| Published Application/Species/Sample/Dilution | Reference |
|---|
- western blot knockout validation; human; 1:1000; loading ...; fig 4d
| Malik N, Yan H, Yang H, Ayaz G, DuBois W, Tseng Y, et al. CBFB cooperates with p53 to maintain TAp73 expression and suppress breast cancer. PLoS Genet. 2021;17:e1009553 pubmed publisher |
- western blot knockout validation; mouse; 1:500
| Ahronian L, Driscoll D, Klimstra D, Lewis B. The p53R172H mutant does not enhance hepatocellular carcinoma development and progression. PLoS ONE. 2015;10:e0123816 pubmed publisher |
- western blot knockout validation; mouse; fig e1
| Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015;517:626-30 pubmed publisher |
- western blot; human; loading ...; fig 6
| Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher |
| Brahimi Horn M, Lacas Gervais S, Adaixo R, Ilc K, Rouleau M, Notte A, et al. Local mitochondrial-endolysosomal microfusion cleaves voltage-dependent anion channel 1 to promote survival in hypoxia. Mol Cell Biol. 2015;35:1491-505 pubmed publisher |
- immunoprecipitation; human
| El Machhour F, Keuylian Z, Kavvadas P, Dussaule J, Chatziantoniou C. Activation of Notch3 in Glomeruli Promotes the Development of Rapidly Progressive Renal Disease. J Am Soc Nephrol. 2015;26:1561-75 pubmed publisher |
- immunoprecipitation; human
- western blot; human
| Chowdhury P, Lin G, Liu K, Song Y, Lin F, Lin W. Targeting TopBP1 at a convergent point of multiple oncogenic pathways for cancer therapy. Nat Commun. 2014;5:5476 pubmed publisher |
| Lu H, Yan C, Quan X, Yang X, Zhang J, Bian Y, et al. CK2 phosphorylates and inhibits TAp73 tumor suppressor function to promote expression of cancer stem cell genes and phenotype in head and neck cancer. Neoplasia. 2014;16:789-800 pubmed publisher |
- immunoprecipitation; mouse
| Cho M, Chan I, Flores E. ?Np63 transcriptionally regulates brachyury, a gene with diverse roles in limb development, tumorigenesis and metastasis. Cell Cycle. 2010;9:2434-41 pubmed |
| Liu K, Bellam N, Lin H, Wang B, Stockard C, Grizzle W, et al. Regulation of p53 by TopBP1: a potential mechanism for p53 inactivation in cancer. Mol Cell Biol. 2009;29:2673-93 pubmed publisher |
| Tomasini R, Tsuchihara K, Tsuda C, Lau S, Wilhelm M, Rufini A, et al. TAp73 regulates the spindle assembly checkpoint by modulating BubR1 activity. Proc Natl Acad Sci U S A. 2009;106:797-802 pubmed publisher |
| Sampath D, Calin G, Puduvalli V, Gopisetty G, Taccioli C, Liu C, et al. Specific activation of microRNA106b enables the p73 apoptotic response in chronic lymphocytic leukemia by targeting the ubiquitin ligase Itch for degradation. Blood. 2009;113:3744-53 pubmed publisher |
| Ma Y, Yu W, Hershberger P, Flynn G, Kong R, Trump D, et al. 1alpha,25-Dihydroxyvitamin D3 potentiates cisplatin antitumor activity by p73 induction in a squamous cell carcinoma model. Mol Cancer Ther. 2008;7:3047-55 pubmed publisher |
- chromatin immunoprecipitation; human
| Rosenbluth J, Mays D, Pino M, Tang L, Pietenpol J. A gene signature-based approach identifies mTOR as a regulator of p73. Mol Cell Biol. 2008;28:5951-64 pubmed publisher |
- immunocytochemistry; mouse
| Alvarez A, Klein A, Castro J, Cancino G, Amigo J, Mosqueira M, et al. Imatinib therapy blocks cerebellar apoptosis and improves neurological symptoms in a mouse model of Niemann-Pick type C disease. FASEB J. 2008;22:3617-27 pubmed publisher |
