Ly-6G/Ly-6C Antibody (RB6-8C5) | Novus Biologicals NBP2-00441 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Ly-6G/Ly-6C Antibody (RB6-8C5)

catalog :

NBP2-00441

quantity :

100 ug (also 25 ug)

price :

279 USD

clonality :

monoclonal

host :

rat

conjugate :

nonconjugated

clone name :

RB6-8C5

reactivity :

mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 64

Reference
Kondreddy V, Pendurthi U, Xu X, Griffin J, Rao L. FVIIa (Factor VIIa) Induces Biased Cytoprotective Signaling in Mice Through the Cleavage of PAR (Protease-Activated Receptor)-1 at Canonical Arg41 (Arginine41) Site. Arterioscler Thromb Vasc Biol. 2020;40:1275-1288 pubmed publisher
Zhang K, Shi Z, Zhang M, Dong X, Zheng L, Li G, et al. Silencing lncRNA Lfar1 alleviates the classical activation and pyoptosis of macrophage in hepatic fibrosis. Cell Death Dis. 2020;11:132 pubmed publisher
Yoon J, Shin J, Pham T, Choi Y, Ryu H, Oh S, et al. Methyl lucidone induces apoptosis and G2/M phase arrest via the PI3K/Akt/NF-κB pathway in ovarian cancer cells. Pharm Biol. 2020;58:51-59 pubmed publisher
Rizwan H, Pal S, Sabnam S, Pal A. High glucose augments ROS generation regulates mitochondrial dysfunction and apoptosis via stress signalling cascades in keratinocytes. Life Sci. 2020;241:117148 pubmed publisher
Miyabe C, Miyabe Y, Bricio Moreno L, Lian J, Rahimi R, Miura N, et al. Dectin-2-induced CCL2 production in tissue-resident macrophages ignites cardiac arteritis. J Clin Invest. 2019;130:3610-3624 pubmed publisher
Hathaway Schrader J, Steinkamp H, Chavez M, Poulides N, Kirkpatrick J, Chew M, et al. Antibiotic Perturbation of Gut Microbiota Dysregulates Osteoimmune Cross Talk in Postpubertal Skeletal Development. Am J Pathol. 2019;189:370-390 pubmed publisher
Saladini S, Aventaggiato M, Barreca F, Morgante E, Sansone L, Russo M, et al. Metformin Impairs Glutamine Metabolism and Autophagy in Tumour Cells. Cells. 2019;8: pubmed publisher
Zhao S, Li W, Cheng F, Rao T, Yu W, Ruan Y, et al. High-pressure carbon dioxide pneumoperitoneum induces oxidative stress and mitochondria-associated apoptotic pathway in rabbit kidneys with severe hydronephrosis. Int J Mol Med. 2019;43:305-315 pubmed publisher
Pennington E, Sullivan E, Fix A, Dadoo S, Zeczycki T, DeSantis A, et al. Proteolipid domains form in biomimetic and cardiac mitochondrial vesicles and are regulated by cardiolipin concentration but not monolyso-cardiolipin. J Biol Chem. 2018;293:15933-15946 pubmed publisher
Kishimoto A, Kimura S, Nio Kobayashi J, Takahashi Iwanaga H, Park A, Iwanaga T. Histochemical characteristics of regressing vessels in the hyaloid vascular system of neonatal mice: Novel implication for vascular atrophy. Exp Eye Res. 2018;172:1-9 pubmed publisher
Li W, Zhao S, Cheng F, Rao T, Yu W, Ruan Y, et al. Oxidative damage and mitochondrial injuries differ following pneumoperitoneum pressure in rabbit models of varying degrees of hydronephrosis. Mol Med Rep. 2018;17:6819-6827 pubmed publisher
Benedicto A, Romayor I, Arteta B. CXCR4 receptor blockage reduces the contribution of tumor and stromal cells to the metastatic growth in the liver. Oncol Rep. 2018;39:2022-2030 pubmed publisher
