product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
beta Amyloid Antibody (MOAB-2) - BSA Free
catalog :
NBP2-13075
quantity :
0.1 ml (also 0.025 ml)
price :
479 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
MOAB-2
reactivity :
human, mouse, rat, rhesus macaque
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry - free floating section, dot blot
more info or order :
citations: 71
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - free floating section; mouse; 1:1000; loading ...; fig 1a
Puntambekar S, Moutinho M, Lin P, Jadhav V, Tumbleson Brink D, Balaji A, et al. CX3CR1 deficiency aggravates amyloid driven neuronal pathology and cognitive decline in Alzheimer's disease. Mol Neurodegener. 2022;17:47 pubmed publisher
Abd Elrahman K, Colson T, Sarasija S, Ferguson S. A M1 muscarinic acetylcholine receptor-specific positive allosteric modulator VU0486846 reduces neurogliosis in female Alzheimer's mice. Biomed Pharmacother. 2024;173:116388 pubmed publisher
Datta D, Perone I, Wijegunawardana D, Liang F, Morozov Y, ARELLANO J, et al. Nanoscale imaging of pT217-tau in aged rhesus macaque entorhinal and dorsolateral prefrontal cortex: Evidence of interneuronal trafficking and early-stage neurodegeneration. Alzheimers Dement. 2024;20:2843-2860 pubmed publisher
Huang Z, Gong Z, Lin Y, Yang F, Chen W, Xiang S, et al. Treatment with glatiramer acetate in APPswe/PS1dE9 mice at an early stage of Alzheimer's disease prior to amyloid-beta deposition delays the disease's pathological development and ameliorates cognitive decline. Front Aging Neurosci. 2024;16:1267780 pubmed publisher
Marshall J, Huynh K, Lancaster G, Ng J, Collins J, Pernes G, et al. Behavioral, metabolic, and lipidomic characterization of the 5xFADxTg30 mouse model of Alzheimer's disease. iScience. 2024;27:108800 pubmed publisher
He J, Liu Y, Li J, Zhao Y, Jiang H, Luo S, et al. Intestinal changes in permeability, tight junction and mucin synthesis in a mouse model of Alzheimer's disease. Int J Mol Med. 2023;52: pubmed publisher
Marinho D, Ferreira I, Lorenzoni R, Cardoso S, Santana I, Rego A. Reduction of class I histone deacetylases ameliorates ER-mitochondria cross-talk in Alzheimer's disease. Aging Cell. 2023;22:e13895 pubmed publisher
Chae C, Yoon J, Lim J, Park J, Cho J, Jung Y, et al. TRIM16-mediated lysophagy suppresses high-glucose-accumulated neuronal Aβ. Autophagy. 2023;19:2752-2768 pubmed publisher
Kim M, Kim S, Lee J, Kim J, Oh E, Kim S, et al. Lignan-Rich Sesame (Sesamum indicum L.) Cultivar Exhibits In Vitro Anti-Cholinesterase Activity, Anti-Neurotoxicity in Amyloid-β Induced SH-SY5Y Cells, and Produces an In Vivo Nootropic Effect in Scopolamine-Induced Memory Impaired Mice. Antioxidants (Basel). 2023;12: pubmed publisher
Li J, Hu T, Zhou X, Zhang T, Guo J, Wang M, et al. The involvement of NLRP3 inflammasome in CUMS-induced AD-like pathological changes and related cognitive decline in mice. J Neuroinflammation. 2023;20:112 pubmed publisher
Panes Fernández J, Godoy P, Gavilan J, Ram xed rez Molina O, Burgos C, Marileo A, et al. TG2 promotes amyloid beta aggregates: Impact on ER-mitochondria crosstalk, calcium homeostasis and synaptic function in Alzheimer's disease. Biomed Pharmacother. 2023;162:114596 pubmed publisher
Wang C, Shen D, Hu Y, Chen J, Liu J, Huang Y, et al. Selective Targeting of Class I HDAC Reduces Microglial Inflammation in the Entorhinal Cortex of Young APP/PS1 Mice. Int J Mol Sci. 2023;24: pubmed publisher
Tiwari V, Singh J, Tiwari P, Chaturvedi S, Gupta S, Mishra A, et al. ACE2/ANG-(1-7)/Mas receptor axis activation prevents inflammation and improves cognitive functions in streptozotocin induced rat model of Alzheimer's disease-like phenotypes. Eur J Pharmacol. 2023;946:175623 pubmed publisher
