product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PKM1 Antibody - BSA Free
catalog :
NBP2-14833
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
R34-34
reactivity :
human, mouse, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 57
Reference
Li Y, Chen X, Huang H, Liao L, Chong H, Li G, et al. A feedback loop between NONHSAT024276 and PTBP1 inhibits tumor progression and glycolysis in HCC by increasing the PKM1/PKM2 ratio. Cancer Sci. 2023;114:1519-1540 pubmed publisher
Deck M, Van Hameren G, Campbell G, Bernard Marissal N, Devaux J, Berthelot J, et al. Physiology of PNS axons relies on glycolytic metabolism in myelinating Schwann cells. PLoS ONE. 2022;17:e0272097 pubmed publisher
Han J, Hyun J, Park J, Jung S, Oh Y, Kim Y, et al. Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease. Cell Rep. 2021;37:110102 pubmed publisher
Tian L, Xiong P, Alizadeh E, Lima P, Potus F, Mewburn J, et al. Supra-coronary aortic banding improves right ventricular function in experimental pulmonary arterial hypertension in rats by increasing systolic right coronary artery perfusion. Acta Physiol (Oxf). 2020;229:e13483 pubmed publisher
Okazaki M, Fushida S, Tsukada T, Kinoshita J, Oyama K, Miyashita T, et al. The effect of HIF-1? and PKM1 expression on acquisition of chemoresistance. Cancer Manag Res. 2018;10:1865-1874 pubmed publisher
Shanmugasundaram K, Nayak B, Friedrichs W, Kaushik D, Rodriguez R, Block K. NOX4 functions as a mitochondrial energetic sensor coupling cancer metabolic reprogramming to drug resistance. Nat Commun. 2017;8:997 pubmed publisher
Zhang H, Wang D, Li M, Plecitá Hlavatá L, D Alessandro A, Tauber J, et al. Metabolic and Proliferative State of Vascular Adventitial Fibroblasts in Pulmonary Hypertension Is Regulated Through a MicroRNA-124/PTBP1 (Polypyrimidine Tract Binding Protein 1)/Pyruvate Kinase Muscle Axis. Circulation. 2017;136:2468-2485 pubmed publisher
Minami K, Taniguchi K, Sugito N, Kuranaga Y, Inamoto T, Takahara K, et al. MiR-145 negatively regulates Warburg effect by silencing KLF4 and PTBP1 in bladder cancer cells. Oncotarget. 2017;8:33064-33077 pubmed publisher
Takai T, Yoshikawa Y, Inamoto T, Minami K, Taniguchi K, Sugito N, et al. A Novel Combination RNAi toward Warburg Effect by Replacement with miR-145 and Silencing of PTBP1 Induces Apoptotic Cell Death in Bladder Cancer Cells. Int J Mol Sci. 2017;18: pubmed publisher
Sugiyama T, Taniguchi K, Matsuhashi N, Tajirika T, Futamura M, Takai T, et al. MiR-133b inhibits growth of human gastric cancer cells by silencing pyruvate kinase muscle-splicer polypyrimidine tract-binding protein 1. Cancer Sci. 2016;107:1767-1775 pubmed publisher
Casson R, Wood J, Han G, Kittipassorn T, Peet D, Chidlow G. M-Type Pyruvate Kinase Isoforms and Lactate Dehydrogenase A in the Mammalian Retina: Metabolic Implications. Invest Ophthalmol Vis Sci. 2016;57:66-80 pubmed publisher
Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Matsuhashi N, et al. Positive feedback of DDX6/c-Myc/PTB1 regulated by miR-124 contributes to maintenance of the Warburg effect in colon cancer cells. Biochim Biophys Acta. 2015;1852:1971-80 pubmed publisher
Taniguchi K, Sugito N, Kumazaki M, Shinohara H, Yamada N, Nakagawa Y, et al. MicroRNA-124 inhibits cancer cell growth through PTB1/PKM1/PKM2 feedback cascade in colorectal cancer. Cancer Lett. 2015;363:17-27 pubmed publisher
Taniguchi K, Ito Y, Sugito N, Kumazaki M, Shinohara H, Yamada N, et al. Organ-specific PTB1-associated microRNAs determine expression of pyruvate kinase isoforms. Sci Rep. 2015;5:8647 pubmed publisher
