product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
CCL2/MCP1 Antibody (2D8) - BSA Free
catalog :
NBP2-22115
quantity :
0.1 ml (also 0.025 ml)
price :
469 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
2D8
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 5e
Jin Y, Liu Y, Xu L, Xu J, Xiong Y, Peng Y, et al. Novel role for caspase 1 inhibitor VX765 in suppressing NLRP3 inflammasome assembly and atherosclerosis via promoting mitophagy and efferocytosis. Cell Death Dis. 2022;13:512 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; loading ...; fig e10g
Ramachandran P, Dobie R, Wilson Kanamori J, Dora E, Henderson B, Luu N, et al. Resolving the fibrotic niche of human liver cirrhosis at single-cell level. Nature. 2019;575:512-518 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:4000; loading ...; fig 3f
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 2d
Pascual García M, Bonfill Teixidor E, Planas Rigol E, Rubio Perez C, Iurlaro R, Arias A, et al. LIF regulates CXCL9 in tumor-associated macrophages and prevents CD8+ T cell tumor-infiltration impairing anti-PD1 therapy. Nat Commun. 2019;10:2416 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 3b
Portillo J, Lopez Corcino Y, Miao Y, Tang J, Sheibani N, Kern T, et al. CD40 in Retinal Müller Cells Induces P2X7-Dependent Cytokine Expression in Macrophages/Microglia in Diabetic Mice and Development of Early Experimental Diabetic Retinopathy. Diabetes. 2017;66:483-493 pubmed publisher
  • western blot; mouse; fig 4
Nishio M, Sugimachi K, Goto H, Wang J, Morikawa T, Miyachi Y, et al. Dysregulated YAP1/TAZ and TGF-β signaling mediate hepatocarcinogenesis in Mob1a/1b-deficient mice. Proc Natl Acad Sci U S A. 2016;113:E71-80 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Chen S, Jiao J, Jiang D, Wan Z, Li L, Li K, et al. T-box transcription factor Brachyury in lung cancer cells inhibits macrophage infiltration by suppressing CCL2 and CCL4 chemokines. Tumour Biol. 2015;36:5881-90 pubmed publisher
Wang C, Cheng F, Han Z, Yan B, Liao P, Yin Z, et al. Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis. Neural Regen Res. 2025;20:518-532 pubmed publisher
Suzuki K, Ohe R, Kabasawa T, Kitaoka T, Kawai M, Motoi F, et al. Histological spatial analysis on the induction of PD-L1+ macrophages by CD8+ T cells at the marginal microenvironment of triple-negative breast cancer. Breast Cancer. 2023;30:1094-1104 pubmed publisher
Huang W, Hong S, Zhu X, Alsaeedi M, Tang H, Krier J, et al. Obesity Blunts the Effect of Mesenchymal Stem Cell-Derived Extracellular Vesicles. Kidney Int Rep. 2023;8:1841-1851 pubmed publisher
Cui Y, Wang X, Xu Y, Cao Y, Luo G, Zhao Z, et al. Ropivacaine Promotes Axon Regeneration by Regulating Nav1.8-mediated Macrophage Signaling after Sciatic Nerve Injury in Rats. Anesthesiology. 2023;139:782-800 pubmed publisher
Xu Z, Wang X, Kuang W, Wang S, Zhao Y. Kaempferol improves acute kidney injury via inhibition of macrophage infiltration in septic mice. Biosci Rep. 2023;43: pubmed publisher
Aamir K, Sethi G, Afrin M, Hossain C, Jusuf P, Sarker S, et al. Arjunolic acid modulate pancreatic dysfunction by ameliorating pattern recognition receptor and canonical Wnt pathway activation in type 2 diabetic rats. Life Sci. 2023;327:121856 pubmed publisher
Bae J, Lee J, Shin E, Lee M, Lee Y, Lee B, et al. The effects of the voglibose on non-alcoholic fatty liver disease in mice model. Sci Rep. 2022;12:13595 pubmed publisher