Das S, Ramanan N. Region-specific heterogeneity in neuronal nuclear morphology in young, aged and in Alzheimer's disease mouse brains. Front Cell Dev Biol. 2023;11:1032504 pubmed publisher
Choi C, Kim H, Oh J, Park C, Kim M, Kim C, et al. DSCR1 deficiency ameliorates the Aβ pathology of Alzheimer's disease by enhancing microglial activity. Life Sci Alliance. 2023;6: pubmed publisher
Bhatia H, Brunner A, xd6 zt xfc rk F, Kapoor S, Rong Z, Mai H, et al. Spatial proteomics in three-dimensional intact specimens. Cell. 2022;185:5040-5058.e19 pubmed publisher
Dong Y, Cheng L, Zhao Y. Resetting the circadian clock of Alzheimer's mice via GLP-1 injection combined with time-restricted feeding. Front Physiol. 2022;13:911437 pubmed publisher
Ngwa D, Agrawal A. Structurally Altered, Not Wild-Type, Pentameric C-Reactive Protein Inhibits Formation of Amyloid-β Fibrils. J Immunol. 2022;209:1180-1188 pubmed publisher
Bryois J, Calini D, Macnair W, Foo L, Urich E, Ortmann W, et al. Cell-type-specific cis-eQTLs in eight human brain cell types identify novel risk genes for psychiatric and neurological disorders. Nat Neurosci. 2022;25:1104-1112 pubmed publisher
Yao P, Parmar V, Choudhary M, Malek G. NURR1 expression regulates retinal pigment epithelial-mesenchymal transition and age-related macular degeneration phenotypes. Proc Natl Acad Sci U S A. 2022;119:e2202256119 pubmed publisher
Liu C, Sang Z, Pan H, Wu Q, Qiu Y, Shi J. A Novel Multifunctional 5,6-Dimethoxy-Indanone-Chalcone-Carbamate Hybrids Alleviates Cognitive Decline in Alzheimer's Disease by Dual Inhibition of Acetylcholinesterase and Inflammation. Front Aging Neurosci. 2022;14:922650 pubmed publisher
Zhong Y, Zhang C, Wang Y, Tang C, Ren J, Wang M, et al. Multiple exposures to sevoflurane across postnatal development may cause cognitive deficits in older age. Pediatr Res. 2022;: pubmed publisher
Chen T, Lee S, Zheng W, Hsu C, Cho K, Kuo L, et al. White matter pathology in alzheimer's transgenic mice with chronic exposure to low-level ambient fine particulate matter. Part Fibre Toxicol. 2022;19:44 pubmed publisher
Simon M, Wang M, Ismail O, Braun M, Schindler A, Reemmer J, et al. Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid β plaque formation in mice. Alzheimers Res Ther. 2022;14:59 pubmed publisher
Tao R, Wang N, Shen T, Tan Y, Ren Y, Wei W, et al. High-fidelity imaging of amyloid-beta deposits with an ultrasensitive fluorescent probe facilitates the early diagnosis and treatment of Alzheimer's Disease. Theranostics. 2022;12:2549-2559 pubmed publisher
Wang J, Zhu X, Li Y, Zhang P, Wang T, Li M. Jiedu-Yizhi Formula Improves Cognitive Impairment in an Aβ 25-35-Induced Rat Model of Alzheimer's Disease by Inhibiting Pyroptosis. Evid Based Complement Alternat Med. 2022;2022:6091671 pubmed publisher
Hud xe1 k A, Letoha A, Vizler C, Letoha T. Syndecan-3 as a Novel Biomarker in Alzheimer's Disease. Int J Mol Sci. 2022;23: pubmed publisher
He Z, Huan P, Wang L, He J. Paeoniflorin ameliorates cognitive impairment in Parkinson's disease via JNK/p53 signaling. Metab Brain Dis. 2022;37:1057-1070 pubmed publisher
Walker J, Kazempour Dehkordi S, Fracassi A, Vanschoiack A, Pavenko A, Taglialatela G, et al. Differential protein expression in the hippocampi of resilient individuals identified by digital spatial profiling. Acta Neuropathol Commun. 2022;10:23 pubmed publisher
Zhao X, Hasan S, Liou B, Lin Y, Sun Y, Liu C. Analysis of the Biomarkers for Neurodegenerative Diseases in Aged Progranulin Deficient Mice. Int J Mol Sci. 2022;23: pubmed publisher