Shinohara H, Taniguchi K, Kumazaki M, Yamada N, Ito Y, Otsuki Y, et al. Anti-cancer fatty-acid derivative induces autophagic cell death through modulation of PKM isoform expression profile mediated by bcr-abl in chronic myeloid leukemia. Cancer Lett. 2015;360:28-38 pubmed publisher
Fong M, Zhou W, Liu L, Alontaga A, Chandra M, Ashby J, et al. Breast-cancer-secreted miR-122 reprograms glucose metabolism in premetastatic niche to promote metastasis. Nat Cell Biol. 2015;17:183-94 pubmed publisher
Palsson McDermott E, Curtis A, Goel G, Lauterbach M, Sheedy F, Gleeson L, et al. Pyruvate kinase M2 regulates Hif-1? activity and IL-1? induction and is a critical determinant of the warburg effect in LPS-activated macrophages. Cell Metab. 2015;21:65-80 pubmed publisher
Bruns D, Brown R, Stenmark K, Buttrick P, Walker L. Mitochondrial integrity in a neonatal bovine model of right ventricular dysfunction. Am J Physiol Lung Cell Mol Physiol. 2015;308:L158-67 pubmed publisher
Faller E, McVey M, MacPherson P. IL-7 receptor recovery on CD8 T-cells isolated from HIV+ patients is inhibited by the HIV Tat protein. PLoS ONE. 2014;9:e102677 pubmed publisher
Larbi A, Mitjavila Garcia M, Flamant S, Valogne Y, Clay D, Usunier B, et al. Generation of multipotent early lymphoid progenitors from human embryonic stem cells. Stem Cells Dev. 2014;23:2983-95 pubmed publisher
Munneke J, Björklund A, Mjösberg J, Garming Legert K, Bernink J, Blom B, et al. Activated innate lymphoid cells are associated with a reduced susceptibility to graft-versus-host disease. Blood. 2014;124:812-21 pubmed publisher
Forsberg A, Bengtsson M, Eringfält A, Ernerudh J, Mjösberg J, Jenmalm M. GATA binding protein 3? group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates. J Allergy Clin Immunol. 2014;134:228-30 pubmed publisher
Peguillet I, Milder M, Louis D, Vincent Salomon A, Dorval T, Piperno Neumann S, et al. High numbers of differentiated effector CD4 T cells are found in patients with cancer and correlate with clinical response after neoadjuvant therapy of breast cancer. Cancer Res. 2014;74:2204-16 pubmed publisher
Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 2014;10:e1003890 pubmed publisher
Compeer E, Flinsenberg T, Boon L, Hoekstra M, Boes M. Tubulation of endosomal structures in human dendritic cells by Toll-like receptor ligation and lymphocyte contact accompanies antigen cross-presentation. J Biol Chem. 2014;289:520-8 pubmed publisher
Yu X, Pappu R, Ramirez Carrozzi V, Ota N, Caplazi P, Zhang J, et al. TNF superfamily member TL1A elicits type 2 innate lymphoid cells at mucosal barriers. Mucosal Immunol. 2014;7:730-40 pubmed publisher
Lozza L, Farinacci M, Faé K, Bechtle M, Stäber M, Dorhoi A, et al. Crosstalk between human DC subsets promotes antibacterial activity and CD8+ T-cell stimulation in response to bacille Calmette-Guérin. Eur J Immunol. 2014;44:80-92 pubmed publisher
Ponchel F, Goeb V, Parmar R, El Sherbiny Y, Boissinot M, El Jawhari J, et al. An immunological biomarker to predict MTX response in early RA. Ann Rheum Dis. 2014;73:2047-53 pubmed publisher
Bernink J, Peters C, Munneke M, te Velde A, Meijer S, Weijer K, et al. Human type 1 innate lymphoid cells accumulate in inflamed mucosal tissues. Nat Immunol. 2013;14:221-9 pubmed publisher
Luckashenak N, Wähe A, Breit K, Brakebusch C, Brocker T. Rho-family GTPase Cdc42 controls migration of Langerhans cells in vivo. J Immunol. 2013;190:27-35 pubmed publisher
Ghazawi F, Faller E, Sugden S, Kakal J, MacPherson P. IL-7 downregulates IL-7R? expression in human CD8 T cells by two independent mechanisms. Immunol Cell Biol. 2013;91:149-58 pubmed publisher
