product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
NLRP3/NALP3 Antibody - BSA Free
catalog :
NBP2-12446
quantity :
0.2 ml (also 0.05 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 350
clone name :
5B12
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 219
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; rat; 1:200; loading ...; fig 5i
  • western blot; rat; 1:1000; loading ...; fig 5k
Wu M, Ma Y, Chen X, Liang N, Qu S, Chen H. Hyperuricemia causes kidney damage by promoting autophagy and NLRP3-mediated inflammation in rats with urate oxidase deficiency. Dis Model Mech. 2021;14: pubmed publisher
  • western blot; rat; 1:500; fig 7a
Liang H, Matei N, McBride D, Xu Y, Zhou Z, Tang J, et al. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation. 2021;18:40 pubmed publisher
Liu C, Zhang Q, Zhou H, Jin L, Liu C, Yang M, et al. GLP-1R activation attenuates the progression of pulmonary fibrosis via disrupting NLRP3 inflammasome/PFKFB3-driven glycolysis interaction and histone lactylation. J Transl Med. 2024;22:954 pubmed publisher
Muela Zarzuela I, Suárez Rivero J, Gallardo Orihuela A, Wang C, Izawa K, de Gregorio Procopio M, et al. NLRP1 inflammasome promotes senescence and senescence-associated secretory phenotype. Inflamm Res. 2024;73:1253-1266 pubmed publisher
Lee Y, Yoon B, Son S, Cho E, Kim K, Choi E, et al. Inhibition of Immunoproteasome Attenuates NLRP3 Inflammasome Response by Regulating E3 Ubiquitin Ligase TRIM31. Cells. 2024;13: pubmed publisher
Mencarelli A, Bist P, Choi H, Khameneh H, Mortellaro A, Abraham S. Anaphylactic degranulation by mast cells requires the mobilization of inflammasome components. Nat Immunol. 2024;25:693-702 pubmed publisher
Lin H, Wang S, Sato K, Zhang Y, He B, Xu J, et al. Uric acid-driven NLRP3 inflammasome activation triggers lens epithelial cell senescence and cataract formation. Cell Death Discov. 2024;10:126 pubmed publisher
Gao F, Xiong D, Sun Z, Shao J, Wei D, Nie S. ARC@DPBNPs suppress LPS-induced acute lung injury via inhibiting macrophage pyroptosis and M1 polarization by ERK pathway in mice. Int Immunopharmacol. 2024;131:111794 pubmed publisher
Bartra C, Yuan Y, Vurai x107 K, Vald xe9 s Quiroz H, Garcia Baucells P, Slevin M, et al. Resveratrol Activates Antioxidant Protective Mechanisms in Cellular Models of Alzheimer's Disease Inflammation. Antioxidants (Basel). 2024;13: pubmed publisher
Zhou H, Zhang Q, Liu C, Fan J, Huang W, Li N, et al. NLRP3 inflammasome mediates abnormal epithelial regeneration and distal lung remodeling in silica‑induced lung fibrosis. Int J Mol Med. 2024;53: pubmed publisher
McElwain C, Musumeci A, Manna S, McCarthy F, McCarthy C. L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus. J Reprod Immunol. 2024;161:104171 pubmed publisher
Sun L, Zhao Z, Guo J, Qin Y, Yu Q, Shi X, et al. Mitochondrial transplantation confers protection against the effects of ischemic stroke by repressing microglial pyroptosis and promoting neurogenesis. Neural Regen Res. 2024;19:1325-1335 pubmed publisher
Liu S, Guo B, Gao Q, Deng Y, Yan B, Zeng Y, et al. Ursolic acid alleviates chronic prostatitis via regulating NLRP3 inflammasome-mediated Caspase-1/GSDMD pyroptosis pathway. Phytother Res. 2024;38:82-97 pubmed publisher
Sguizzato M, Ferrara F, Baraldo N, Bondi A, Guarino A, Drechsler M, et al. Bilosomes and Biloparticles for the Delivery of Lipophilic Drugs: A Preliminary Study. Antioxidants (Basel). 2023;12: pubmed publisher
Luo M, Peng Y, Lv D, Xue Y, Huang L, Hu Y, et al. LncRNA GAS5 downregulates NLRP3 inflammasome activation-mediated pyroptosis in sepsis-induced myocardial injury by targeting SIRT3/AMPKα. Heliyon. 2023;9:e22939 pubmed publisher
Chen T, Du H, Zhou H, He Y, Yang J, Li C, et al. Yinhuapinggan granule ameliorates lung injury caused by multidrug-resistant Acinetobacter baumannii via inhibiting NF-κB/NLRP3 pathway. Heliyon. 2023;9:e21871 pubmed publisher
Gao Q, Gao Z, Su M, Huang Y, Zhang C, Li C, et al. Umbilical Cord Mesenchymal Stem Cells Overexpressing Heme Oxygenase-1 Promotes Symptoms Recovery in Cystitis Rats by Alleviating Neuroinflammation. Stem Cells Int. 2023;2023:8887091 pubmed publisher
Wei J, Leng L, Sui Y, Song S, Owusu F, Li X, et al. Phenolic acids from Prunella vulgaris alleviate cardiac remodeling following myocardial infarction partially by suppressing NLRP3 activation. Phytother Res. 2023;: pubmed publisher
Song G, Wang J, Liu J, Ruan Y. Dimethyl fumarate ameliorates erectile dysfunction in bilateral cavernous nerve injury rats by inhibiting oxidative stress and NLRP3 inflammasome-mediated pyroptosis of nerve via activation of Nrf2/HO-1 signaling pathway. Redox Biol. 2023;68:102938 pubmed publisher
Hitomi M, Venegas J, Kang S, Eng C. Differential cell cycle checkpoint evasion by PTEN germline mutations associated with dichotomous phenotypes of cancer versus autism spectrum disorder. Oncogene. 2023;42:3698-3707 pubmed publisher
Liang Y, Zhou Y, Wang J, He Y. Downregulation of fibromodulin attenuates inflammatory signaling and atrial fibrosis in spontaneously hypertensive rats with atrial fibrillation via inhibiting TLR4/NLRP3 signaling pathway. Immun Inflamm Dis. 2023;11:e1003 pubmed publisher
Yazdankhah M, Ghosh S, Liu H, Hose S, Zigler J, Sinha D. Mitophagy in Astrocytes Is Required for the Health of Optic Nerve. Cells. 2023;12: pubmed publisher
Yang L, Lu P, Qi X, Yang Q, Liu L, Dou T, et al. Metformin inhibits inflammatory response and endoplasmic reticulum stress to improve hypothalamic aging in obese mice. iScience. 2023;26:108082 pubmed publisher
Li L, Li S, Pan Z, Zhang Y, Hua Z. Bilirubin impacts microglial autophagy via the Akt-mTOR signaling pathway. J Neurochem. 2023;167:582-599 pubmed publisher
Wu Q, Meng W, Zhu B, Chen X, Fu J, Zhao C, et al. VEGFC ameliorates salt-sensitive hypertension and hypertensive nephropathy by inhibiting NLRP3 inflammasome via activating VEGFR3-AMPK dependent autophagy pathway. Cell Mol Life Sci. 2023;80:327 pubmed publisher
Chen J, Shan T, Wei T, Jiang Q, Du C, Gu L, et al. SIRT3-dependent mitochondrial redox homeostasis mitigates CHK1 inhibition combined with gemcitabine treatment induced cardiotoxicity in hiPSC-CMs and mice. Arch Toxicol. 2023;97:3209-3226 pubmed publisher
