product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
E-Cadherin Antibody (7H12)
catalog :
NBP2-19051
quantity :
0.1 ml (also 0.025 ml)
price :
579 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
7H12
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 50
Published Application/Species/Sample/DilutionReference
  • western blot; human; loading ...; fig 3a
Lassiter R, Merchen T, Fang X, Wang Y. Protective Role of Kynurenine 3-Monooxygenase in Allograft Rejection and Tubular Injury in Kidney Transplantation. Front Immunol. 2021;12:671025 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 4b
  • western blot; mouse; loading ...; fig 4a
Liao L, Song M, Li X, Tang L, Zhang T, Zhang L, et al. E3 Ubiquitin Ligase UBR5 Drives the Growth and Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2017;77:2090-2101 pubmed publisher
Kleimenova T, Polyakova V, Linkova N, Drobintseva A, Medvedev D, Krasichkov A. The Expression of Kisspeptins and Matrix Metalloproteinases in Extragenital Endometriosis. Biomedicines. 2024;12: pubmed publisher
Yu Z, Dong X, Song M, Xu A, He Q, Li H, et al. Targeting UBR5 inhibits postsurgical breast cancer lung metastases by inducing CDC73 and p53 mediated apoptosis. Int J Cancer. 2024;154:723-737 pubmed publisher
Yano K, Choijookhuu N, Ikenoue M, Fidya -, Fukaya T, Sato K, et al. Spatiotemporal expression of HMGB2 regulates cell proliferation and hepatocyte size during liver regeneration. Sci Rep. 2022;12:11962 pubmed publisher
Burge K, Wilson A, Chaaban H. In Vitro Apical-Out Enteroid Model of Necrotizing Enterocolitis. J Vis Exp. 2022;: pubmed publisher
Karim S, Burzangi A, Ahmad A, Siddiqui N, Ibrahim I, Sharma P, et al. PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer. Int J Mol Sci. 2022;23: pubmed publisher
Jhan J, Hsu W, Lee Y, Li W, Huang A, Lin H, et al. MicroRNA-375-3p Suppresses Upper Tract Urothelial Carcinoma Cell Migration and Invasion via Targeting Derlin-1. Cancers (Basel). 2022;14: pubmed publisher
Zhang X, Tanwar V, Jose C, Lee H, Cuddapah S. Transcriptional repression of E-cadherin in nickel-exposed lung epithelial cells mediated by loss of Sp1 binding at the promoter. Mol Carcinog. 2022;61:99-110 pubmed publisher
Padder R, Bhat Z, Ahmad Z, Singh N, Husain M. DRP1 Promotes BRAFV600E-Driven Tumor Progression and Metabolic Reprogramming in Colorectal Cancer. Front Oncol. 2020;10:592130 pubmed publisher
Song M, YEKU O, Rafiq S, Purdon T, Dong X, Zhu L, et al. Tumor derived UBR5 promotes ovarian cancer growth and metastasis through inducing immunosuppressive macrophages. Nat Commun. 2020;11:6298 pubmed publisher
McMichael B, Perego M, Darling C, Perry R, Coleman S, Bain L. Long-term arsenic exposure impairs differentiation in mouse embryonal stem cells. J Appl Toxicol. 2021;41:1089-1102 pubmed publisher
Kuma Y, Hosomichi J, Maeda H, Oishi S, Usumi Fujita R, Shimizu Y, et al. Intermittent hypoxia induces turbinate mucosal hypertrophy via upregulating the gene expression related to inflammation and EMT in rats. Sleep Breath. 2020;: pubmed publisher
Song M, Wang C, Wang H, Zhang T, Li J, Benezra R, et al. Targeting ubiquitin protein ligase E3 component N-recognin 5 in cancer cells induces a CD8+ T cell mediated immune response. Oncoimmunology. 2020;9:1746148 pubmed publisher
Srisomboon Y, Squillace D, Maniak P, Kita H, O Grady S. Fungal allergen-induced IL-33 secretion involves cholesterol-dependent, VDAC-1-mediated ATP release from the airway epithelium. J Physiol. 2020;598:1829-1845 pubmed publisher
Kim S, Kim S, Choi Y, Yoon H, Kim A, Lee J. Retinal VEGFA maintains the ultrastructure and function of choriocapillaris by preserving the endothelial PLVAP. Biochem Biophys Res Commun. 2020;522:240-246 pubmed publisher
Collin de l Hortet A, Takeishi K, Guzman Lepe J, Morita K, Achreja A, Popovic B, et al. Generation of Human Fatty Livers Using Custom-Engineered Induced Pluripotent Stem Cells with Modifiable SIRT1 Metabolism. Cell Metab. 2019;30:385-401.e9 pubmed publisher