Han J, Hyun J, Park J, Jung S, Oh Y, Kim Y, et al. Aberrant role of pyruvate kinase M2 in the regulation of gamma-secretase and memory deficits in Alzheimer's disease. Cell Rep. 2021;37:110102 pubmed publisher
Bhargavan B, Woollard S, McMillan J, Kanmogne G. CCR5 antagonist reduces HIV-induced amyloidogenesis, tau pathology, neurodegeneration, and blood-brain barrier alterations in HIV-infected hu-PBL-NSG mice. Mol Neurodegener. 2021;16:78 pubmed publisher
Rimal S, Li Y, Vartak R, Geng J, Tantray I, Li S, et al. Inefficient quality control of ribosome stalling during APP synthesis generates CAT-tailed species that precipitate hallmarks of Alzheimer's disease. Acta Neuropathol Commun. 2021;9:169 pubmed publisher
Tikhonova M, Amstislavskaya T, Ho Y, Akopyan A, Tenditnik M, Ovsyukova M, et al. Neuroprotective Effects of Ceftriaxone Involve the Reduction of Aβ Burden and Neuroinflammatory Response in a Mouse Model of Alzheimer's Disease. Front Neurosci. 2021;15:736786 pubmed publisher
Godoy P, Mennickent D, Cuchillo Ibanez I, Ramírez Molina O, Silva Grecchi T, Panes Fernández J, et al. Increased P2×2 receptors induced by amyloid-β peptide participates in the neurotoxicity in alzheimer's disease. Biomed Pharmacother. 2021;142:111968 pubmed publisher
Choi C, Park J, Kim H, Chang K, Park J, MIN K. DSCR1 upregulation enhances dural meningeal lymphatic drainage to attenuate amyloid pathology of Alzheimer's disease. J Pathol. 2021;255:296-310 pubmed publisher
Wang M, Feng L, Li Z, Ma K, Chang K, Chen X, et al. Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice. J Neuroinflammation. 2021;18:146 pubmed publisher
Yang Y, Zhang J, Yang X, Li Z, Wang J, Lu C, et al. Dysregulated APP expression and α-secretase processing of APP is involved in manganese-induced cognitive impairment. Ecotoxicol Environ Saf. 2021;220:112365 pubmed publisher
Souder D, Dreischmeier I, Smith A, Wright S, Martin S, Sagar M, et al. Rhesus monkeys as a translational model for late-onset Alzheimer's disease. Aging Cell. 2021;20:e13374 pubmed publisher
Hanna R, Flamier A, Barabino A, Bernier G. G-quadruplexes originating from evolutionary conserved L1 elements interfere with neuronal gene expression in Alzheimer's disease. Nat Commun. 2021;12:1828 pubmed publisher
Liu Y, Hanson K, McCormack G, Atkinson R, Dittmann J, Vickers J, et al. Enhanced Anti-Amyloid Effect of Combined Leptin and Pioglitazone in APP/PS1 Transgenic Mice. Curr Alzheimer Res. 2020;17:1294-1301 pubmed publisher
Fernández Pérez E, Gallegos S, Armijo Weingart L, Araya A, Riffo Lepe N, Cayumán F, et al. Changes in neuronal excitability and synaptic transmission in nucleus accumbens in a transgenic Alzheimer's disease mouse model. Sci Rep. 2020;10:19606 pubmed publisher
Balczon R, Morrow K, Leavesley S, Francis C, Stevens T, Agwaramgbo E, et al. Cystatin C regulates the cytotoxicity of infection-induced endothelial-derived β-amyloid. FEBS Open Bio. 2020;10:2464-2477 pubmed publisher
Heckmann B, Teubner B, Boada Romero E, Tummers B, Guy C, Fitzgerald P, et al. Noncanonical function of an autophagy protein prevents spontaneous Alzheimer's disease. Sci Adv. 2020;6:eabb9036 pubmed publisher
Hernández Rodríguez M, Arciniega Martinez I, García Marín I, Correa Basurto J, Rosales Hernández M. Chronic Administration of Scopolamine Increased GSK3βP9, Beta Secretase, Amyloid Beta, and Oxidative Stress in the Hippocampus of Wistar Rats. Mol Neurobiol. 2020;57:3979-3988 pubmed publisher
Acharya A, Stockmann J, Beyer L, Rudack T, Nabers A, GUMBART J, et al. The Effect of (-)-Epigallocatechin-3-Gallate on the Amyloid-β Secondary Structure. Biophys J. 2020;119:349-359 pubmed publisher