Murase T, Yamamoto T, Koide A, Yagi Y, Kagawa S, Tsuruya S, et al. Temporal expression of chitinase-like 3 in wounded murine skin. Int J Legal Med. 2017;131:1623-1631 pubmed publisher
Patel N, Garikapati K, Ramaiah M, Polavarapu K, Bhadra U, Bhadra M. miR-15a/miR-16 induces mitochondrial dependent apoptosis in breast cancer cells by suppressing oncogene BMI1. Life Sci. 2016;164:60-70 pubmed publisher
Huang X, Huang R, Gou S, Wang Z, Liao Z, Wang H. Combretastatin A-4 Analogue: A Dual-Targeting and Tubulin Inhibitor Containing Antitumor Pt(IV) Moiety with a Unique Mode of Action. Bioconjug Chem. 2016;27:2132-48 pubmed publisher
Dhumale S, Waghela B, Pathak C. Quercetin protects necrotic insult and promotes apoptosis by attenuating the expression of RAGE and its ligand HMGB1 in human breast adenocarcinoma cells. IUBMB Life. 2015;67:361-73 pubmed publisher
Stremnitzer C, Manzano Szalai K, Willensdorfer A, Starkl P, Pieper M, KÃ¶nig P, et al. Papain Degrades Tight Junction Proteins of Human Keratinocytes In Vitro and Sensitizes C57BL/6 Mice via the Skin Independent of its Enzymatic Activity or TLR4 Activation. J Invest Dermatol. 2015;135:1790-1800 pubmed publisher
Waghela B, Sharma A, Dhumale S, Pandey S, Pathak C. Curcumin conjugated with PLGA potentiates sustainability, anti-proliferative activity and apoptosis in human colon carcinoma cells. PLoS ONE. 2015;10:e0117526 pubmed publisher
Nogami K, Takahama K, Okushima A, Oyoshi T, Fujimoto K, Inouye M. Tailor-made designer helical peptides that induce mitochondrion-mediated cell death without necrosis. Chembiochem. 2014;15:2571-6 pubmed publisher
Sagar S, Kumar P, Behera R, Pal A. Effects of CEES and LPS synergistically stimulate oxidative stress inactivates OGG1 signaling in macrophage cells. J Hazard Mater. 2014;278:236-49 pubmed publisher
Kumar P, Rao G, Pal B, Pal A. Hyperglycemia-induced oxidative stress induces apoptosis by inhibiting PI3-kinase/Akt and ERK1/2 MAPK mediated signaling pathway causing downregulation of 8-oxoG-DNA glycosylase levels in glial cells. Int J Biochem Cell Biol. 2014;53:302-19 pubmed publisher
Wang J, Schilling J, Niesman I, Headrick J, Finley J, Kwan E, et al. Cardioprotective trafficking of caveolin to mitochondria is Gi-protein dependent. Anesthesiology. 2014;121:538-48 pubmed publisher
Pradhan N, Pratheek B, Garai A, Kumar A, Meena V, Ghosh S, et al. Induction of apoptosis by Fe(salen)Cl through caspase-dependent pathway specifically in tumor cells. Cell Biol Int. 2014;38:1118-31 pubmed publisher
Zhang W, Wang X, Chen T. Resveratrol induces apoptosis via a Bak-mediated intrinsic pathway in human lung adenocarcinoma cells. Cell Signal. 2012;24:1037-46 pubmed publisher
Csak T, Dolganiuc A, Kodys K, Nath B, Petrasek J, Bala S, et al. Mitochondrial antiviral signaling protein defect links impaired antiviral response and liver injury in steatohepatitis in mice. Hepatology. 2011;53:1917-31 pubmed publisher
Pickens S, Chamberlain N, Volin M, Mandelin A, Agrawal H, Matsui M, et al. Local expression of interleukin-27 ameliorates collagen-induced arthritis. Arthritis Rheum. 2011;63:2289-98 pubmed publisher