Sun Y, Lv D, Xie Y, Xu H, Li X, Li F, et al. PINK1-mediated mitophagy induction protects against preeclampsia by decreasing ROS and trophoblast pyroptosis. Placenta. 2023;143:1-11 pubmed publisher
Omatsu M, Nakanishi Y, Iwane K, Aoyama N, Duran A, Muta Y, et al. THBS1-producing tumor-infiltrating monocyte-like cells contribute to immunosuppression and metastasis in colorectal cancer. Nat Commun. 2023;14:5534 pubmed publisher
Chen W, Luo Y, Quan J, Zhou J, Yi B, Huang Z. PM2.5 induces renal tubular injury by activating NLRP3-mediated pyroptosis. Ecotoxicol Environ Saf. 2023;265:115490 pubmed publisher
Quan J, Gao F, Ma T, Ye W, Gao X, Deng M, et al. Toxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome. Am J Pathol. 2023;193:2047-2065 pubmed publisher
Fan H, Tian H, Jin F, Zhang X, Su S, Liu Y, et al. CypD induced ROS output promotes intracranial aneurysm formation and rupture by 8-OHdG/NLRP3/MMP9 pathway. Redox Biol. 2023;67:102887 pubmed publisher
Wu S, Liao J, Hu G, Yan L, Su X, Ye J, et al. Corilagin alleviates LPS-induced sepsis through inhibiting pyroptosis via targeting TIR domain of MyD88 and binding CARD of ASC in macrophages. Biochem Pharmacol. 2023;217:115806 pubmed publisher
Lan T, Zeng Q, Zhu Y, Zheng G, Chen K, Jiang W, et al. Xin-Li formula attenuates heart failure induced by a combination of hyperlipidemia and myocardial infarction in rats via Treg immunomodulation and NLRP3 inflammasome inhibition. J Tradit Complement Med. 2023;13:441-453 pubmed publisher
Seo H, Ha T, Ko G, Jang A, Choi J, Lee D, et al. Scutellaria baicalensis Attenuated Neurological Impairment by Regulating Programmed Cell Death Pathway in Ischemic Stroke Mice. Cells. 2023;12: pubmed publisher
Konaka H, Kato Y, Hirano T, Tsujimoto K, Park J, Koba T, et al. Secretion of mitochondrial DNA via exosomes promotes inflammation in Behçet's syndrome. EMBO J. 2023;42:e112573 pubmed publisher
Nie C, A R, Wang J, Pan S, Zou R, Wang B, et al. Controlled Release of Hydrogen-Carrying Perfluorocarbons for Ischemia Myocardium-Targeting 19 F MRI-Guided Reperfusion Injury Therapy. Adv Sci (Weinh). 2023;10:e2304178 pubmed publisher
Li Z, Dai R, Chen M, Huang L, Zhu K, Li M, et al. p55γ degrades RIP3 via MG53 to suppress ischaemia-induced myocardial necroptosis and mediates cardioprotection of preconditioning. Cardiovasc Res. 2023;119:2421-2440 pubmed publisher
Wei H, Liu B, Yin C, Zeng D, Nie H, Li Y, et al. Electroacupuncture improves gout arthritis pain via attenuating ROS-mediated NLRP3 inflammasome overactivation. Chin Med. 2023;18:86 pubmed publisher
Jin B, Lim C, Kim H, Lee M, An H. Antioxidant mitoquinone suppresses benign prostatic hyperplasia by regulating the AR-NLRP3 pathway. Redox Biol. 2023;65:102816 pubmed publisher
Park J, Hwang J, Lee H, Jang G, Jeong Y, Cho J, et al. Lomerizine inhibits LPS-mediated neuroinflammation and tau hyperphosphorylation by modulating NLRP3, DYRK1A, and GSK3α/β. Front Immunol. 2023;14:1150940 pubmed publisher
Kim D, Ban K, Lee G, Jun H. Lysophosphatidic Acid Induces Podocyte Pyroptosis in Diabetic Nephropathy by an Increase of Egr1 Expression via Downregulation of EzH2. Int J Mol Sci. 2023;24: pubmed publisher
Yang X, Chen Z, Luo Z, Yang D, Hao Y, Hu J, et al. STING deletion alleviates podocyte injury through suppressing inflammation by targeting NLRP3 in diabetic kidney disease. Cell Signal. 2023;109:110777 pubmed publisher
Gastaldi S, Rocca C, Gianquinto E, Granieri M, Boscaro V, Blua F, et al. Discovery of a novel 1,3,4-oxadiazol-2-one-based NLRP3 inhibitor as a pharmacological agent to mitigate cardiac and metabolic complications in an experimental model of diet-induced metaflammation. Eur J Med Chem. 2023;257:115542 pubmed publisher
Fang L, Ohashi K, Hayakawa S, Ogawa H, Otaka N, Kawanishi H, et al. Adipolin protects against renal injury via PPARα-dependent reduction of inflammasome activation. iScience. 2023;26:106591 pubmed publisher
Cui S, Wu H, He Q, Wang L, Yi X, Feng G, et al. Fucoxanthin alleviated atherosclerosis by regulating PI3K/AKT and TLR4/NFκB mediated pyroptosis in endothelial cells. Int Immunopharmacol. 2023;120:110370 pubmed publisher
Liu S, Ge J, Chu Y, Cai S, Wu J, Gong A, et al. Identification of hub cuproptosis related genes and immune cell infiltration characteristics in periodontitis. Front Immunol. 2023;14:1164667 pubmed publisher
Tang G, Li S, Xu Y, Zhang C, Xu X, Xu L, et al. Renal herb formula protects against hyperuricemic nephropathy by inhibiting apoptosis and inflammation. Phytomedicine. 2023;116:154812 pubmed publisher
Wei B, Su Z, Yang H, Feng Y, Meng C, Liang Z. Inhibition of TRAF6 improves hyperlipidemic acute pancreatitis by alleviating pyroptosis in vitro and in vivo rat models. Biol Direct. 2023;18:23 pubmed publisher
Zheng S, Zhang K, Zhang Y, He J, Ouyang Y, Lang R, et al. Human Umbilical Cord Mesenchymal Stem Cells Inhibit Pyroptosis of Renal Tubular Epithelial Cells through miR-342-3p/Caspase1 Signaling Pathway in Diabetic Nephropathy. Stem Cells Int. 2023;2023:5584894 pubmed publisher
Yan Y, Zheng R, Liu Y, Ruan Y, Lin Z, Xue N, et al. Parkin regulates microglial NLRP3 and represses neurodegeneration in Parkinson's disease. Aging Cell. 2023;22:e13834 pubmed publisher
Lien C, Lin C, Shyue S, Hsieh P, Chen S, Lin Y, et al. Peroxisome proliferator-activated receptor δ improves the features of atherosclerotic plaque vulnerability by regulating smooth muscle cell phenotypic switching. Br J Pharmacol. 2023;180:2085-2101 pubmed publisher
de Dios C, Abadin X, Roca Agujetas V, Jimenez Martinez M, Morales A, Trullas R, et al. Inflammasome activation under high cholesterol load triggers a protective microglial phenotype while promoting neuronal pyroptosis. Transl Neurodegener. 2023;12:10 pubmed publisher
Wu M, Ding H, Tang X, Chen J, Zhang M, Yang Z, et al. Efficiency of a novel thermosensitive enema in situ hydrogel carrying Periplaneta americana extracts for the treatment of ulcerative colitis. Front Pharmacol. 2023;14:1111267 pubmed publisher
Park E, Choi H, Truong C, Jun H. The Inhibition of Autophagy and Pyroptosis by an Ethanol Extract of Nelumbo nucifera Leaf Contributes to the Amelioration of Dexamethasone-Induced Muscle Atrophy. Nutrients. 2023;15: pubmed publisher
Chen M, Li M, Wu L, Wang R, Long X, Zhang L, et al. Oridonin employs interleukin 1 receptor type 2 to treat noise-induced hearing loss by blocking inner ear inflammation. Biochem Pharmacol. 2023;210:115457 pubmed publisher
Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination. J Neuroinflammation. 2023;20:41 pubmed publisher
Muela Zarzuela I, Suárez Rivero J, Gallardo Orihuela A, Wang C, Izawa K, de Gregorio Procopio M, et al. NLRP1 inflammasome modulates senescence and senescence-associated secretory phenotype. bioRxiv. 2023;: pubmed publisher
Zhang H, Xie Z, Peng Y, Xie A, Fu C, Zheng D, et al. PARP1 promotes NLRP3 activation via blocking TFEB-mediated autophagy in rotenone-induced neurodegeneration. Ecotoxicol Environ Saf. 2023;252:114630 pubmed publisher
Lin W, Li Z, Liang G, Zhou R, Zheng X, Tao R, et al. TNEA therapy promotes the autophagic degradation of NLRP3 inflammasome in a transgenic mouse model of Alzheimer's disease via TFEB/TFE3 activation. J Neuroinflammation. 2023;20:21 pubmed publisher
Yue R, Li Y, Su B, Li C, Zeng R. Atorvastatin reduces contrast media-induced pyroptosis of renal tubular epithelial cells by inhibiting the TLR4/MyD88/NF-κB signaling pathway. BMC Nephrol. 2023;24:25 pubmed publisher
Zhou J, Zhang C, Fang X, Zhang N, Zhang X, Zhu Z. Activation of autophagy inhibits the activation of NLRP3 inflammasome and alleviates sevoflurane-induced cognitive dysfunction in elderly rats. BMC Neurosci. 2023;24:9 pubmed publisher
Lee K, Kim H, Kim H, Kim M, Kim J, Park K. Magnolia officinalis Bark Extract Prevents Enterocyte Death in a Colitis Mouse Model by Inhibiting ROS-Mediated Necroptosis. Antioxidants (Basel). 2022;11: pubmed publisher
Xiao Q, Kang Z, Liu C, Tang B. Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats. Front Biosci (Landmark Ed). 2022;27:300 pubmed publisher
P xe9 rez Cremades D, Bueno Bet xed C, Garc xed a Gim xe9 nez J, Iba xf1 ez Cabellos J, Pallard xf3 F, Hermenegildo C, et al. Extracellular histones trigger oxidative stress-dependent induction of the NF-kB/CAM pathway via TLR4 in endothelial cells. J Physiol Biochem. 2022;: pubmed publisher
Lin J, Lai X, Fan X, Ye B, Zhong L, Zhang Y, et al. Oridonin Protects against Myocardial Ischemia-Reperfusion Injury by Inhibiting GSDMD-Mediated Pyroptosis. Genes (Basel). 2022;13: pubmed publisher
Theivanthiran B, Yarla N, Haykal T, Nguyen Y, Cao L, Ferreira M, et al. Tumor-intrinsic NLRP3-HSP70-TLR4 axis drives premetastatic niche development and hyperprogression during anti-PD-1 immunotherapy. Sci Transl Med. 2022;14:eabq7019 pubmed publisher
Li S, Li H, Zhangdi H, Xu R, Zhang X, Liu J, et al. Hair follicle-MSC-derived small extracellular vesicles as a novel remedy for acute pancreatitis. J Control Release. 2022;352:1104-1115 pubmed publisher
Kim J, Kim S, Jeong H, Park J, Moon M, HOE H. Inhibiting EGFR/HER-2 ameliorates neuroinflammatory responses and the early stage of tau pathology through DYRK1A. Front Immunol. 2022;13:903309 pubmed publisher
Kornelius E, Tsou S, Chang C, Ho Y, Lin S, Chen W, et al. Liraglutide Attenuates Glucolipotoxicity-Induced RSC96 Schwann Cells' Inflammation and Dysfunction. Biomolecules. 2022;12: pubmed publisher
Zheng L, Xu H, Zheng F, Lai Y, Li J, Lv W, et al. Intervention time decides the status of autophagy, NLRP3 activity and apoptosis in macrophages induced by ox-LDL. Lipids Health Dis. 2022;21:107 pubmed publisher
Yamashita S, Takasu C, Morine Y, Ishibashi H, Ikemoto T, Mori H, et al. Characteristic submucosal alteration in biliary carcinogenesis of pancreaticobiliary maljunction with a focus on inflammasome activation. J Hepatobiliary Pancreat Sci. 2022;: pubmed publisher
Li M, Wu L, Chen M, Dong Y, Zheng L, Chen D, et al. Co-activation of Caspase-1 and Caspase-8 in CMV-induced SGN death by inflammasome-associated pyroptosis and apoptosis. Int Immunopharmacol. 2022;113:109305 pubmed publisher
Vargas Pozada E, Ramos Tovar E, Rodriguez Callejas J, Cardoso Lezama I, Galindo G xf3 mez S, Talam xe1 s Lara D, et al. Caffeine Inhibits NLRP3 Inflammasome Activation by Downregulating TLR4/MAPK/NF-κB Signaling Pathway in an Experimental NASH Model. Int J Mol Sci. 2022;23: pubmed publisher
Li H, Li T, Chen Z, Li L. Tanshinone IIA reduces pyroptosis in rats with coronary microembolization by inhibiting the TLR4/MyD88/NF-κB/NLRP3 pathway. Korean J Physiol Pharmacol. 2022;26:335-345 pubmed publisher
Zhou Z, Ying C, Zhou X, Shi Y, Xu J, Zhu Y, et al. Aerobic exercise training alleviates renal injury in db/db mice through inhibiting Nox4-mediated NLRP3 inflammasome activation. Exp Gerontol. 2022;168:111934 pubmed publisher
Eggelbusch M, Shi A, Broeksma B, V xe1 zquez Cruz M, Soares M, de Wit G, et al. The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle. J Cachexia Sarcopenia Muscle. 2022;13:3048-3061 pubmed publisher
Wu J, Chen S, Wu P, Wang Y, Qi X, Zhang R, et al. Cathepsin B/HSP70 complex induced by Ilexsaponin I suppresses NLRP3 inflammasome activation in myocardial ischemia/reperfusion injury. Phytomedicine. 2022;105:154358 pubmed publisher
Yoon B, Yun Y, Kim K, Kim D. Inhibition of immunoproteasome attenuates NLRP3 inflammasome formation in tumor necrosis factor α-stimulated intestinal epithelial cell. Biochem Biophys Res Commun. 2022;624:157-163 pubmed publisher
Tabandeh M, Jozaie S, Ghotbedin Z, Gorani S. Dimethyl itaconic acid improves viability and steroidogenesis and suppresses cytokine production in LPS-treated bovine ovarian granulosa cells by regulating TLR4/nfkβ, NLRP3, JNK signaling pathways. Res Vet Sci. 2022;152:89-98 pubmed publisher
Beltr xe1 n Garc xed a J, Osca Verdegal R, P xe9 rez Cremades D, Novella S, Hermenegildo C, Pallard xf3 F, et al. Extracellular Histones Activate Endothelial NLRP3 Inflammasome and are Associated with a Severe Sepsis Phenotype. J Inflamm Res. 2022;15:4217-4238 pubmed publisher
Luo M, Hu Y, Lv D, Xie L, Yang S, Zuo D, et al. Recurrent Hypoglycemia Impaired Vascular Function in Advanced T2DM Rats by Inducing Pyroptosis. Oxid Med Cell Longev. 2022;2022:7812407 pubmed publisher
Zhou L, Zhang J, Han X, Fang J, Zhou S, Lu L, et al. CysLT2R Antagonist HAMI 3379 Ameliorates Post-Stroke Depression through NLRP3 Inflammasome/Pyroptosis Pathway in Gerbils. Brain Sci. 2022;12: pubmed publisher
Ge C, Zhao Y, Liang Y, He Y. Silencing of TLR4 Inhibits Atrial Fibrosis and Susceptibility to Atrial Fibrillation via Downregulation of NLRP3-TGF-β in Spontaneously Hypertensive Rats. Dis Markers. 2022;2022:2466150 pubmed publisher