Youngblood R, Sampson J, Lebioda K, Shea L. Microporous scaffolds support assembly and differentiation of pancreatic progenitors into β-cell clusters. Acta Biomater. 2019;96:111-122 pubmed publisher
Chu J, Chau M, Chan C, Tai A, Cheung K, Chan T, et al. miR-200c Prevents TGF-β1-Induced Epithelial-to-Mesenchymal Transition and Fibrogenesis in Mesothelial Cells by Targeting ZEB2 and Notch1. Mol Ther Nucleic Acids. 2019;17:78-91 pubmed publisher
Tanwar V, Zhang X, Jagannathan L, Jose C, Cuddapah S. Cadmium exposure upregulates SNAIL through miR-30 repression in human lung epithelial cells. Toxicol Appl Pharmacol. 2019;373:1-9 pubmed publisher
Ren W, Hou J, Yang C, Wang H, Wu S, Wu Y, et al. Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery. J Exp Clin Cancer Res. 2019;38:62 pubmed publisher
Qi M, Zhou Y, Liu J, Ou X, Li M, Long X, et al. AngII induces HepG2 cells to activate epithelial-mesenchymal transition. Exp Ther Med. 2018;16:3471-3477 pubmed publisher
Chuang C, Wang L, Wong Y, Lin E. Anti-metastatic effects of isolinderalactone via the inhibition of MMP-2 and up regulation of NM23-H1 expression in human lung cancer A549 cells. Oncol Lett. 2018;15:4690-4696 pubmed publisher
Jose C, Jagannathan L, Tanwar V, Zhang X, Zang C, Cuddapah S. Nickel exposure induces persistent mesenchymal phenotype in human lung epithelial cells through epigenetic activation of ZEB1. Mol Carcinog. 2018;57:794-806 pubmed publisher
de Andrade Mello P, Bian S, Savio L, Zhang H, Zhang J, Junger W, et al. Hyperthermia and associated changes in membrane fluidity potentiate P2X7 activation to promote tumor cell death. Oncotarget. 2017;8:67254-67268 pubmed publisher
Liu C, Liu T, Yu X, Gu Y. A preliminary study on the interaction between Asn-Gly-Arg (NGR)-modified multifunctional nanoparticles and vascular epithelial cells. Acta Pharm Sin B. 2017;7:361-372 pubmed publisher
Thamotharan S, Chu A, Kempf K, Janzen C, Grogan T, Elashoff D, et al. Differential microRNA expression in human placentas of term intra-uterine growth restriction that regulates target genes mediating angiogenesis and amino acid transport. PLoS ONE. 2017;12:e0176493 pubmed publisher
Zhang Y, Kong N, Zhang Y, Yang W, Yan F. Size-dependent Effects of Gold Nanoparticles on Osteogenic Differentiation of Human Periodontal Ligament Progenitor Cells. Theranostics. 2017;7:1214-1224 pubmed publisher
Elıyatkin N, Aktas S, Diniz G, Ozgur H, Ekin Z, Kupelioglu A. Expression of Stromal Caveolin- 1 May Be a Predictor for Aggressive Behaviour of Breast Cancer. Pathol Oncol Res. 2018;24:59-65 pubmed publisher
Arima M, Cui D, Kimura T, Sonoda K, Ishibashi T, Matsuda S, et al. Basigin can be a therapeutic target to restore the retinal vascular barrier function in the mouse model of diabetic retinopathy. Sci Rep. 2016;6:38445 pubmed publisher
Agarwalla P, Mukherjee S, Sreedhar B, Banerjee R. Glucocorticoid receptor-mediated delivery of nano gold-withaferin conjugates for reversal of epithelial-to-mesenchymal transition and tumor regression. Nanomedicine (Lond). 2016;11:2529-46 pubmed publisher
Ayaz D, Diniz G, Kahraman D, Sayhan S, Uncel M, Karadeniz T, et al. The evaluation of the caveolin-1 and AT-rich interactive domain 1 alpha expressions in uterine smooth muscle tumors. Indian J Pathol Microbiol. 2016;59:301-4 pubmed publisher
Mondal S, Jinka S, Pal K, Nelli S, Dutta S, Wang E, et al. Glucocorticoid Receptor-Targeted Liposomal Codelivery of Lipophilic Drug and Anti-Hsp90 Gene: Strategy to Induce Drug-Sensitivity, EMT-Reversal, and Reduced Malignancy in Aggressive Tumors. Mol Pharm. 2016;13:2507-23 pubmed publisher
Li Z, Scott M, Fan E, Li Y, Liu J, Xiao G, et al. Tissue damage negatively regulates LPS-induced macrophage necroptosis. Cell Death Differ. 2016;23:1428-47 pubmed publisher
Gabanella F, Pisani C, Borreca A, Farioli Vecchioli S, Ciotti M, Ingegnere T, et al. SMN affects membrane remodelling and anchoring of the protein synthesis machinery. J Cell Sci. 2016;129:804-16 pubmed publisher
Cai J, Shen G, Liu S, Meng Q. Downregulation of HMGA2 inhibits cellular proliferation and invasion, improves cellular apoptosis in prostate cancer. Tumour Biol. 2016;37:699-707 pubmed publisher
