Bcl-2 Antibody (100/D5) | Novus Biologicals NBP2-15200 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Bcl-2 Antibody (100/D5)

catalog :

NBP2-15200

quantity :

0.02 mg

price :

149 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

100/D5

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 8

Reference
Olszewska B, Zawrocki A, Lakomy J, Karczewska J, Gleń J, Zabłotna M, et al. Mapping signal transducer and activator of transcription (STAT) activity in different stages of mycosis fungoides and Sezary syndrome. Int J Dermatol. 2020;59:1106-1112 pubmed publisher
Sławińska M, Lakomy J, Biernat W, Sokołowska Wojdyło M, Karczewska J, Zabłotna M, et al. STAT3, STAT5A, STAT5B and STAT6 proteins are overexpressed in human basal cell carcinoma. Clin Exp Dermatol. 2019;: pubmed publisher
Mega Tiber P, Kocyigit Sevinc S, Kilinc O, Orun O. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562. Gene. 2019;692:217-222 pubmed publisher
Pradhan N, Pratheek B, Garai A, Kumar A, Meena V, Ghosh S, et al. Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol Int. 2014;38:1118-31 pubmed publisher
Moschovi M, Koultouki E, Stefanaki K, Sfakianos G, Tourkantoni N, Prodromou N, et al. Prognostic significance of angiogenesis in relation to Ki-67, p-53, p-27, and bcl-2 expression in embryonal tumors. Pediatr Neurosurg. 2011;47:241-7 pubmed publisher
Tralongo V, Becchina G, Nagar C, Ottoveggio G, Mason S, Seno B, et al. Primary follicular lymphoma of the epididymis positive for t(14;18)(q32;q21)/IGH-BCL2 and negative for BCL2 protein expression: a case report. J Med Case Rep. 2012;6:24 pubmed publisher
Kren L, Brazdil J, Hermanova M, Goncharuk V, Kallakury B, Kaur P, et al. Prognostic significance of anti-apoptosis proteins survivin and bcl-2 in non-small cell lung carcinomas: a clinicopathologic study of 102 cases. Appl Immunohistochem Mol Morphol. 2004;12:44-9 pubmed
Kaur P, Kallakury B, Sheehan C, Fisher H, Kaufman R, Ross J. Survivin and Bcl-2 expression in prostatic adenocarcinomas. Arch Pathol Lab Med. 2004;128:39-43 pubmed

product information

brand :

Novus

master code :

NBP2-15200

SKU :

NBP2-15200-0.02mg

product name :

Bcl-2 Antibody (100/D5)

description :

The Bcl-2 Antibody (100/D5) from Novus Biologicals is a mouse monoclonal antibody to Bcl-2. This antibody reacts with human, mouse (negative), rat (negative). The Bcl-2 Antibody (100/D5) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular).

target :

Bcl-2

category :

Primary Antibodies

unit size :

0.02 mg

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

100/D5

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

The synthetic peptide corresponding to amino acids range from 41-64 (GAAPAPGIFSSQPG-Cys), of human Bcl-2 was used as immunogen to generate the antibody; GenBank no. NP_000648.2 (Pezzella et al, 1990).

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human, Mouse (Negative), Rat (Negative)

specificity :

This antibody recognizes a protein of 25-26kDa, identified as the bcl-2alpha oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2alpha oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2alpha protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.

theoretical molecular weight :

25 kDa

gene symbol :

BCL2

catalog number base :

NBP2-15200

accessionNumbers :

P10415

applications :

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular)

2020 USD :

129

2021 USD :

149 USD

alt names :

apoptosis regulator Bcl-2, B-cell CLL/lymphoma 2, Bcl-2

storage :

Store at 4C.