Park S, Kang J, Lee T, Nam D, Jeon C, Kim J. SPON1 Can Reduce Amyloid Beta and Reverse Cognitive Impairment and Memory Dysfunction in Alzheimer's Disease Mouse Model. Cells. 2020;9: pubmed publisher
Voth S, Gwin M, FRANCIS C, Balczon R, Frank D, Pittet J, et al. Virulent Pseudomonas aeruginosa infection converts antimicrobial amyloids into cytotoxic prions. FASEB J. 2020;34:9156-9179 pubmed publisher
Liu X, Deng Y, Dai Z, Hu T, Cai W, Liu H, et al. Sodium tanshinone IIA sulfonate protects against Aβ1-42-induced cellular toxicity by modulating Aβ-degrading enzymes in HT22 cells. Int J Biol Macromol. 2020;151:47-55 pubmed publisher
He Y, Ruganzu J, Lin C, Ding B, Zheng Q, Wu X, et al. Tanshinone IIA ameliorates cognitive deficits by inhibiting endoplasmic reticulum stress-induced apoptosis in APP/PS1 transgenic mice. Neurochem Int. 2020;133:104610 pubmed publisher
Joseph E, Villalobos Acosta D, Torres Ramos M, Farfán García E, Gómez López M, Miliar Garcia A, et al. Neuroprotective Effects of Apocynin and Galantamine During the Chronic Administration of Scopolamine in an Alzheimer's Disease Model. J Mol Neurosci. 2020;70:180-193 pubmed publisher
Prokop S, Miller K, Labra S, Pitkin R, Hoxha K, Narasimhan S, et al. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta Neuropathol. 2019;138:613-630 pubmed publisher
Balczon R, Pittet J, Wagener B, Moser S, Voth S, Vorhees C, et al. Infection-induced endothelial amyloids impair memory. FASEB J. 2019;33:10300-10314 pubmed publisher
Tian C, Liu G, Gao L, Soltys D, Pan C, Stewart T, et al. Erythrocytic α-Synuclein as a potential biomarker for Parkinson's disease. Transl Neurodegener. 2019;8:15 pubmed publisher
El Hajjar J, Chatoo W, Hanna R, Nkanza P, Tétreault N, Tse Y, et al. Heterochromatic genome instability and neurodegeneration sharing similarities with Alzheimer's disease in old Bmi1+/- mice. Sci Rep. 2019;9:594 pubmed publisher
Cristiano C, Volpicelli F, Lippiello P, Buono B, Raucci F, Piccolo M, et al. Neutralization of interleukin-17 rescues amyloid-β-induced neuroinflammation and memory impairment. Br J Pharmacol. 2019;: pubmed publisher
Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J. Age moderates the effects of traumatic brain injury on beta-amyloid plaque load in APP/PS1 mice. J Neurotrauma. 2019;: pubmed publisher
Kim D, Lee D, Lim H, Choi S, Oh W, Yang Y, et al. Effect of growth differentiation factor-15 secreted by human umbilical cord blood-derived mesenchymal stem cells on amyloid beta levels in in vitro and in vivo models of Alzheimer's disease. Biochem Biophys Res Commun. 2018;504:933-940 pubmed publisher
Woodhouse A, Fernández Martos C, Atkinson R, Hanson K, Collins J, O Mara A, et al. Repeat propofol anesthesia does not exacerbate plaque deposition or synapse loss in APP/PS1 Alzheimer's disease mice. BMC Anesthesiol. 2018;18:47 pubmed publisher
Kim D, Lim H, Lee D, Choi S, Oh W, Yang Y, et al. Thrombospondin-1 secreted by human umbilical cord blood-derived mesenchymal stem cells rescues neurons from synaptic dysfunction in Alzheimer's disease model. Sci Rep. 2018;8:354 pubmed publisher
Paspalas C, Carlyle B, Leslie S, Preuss T, Crimins J, Huttner A, et al. The aged rhesus macaque manifests Braak stage III/IV Alzheimer's-like pathology. Alzheimers Dement. 2018;14:680-691 pubmed publisher
Muthukumaran K, Kanwar A, Vegh C, Marginean A, Elliott A, Guilbeault N, et al. Ubisol-Q10 (a Nanomicellar Water- Soluble Formulation of CoQ10) Treatment Inhibits Alzheimer-Type Behavioral and Pathological Symptoms in a Double Transgenic Mouse (TgAPEswe, PSEN1dE9) Model of Alzheimer's Disease. J Alzheimers Dis. 2017;: pubmed publisher