Guo X, Guo Y, Wang Z, Cao B, Zheng C, Zeng Z, et al. Reducing the Damage of Ox-LDL/LOX-1 Pathway to Vascular Endothelial Barrier Can Inhibit Atherosclerosis. Oxid Med Cell Longev. 2022;2022:7541411 pubmed publisher
Go R, Lee S, Shin Y, Kim M, Park C, Ko E, et al. Time-dependent effect of inhaled cigarette smoke exposure in the bleomycin-induced lung injury rat model. Environ Toxicol. 2022;37:1231-1243 pubmed publisher
Dajnoki Z, Somogyi O, Medgyesi B, Jenei A, Szab xf3 L, G xe1 sp xe1 r K, et al. Primary alterations during the development of hidradenitis suppurativa. J Eur Acad Dermatol Venereol. 2022;36:462-471 pubmed publisher
Phipps B, Suwannasual U, Lucero J, Mitchell N, Lund A. Vehicle emissions-exposure alters expression of systemic and tissue-specific components of the renin-angiotensin system and promotes outcomes associated with cardiovascular disease and obesity in wild-type C57BL/6 male mice. Toxicol Rep. 2021;8:846-862 pubmed publisher
Sorrentino G, Rezakhani S, Yıldız E, Nuciforo S, Heim M, Lutolf M, et al. Mechano-modulatory synthetic niches for liver organoid derivation. Nat Commun. 2020;11:3416 pubmed publisher
Hamada N, Hamazaki N, Shimamoto S, Hikabe O, Nagamatsu G, Takada Y, et al. Germ cell-intrinsic effects of sex chromosomes on early oocyte differentiation in mice. PLoS Genet. 2020;16:e1008676 pubmed publisher
Zhang B, Tang Z, Li L, Lu L. NBS1 is required for SPO11-linked DNA double-strand break repair in male meiosis. Cell Death Differ. 2020;27:2176-2190 pubmed publisher
Zhang Y, Schroeder L, Lessard M, Kidd P, Chung J, Song Y, et al. Nanoscale subcellular architecture revealed by multicolor three-dimensional salvaged fluorescence imaging. Nat Methods. 2020;17:225-231 pubmed publisher
Upmanyu N, Bulldan A, Failing K, Scheiner Bobis G. DHEAS prevents pro-metastatic and proliferative effects of 17ß-estradiol on MCF-7 breast cancer cells. Biochim Biophys Acta Mol Cell Res. 2020;1867:118600 pubmed publisher
Hua R, Wei H, Liu C, Zhang Y, Liu S, Guo Y, et al. FBXO47 regulates telomere-inner nuclear envelope integration by stabilizing TRF2 during meiosis. Nucleic Acids Res. 2019;47:11755-11770 pubmed publisher
Wenstedt E, Verberk S, Kroon J, Neele A, Baardman J, Claessen N, et al. Salt increases monocyte CCR2 expression and inflammatory responses in humans. JCI Insight. 2019;4: pubmed publisher
Lam K, Brick K, Cheng G, Pratto F, Camerini Otero R. Cell-type-specific genomics reveals histone modification dynamics in mammalian meiosis. Nat Commun. 2019;10:3821 pubmed publisher
Wolf M, Clay S, Zheng S, Pan P, Chan M. MMP12 Inhibits Corneal Neovascularization and Inflammation through Regulation of CCL2. Sci Rep. 2019;9:11579 pubmed publisher
Eyster C, Chuong H, Lee C, Pezza R, Dawson D. The pericentromeric heterochromatin of homologous chromosomes remains associated after centromere pairing dissolves in mouse spermatocyte meiosis. Chromosoma. 2019;: pubmed publisher
Do C, Drel V, Tan C, Lee D, Wagner B. 'Nephrogenic' systemic fibrosis is mediated by myeloid C-C chemokine receptor 2. J Invest Dermatol. 2019;: pubmed publisher
Tsang M, Gantchev J, Netchiporouk E, Moreau L, Ghazawi F, Glassman S, et al. A study of meiomitosis and novel pathways of genomic instability in cutaneous T-cell lymphomas (CTCL). Oncotarget. 2018;9:37647-37661 pubmed publisher
Huang G, Kaufman A, Ryan R, Romin Y, Huryn L, Bains S, et al. Mouse DCUN1D1 (SCCRO) is required for spermatogenetic individualization. PLoS ONE. 2019;14:e0209995 pubmed publisher
Rojo J, Jaworski J, PELUFFO M. Direct role of the C-C motif chemokine receptor 2/monocyte chemoattractant protein 1 system in the feline cumulus oocyte complex†. Biol Reprod. 2019;100:1046-1056 pubmed publisher