Yatim A, Benne C, Sobhian B, Laurent Chabalier S, Déas O, Judde J, et al. NOTCH1 nuclear interactome reveals key regulators of its transcriptional activity and oncogenic function. Mol Cell. 2012;48:445-58 pubmed publisher
Petrovas C, Yamamoto T, Gerner M, Boswell K, Wloka K, Smith E, et al. CD4 T follicular helper cell dynamics during SIV infection. J Clin Invest. 2012;122:3281-94 pubmed publisher
Noakes P, Vlachava M, Kremmyda L, Diaper N, Miles E, Erlewyn Lajeunesse M, et al. Increased intake of oily fish in pregnancy: effects on neonatal immune responses and on clinical outcomes in infants at 6 mo. Am J Clin Nutr. 2012;95:395-404 pubmed publisher
Young C, Angel J. HIV infection of thymocytes inhibits IL-7 activity without altering CD127 expression. Retrovirology. 2011;8:72 pubmed publisher
Mjösberg J, Trifari S, Crellin N, Peters C, van Drunen C, Piet B, et al. Human IL-25- and IL-33-responsive type 2 innate lymphoid cells are defined by expression of CRTH2 and CD161. Nat Immunol. 2011;12:1055-62 pubmed publisher
Pankewycz O, Leca N, Kohli R, Wallace P, Said M, Feng L, et al. Low-dose rabbit antithymocyte globulin induction therapy results in prolonged selective lymphocyte depletion irrespective of maintenance immunosuppression. Transplant Proc. 2011;43:462-5 pubmed publisher
van Roon J, Hartgring S, van der Wurff Jacobs K, Bijlsma J, Lafeber F. Numbers of CD25+Foxp3+ T cells that lack the IL-7 receptor are increased intra-articularly and have impaired suppressive function in RA patients. Rheumatology (Oxford). 2010;49:2084-9 pubmed publisher
Engram J, Cervasi B, Borghans J, Klatt N, Gordon S, Chahroudi A, et al. Lineage-specific T-cell reconstitution following in vivo CD4+ and CD8+ lymphocyte depletion in nonhuman primates. Blood. 2010;116:748-58 pubmed publisher
Crawley A, Faucher S, Angel J. Soluble IL-7R alpha (sCD127) inhibits IL-7 activity and is increased in HIV infection. J Immunol. 2010;184:4679-87 pubmed publisher
Presicce P, Moreno Fernandez M, Lages C, Orsborn K, Chougnet C. Association of two clones allows for optimal detection of human FOXP3. Cytometry A. 2010;77:571-9 pubmed publisher
Valencia J, Hernández López C, Martínez V, Hidalgo L, Zapata A, Vicente A, et al. Transient beta-catenin stabilization modifies lineage output from human thymic CD34+CD1a- progenitors. J Leukoc Biol. 2010;87:405-14 pubmed publisher
Portevin D, Poupot M, Rolland O, Turrin C, Fournie J, Majoral J, et al. Regulatory activity of azabisphosphonate-capped dendrimers on human CD4+ T cell proliferation enhances ex-vivo expansion of NK cells from PBMCs for immunotherapy. J Transl Med. 2009;7:82 pubmed publisher
Vudattu N, Kuhlmann Berenzon S, Khademi M, Seyfert V, Olsson T, Maeurer M. Increased numbers of IL-7 receptor molecules on CD4+CD25-CD107a+ T-cells in patients with autoimmune diseases affecting the central nervous system. PLoS ONE. 2009;4:e6534 pubmed publisher
Sauce D, Larsen M, Abbott R, Hislop A, Leese A, Khan N, et al. Upregulation of interleukin 7 receptor alpha and programmed death 1 marks an epitope-specific CD8+ T-cell response that disappears following primary Epstein-Barr virus infection. J Virol. 2009;83:9068-78 pubmed publisher
Łuczyński W, Wawrusiewicz Kurylonek N, Stasiak Barmuta A, Urban R, Iłendo E, Urban M, et al. Diminished expression of ICOS, GITR and CTLA-4 at the mRNA level in T regulatory cells of children with newly diagnosed type 1 diabetes. Acta Biochim Pol. 2009;56:361-70 pubmed