Xie D, Hu G, Chen C, Ahmadinejad F, Wang W, Li P, et al. Loss of sphingosine kinase 2 protects against cisplatin-induced kidney injury. Am J Physiol Renal Physiol. 2022;323:F322-F334 pubmed publisher
Mavrogiannis E, Hagdorn Q, Bazioti V, Douwes J, van der Feen D, Oberdorf Maass S, et al. Pirfenidone ameliorates pulmonary arterial pressure and neointimal remodeling in experimental pulmonary arterial hypertension by suppressing NLRP3 inflammasome activation. Pulm Circ. 2022;12:e12101 pubmed publisher
Zhou H, Zhang W, Qin D, Liu P, Fan W, Lv H, et al. Activation of NLRP3 inflammasome contributes to the inflammatory response to allergic rhinitis via macrophage pyroptosis. Int Immunopharmacol. 2022;110:109012 pubmed publisher
Liu B, Wang D, Cao Y, Wu J, Zhou Y, Wu W, et al. MitoTEMPO protects against podocyte injury by inhibiting NLRP3 inflammasome via PINK1/Parkin pathway-mediated mitophagy. Eur J Pharmacol. 2022;929:175136 pubmed publisher
Liu X, Fan T, Guan J, Luo A, Yu Y, Chen D, et al. Dopamine relieves inflammatory responses through the D2 receptor after electroacupuncture at ST36 in a mouse model of chronic obstructive pulmonary disease. Acupunct Med. 2022;:9645284221107684 pubmed publisher
Saieva S, Taglialatela G. Near-infrared light reduces glia activation and modulates neuroinflammation in the brains of diet-induced obese mice. Sci Rep. 2022;12:10848 pubmed publisher
Wang C, Wang Y, Song D, Su J, Zhang F. Therapeutic Effects of Modified Si-Miao-Yong-An Decoction in the Treatment of Rat Myocardial Ischemia/Reperfusion Injury. Evid Based Complement Alternat Med. 2022;2022:1442405 pubmed publisher
Al Qazazi R, Lima P, Prisco S, Potus F, Dasgupta A, Chen K, et al. Macrophage-NLRP3 Activation Promotes Right Ventricle Failure in Pulmonary Arterial Hypertension. Am J Respir Crit Care Med. 2022;206:608-624 pubmed publisher
Zhang Y, Chen R, Hu Q, Wang J, Nie H, Yin C, et al. Electroacupuncture Ameliorates Mechanical Allodynia of a Rat Model of CRPS-I via Suppressing NLRP3 Inflammasome Activation in Spinal Cord Dorsal Horn Neurons. Front Cell Neurosci. 2022;16:826777 pubmed publisher
Yu W, Zong S, Zhou P, Wei J, Wang E, Ming R, et al. Cochlear Marginal Cell Pyroptosis Is Induced by Cisplatin via NLRP3 Inflammasome Activation. Front Immunol. 2022;13:823439 pubmed publisher
Lian H, Fang X, Li Q, Liu S, Wei Q, Hua X, et al. NLRP3 Inflammasome-Mediated Pyroptosis Pathway Contributes to the Pathogenesis of Candida albicans Keratitis. Front Med (Lausanne). 2022;9:845129 pubmed publisher
Wu Z, Zhou G, Wang H, Yao P. Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs. Int J Mol Sci. 2022;23: pubmed publisher
Fang J, Ouyang M, Qu Y, Wang M, Huang X, Lan J, et al. Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts. J Invest Dermatol. 2022;142:2591-2602.e8 pubmed publisher
Zhang C, Huang Y, Ouyang F, Su M, Li W, Chen J, et al. Extracellular vesicles derived from mesenchymal stem cells alleviate neuroinflammation and mechanical allodynia in interstitial cystitis rats by inhibiting NLRP3 inflammasome activation. J Neuroinflammation. 2022;19:80 pubmed publisher
Zou R, Nie C, Pan S, Wang B, Hong X, Xi S, et al. Co-administration of hydrogen and metformin exerts cardioprotective effects by inhibiting pyroptosis and fibrosis in diabetic cardiomyopathy. Free Radic Biol Med. 2022;183:35-50 pubmed publisher
Shiau A, Fang S, Hsu C, Chiu M, Lam C, Wu C, et al. Prothymosin α Gene Transfer Modulates Myocardial Remodeling after Ischemia-Reperfusion Injury. Acta Cardiol Sin. 2022;38:187-200 pubmed publisher
Liu H, Wang L, Xu Q, Wang J, Zhang Y, Luo J, et al. UHRF1 shapes both the trophoblast invasion and decidual macrophage differentiation in early pregnancy. FASEB J. 2022;36:e22247 pubmed publisher
Li Y, Shi D, Zhang H, Yao X, Ren K. Magnetic Resonance Imaging of Contrast-Induced Acute Renal Injury and Related Pathological Alterations In Vivo. Anal Cell Pathol (Amst). 2022;2022:6984200 pubmed publisher
Ye Y, Feng Z, Tian S, Yang Y, Jia Y, Wang G, et al. HBO Alleviates Neural Stem Cell Pyroptosis via lncRNA-H19/miR-423-5p/NLRP3 Axis and Improves Neurogenesis after Oxygen Glucose Deprivation. Oxid Med Cell Longev. 2022;2022:9030771 pubmed publisher
Kang H, Seo E, Oh Y, Jun H. TGF-β activates NLRP3 inflammasome by an autocrine production of TGF-β in LX-2 human hepatic stellate cells. Mol Cell Biochem. 2022;477:1329-1338 pubmed publisher
Chen X, Lin S, Dai S, Han J, Shan P, Wang W, et al. Trimetazidine affects pyroptosis by targeting GSDMD in myocardial ischemia/reperfusion injury. Inflamm Res. 2022;71:227-241 pubmed publisher
Hosoya T, Uchida S, Shibata S, Tomioka N, Matsumoto K, Hosoyamada M. Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice. J Am Soc Nephrol. 2022;33:326-341 pubmed publisher
Penolazzi L, Bergamin L, Lambertini E, Poma V, Sarti A, De Bonis P, et al. The P2X7 purinergic receptor in intervertebral disc degeneration. J Cell Physiol. 2022;237:1418-1428 pubmed publisher
Li C, Zhu Y, Wu Y, Fu M, Wu Y, Wu Y, et al. Oridonin Alleviates LPS-Induced Depression by Inhibiting NLRP3 Inflammasome via Activation of Autophagy. Front Med (Lausanne). 2021;8:813047 pubmed publisher
Liu J, Ma W, Zang C, Wang G, Zhang S, Wu H, et al. Salidroside inhibits NLRP3 inflammasome activation and apoptosis in microglia induced by cerebral ischemia/reperfusion injury by inhibiting the TLR4/NF-κB signaling pathway. Ann Transl Med. 2021;9:1694 pubmed publisher
Chen J, Mao K, Yu H, Wen Y, She H, Zhang H, et al. p38-TFEB pathways promote microglia activation through inhibiting CMA-mediated NLRP3 degradation in Parkinson's disease. J Neuroinflammation. 2021;18:295 pubmed publisher
Zhu Y, Huang G, Yang Y, Yong C, Yu X, Wang G, et al. Chinese Herbal Medicine Suyin Detoxification Granule Inhibits Pyroptosis and Epithelial-Mesenchymal Transition by Downregulating MAVS/NLRP3 to Alleviate Renal Injury. J Inflamm Res. 2021;14:6601-6618 pubmed publisher
Park M, Kim H, Shin H, Lee S, Hwang D, Lew H. Human Pluripotent Stem Cell-Derived Neural Progenitor Cells Promote Retinal Ganglion Cell Survival and Axon Recovery in an Optic Nerve Compression Animal Model. Int J Mol Sci. 2021;22: pubmed publisher