Zall H, Weber A, Besch R, Zantl N, Hacker G. Chemotherapeutic drugs sensitize human renal cell carcinoma cells to ABT-737 by a mechanism involving the Noxa-dependent inactivation of Mcl-1 or A1. Mol Cancer. 2010;9:164 pubmed publisher
Douglas R, Ryu J, Kanaan A, Del Carmen Rivero M, Dugan L, Haddad G, et al. Neuronal death during combined intermittent hypoxia/hypercapnia is due to mitochondrial dysfunction. Am J Physiol Cell Physiol. 2010;298:C1594-602 pubmed publisher
Kamal A, Sreekanth K, Kumar P, Shankaraiah N, Balakishan G, Ramaiah M, et al. Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines. Eur J Med Chem. 2010;45:2173-81 pubmed publisher
Huang B, Zhao J, Shen S, Li H, He K, Shen G, et al. Listeria monocytogenes promotes tumor growth via tumor cell toll-like receptor 2 signaling. Cancer Res. 2007;67:4346-52 pubmed
Sasmono R, Ehrnsperger A, Cronau S, Ravasi T, Kandane R, Hickey M, et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J Leukoc Biol. 2007;82:111-23 pubmed
Kumar P, Coltas I, Kumar B, Chepeha D, Bradford C, Polverini P. Bcl-2 protects endothelial cells against gamma-radiation via a Raf-MEK-ERK-survivin signaling pathway that is independent of cytochrome c release. Cancer Res. 2007;67:1193-202 pubmed
De Chiara G, Marcocci M, Torcia M, Lucibello M, Rosini P, Bonini P, et al. Bcl-2 Phosphorylation by p38 MAPK: identification of target sites and biologic consequences. J Biol Chem. 2006;281:21353-61 pubmed
Chen M, Gan H, Remold H. A mechanism of virulence: virulent Mycobacterium tuberculosis strain H37Rv, but not attenuated H37Ra, causes significant mitochondrial inner membrane disruption in macrophages leading to necrosis. J Immunol. 2006;176:3707-16 pubmed
Meyer L, Karawajew L, Schrappe M, Ludwig W, Debatin K, Stahnke K. Cytochrome c-related caspase-3 activation determines treatment response and relapse in childhood precursor B-cell ALL. Blood. 2006;107:4524-31 pubmed
Yamasaki E, Wada A, Kumatori A, Nakagawa I, Funao J, Nakayama M, et al. Helicobacter pylori vacuolating cytotoxin induces activation of the proapoptotic proteins Bax and Bak, leading to cytochrome c release and cell death, independent of vacuolation. J Biol Chem. 2006;281:11250-9 pubmed
Zhu C, Xu F, Wang X, Shibata M, Uchiyama Y, Blomgren K, et al. Different apoptotic mechanisms are activated in male and female brains after neonatal hypoxia-ischaemia. J Neurochem. 2006;96:1016-27 pubmed
Fan J, Li Y, Vodovotz Y, Billiar T, Wilson M. Hemorrhagic shock-activated neutrophils augment TLR4 signaling-induced TLR2 upregulation in alveolar macrophages: role in hemorrhage-primed lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2006;290:L738-L746 pubmed
Wong S, Chen Y, Chan C, Chan C, Chan P, Chui Y, et al. In vivo functional characterization of the SARS-Coronavirus 3a protein in Drosophila. Biochem Biophys Res Commun. 2005;337:720-9 pubmed
Arnoult D, Grodet A, Lee Y, Estaquier J, Blackstone C. Release of OPA1 during apoptosis participates in the rapid and complete release of cytochrome c and subsequent mitochondrial fragmentation. J Biol Chem. 2005;280:35742-50 pubmed
