Y, et al. Improving the ex vivo expansion of human tumor-reactive CD8 + T cells by targeting toll-like receptors. Front Bioeng Biotechnol. 2022;10:1027619 pubmed publisher
Beilmann Lehtonen I, Hagstrom J, Mustonen H, Koskensalo S, Haglund C, Böckelman C. High Tissue TLR5 Expression Predicts Better Outcomes in Colorectal Cancer Patients. Oncology. 2021;99:589-600 pubmed publisher
Kairaluoma V, Kemi N, Huhta H, Pohjanen V, Helminen O. Toll-like receptor 5 and 8 in hepatocellular carcinoma. APMIS. 2021;129:470-479 pubmed publisher
Kitaura A, Nishinaka T, Hamasaki S, Hatipoglu O, Wake H, Nishibori M, et al. Advanced glycation end-products reduce lipopolysaccharide uptake by macrophages. PLoS ONE. 2021;16:e0245957 pubmed publisher
Shang L, Deng D, Roffel S, Gibbs S. Differential influence of Streptococcus mitis on host response to metals in reconstructed human skin and oral mucosa. Contact Dermatitis. 2020;83:347-360 pubmed publisher
Kylmä A, Tolvanen T, Carpén T, Haglund C, Mäkitie A, Mattila P, et al. Elevated TLR5 expression in vivo and loss of NF-κΒ activation via TLR5 in vitro detected in HPV-negative oropharyngeal squamous cell carcinoma. Exp Mol Pathol. 2020;114:104435 pubmed publisher
Kasurinen A, Hagstrom J, Laitinen A, Kokkola A, Böckelman C, Haglund C. Evaluation of toll-like receptors as prognostic biomarkers in gastric cancer: high tissue TLR5 predicts a better outcome. Sci Rep. 2019;9:12553 pubmed publisher
Lanki M, Seppänen H, Mustonen H, Hagstrom J, Haglund C. Toll-like receptor 1 predicts favorable prognosis in pancreatic cancer. PLoS ONE. 2019;14:e0219245 pubmed publisher
Ruuskanen M, Leivo I, Minn H, Vahlberg T, Haglund C, Hagstrom J, et al. Expression of toll-like receptors in non-endemic nasopharyngeal carcinoma. BMC Cancer. 2019;19:624 pubmed publisher
Haeggblom L, Näsman A, Ramqvist T, Haglund C, Hagstrom J, Mäkitie A, et al. TLR5 and TLR7 are differentially expressed in human papillomavirus-positive and negative base of tongue squamous cell carcinoma, and TLR7 may have an independent prognostic influence. Acta Otolaryngol. 2019;139:206-210 pubmed publisher
Kylmä A, Jouhi L, Listyarifah D, Mohamed H, Mäkitie A, Remes S, et al. Treponema denticola chymotrypsin-like protease as associated with HPV-negative oropharyngeal squamous cell carcinoma. Br J Cancer. 2018;119:89-95 pubmed publisher
Listyarifah D, Nieminen M, M xe4 kinen L, Haglund C, Grenier D, H xe4 yry V, et al. Treponema denticola chymotrypsin-like proteinase is present in early-stage mobile tongue squamous cell carcinoma and related to the clinicopathological features. J Oral Pathol Med. 2018;47:764-772 pubmed publisher
Na B, Hoang T, Kim J. Hsp90 Inhibition Reduces TLR5 Surface Expression and NF-κB Activation in Human Myeloid Leukemia THP-1 Cells. Biomed Res Int. 2018;2018:4319369 pubmed publisher
Larsson O, Tengroth L, Xu Y, Uddman R, Kumlien Georén S, Cardell L. Substance P represents a novel first-line defense mechanism in the nose. J Allergy Clin Immunol. 2018;141:128-136.e3 pubmed publisher
Helminen O, Huhta H, Leppänen J, Kauppila J, Takala H, Lehenkari P, et al. Nuclear localization of Toll-like receptor 5 in Barrett's esophagus and esophageal adenocarcinoma is associated with metastatic behavior. Virchows Arch. 2016;469:465-70 pubmed publisher
Huhta H, Helminen O, Kauppila J, Salo T, Porvari K, Saarnio J, et al. The Expression of Toll-like Receptors in Normal Human and Murine Gastrointestinal Organs and the Effect of Microbiome and Cancer. J Histochem Cytochem. 2016;64:470-82 pubmed publisher
Jeon Y, Kim C, Koh J, Chung D, Ha G. Pellino-1 confers chemoresistance in lung cancer cells by upregulating cIAP2 through Lys63-mediated polyubiquitination. Oncotarget. 2016;7:41811-41824 pubmed publisher
Renkonen J, Toppila Salmi S, Joenväärä S, Mattila P, Parviainen V, Hagström J, et al. Expression of Toll-like receptors in nasal epithelium in allergic rhinitis. APMIS. 2015;123:716-25 pubmed publisher