Tian H, Billings T, Petkov P. CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. PLoS Genet. 2018;14:e1007657 pubmed publisher
Abreu C, Prakash R, Romanienko P, Roig I, Keeney S, Jasin M. Shu complex SWS1-SWSAP1 promotes early steps in mouse meiotic recombination. Nat Commun. 2018;9:3961 pubmed publisher
Guiraldelli M, Felberg A, Almeida L, Parikh A, de Castro R, Pezza R. SHOC1 is a ERCC4-(HhH)2-like protein, integral to the formation of crossover recombination intermediates during mammalian meiosis. PLoS Genet. 2018;14:e1007381 pubmed publisher
Béke G, Dajnoki Z, Kapitany A, Gáspár K, Medgyesi B, Poliska S, et al. Immunotopographical Differences of Human Skin. Front Immunol. 2018;9:424 pubmed publisher
Garzia L, Kijima N, Morrissy A, De Antonellis P, Guerreiro Stucklin A, Holgado B, et al. A Hematogenous Route for Medulloblastoma Leptomeningeal Metastases. Cell. 2018;172:1050-1062.e14 pubmed publisher
Linde N, Casanova Acebes M, Sosa M, Mortha A, Rahman A, Farias E, et al. Macrophages orchestrate breast cancer early dissemination and metastasis. Nat Commun. 2018;9:21 pubmed publisher
Zhi L, Yao S, Liu H, Li M, Duan N, Ma J. Hydroxytyrosol inhibits the inflammatory response of osteoarthritis chondrocytes via SIRT6-mediated autophagy. Mol Med Rep. 2018;17:4035-4042 pubmed publisher
Miyauchi H, Ohta H, Nagaoka S, Nakaki F, Sasaki K, Hayashi K, et al. Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice. EMBO J. 2017;36:3100-3119 pubmed publisher
Casey A, Daish T, Barbero J, Grützner F. Differential cohesin loading marks paired and unpaired regions of platypus sex chromosomes at prophase I. Sci Rep. 2017;7:4217 pubmed publisher
Xu L, Lu Y, Han D, Yao R, Wang H, Zhong S, et al. Rnf138 deficiency promotes apoptosis of spermatogonia in juvenile male mice. Cell Death Dis. 2017;8:e2795 pubmed publisher
Faisal I, Kauppi L. Reduced MAD2 levels dampen the apoptotic response to non-exchange sex chromosomes and lead to sperm aneuploidy. Development. 2017;144:1988-1996 pubmed publisher
Kuwahara G, Hashimoto T, Tsuneki M, Yamamoto K, Assi R, Foster T, et al. CD44 Promotes Inflammation and Extracellular Matrix Production During Arteriovenous Fistula Maturation. Arterioscler Thromb Vasc Biol. 2017;37:1147-1156 pubmed publisher
Dai J, Voloshin O, Potapova S, Camerini Otero R. Meiotic Knockdown and Complementation Reveals Essential Role of RAD51 in Mouse Spermatogenesis. Cell Rep. 2017;18:1383-1394 pubmed publisher
Taylor L, Carlson D, Nandi S, Sherman A, Fahrenkrug S, McGrew M. Efficient TALEN-mediated gene targeting of chicken primordial germ cells. Development. 2017;144:928-934 pubmed publisher
Jordan P, Eyster C, Chen J, Pezza R, Rankin S. Sororin is enriched at the central region of synapsed meiotic chromosomes. Chromosome Res. 2017;25:115-128 pubmed publisher
Parvanov E, Tian H, Billings T, Saxl R, Spruce C, Aithal R, et al. PRDM9 interactions with other proteins provide a link between recombination hotspots and the chromosomal axis in meiosis. Mol Biol Cell. 2017;28:488-499 pubmed publisher
Fu C, Begum K, Jordan P, He Y, Overbeek P. Dearth and Delayed Maturation of Testicular Germ Cells in Fanconi Anemia E Mutant Male Mice. PLoS ONE. 2016;11:e0159800 pubmed publisher
Hanna R, Moffett D, Forster F, Trudgett A, Brennan G, Fairweather I. Fasciola hepatica: a light and electron microscope study of the ovary and of the development of oocytes within eggs in the uterus provides an insight into reproductive strategy. Vet Parasitol. 2016;221:93-103 pubmed publisher