Adamowski M, Wo x142 odko K, Oliveira J, Castillo Fernandez J, Murta D, Kelsey G, et al. Leptin Signaling in the Ovary of Diet-Induced Obese Mice Regulates Activation of NOD-Like Receptor Protein 3 Inflammasome. Front Cell Dev Biol. 2021;9:738731 pubmed publisher
Liu Y, Shang L, Zhou J, Pan G, Zhou F, Yang S. Emodin Attenuates LPS-Induced Acute Lung Injury by Inhibiting NLRP3 Inflammasome-Dependent Pyroptosis Signaling Pathway In vitro and In vivo. Inflammation. 2021;: pubmed publisher
Lauro F, Giancotti L, Kolar G, Harada C, Harmon T, Garrett T, et al. Role of Adenosine Kinase in Sphingosine-1-Phosphate Receptor 1-Induced Mechano-Hypersensitivities. Cell Mol Neurobiol. 2021;: pubmed publisher
Zhang M, Lei Y, Meng X, Liu H, Li L, Zhang J, et al. Iguratimod Alleviates Myocardial Ischemia/Reperfusion Injury Through Inhibiting Inflammatory Response Induced by Cardiac Fibroblast Pyroptosis via COX2/NLRP3 Signaling Pathway. Front Cell Dev Biol. 2021;9:746317 pubmed publisher
Wu J, Raman A, Coffey N, Sheng X, Wahba J, Seasock M, et al. The key role of NLRP3 and STING in APOL1-associated podocytopathy. J Clin Invest. 2021;131: pubmed publisher
Wei B, Gong Y, Yang H, Zhou J, Su Z, Liang Z. Role of tumor necrosis factor receptor‑associated factor 6 in pyroptosis during acute pancreatitis. Mol Med Rep. 2021;24: pubmed publisher
Borges Rodriguez M, Shields C, Travis O, Tramel R, Baik C, Giachelli C, et al. Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury. Int J Mol Sci. 2021;22: pubmed publisher
Luo D, Dai W, Feng X, Ding C, Shao Q, Xiao R, et al. Suppression of lncRNA NLRP3 inhibits NLRP3-triggered inflammatory responses in early acute lung injury. Cell Death Dis. 2021;12:898 pubmed publisher
Huang J, An Q, Ju B, Zhang J, Fan P, He L, et al. Role of vitamin D/VDR nuclear translocation in down-regulation of NF-κB/NLRP3/caspase-1 axis in lupus nephritis. Int Immunopharmacol. 2021;100:108131 pubmed publisher
Tang B, She X, Deng C. Effect of the combination of astragaloside IV and Panax notoginseng saponins on pyroptosis and necroptosis in rat models of cerebral ischemia-reperfusion. Exp Ther Med. 2021;22:1123 pubmed publisher
Guo S, Geng X, Lee H, Ding Y. Phenothiazine Inhibits Neuroinflammation and Inflammasome Activation Independent of Hypothermia After Ischemic Stroke. Mol Neurobiol. 2021;58:6136-6152 pubmed publisher
Feng X, Zhan F, Luo D, Hu J, Wei G, Hua F, et al. LncRNA 4344 promotes NLRP3-related neuroinflammation and cognitive impairment by targeting miR-138-5p. Brain Behav Immun. 2021;98:283-298 pubmed publisher
Nie C, Zou R, Pan S, A R, Gao Y, Yang H, et al. Hydrogen gas inhalation ameliorates cardiac remodelling and fibrosis by regulating NLRP3 inflammasome in myocardial infarction rats. J Cell Mol Med. 2021;25:8997-9010 pubmed publisher
Yin K, Zhou X, Jiang W, Wang L, Dai Z, Tang B. Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. Dis Markers. 2021;2021:9963534 pubmed publisher
Dai S, Ye B, Chen L, Hong G, Zhao G, Lu Z. Emodin alleviates LPS-induced myocardial injury through inhibition of NLRP3 inflammasome activation. Phytother Res. 2021;35:5203-5213 pubmed publisher
Lin X, Zhan J, Jiang J, Ren Y. Upregulation of Neuronal Cylindromatosis Expression is Essential for Electroacupuncture-Mediated Alleviation of Neuroinflammatory Injury by Regulating Microglial Polarization in Rats Subjected to Focal Cerebral Ischemia/Reperfusion. J Inflamm Res. 2021;14:2061-2078 pubmed publisher
Song X, Cui Z, He J, Yang T, Sun X. κ‑opioid receptor agonist, U50488H, inhibits pyroptosis through NLRP3 via the Ca2+/CaMKII/CREB signaling pathway and improves synaptic plasticity in APP/PS1 mice. Mol Med Rep. 2021;24: pubmed publisher
Feng X, Hu J, Zhan F, Luo D, Hua F, Xu G. MicroRNA-138-5p Regulates Hippocampal Neuroinflammation and Cognitive Impairment by NLRP3/Caspase-1 Signaling Pathway in Rats. J Inflamm Res. 2021;14:1125-1143 pubmed publisher
Wang W, Cao Z, Liang H, Zhao C, Gong B, Hu J. Effect of low-dose ethanol on NLRP3 inflammasome in diabetes-induced lung injury. Exp Anim. 2021;: pubmed publisher
Mauro A, Bonaventura A, Vecchie A, Mezzaroma E, Carbone S, Narayan P, et al. The Role of NLRP3 Inflammasome in Pericarditis: Potential for Therapeutic Approaches. JACC Basic Transl Sci. 2021;6:137-150 pubmed publisher
Nie C, Ding X, A R, Zheng M, Li Z, Pan S, et al. Hydrogen gas inhalation alleviates myocardial ischemia-reperfusion injury by the inhibition of oxidative stress and NLRP3-mediated pyroptosis in rats. Life Sci. 2021;272:119248 pubmed publisher
Yang G, Tang X, Tan L, Nong D, Yang P, Ning H. Upregulation of miR-144-3p protects myocardial function from ischemia-reperfusion injury through inhibition of TMEM16A Ca2+-activated chloride channel. Hum Cell. 2021;34:360-371 pubmed publisher
Lliberós C, Liew S, Zareie P, La Gruta N, Mansell A, Hutt K. Evaluation of inflammation and follicle depletion during ovarian ageing in mice. Sci Rep. 2021;11:278 pubmed publisher
Wang M, Liu Z, Hu S, Duan X, Zhang Y, Peng C, et al. Taohong Siwu Decoction Ameliorates Ischemic Stroke Injury Via Suppressing Pyroptosis. Front Pharmacol. 2020;11:590453 pubmed publisher
Ma D, Zhang N, Zhang Y, Chen H. Salvianolic Acids for Injection alleviates cerebral ischemia/reperfusion injury by switching M1/M2 phenotypes and inhibiting NLRP3 inflammasome/pyroptosis axis in microglia in vivo and in vitro. J Ethnopharmacol. 2021;270:113776 pubmed publisher
Cheng Y, Cheng L, Gao X, Chen S, Wu P, Wang C, et al. Covalent modification of Keap1 at Cys77 and Cys434 by pubescenoside a suppresses oxidative stress-induced NLRP3 inflammasome activation in myocardial ischemia-reperfusion injury. Theranostics. 2021;11:861-877 pubmed publisher
Wu D, Zhang H, Wu Q, Li F, Wang Y, Liu S, et al. Sestrin 2 protects against LPS-induced acute lung injury by inducing mitophagy in alveolar macrophages. Life Sci. 2021;267:118941 pubmed publisher
Li J, Tian S, Wang H, Wang Y, Du C, Fang J, et al. Protection of hUC-MSCs against neuronal complement C3a receptor-mediated NLRP3 activation in CUMS-induced mice. Neurosci Lett. 2021;741:135485 pubmed publisher
Sukhanov S, Higashi Y, Yoshida T, Mummidi S, Aroor A, Jeffrey Russell J, et al. The SGLT2 inhibitor Empagliflozin attenuates interleukin-17A-induced human aortic smooth muscle cell proliferation and migration by targeting TRAF3IP2/ROS/NLRP3/Caspase-1-dependent IL-1β and IL-18 secretion. Cell Signal. 2021;77:109825 pubmed publisher