Uchida M, Oyanagi E, Kawanishi N, Iemitsu M, Miyachi M, Kremenik M, et al. Exhaustive exercise increases the TNF-? production in response to flagellin via the upregulation of toll-like receptor 5 in the large intestine in mice. Immunol Lett. 2014;158:151-8 pubmed publisher
Kauppila J, Mattila A, Karttunen T, Salo T. Toll-like receptor 5 (TLR5) expression is a novel predictive marker for recurrence and survival in squamous cell carcinoma of the tongue. Br J Cancer. 2013;108:638-43 pubmed publisher
Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
Smith N, Varley C, Eardley I, Feather S, Trejdosiewicz L, Southgate J. Toll-like receptor responses of normal human urothelial cells to bacterial flagellin and lipopolysaccharide. J Urol. 2011;186:1084-92 pubmed publisher
Faham A, Altin J. Antigen-containing liposomes engrafted with flagellin-related peptides are effective vaccines that can induce potent antitumor immunity and immunotherapeutic effect. J Immunol. 2010;185:1744-54 pubmed publisher
Wu J, Meng Z, Jiang M, Zhang E, Trippler M, Broering R, et al. Toll-like receptor-induced innate immune responses in non-parenchymal liver cells are cell type-specific. Immunology. 2010;129:363-74 pubmed publisher
Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
Fukata M, Breglio K, Chen A, Vamadevan A, Goo T, Hsu D, et al. The myeloid differentiation factor 88 (MyD88) is required for CD4+ T cell effector function in a murine model of inflammatory bowel disease. J Immunol. 2008;180:1886-94 pubmed
Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
Crellin N, Garcia R, Hadisfar O, Allan S, Steiner T, Levings M. Human CD4+ T cells express TLR5 and its ligand flagellin enhances the suppressive capacity and expression of FOXP3 in CD4+CD25+ T regulatory cells. J Immunol. 2005;175:8051-9 pubmed
Miller L, Sørensen O, Liu P, Jalian H, Eshtiaghpour D, Behmanesh B, et al. TGF-alpha regulates TLR expression and function on epidermal keratinocytes. J Immunol. 2005;174:6137-43 pubmed
Francois S, El Benna J, Dang P, Pedruzzi E, Gougerot Pocidalo M, Elbim C. Inhibition of neutrophil apoptosis by TLR agonists in whole blood: involvement of the phosphoinositide 3-kinase/Akt and NF-kappaB signaling pathways, leading to increased levels of Mcl-1, A1, and phosphorylated Bad. J Immunol. 2005;174:3633-42 pubmed
product information
master code :
NBP2-24787
SKU :
NBP2-24787
product name :
TLR5 Antibody (19D759.2) - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The TLR5 Antibody (19D759.2) - BSA Free from Novus is a mouse monoclonal antibody to TLR5. This antibody reacts with canine,human,mouse. The TLR5 Antibody (19D759.2) - BSA Free has been validated for the following applications: Western Blot,Flow Cytometry,Block/Neutralize,Cytometric Bead Assay Standard,Flow Cytometry Control,IF/IHC,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Frozen,Dot Blot,Flow (Intracellular).
target :
TLR5
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
19D759.2
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This antibody was developed against KLH-conjugated synthetic peptide corresponding to a portion of human TLR5 between amino acids 700-800. The antibody also reacts with mouse TLR5.
isotype :
IgG2a Kappa
purity :
Protein G purified
species :
Canine,Human,Mouse
gene symbol :
TLR5
Antibody validation :
Biological Validation
applications :
Flow Cytometry,Block/Neutralize,Cytometric Bead Assay Standard,Flow Cytometry Control,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Flow (Cell Surface),Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Frozen,Dot Blot,Flow (Intracellular)
USD :
399 USD
alt names :
MGC126430, MGC126431, SLEB1FLJ10052, TIL3Toll/interleukin-1 receptor-like protein 3, toll-like receptor 5
storage :
Store at -20C. Avoid freeze-thaw cycles.
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.