| Lunghi P, Giuliani N, Mazzera L, Lombardi G, Ricca M, Corradi A, et al. Targeting MEK/MAPK signal transduction module potentiates ATO-induced apoptosis in multiple myeloma cells through multiple signaling pathways. Blood. 2008;112:2450-62 pubmed publisher |
| Cancino G, Toledo E, Leal N, Hernandez D, Yévenes L, Inestrosa N, et al. STI571 prevents apoptosis, tau phosphorylation and behavioural impairments induced by Alzheimer's beta-amyloid deposits. Brain. 2008;131:2425-42 pubmed publisher |
| Li L, Morales J, Hwang A, Wagner M, Boothman D. DNA mismatch repair-dependent activation of c-Abl/p73alpha/GADD45alpha-mediated apoptosis. J Biol Chem. 2008;283:21394-403 pubmed publisher |
| Mor I, Sklan E, Podoly E, Pick M, Kirschner M, Yogev L, et al. Acetylcholinesterase-R increases germ cell apoptosis but enhances sperm motility. J Cell Mol Med. 2008;12:479-95 pubmed publisher |
| Thottassery J, Westbrook L, Someya H, Parker W. c-Abl-independent p73 stabilization during gemcitabine- or 4'-thio-beta-D-arabinofuranosylcytosine-induced apoptosis in wild-type and p53-null colorectal cancer cells. Mol Cancer Ther. 2006;5:400-10 pubmed |
- immunohistochemistry - frozen section; human
| Dominguez G, Garcia J, Peña C, Silva J, Garcia V, Martínez L, et al. DeltaTAp73 upregulation correlates with poor prognosis in human tumors: putative in vivo network involving p73 isoforms, p53, and E2F-1. J Clin Oncol. 2006;24:805-15 pubmed |
- immunoprecipitation; human
| Sayan A, Paradisi A, Vojtesek B, Knight R, Melino G, Candi E. New antibodies recognizing p73: comparison with commercial antibodies. Biochem Biophys Res Commun. 2005;330:186-93 pubmed |
- immunocytochemistry; human
- western blot; human
| Frasca F, Vella V, Aloisi A, Mandarino A, Mazzon E, Vigneri R, et al. p73 tumor-suppressor activity is impaired in human thyroid cancer. Cancer Res. 2003;63:5829-37 pubmed |
| Acton A, Placzek W. Myeloid Cell Leukemia 1 Small Molecule Inhibitor S63845 Synergizes with Cisplatin in Triple-Negative Breast Cancer. Cancers (Basel). 2023;15: pubmed publisher |
| Suzuki K, Tange M, Yamagishi R, Hanada H, Mukai S, Sato T, et al. SMG6 regulates DNA damage and cell survival in Hippo pathway kinase LATS2-inactivated malignant mesothelioma. Cell Death Discov. 2022;8:446 pubmed publisher |
| C x103 inap C, Bochi x15f O, Vlad C, Popita R, Achima x15f Cadariu P, Havasi A, et al. Doubling the Dose of Bevacizumab Beyond Progression in Metastatic Colorectal Cancer-the Experience of a Tertiary Cancer Center. Front Pharmacol. 2021;12:487316 pubmed publisher |
| Widden H, Kaczmarczyk A, Subedi A, Whitaker R, Placzek W. MCL1 binds and negatively regulates the transcriptional function of tumor suppressor p73. Cell Death Dis. 2020;11:946 pubmed publisher |
| Wang C, Teo C, Sabapathy K. p53-Related Transcription Targets of TAp73 in Cancer Cells-Bona Fide or Distorted Reality?. Int J Mol Sci. 2020;21: pubmed publisher |
| Oh S, Stark A, Reichrath J. The p53 Signalling Pathway in Cutaneous Basal Cell Carcinoma: An Immunohistochemical Description. Acta Derm Venereol. 2020;100:adv00098 pubmed publisher |
| Kumar S, Talluri S, Pal J, Yuan X, Lu R, Nanjappa P, et al. Role of apurinic/apyrimidinic nucleases in the regulation of homologous recombination in myeloma: mechanisms and translational significance. Blood Cancer J. 2018;8:92 pubmed publisher |
| Makino E, Gutmann V, Kosnopfel C, Niessner H, Forschner A, Garbe C, et al. Melanoma cells resistant towards MAPK inhibitors exhibit reduced TAp73 expression mediating enhanced sensitivity to platinum-based drugs. Cell Death Dis. 2018;9:930 pubmed publisher |
