Melan-A/MART-1 Antibody (M2-7C10) | Novus Biologicals NBP2-15197 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Melan-A/MART-1 Antibody (M2-7C10)

catalog :

NBP2-15197

quantity :

0.1 mg (also 20 ug, 0.2 mg)

price :

349 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

M2-7C10

reactivity :

human, mouse, rat

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 17

Reference
Roberts J, Poklepovic A, Booth L, Dent P. The multi-kinase inhibitor lenvatinib interacts with the HDAC inhibitor entinostat to kill liver cancer cells. Cell Signal. 2020;70:109573 pubmed publisher
Dent P, Booth L, Roberts J, Poklepovic A, Hancock J. Fingolimod Augments Monomethylfumarate Killing of GBM Cells. Front Oncol. 2020;10:22 pubmed publisher
Zachari M, Rainard J, Pandarakalam G, Robinson L, Gillespie J, Rajamanickam M, et al. The identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochem J. 2020;477:801-814 pubmed publisher
Dent P, Booth L, Roberts J, Poklepovic A, Hancock J. (Curcumin+sildenafil) enhances the efficacy of 5FU and anti-PD1 therapies in vivo. J Cell Physiol. 2020;: pubmed publisher
Booth L, Roberts J, West C, Von Hoff D, Dent P. GZ17-6.02 initiates DNA damage causing autophagosome-dependent HDAC degradation resulting in enhanced anti-PD1 checkpoint inhibitory antibody efficacy. J Cell Physiol. 2020;: pubmed publisher
Demas D, Demo S, Fallah Y, Clarke R, Nephew K, Althouse S, et al. Glutamine Metabolism Drives Growth in Advanced Hormone Receptor Positive Breast Cancer. Front Oncol. 2019;9:686 pubmed publisher
Booth L, Roberts J, Poklepovic A, Dent P. The Lethality of [Pazopanib + HDAC Inhibitors] Is Enhanced by Neratinib. Front Oncol. 2019;9:650 pubmed publisher
Dent P, Booth L, Roberts J, Liu J, Poklepovic A, Lalani A, et al. Neratinib inhibits Hippo/YAP signaling, reduces mutant K-RAS expression, and kills pancreatic and blood cancer cells. Oncogene. 2019;38:5890-5904 pubmed publisher
Yang S, Wei J, Cui Y, Park G, Shah P, Deng Y, et al. m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade. Nat Commun. 2019;10:2782 pubmed publisher
Prakash R, Izraely S, Thareja N, Lee R, Rappaport M, Kawaguchi R, et al. Regeneration Enhances Metastasis: A Novel Role for Neurovascular Signaling in Promoting Melanoma Brain Metastasis. Front Neurosci. 2019;13:297 pubmed publisher
Shoemaker C, Huang T, Weir N, Polyakov N, Schultz S, Denic V. CRISPR screening using an expanded toolkit of autophagy reporters identifies TMEM41B as a novel autophagy factor. PLoS Biol. 2019;17:e2007044 pubmed publisher
Booth L, Roberts J, Spiegel S, Poklepovic A, Dent P. Fingolimod augments Pemetrexed killing of non-small cell lung cancer and overcomes resistance to ERBB inhibition. Cancer Biol Ther. 2019;20:597-607 pubmed publisher
Booth L, Roberts J, Samuel P, Avogadri Connors F, Cutler R, Lalani A, et al. The irreversible ERBB1/2/4 inhibitor neratinib interacts with the PARP1 inhibitor niraparib to kill ovarian cancer cells. Cancer Biol Ther. 2018;19:525-533 pubmed publisher
Collins G, Essary L, Strauss J, Hino P, Cockerell C. Incidentally discovered distant cutaneous metastasis of sacral chordoma: a case with variation in S100 protein expression (compared to the primary tumor) and review of the literature. J Cutan Pathol. 2012;39:637-43 pubmed publisher
Mihic Probst D, Ikenberg K, Tinguely M, Schraml P, Behnke S, Seifert B, et al. Tumor cell plasticity and angiogenesis in human melanomas. PLoS ONE. 2012;7:e33571 pubmed publisher
Hoashi T, Watabe H, Muller J, Yamaguchi Y, Vieira W, Hearing V. MART-1 is required for the function of the melanosomal matrix protein PMEL17/GP100 and the maturation of melanosomes. J Biol Chem. 2005;280:14006-16 pubmed
Puri N, Eller M, Byers H, Dykstra S, Kubera J, Gilchrest B. Telomere-based DNA damage responses: a new approach to melanoma. FASEB J. 2004;18:1373-81 pubmed

product information

brand :

Novus

master code :

NBP2-15197

SKU :

NBP2-15197-0.1mg

product name :

Melan-A/MART-1 Antibody (M2-7C10)

description :

The Melan-A/MART-1 Antibody (M2-7C10) from Novus Biologicals is a mouse monoclonal antibody to Melan-A/MART-1. This antibody reacts with human, mouse (negative), rat (negative). The Melan-A/MART-1 Antibody (M2-7C10) has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen.

target :

Melan-A/MART-1

category :

Primary Antibodies

unit size :

0.1 mg (also 20 ug, 0.2 mg)

buffer :

10 mM PBS with 0.05% BSA

clonality :

Monoclonal

clone :

M2-7C10

concentration :

0.2 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Recombinant human Melan-A protein was used as immunogen to generate the Melan-A antibody.

isotype :

IgG2b Kappa

purity :

Protein G purified

species :

Human, Mouse (Negative), Rat (Negative)

specificity :

This antibody recognizes a protein doublet of 20-22kDa, identified as MART-1 (Melanoma Antigen Recognized by T cells 1) or Melan-A. MART-1 is a newly identified melanocyte differentiation antigen recognized by autologous cytotoxic T lymphocytes. Seven other melanoma associated antigens recognized by autologous cytotoxic T cells include MAGE-1, MAGE-3, tyrosinase, gp100, gp75, BAGE-1, and GAGE-1. Subcellular fractionation shows that MART-1 is present in melanosomes and endoplasmic reticulum. This MAb labels melanomas and other tumors showing melanocytic differentiation. It is also a useful positive-marker for angiomyolipomas. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.

gene symbol :

MLANA

catalog number base :

NBP2-15197

accessionNumbers :

Q16655

applications :

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen

2020 USD :

329

2021 USD :

349 USD

alt names :

Antigen LB39-AA, Antigen SK29-AA, Mart 1 Melan A, MART1MART-1, melan-A, melanoma antigen recognized by T-cells 1, Protein Melan-A

storage :

Store at 4C.