Lee D, Hwang C, Choi J, Park M, Song M, Oh K, et al. KRICT-9 inhibits neuroinflammation, amyloidogenesis and memory loss in Alzheimer's disease models. Oncotarget. 2017;8:68654-68667 pubmed publisher
Stuart K, King A, Fernandez Martos C, Summers M, Vickers J. Environmental novelty exacerbates stress hormones and Aβ pathology in an Alzheimer's model. Sci Rep. 2017;7:2764 pubmed publisher
Balczon R, Morrow K, Zhou C, Edmonds B, Alexeyev M, Pittet J, et al. Pseudomonas aeruginosa infection liberates transmissible, cytotoxic prion amyloids. FASEB J. 2017;31:2785-2796 pubmed publisher
Stuart K, King A, Fernandez Martos C, Dittmann J, Summers M, Vickers J. Mid-life environmental enrichment increases synaptic density in CA1 in a mouse model of A?-associated pathology and positively influences synaptic and cognitive health in healthy ageing. J Comp Neurol. 2017;525:1797-1810 pubmed publisher
Yu Y, Hsieh T, Chen K, Wu J, Hoffer B, Greig N, et al. Glucose-Dependent Insulinotropic Polypeptide Ameliorates Mild Traumatic Brain Injury-Induced Cognitive and Sensorimotor Deficits and Neuroinflammation in Rats. J Neurotrauma. 2016;33:2044-2054 pubmed
Collins J, King A, Woodhouse A, Kirkcaldie M, Vickers J. The effect of focal brain injury on beta-amyloid plaque deposition, inflammation and synapses in the APP/PS1 mouse model of Alzheimer's disease. Exp Neurol. 2015;267:219-29 pubmed publisher
Kim J, Yun H, Jin P, Lee H, Han J, Udumula V, et al. Inhibitory effect of a 2,4-bis(4-hydroxyphenyl)-2-butenal diacetate on neuro-inflammatory reactions via inhibition of STAT1 and STAT3 activation in cultured astrocytes and microglial BV-2 cells. Neuropharmacology. 2014;79:476-87 pubmed publisher
Youmans K, Tai L, Nwabuisi Heath E, JUNGBAUER L, Kanekiyo T, Gan M, et al. APOE4-specific changes in A? accumulation in a new transgenic mouse model of Alzheimer disease. J Biol Chem. 2012;287:41774-86 pubmed publisher
Youmans K, Tai L, Kanekiyo T, Stine W, Michon S, Nwabuisi Heath E, et al. Intraneuronal A? detection in 5xFAD mice by a new A?-specific antibody. Mol Neurodegener. 2012;7:8 pubmed publisher
product information
master code :
NBP2-13075
SKU :
NBP2-13075
product name :
beta Amyloid Antibody (MOAB-2) - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The beta Amyloid Antibody (MOAB-2) - BSA Free from Novus is a mouse monoclonal antibody to beta Amyloid. This antibody reacts with bacteria,human,monkey,mouse,primate - macaca mulatta (rhesus macaque),rat. The beta Amyloid Antibody (MOAB-2) - BSA Free has been validated for the following applications: Cytometric Bead Assay Standard,Immunoprecipitation,Western Blot,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,IF/IHC,ELISA,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating,Immunoblotting,Dot Blot.
target :
beta Amyloid
category :
Primary Antibodies
buffer :
PBS
clonality :
Monoclonal
clone :
MOAB-2
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Mouse
immunogen :
This beta Amyloid antibody was developed against recombinant human beta Amyloid 42.
isotype :
IgG2b
purity :
Protein G purified
species :
Bacteria,Human,Monkey,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat
specificity :
Beta Amyloid antibody (MOAB-2) recognizes unaggregated, oligomeric and fibrillar forms of beta Amyloid 42 and unaggregated beta Amyloid 40
theoretical molecular weight :
5 kDa
gene symbol :
APP
accessionNumbers :
P05067
applications :
Immunohistochemistry,Western Blot,Immunocytochemistry/ Immunofluorescence,Cytometric Bead Assay Standard,IF/IHC,ELISA,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating,Immunoblotting,Dot Blot
USD :
479 USD
alt names :
Abeta, Amyloid beta, beta-amyloid peptide
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.