| Yang L, Yang X, Tang Y, Zhang D, Zhu L, Wang S, et al. Inhibition of DNA‑PK activity sensitizes A549 cells to X‑ray irradiation by inducing the ATM‑dependent DNA damage response. Mol Med Rep. 2018;17:7545-7552 pubmed publisher |
| Gong H, Zhang Y, Jiang K, Ye S, Chen S, Zhang Q, et al. p73 coordinates with Δ133p53 to promote DNA double-strand break repair. Cell Death Differ. 2018;25:1063-1079 pubmed publisher |
| Papaspyropoulos A, Bradley L, Thapa A, Leung C, Toskas K, Koennig D, et al. RASSF1A uncouples Wnt from Hippo signalling and promotes YAP mediated differentiation via p73. Nat Commun. 2018;9:424 pubmed publisher |
| Gonzalez R, De La Rosa A, Rufini A, Rodríguez Hernández M, Navarro Villarán E, Marchal T, et al. Role of p63 and p73 isoforms on the cell death in patients with hepatocellular carcinoma submitted to orthotopic liver transplantation. PLoS ONE. 2017;12:e0174326 pubmed publisher |
| Prabhu V, Hong B, Allen J, Zhang S, Lulla A, Dicker D, et al. Small-Molecule Prodigiosin Restores p53 Tumor Suppressor Activity in Chemoresistant Colorectal Cancer Stem Cells via c-Jun-Mediated ΔNp73 Inhibition and p73 Activation. Cancer Res. 2016;76:1989-99 pubmed publisher |
| Zoric A, Horvat A, Slade N. Differential effects of diverse p53 isoforms on TAp73 transcriptional activity and apoptosis. Carcinogenesis. 2013;34:522-9 pubmed publisher |
| Malatesta M, Peschiaroli A, Memmi E, Zhang J, Antonov A, Green D, et al. The Cul4A-DDB1 E3 ubiquitin ligase complex represses p73 transcriptional activity. Oncogene. 2013;32:4721-6 pubmed publisher |
| Santag S, Jager W, Karsten C, Kati S, Pietrek M, Steinemann D, et al. Recruitment of the tumour suppressor protein p73 by Kaposi's Sarcoma Herpesvirus latent nuclear antigen contributes to the survival of primary effusion lymphoma cells. Oncogene. 2013;32:3676-85 pubmed publisher |
| Brune M, Muller M, Melino G, Bierhaus A, Schilling T, Nawroth P. Depletion of the receptor for advanced glycation end products (RAGE) sensitizes towards apoptosis via p53 and p73 posttranslational regulation. Oncogene. 2013;32:1460-8 pubmed publisher |
| Hu X, Wu N, Xia P, Yu S, Sun F, Chen J. Correlation between low-level expression of the tumor suppressor gene TAp73 and the chemoresistance of human glioma stem cells. Cancer Chemother Pharmacol. 2012;69:1205-12 pubmed publisher |
| Agostini M, Tucci P, Steinert J, Shalom Feuerstein R, Rouleau M, Aberdam D, et al. microRNA-34a regulates neurite outgrowth, spinal morphology, and function. Proc Natl Acad Sci U S A. 2011;108:21099-104 pubmed publisher |
| Moceri P, Doyen D, Cerboni P, Ferrari E. Doubling the dose of clopidogrel restores the loss of antiplatelet effect induced by esomeprazole. Thromb Res. 2011;128:458-62 pubmed publisher |
| Jankowski V, Tölle M, Santos R, Günthner T, Krause E, Beyermann M, et al. Angioprotectin: an angiotensin II-like peptide causing vasodilatory effects. FASEB J. 2011;25:2987-95 pubmed publisher |
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| Tebbi A, Guittet O, Cottet M, Vesin M, Lepoivre M. TAp73 induction by nitric oxide: regulation by checkpoint kinase 1 (CHK1) and protection against apoptosis. J Biol Chem. 2011;286:7873-84 pubmed publisher |