Faller E, Kakal J, Kumar R, MacPherson P. IL-7 and the HIV Tat protein act synergistically to down-regulate CD127 expression on CD8 T cells. Int Immunol. 2009;21:203-16 pubmed publisher
Sharma T, Hughes J, Murillo A, Riley J, Soares A, Little F, et al. CD8+ T-cell interleukin-7 receptor alpha expression as a potential indicator of disease status in HIV-infected children. PLoS ONE. 2008;3:e3986 pubmed publisher
Mason R, Rose R, Seddiki N, Kelleher A, Kent S. Low pre-infection levels and loss of central memory CD4+ T cells may predict rapid progression in SIV-infected pigtail macaques. Virology. 2008;381:11-5 pubmed publisher
Johnson S, Shah N, Bajer A, Lebien T. IL-7 activates the phosphatidylinositol 3-kinase/AKT pathway in normal human thymocytes but not normal human B cell precursors. J Immunol. 2008;180:8109-17 pubmed
Zonios D, Falloon J, Bennett J, Shaw P, Chaitt D, Baseler M, et al. Idiopathic CD4+ lymphocytopenia: natural history and prognostic factors. Blood. 2008;112:287-94 pubmed publisher
Esquerré M, Tauzin B, Guiraud M, Müller S, Saoudi A, Valitutti S. Human regulatory T cells inhibit polarization of T helper cells toward antigen-presenting cells via a TGF-beta-dependent mechanism. Proc Natl Acad Sci U S A. 2008;105:2550-5 pubmed publisher
Esendagli G, Bruderek K, Goldmann T, Busche A, Branscheid D, Vollmer E, et al. Malignant and non-malignant lung tissue areas are differentially populated by natural killer cells and regulatory T cells in non-small cell lung cancer. Lung Cancer. 2008;59:32-40 pubmed
Scupoli M, Perbellini O, Krampera M, Vinante F, Cioffi F, Pizzolo G. Interleukin 7 requirement for survival of T-cell acute lymphoblastic leukemia and human thymocytes on bone marrow stroma. Haematologica. 2007;92:264-6 pubmed
Hartigan O Connor D, Poon C, Sinclair E, McCune J. Human CD4+ regulatory T cells express lower levels of the IL-7 receptor alpha chain (CD127), allowing consistent identification and sorting of live cells. J Immunol Methods. 2007;319:41-52 pubmed publisher
Higgins J, Metcalf J, Stevens R, Baseler M, Nason M, Lane H, et al. Effects of lymphocyte isolation and timing of processing on detection of CD127 expression on T cells in human immunodeficiency virus-infected patients. Clin Diagn Lab Immunol. 2005;12:228-30 pubmed
Ito T, Amakawa R, Inaba M, Ikehara S, Inaba K, Fukuhara S. Differential regulation of human blood dendritic cell subsets by IFNs. J Immunol. 2001;166:2961-9 pubmed
product information
master code :
NBP2-14833
SKU :
NBP2-14833
product name :
PKM1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The PKM1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to PKM1. This antibody reacts with bovine,human,mouse. The PKM1 Antibody - BSA Free has been validated for the following applications: Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunoblotting,Simple Western.
target :
PKM1
category :
Primary Antibodies
buffer :
PBS and 30% Glycerol
clonality :
Polyclonal
concentration :
1.17 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to a C-terminal portion of the human PKM1 protein (between residues 350-450) [UniProt P14618-2].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Bovine,Human,Mouse
specificity :
This antibody is specific for the M1 isoform of PKM
gene symbol :
PKM
Antibody validation :
Biological Validation
accessionNumbers :
P14618, P52480
applications :
Western Blot,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Immunoblotting,Simple Western
USD :
409 USD
alt names :
PK1, Pyruvate kinase isozyme M1, Pyruvate kinase isozymes M1, Pyruvate kinase M1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.