Davies B, Hatton E, Altemose N, Hussin J, Pratto F, Zhang G, et al. Re-engineering the zinc fingers of PRDM9 reverses hybrid sterility in mice. Nature. 2016;530:171-176 pubmed publisher
Daish T, Casey A, Grützner F. Lack of sex chromosome specific meiotic silencing in platypus reveals origin of MSCI in therian mammals. BMC Biol. 2015;13:106 pubmed publisher
Kent T, Arnold S, Fasnacht R, Rowsey R, Mitchell D, Hogarth C, et al. ALDH Enzyme Expression Is Independent of the Spermatogenic Cycle, and Their Inhibition Causes Misregulation of Murine Spermatogenic Processes. Biol Reprod. 2016;94:12 pubmed publisher
Faisal I, Kauppi L. Sex chromosome recombination failure, apoptosis, and fertility in male mice. Chromosoma. 2016;125:227-35 pubmed publisher
Lambrot R, Lafleur C, Kimmins S. The histone demethylase KDM1A is essential for the maintenance and differentiation of spermatogonial stem cells and progenitors. FASEB J. 2015;29:4402-16 pubmed publisher
Yamamoto S, Zhong J, Yancey P, Zuo Y, Linton M, Fazio S, et al. Atherosclerosis following renal injury is ameliorated by pioglitazone and losartan via macrophage phenotype. Atherosclerosis. 2015;242:56-64 pubmed publisher
Casey A, Daish T, Grützner F. Identification and characterisation of synaptonemal complex genes in monotremes. Gene. 2015;567:146-53 pubmed publisher
Sun F, Fujiwara Y, Reinholdt L, Hu J, Saxl R, Baker C, et al. Nuclear localization of PRDM9 and its role in meiotic chromatin modifications and homologous synapsis. Chromosoma. 2015;124:397-415 pubmed publisher
Fujiwara Y, Matsumoto H, Akiyama K, Srivastava A, Chikushi M, Ann Handel M, et al. An ENU-induced mutation in the mouse Rnf212 gene is associated with male meiotic failure and infertility. Reproduction. 2015;149:67-74 pubmed publisher
product information
master code :
NBP2-22115
SKU :
NBP2-22115
product name :
CCL2/MCP1 Antibody (2D8) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The CCL2/MCP1 Antibody (2D8) - BSA Free from Novus is a mouse monoclonal antibody to CCL2/MCP1. This antibody reacts with feline,human,mouse,primate,rat. The CCL2/MCP1 Antibody (2D8) - BSA Free has been validated for the following applications: Western Blot,Flow Cytometry,Knockdown Validated,IF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,Surface Plasmon Resonance,Immunocytochemistry/ Immunofluorescence,ELISA.
target :
CCL2/MCP1
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
2D8
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
Full lenght human MCP1 expressed in E. coli. [Uniprot: P13500]
isotype :
IgG1
purity :
Protein A or G purified
species :
Feline,Human,Mouse,Primate,Rat
theoretical molecular weight :
11 kDa
gene symbol :
CCL2
Antibody validation :
Biological Validation
accessionNumbers :
P13500
applications :
Western Blot,Flow Cytometry,Knockdown Validated,IF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,Surface Plasmon Resonance,Immunocytochemistry/ Immunofluorescence,ELISA
USD :
469 USD
alt names :
C-C motif chemokine 2, chemokine (C-C motif) ligand 2, GDCF-2, HC11Monocyte secretory protein JE, MCAFMonocyte chemotactic and activating factor, MCP1 Monocyte chemotactic protein 1, MCP-1 Small-inducible cytokine A2, MGC9434, Monocyte chemoattractant protein 1, monocyte chemoattractant protein-1, SCYA2HSMCR30, small inducible cytokine A2 (monocyte chemotactic protein 1, homologous tomouse Sig-je), small inducible cytokine subfamily A (Cys-Cys), member 2, SMC-CF
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.