Boyce A, Kim M, Wicki Stordeur L, Swayne L. ATP stimulates pannexin 1 internalization to endosomal compartments. Biochem J. 2015;470:319-30 pubmed publisher
Yokomori H, Ando W, Yoshimura K, Yamazaki H, Takahashi Y, Oda M. Increases in endothelial caveolin-1 and cavins correlate with cirrhosis progression. Micron. 2015;76:52-61 pubmed publisher
Kallenborn Gerhardt W, Lu R, Bothe A, Thomas D, Schlaudraff J, Lorenz J, et al. Phosphodiesterase 2A localized in the spinal cord contributes to inflammatory pain processing. Anesthesiology. 2014;121:372-82 pubmed publisher
Czeredys M, Samluk Ł, Michalec K, Tułodziecka K, Skowronek K, Nałęcz K. Caveolin-1--a novel interacting partner of organic cation/carnitine transporter (Octn2): effect of protein kinase C on this interaction in rat astrocytes. PLoS ONE. 2013;8:e82105 pubmed publisher
Bielaszewska M, Rüter C, Kunsmann L, Greune L, Bauwens A, Zhang W, et al. Enterohemorrhagic Escherichia coli hemolysin employs outer membrane vesicles to target mitochondria and cause endothelial and epithelial apoptosis. PLoS Pathog. 2013;9:e1003797 pubmed publisher
Charfi C, Levros L, Edouard E, Rassart E. Characterization and identification of PARM-1 as a new potential oncogene. Mol Cancer. 2013;12:84 pubmed publisher
Grenon S, Jeanne M, Aguado Zuniga J, Conte M, Hughes Fulford M. Effects of gravitational mechanical unloading in endothelial cells: association between caveolins, inflammation and adhesion molecules. Sci Rep. 2013;3:1494 pubmed publisher
Teng R, Du J, Afolayan A, Eis A, Shi Y, Konduri G. AMP kinase activation improves angiogenesis in pulmonary artery endothelial cells with in utero pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 2013;304:L29-42 pubmed publisher
Munjal C, Tyagi N, Lominadze D, Tyagi S. Matrix metalloproteinase-9 in homocysteine-induced intestinal microvascular endothelial paracellular and transcellular permeability. J Cell Biochem. 2012;113:1159-69 pubmed publisher
Rudnick J, Arendt L, Klebba I, Hinds J, Iyer V, Gupta P, et al. Functional heterogeneity of breast fibroblasts is defined by a prostaglandin secretory phenotype that promotes expansion of cancer-stem like cells. PLoS ONE. 2011;6:e24605 pubmed publisher
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Davalos A, Fernandez Hernando C, Sowa G, Derakhshan B, Lin M, Lee J, et al. Quantitative proteomics of caveolin-1-regulated proteins: characterization of polymerase i and transcript release factor/CAVIN-1 IN endothelial cells. Mol Cell Proteomics. 2010;9:2109-24 pubmed publisher
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product information
master code :
NBP2-19051
SKU :
NBP2-19051
product name :
E-Cadherin Antibody (7H12)
unit size :
0.1 ml (also 0.025 ml)
description :
The E-Cadherin Antibody (7H12) from Novus is a mouse monoclonal antibody to E-Cadherin. This antibody reacts with human,monkey,mouse. The E-Cadherin Antibody (7H12) has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Western Blot,Multiplex Immunofluorescence,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Flow Cytometry,ELISA.
target :
E-Cadherin
category :
Primary Antibodies
buffer :
Ascites
clonality :
Monoclonal
clone :
7H12
conjugate :
Unconjugated
host :
Mouse
immunogen :
Purified recombinant fragment of human E-Cadherin expressed in E. Coli.
isotype :
IgG1
purity :
Unpurified
species :
Human,Monkey,Mouse
theoretical molecular weight :
135 kDa
gene symbol :
CDH1
Antibody validation :
Biological Validation
accessionNumbers :
P12830
applications :
Immunohistochemistry,Western Blot,Multiplex Immunofluorescence,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,ELISA
USD :
579 USD
alt names :
Arc-1, cadherin 1, E-cadherin (epithelial), cadherin 1, type 1, E-cadherin (epithelial), cadherin-1, calcium-dependent adhesion protein, epithelial, CAM 120/80, CD324, CD324 antigen, CDHE, cell-CAM 120/80, ECAD, E-cadherin, Epithelial cadherin, LCAM, UVOE-Cadherin, uvomorulin
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.