Rat Monoclonal TLR4 Antibody (MTS510) [PE] | Novus Biologicals NBP2-24741 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Rat Monoclonal TLR4 Antibody (MTS510) [PE]

catalog :

NBP2-24741

quantity :

0.1 ml

price :

369 USD

clonality :

monoclonal

host :

rat

conjugate :

clone name :

MTS510

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse	Ma C, Shi G, Shi C, Kao Y, Lin S, Wu H. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012;188:6328-37 pubmed publisher
western blot; mouse	Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, et al. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochem Biophys Res Commun. 2010;396:721-5 pubmed publisher
flow cytometry; mouse	Macedo G, Magnani D, Carvalho N, Bruna Romero O, Gazzinelli R, Oliveira S. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. J Immunol. 2008;180:1080-7 pubmed
	Tsai C, Lin C, Tsai H, Chen C, Li W, Yu H, et al. The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem. 2013;288:17689-97 pubmed publisher
	Kim M, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, et al. hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain. J Virol. 2013;87:998-1009 pubmed publisher
	Bruscia E, Zhang P, Satoh A, Caputo C, Medzhitov R, Shenoy A, et al. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol. 2011;186:6990-8 pubmed publisher
	Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int Immunol. 2010;22:271-80 pubmed publisher
	Corbucci C, Cenci E, Skrzypek F, Gabrielli E, Mosci P, Ernst J, et al. Immune response to Candida albicans is preserved despite defect in O-mannosylation of secretory proteins. Med Mycol. 2007;45:709-19 pubmed
	El Shikh M, El Sayed R, Wu Y, Szakal A, Tew J. TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity. J Immunol. 2007;179:4444-50 pubmed
	Konno K, Wakabayashi Y, Akashi Takamura S, Ishii T, Kobayashi M, Takahashi K, et al. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. Biochem Biophys Res Commun. 2006;339:1076-82 pubmed
	Jung D, Lee H, Jung B, Ock J, Lee M, Lee W, et al. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol. 2005;174:6467-76 pubmed

product information

Catalog Number :

NBP2-24741

Product Name :

Rat Monoclonal TLR4 Antibody (MTS510) [PE]

List Price :

369 USD

product type :

Primary Antibodies

Package Size :

0.1 ml

AltNames :

ARMD10, CD284, CD284 antigen, hTollhomolog of Drosophila toll, TOLL, toll-like receptor 4

Buffer :

PBS

Clonality :

Monoclonal

Clone :

MTS510

Conjugate :

Application Summary :

Flow Cytometry

Host :

Rat

Immunogen :

This antibody was developed by immunizing rats with the Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al, 2000).

Isotype :

IgG2a Kappa

Preservative :

0.05% Sodium Azide

Purity :

Protein G purified

CrossReactivity :

Mouse

Specificity :

In FA, the antibody blocks activation of monocytes with LPS (Akashi et al. 2000). This antibody preferentially recognizes TLR4-MD-2 complex than of TLR4 alone. The optimal condition has to be determined for individual experiments.

Storage :

Store at 4C in the dark.

Swissprot Human :

O00206

Research Area :

Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Toll Like Receptors