Ghoneim M, Abdallah D, Shebl A, El Abhar H. The interrupted cross-talk of inflammatory and oxidative stress trajectories signifies the effect of artesunate against hepatic ischemia/reperfusion-induced inflammasomopathy. Toxicol Appl Pharmacol. 2020;409:115309 pubmed publisher
Lu Q, Zhang Y, Kasetti R, Gaddipati S, Cvm N, Borchman D, et al. Heterozygous Loss of Yap1 in Mice Causes Progressive Cataracts. Invest Ophthalmol Vis Sci. 2020;61:21 pubmed publisher
Bustos F, Segarra Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, et al. Functional Diversification of SRSF Protein Kinase to Control Ubiquitin-Dependent Neurodevelopmental Signaling. Dev Cell. 2020;55:629-647.e7 pubmed publisher
Gao P, Zha Y, Gong X, Qiao F, Liu H. The role of maternal-foetal interface inflammation mediated by NLRP3 inflammasome in the pathogenesis of recurrent spontaneous abortion. Placenta. 2020;101:221-229 pubmed publisher
Ma D, Zhang N, Zhang Y, Chen H. Kv1.3 channel blockade alleviates cerebral ischemia/reperfusion injury by reshaping M1/M2 phenotypes and compromising the activation of NLRP3 inflammasome in microglia. Exp Neurol. 2020;332:113399 pubmed publisher
Yang M, So K, Lo A, Lam W. The Effect of Lycium barbarum Polysaccharides on Pyroptosis-Associated Amyloid β1-40 Oligomers-Induced Adult Retinal Pigment Epithelium 19 Cell Damage. Int J Mol Sci. 2020;21: pubmed publisher
Zhang X, Fan X, Li F, Qiu J, Zhang Y. Effects of PYRIN-containing Apaf1-like protein 1 on isoflurane-induced postoperative cognitive dysfunction in aged rats. Mol Med Rep. 2020;22:1391-1399 pubmed publisher
Wang Y, Ji N, Gong X, Ni S, Xu L, Zhang H. Thioredoxin-1 attenuates atherosclerosis development through inhibiting NLRP3 inflammasome. Endocrine. 2020;70:65-70 pubmed publisher
Tang B, Liu D, Chen L, Liu Y. NLRP3 inflammasome inhibitor MCC950 attenuates primary dysmenorrhea in mice via the NF-κB/COX-2/PG pathway. J Inflamm (Lond). 2020;17:22 pubmed publisher
Zhou X, Liu Z, Ying K, Wang H, Liu P, Ji X, et al. WJ-39, an Aldose Reductase Inhibitor, Ameliorates Renal Lesions in Diabetic Nephropathy by Activating Nrf2 Signaling. Oxid Med Cell Longev. 2020;2020:7950457 pubmed publisher
Cornelius D, Travis O, Tramel R, Borges Rodriguez M, Baik C, Greer M, et al. NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture. PLoS ONE. 2020;15:e0234039 pubmed publisher
Wang Q, Ding H, Chen S, Liu X, Deng Y, Jiang W, et al. Hypertonic saline mediates the NLRP3/IL-1β signaling axis in microglia to alleviate ischemic blood-brain barrier permeability by downregulating astrocyte-derived VEGF in rats. CNS Neurosci Ther. 2020;: pubmed publisher
Chen R, Yin C, Hu Q, Liu B, Tai Y, Zheng X, et al. Expression profiling of spinal cord dorsal horn in a rat model of complex regional pain syndrome type-I uncovers potential mechanisms mediating pain and neuroinflammation responses. J Neuroinflammation. 2020;17:162 pubmed publisher
Lalitha N, Sadashivaiah B, Ramaprasad T, Singh S. Anti-hyperglycemic activity of myricetin, through inhibition of DPP-4 and enhanced GLP-1 levels, is attenuated by co-ingestion with lectin-rich protein. PLoS ONE. 2020;15:e0231543 pubmed publisher
Yadav S, Kambis T, Kar S, Park S, Mishra P. MMP9 mediates acute hyperglycemia-induced human cardiac stem cell death by upregulating apoptosis and pyroptosis in vitro. Cell Death Dis. 2020;11:186 pubmed publisher
Arita Y, Yoshinaga Y, Kaneko T, Kawahara Y, Nakamura K, Ohgi K, et al. Glyburide inhibits the bone resorption induced by traumatic occlusion in rats. J Periodontal Res. 2020;55:464-471 pubmed publisher
Thakur V, Sadanandan J, Chattopadhyay M. High-Mobility Group Box 1 Protein Signaling in Painful Diabetic Neuropathy. Int J Mol Sci. 2020;21: pubmed publisher
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, et al. Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice. FASEB J. 2020;34:4107-4119 pubmed publisher
Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, et al. Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway. J Diabetes Res. 2019;2019:8905917 pubmed publisher
Yin C, Liu B, Wang P, Li X, Li Y, Zheng X, et al. Eucalyptol alleviates inflammation and pain responses in a mouse model of gout arthritis. Br J Pharmacol. 2020;177:2042-2057 pubmed publisher
Nie S, Wang X, Wang H. NLRP3 Inflammasome Mediated Interleukin-1β Production in Cancer-Associated Fibroblast Contributes to ALA-PDT for Cutaneous Squamous Cell Carcinoma. Cancer Manag Res. 2019;11:10257-10267 pubmed publisher
Kar S, Shahshahan H, Hackfort B, Yadav S, Yadav R, Kambis T, et al. Exercise Training Promotes Cardiac Hydrogen Sulfide Biosynthesis and Mitigates Pyroptosis to Prevent High-Fat Diet-Induced Diabetic Cardiomyopathy. Antioxidants (Basel). 2019;8: pubmed publisher
Zhang H, Gong X, Ni S, Wang Y, Zhu L, Ji N. C1q/TNF-related protein-9 attenuates atherosclerosis through AMPK-NLRP3 inflammasome singling pathway. Int Immunopharmacol. 2019;77:105934 pubmed publisher
Chen X, Li H, Wang K, Liang X, Wang W, Hu X, et al. Aerobic Exercise Ameliorates Myocardial Inflammation, Fibrosis and Apoptosis in High-Fat-Diet Rats by Inhibiting P2X7 Purinergic Receptors. Front Physiol. 2019;10:1286 pubmed publisher
Bao Z, Fan L, Zhao L, Xu X, Liu Y, Chao H, et al. Silencing of A20 Aggravates Neuronal Death and Inflammation After Traumatic Brain Injury: A Potential Trigger of Necroptosis. Front Mol Neurosci. 2019;12:222 pubmed publisher
Kron J, Mauro A, Bonaventura A, Toldo S, Salloum F, Ellenbogen K, et al. Inflammasome Formation in Granulomas in Cardiac Sarcoidosis. Circ Arrhythm Electrophysiol. 2019;12:e007582 pubmed publisher
Al Rihani S, Darakjian L, Kaddoumi A. Oleocanthal-Rich Extra-Virgin Olive Oil Restores the Blood-Brain Barrier Function through NLRP3 Inflammasome Inhibition Simultaneously with Autophagy Induction in TgSwDI Mice. ACS Chem Neurosci. 2019;10:3543-3554 pubmed publisher
Yoshida S, Hagiwara Y, Tsuchiya M, Shinoda M, Koide M, Hatakeyama H, et al. Involvement of inflammasome activation via elevation of uric acid level in nociception in a mouse model of muscle pain. Mol Pain. 2019;15:1744806919858797 pubmed publisher
