Rat Monoclonal TLR4 Antibody (MTS510) [FITC] | Novus Biologicals NBP2-24450 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Rat Monoclonal TLR4 Antibody (MTS510) [FITC]

catalog :

NBP2-24450

quantity :

0.1 ml

price :

369 USD

clonality :

monoclonal

host :

rat

conjugate :

FITC

clone name :

MTS510

reactivity :

human, mouse

application :

western blot, immunocytochemistry, flow cytometry

citations: 11

Published Application/Species/Sample/Dilution	Reference
immunocytochemistry; mouse	Ma C, Shi G, Shi C, Kao Y, Lin S, Wu H. Monocytic thrombomodulin triggers LPS- and gram-negative bacteria-induced inflammatory response. J Immunol. 2012;188:6328-37 pubmed publisher
immunocytochemistry; human western blot; human immunocytochemistry; mouse western blot; mouse	Bruscia E, Zhang P, Satoh A, Caputo C, Medzhitov R, Shenoy A, et al. Abnormal trafficking and degradation of TLR4 underlie the elevated inflammatory response in cystic fibrosis. J Immunol. 2011;186:6990-8 pubmed publisher
western blot; mouse	Park H, Hong J, Kwon H, Kim Y, Lee K, Kim J, et al. TLR4-mediated activation of mouse macrophages by Korean mistletoe lectin-C (KML-C). Biochem Biophys Res Commun. 2010;396:721-5 pubmed publisher
flow cytometry; mouse	Macedo G, Magnani D, Carvalho N, Bruna Romero O, Gazzinelli R, Oliveira S. Central role of MyD88-dependent dendritic cell maturation and proinflammatory cytokine production to control Brucella abortus infection. J Immunol. 2008;180:1080-7 pubmed
	Tsai C, Lin C, Tsai H, Chen C, Li W, Yu H, et al. The immunologically active oligosaccharides isolated from wheatgrass modulate monocytes via Toll-like receptor-2 signaling. J Biol Chem. 2013;288:17689-97 pubmed publisher
	Kim M, Shu Y, Carsillo T, Zhang J, Yu L, Peterson C, et al. hsp70 and a novel axis of type I interferon-dependent antiviral immunity in the measles virus-infected brain. J Virol. 2013;87:998-1009 pubmed publisher
	Tsukamoto H, Fukudome K, Takao S, Tsuneyoshi N, Kimoto M. Lipopolysaccharide-binding protein-mediated Toll-like receptor 4 dimerization enables rapid signal transduction against lipopolysaccharide stimulation on membrane-associated CD14-expressing cells. Int Immunol. 2010;22:271-80 pubmed publisher
	Corbucci C, Cenci E, Skrzypek F, Gabrielli E, Mosci P, Ernst J, et al. Immune response to Candida albicans is preserved despite defect in O-mannosylation of secretory proteins. Med Mycol. 2007;45:709-19 pubmed
	El Shikh M, El Sayed R, Wu Y, Szakal A, Tew J. TLR4 on follicular dendritic cells: an activation pathway that promotes accessory activity. J Immunol. 2007;179:4444-50 pubmed
	Konno K, Wakabayashi Y, Akashi Takamura S, Ishii T, Kobayashi M, Takahashi K, et al. A molecule that is associated with Toll-like receptor 4 and regulates its cell surface expression. Biochem Biophys Res Commun. 2006;339:1076-82 pubmed
	Jung D, Lee H, Jung B, Ock J, Lee M, Lee W, et al. TLR4, but not TLR2, signals autoregulatory apoptosis of cultured microglia: a critical role of IFN-beta as a decision maker. J Immunol. 2005;174:6467-76 pubmed

product information

Catalog Number :

NBP2-24450

Product Name :

Rat Monoclonal TLR4 Antibody (MTS510) [FITC]

List Price :

369 USD

product type :

Primary Antibodies

Package Size :

0.1 ml

AltNames :

ARMD10, CD284, CD284 antigen, hTollhomolog of Drosophila toll, TOLL, toll-like receptor 4

Buffer :

50mM Sodium Borate

Clonality :

Monoclonal

Clone :

MTS510

Conjugate :

FITC

Application Summary :

Flow Cytometry

Host :

Rat

Immunogen :

This antibody was developed by immunizing rats with the Ba/F3 cell line expressing mouse TLR4 and MD-2 (Akashi et al, 2000).

Isotype :

IgG2a Kappa

Preservative :

0.05% Sodium Azide

Purity :

Protein G purified

CrossReactivity :

Mouse

Specificity :

In FA, the antibody blocks activation of monocytes with LPS (Akashi et al. 2000). This antibody preferentially recognizes TLR4-MD-2 complex than of TLR4 alone. The optimal condition has to be determined for individual experiments.

Storage :

Store at 4C in the dark.

Swissprot Human :

O00206

Research Area :

Adaptive Immunity, Cytokine Research, Immunology, Innate Immunity, Signal Transduction, Toll Like Receptors