| Kruewel T, Schenone S, Radi M, Maga G, Rohrbeck A, Botta M, et al. Molecular characterization of c-Abl/c-Src kinase inhibitors targeted against murine tumour progenitor cells that express stem cell markers. PLoS ONE. 2010;5:e14143 pubmed publisher |
| Tonino S, van Laar J, Van Oers M, Wang J, Eldering E, Kater A. ROS-mediated upregulation of Noxa overcomes chemoresistance in chronic lymphocytic leukemia. Oncogene. 2011;30:701-13 pubmed publisher |
| Klein A, Maldonado C, Vargas L, Gonzalez M, Robledo F, Perez de Arce K, et al. Oxidative stress activates the c-Abl/p73 proapoptotic pathway in Niemann-Pick type C neurons. Neurobiol Dis. 2011;41:209-18 pubmed publisher |
| Wierda W, Castro J, Aguillon R, Sampath D, Jalayer A, McMannis J, et al. A phase I study of immune gene therapy for patients with CLL using a membrane-stable, humanized CD154. Leukemia. 2010;24:1893-900 pubmed publisher |
| Arfaoui A, Kriaa L, El Hadj O, Ben Hmida M, Khiari M, Khalfallah T, et al. Association of a p73 exon 2 GC/AT polymorphism with colorectal cancer risk and survival in Tunisian patients. Virchows Arch. 2010;457:359-68 pubmed publisher |
| Ma Y, Yu W, Trump D, Johnson C. 1,25D3 enhances antitumor activity of gemcitabine and cisplatin in human bladder cancer models. Cancer. 2010;116:3294-303 pubmed publisher |
| Rosenbluth J, Johnson K, Tang L, Triplett T, Pietenpol J. Evaluation of p63 and p73 antibodies for cross-reactivity. Cell Cycle. 2009;8:3702-6 pubmed |
| Alonso R, Lopez Guerra M, Upshaw R, Bantia S, Smal C, Bontemps F, et al. Forodesine has high antitumor activity in chronic lymphocytic leukemia and activates p53-independent mitochondrial apoptosis by induction of p73 and BIM. Blood. 2009;114:1563-75 pubmed publisher |
| Marqués García F, Ferrandiz N, Fernández Alonso R, González Cano L, Herreros Villanueva M, Rosa Garrido M, et al. p73 plays a role in erythroid differentiation through GATA1 induction. J Biol Chem. 2009;284:21139-56 pubmed publisher |
| Marinovic Terzic I, Yoshioka Yamashita A, Shimodaira H, Avdievich E, Hunton I, Kolodner R, et al. Apoptotic function of human PMS2 compromised by the nonsynonymous single-nucleotide polymorphic variant R20Q. Proc Natl Acad Sci U S A. 2008;105:13993-8 pubmed publisher |
| Kurihara A, Nagoshi H, Yabuki M, Okuyama R, Obinata M, Ikawa S. Ser46 phosphorylation of p53 is not always sufficient to induce apoptosis: multiple mechanisms of regulation of p53-dependent apoptosis. Genes Cells. 2007;12:853-61 pubmed |
| Bozzetti C, Nizzoli R, Musolino A, Martella E, Crafa P, Lagrasta C, et al. p73 and p53 pathway in human breast cancers. J Clin Oncol. 2007;25:1451-3; author reply 1453-4 pubmed |
| Limesand K, Schwertfeger K, Anderson S. MDM2 is required for suppression of apoptosis by activated Akt1 in salivary acinar cells. Mol Cell Biol. 2006;26:8840-56 pubmed |
| Cui R, Nguyen T, Taube J, Stratton S, Feuerman M, Barton M. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005;280:39152-60 pubmed |
| Bernassola F, Salomoni P, Oberst A, Di Como C, Pagano M, Melino G, et al. Ubiquitin-dependent degradation of p73 is inhibited by PML. J Exp Med. 2004;199:1545-57 pubmed |
| Vella V, Zhu J, Frasca F, Li C, Vigneri P, Vigneri R, et al. Exclusion of c-Abl from the nucleus restrains the p73 tumor suppression function. J Biol Chem. 2003;278:25151-7 pubmed |
| Shimodaira H, Yoshioka Yamashita A, Kolodner R, Wang J. Interaction of mismatch repair protein PMS2 and the p53-related transcription factor p73 in apoptosis response to cisplatin. Proc Natl Acad Sci U S A. 2003;100:2420-5 pubmed |