Yang X, Wang X, Shao L, Jiang G, Min J, Mei X, et al. TRPV1 mediates astrocyte activation and interleukin-1β release induced by hypoxic ischemia (HI). J Neuroinflammation. 2019;16:114 pubmed publisher
Gong W, Zhang S, Zong Y, Halim M, Ren Z, Wang Y, et al. Involvement of the microglial NLRP3 inflammasome in the anti-inflammatory effect of the antidepressant clomipramine. J Affect Disord. 2019;254:15-25 pubmed publisher
Cornelius D, Baik C, Travis O, White D, Young C, Austin Pierce W, et al. NLRP3 inflammasome activation in platelets in response to sepsis. Physiol Rep. 2019;7:e14073 pubmed publisher
Chiozzi P, Sarti A, Sanz J, Giuliani A, Adinolfi E, Vultaggio Poma V, et al. Amyloid β-dependent mitochondrial toxicity in mouse microglia requires P2X7 receptor expression and is prevented by nimodipine. Sci Rep. 2019;9:6475 pubmed publisher
Liu B, Lu R, Li H, Zhou Y, Zhang P, Bai L, et al. Zhen-wu-tang ameliorates membranous nephropathy rats through inhibiting NF-κB pathway and NLRP3 inflammasome. Phytomedicine. 2019;59:152913 pubmed publisher
Ye B, Chen X, Dai S, Han J, Liang X, Lin S, et al. Emodin alleviates myocardial ischemia/reperfusion injury by inhibiting gasdermin D-mediated pyroptosis in cardiomyocytes. Drug Des Devel Ther. 2019;13:975-990 pubmed publisher
Li J, Liu Y, Liu B, Li F, Hu J, Wang Q, et al. Mechanisms of Aerobic Exercise Upregulating the Expression of Hippocampal Synaptic Plasticity-Associated Proteins in Diabetic Rats. Neural Plast. 2019;2019:7920540 pubmed publisher
Doyle T, Chen Z, Durante M, Salvemini D. Activation of sphingosine-1-phosphate receptor 1 in the spinal cord produces mechano-hypersensitivity through the activation of inflammasome and IL-1β pathway. J Pain. 2019;: pubmed publisher
Lyu C, Zhang Y, Gu M, Huang Y, Liu G, Wang C, et al. IRAK-M Deficiency Exacerbates Ischemic Neurovascular Injuries in Experimental Stroke Mice. Front Cell Neurosci. 2018;12:504 pubmed publisher
Zhang D, Qian J, Zhang P, Li H, Shen H, Li X, et al. Gasdermin D serves as a key executioner of pyroptosis in experimental cerebral ischemia and reperfusion model both in vivo and in vitro. J Neurosci Res. 2019;97:645-660 pubmed publisher
Hou X, Dong H, Sun L, Yang M, Cheng H, Chen Y. Purinergic 2X7 Receptor is Involved in the Podocyte Damage of Obesity-Related Glomerulopathy via Activating Nucleotide-Binding and Oligomerization Domain-Like Receptor Protein 3 Inflammasome. Chin Med J (Engl). 2018;131:2713-2725 pubmed publisher
Ma X, Wen J, Gao S, He X, Li P, Yang Y, et al. Paeonia lactiflora Pall. regulates the NF-κB-NLRP3 inflammasome pathway to alleviate cholestasis in rats. J Pharm Pharmacol. 2018;70:1675-1687 pubmed publisher
Li X, Wang T, Zhang D, Li H, Shen H, Ding X, et al. Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction. Neuropharmacology. 2018;141:305-315 pubmed publisher
Fujiwara H, Docampo M, Riwes M, Peltier D, Toubai T, Henig I, et al. Microbial metabolite sensor GPR43 controls severity of experimental GVHD. Nat Commun. 2018;9:3674 pubmed publisher
Li D, Ren W, Jiang Z, Zhu L. Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury. Mol Med Rep. 2018;18:4399-4409 pubmed publisher
Li Y, Wu J, Niu Y, Chen H, Tang Q, Zhong Y, et al. Milk Fat Globule Membrane Inhibits NLRP3 Inflammasome Activation and Enhances Intestinal Barrier Function in a Rat Model of Short Bowel. JPEN J Parenter Enteral Nutr. 2019;43:677-685 pubmed publisher
Jiao H, Rutar M, Fernando N, Yednock T, Sankaranarayanan S, Aggio Bruce R, et al. Subretinal macrophages produce classical complement activator C1q leading to the progression of focal retinal degeneration. Mol Neurodegener. 2018;13:45 pubmed publisher
Song Y, Sun R, Ji Z, Li X, Fu Q, Ma S. Perilla aldehyde attenuates CUMS-induced depressive-like behaviors via regulating TXNIP/TRX/NLRP3 pathway in rats. Life Sci. 2018;206:117-124 pubmed publisher
Yang Q, Fu C, Xiao J, Ye Z. Uric acid upregulates the adiponectin‑adiponectin receptor 1 pathway in renal proximal tubule epithelial cells. Mol Med Rep. 2018;17:3545-3554 pubmed publisher
Wu Y, He F, Li Y, Wang H, Shi L, Wan Q, et al. Effects of Shizhifang on NLRP3 Inflammasome Activation and Renal Tubular Injury in Hyperuricemic Rats. Evid Based Complement Alternat Med. 2017;2017:7674240 pubmed publisher
Liang Y, Liang S, Zhang Y, Deng Y, He Y, Chen Y, et al. Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats. Probiotics Antimicrob Proteins. 2019;11:175-185 pubmed publisher
Kosmidou C, Efstathiou N, Hoang M, Notomi S, Konstantinou E, Hirano M, et al. Issues with the Specificity of Immunological Reagents for NLRP3: Implications for Age-related Macular Degeneration. Sci Rep. 2018;8:461 pubmed publisher
Qiu Z, Lei S, Zhao B, Wu Y, Su W, Liu M, et al. NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats. Oxid Med Cell Longev. 2017;2017:9743280 pubmed publisher
Szpigel A, Hainault I, Carlier A, Venteclef N, Batto A, Hajduch E, et al. Lipid environment induces ER stress, TXNIP expression and inflammation in immune cells of individuals with type 2 diabetes. Diabetologia. 2018;61:399-412 pubmed publisher
Wang Y, Yu B, Wang L, Yang M, Xia Z, Wei W, et al. Pioglitazone ameliorates glomerular NLRP3 inflammasome activation in apolipoprotein E knockout mice with diabetes mellitus. PLoS ONE. 2017;12:e0181248 pubmed publisher
Xu X, Chen Y, Song J, Hou F, Ma X, Liu B, et al. Mangiferin suppresses endoplasmic reticulum stress in perivascular adipose tissue and prevents insulin resistance in the endothelium. Eur J Nutr. 2018;57:1563-1575 pubmed publisher
Yin J, Zhao F, Chojnacki J, Fulp J, Klein W, Zhang S, et al. NLRP3 Inflammasome Inhibitor Ameliorates Amyloid Pathology in a Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2018;55:1977-1987 pubmed publisher
Beckerman P, Bi Karchin J, Park A, Qiu C, Dummer P, Soomro I, et al. Transgenic expression of human APOL1 risk variants in podocytes induces kidney disease in mice. Nat Med. 2017;23:429-438 pubmed publisher
Boyanova L. Stress hormone epinephrine (adrenaline) and norepinephrine (noradrenaline) effects on the anaerobic bacteria. Anaerobe. 2017;44:13-19 pubmed publisher
Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017;639:114-119 pubmed publisher
Li Y, Zheng J, Liu J, Yang J, Liu Y, Wang C, et al. Succinate/NLRP3 Inflammasome Induces Synovial Fibroblast Activation: Therapeutical Effects of Clematichinenoside AR on Arthritis. Front Immunol. 2016;7:532 pubmed publisher
Xiao Y, Huang Y, Wang H, Wu Y, Leng Y, Liu M, et al. Thioredoxin-Interacting Protein Mediates NLRP3 Inflammasome Activation Involved in the Susceptibility to Ischemic Acute Kidney Injury in Diabetes. Oxid Med Cell Longev. 2016;2016:2386068 pubmed
Yeh W, Yang H, Pai M, Wu C, Chen J. Long-term administration of advanced glycation end-product stimulates the activation of NLRP3 inflammasome and sparking the development of renal injury. J Nutr Biochem. 2017;39:68-76 pubmed publisher
Chen W, Wang J, Luo Y, Wang T, Li X, Li A, et al. Ginsenoside Rb1 and compound K improve insulin signaling and inhibit ER stress-associated NLRP3 inflammasome activation in adipose tissue. J Ginseng Res. 2016;40:351-358 pubmed
Billant O, Léon A, Le Guellec S, Friocourt G, Blondel M, Voisset C. The dominant-negative interplay between p53, p63 and p73: A family affair. Oncotarget. 2016;7:69549-69564 pubmed publisher
Cinar R, Iyer M, Liu Z, Cao Z, Jourdan T, Erdélyi K, et al. Hybrid inhibitor of peripheral cannabinoid-1 receptors and inducible nitric oxide synthase mitigates liver fibrosis. JCI Insight. 2016;1: pubmed publisher
Kadono K, Uchida Y, Hirao H, Miyauchi T, Watanabe T, Iida T, et al. Thrombomodulin Attenuates Inflammatory Damage Due to Liver Ischemia and Reperfusion Injury in Mice in Toll-Like Receptor 4-Dependent Manner. Am J Transplant. 2017;17:69-80 pubmed publisher
Lampropoulou V, Sergushichev A, Bambousková M, Nair S, Vincent E, Loginicheva E, et al. Itaconate Links Inhibition of Succinate Dehydrogenase with Macrophage Metabolic Remodeling and Regulation of Inflammation. Cell Metab. 2016;24:158-66 pubmed publisher
Li Y, Zhou Z, Chen M, Yang J, Leng J, Cao G, et al. Inhibition of Mitochondrial Fission and NOX2 Expression Prevent NLRP3 Inflammasome Activation in the Endothelium: The Role of Corosolic Acid Action in the Amelioration of Endothelial Dysfunction. Antioxid Redox Signal. 2016;24:893-908 pubmed publisher
Ge C, Yu R, Xu M, Li P, Fan C, Li J, et al. Betaine prevented fructose-induced NAFLD by regulating LXRα/PPARα pathway and alleviating ER stress in rats. Eur J Pharmacol. 2016;770:154-64 pubmed publisher
Kim S, Joe Y, Chen Y, Ryu J, Lee J, Cho G, et al. Carbon monoxide decreases interleukin-1β levels in the lung through the induction of pyrin. Cell Mol Immunol. 2017;14:349-359 pubmed publisher
Lu C, Zhang F, Xu W, Wu X, Lian N, Jin H, et al. Curcumin attenuates ethanol-induced hepatic steatosis through modulating Nrf2/FXR signaling in hepatocytes. IUBMB Life. 2015;67:645-58 pubmed publisher
Li J, Wang Y, Wang Y, Wen X, Ma X, Chen W, et al. Pharmacological activation of AMPK prevents Drp1-mediated mitochondrial fission and alleviates endoplasmic reticulum stress-associated endothelial dysfunction. J Mol Cell Cardiol. 2015;86:62-74 pubmed publisher
Wang X, Li R, Wang X, Fu Q, Ma S. Umbelliferone ameliorates cerebral ischemia-reperfusion injury via upregulating the PPAR gamma expression and suppressing TXNIP/NLRP3 inflammasome. Neurosci Lett. 2015;600:182-7 pubmed publisher
Li Y, Yang J, Chen M, Wang Q, Qin M, Zhang T, et al. Ilexgenin A inhibits endoplasmic reticulum stress and ameliorates endothelial dysfunction via suppression of TXNIP/NLRP3 inflammasome activation in an AMPK dependent manner. Pharmacol Res. 2015;99:101-15 pubmed publisher
Zhao Y, Li Q, Zhao W, Li J, Sun Y, Liu K, et al. Astragaloside IV and cycloastragenol are equally effective in inhibition of endoplasmic reticulum stress-associated TXNIP/NLRP3 inflammasome activation in the endothelium. J Ethnopharmacol. 2015;169:210-8 pubmed publisher
Li Y, Li J, Li S, Li Y, Wang X, Liu B, et al. Curcumin attenuates glutamate neurotoxicity in the hippocampus by suppression of ER stress-associated TXNIP/NLRP3 inflammasome activation in a manner dependent on AMPK. Toxicol Appl Pharmacol. 2015;286:53-63 pubmed publisher
Gabrielli E, Pericolini E, Luciano E, Sabbatini S, Roselletti E, Perito S, et al. Induction of caspase-11 by aspartyl proteinases of Candida albicans and implication in promoting inflammatory response. Infect Immun. 2015;83:1940-8 pubmed publisher
Zhang X, Zhang J, Chen X, Hu Q, Wang M, Jin R, et al. Reactive oxygen species-induced TXNIP drives fructose-mediated hepatic inflammation and lipid accumulation through NLRP3 inflammasome activation. Antioxid Redox Signal. 2015;22:848-70 pubmed publisher
Song J, Li J, Hou F, Wang X, Liu B. Mangiferin inhibits endoplasmic reticulum stress-associated thioredoxin-interacting protein/NLRP3 inflammasome activation with regulation of AMPK in endothelial cells. Metabolism. 2015;64:428-37 pubmed publisher
Joshi S, Wang W, Peck A, Khan S. Activation of the NLRP3 inflammasome in association with calcium oxalate crystal induced reactive oxygen species in kidneys. J Urol. 2015;193:1684-91 pubmed publisher
product information
master code :
NBP2-12446
SKU :
NBP2-12446
product name :
NLRP3/NALP3 Antibody - BSA Free
unit size :
0.2 ml (also 0.05 ml)
description :
The NLRP3/NALP3 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to NLRP3/NALP3. This antibody reacts with bovine,human,mouse,rat. The NLRP3/NALP3 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunomicroscopy,Knockout Validated,Knockdown Validated.
target :
NLRP3/NALP3
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This NLRP3/NALP3 antibody was raised against a portion of amino acids 1-50 of human NLRP3/NALP3.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Bovine,Human,Mouse,Rat
theoretical molecular weight :
118 kDa
gene symbol :
NLRP3
accessionNumbers :
Q96P20
applications :
Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunomicroscopy,Knockout Validated,Knockdown Validated
USD :
459 USD
alt names :
AII, AII/AVP, Angiotensin/vasopressin receptor AII/AVP-like, anti-mouse NLRP3, anti-NLRP3, AVP, C1orf7, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCU, Leucine-rich repeat-, and PYD-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, LRR and PYD containing protein 3, NACHT, LRR and PYD domains-containing protein 3, NALP3, NLR family, pyrin domain containing 3, NLRP3, NLRP3 mouse, NLRP3 polyclonal, NLRP3 rat, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3, PYPAF1, PYRIN-containing APAF1-like protein 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.