Alvarez M, Prada F, Salvatierra E, Bravo A, Lutzky V, Carbone C, et al. Secreted protein acidic and rich in cysteine produced by human melanoma cells modulates polymorphonuclear leukocyte recruitment and antitumor cytotoxic capacity. Cancer Res. 2005;65:5123-32 pubmed
Boden G, Homko C, Mozzoli M, Showe L, Nichols C, Cheung P. Thiazolidinediones upregulate fatty acid uptake and oxidation in adipose tissue of diabetic patients. Diabetes. 2005;54:880-5 pubmed
Liang Y, Eid M, Lewis R, Kumar M. Mitochondria from TRAIL-resistant prostate cancer cells are capable of responding to apoptotic stimuli. Cell Signal. 2005;17:243-51 pubmed
Mohr A, Zwacka R, Debatin K, Stahnke K. A novel method for the combined flow cytometric analysis of cell cycle and cytochrome c release. Cell Death Differ. 2004;11:1153-4 pubmed
Liu C, Lee C, Hong C, Wei Y. Mitochondrial DNA mutation and depletion increase the susceptibility of human cells to apoptosis. Ann N Y Acad Sci. 2004;1011:133-45 pubmed
Zhu C, Wang X, Cheng X, Qiu L, Xu F, Simbruner G, et al. Post-ischemic hypothermia-induced tissue protection and diminished apoptosis after neonatal cerebral hypoxia-ischemia. Brain Res. 2004;996:67-75 pubmed
Brown C, Blaho V, Loiacono C. Susceptibility to experimental Lyme arthritis correlates with KC and monocyte chemoattractant protein-1 production in joints and requires neutrophil recruitment via CXCR2. J Immunol. 2003;171:893-901 pubmed
Colell A, Garcia Ruiz C, Lluis J, Coll O, Mari M, Fernandez Checa J. Cholesterol impairs the adenine nucleotide translocator-mediated mitochondrial permeability transition through altered membrane fluidity. J Biol Chem. 2003;278:33928-35 pubmed
Eid M, Lewis R, Kumar M. Mifepristone pretreatment overcomes resistance of prostate cancer cells to tumor necrosis factor alpha-related apoptosis-inducing ligand (TRAIL). Mol Cancer Ther. 2002;1:831-40 pubmed
Chandra D, Liu J, Tang D. Early mitochondrial activation and cytochrome c up-regulation during apoptosis. J Biol Chem. 2002;277:50842-54 pubmed
Bitzer M, Armeanu S, Prinz F, Ungerechts G, Wybranietz W, Spiegel M, et al. Caspase-8 and Apaf-1-independent caspase-9 activation in Sendai virus-infected cells. J Biol Chem. 2002;277:29817-24 pubmed
McLellan A, Kapp M, Eggert A, Linden C, Bommhardt U, Brocker E, et al. Anatomic location and T-cell stimulatory functions of mouse dendritic cell subsets defined by CD4 and CD8 expression. Blood. 2002;99:2084-93 pubmed
Miura M, Fu X, Zhang Q, Remick D, Fairchild R. Neutralization of Gro alpha and macrophage inflammatory protein-2 attenuates renal ischemia/reperfusion injury. Am J Pathol. 2001;159:2137-45 pubmed
Takuma K, Phuagphong P, Lee E, Mori K, Baba A, Matsuda T. Anti-apoptotic effect of cGMP in cultured astrocytes: inhibition by cGMP-dependent protein kinase of mitochondrial permeable transition pore. J Biol Chem. 2001;276:48093-9 pubmed
Junn E, Mouradian M. Apoptotic signaling in dopamine-induced cell death: the role of oxidative stress, p38 mitogen-activated protein kinase, cytochrome c and caspases. J Neurochem. 2001;78:374-83 pubmed
Wang G, Klein J, Kang Y. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther. 2001;298:461-8 pubmed
Shen H, Yang C, Ding W, Liu J, Ong C. Superoxide radical-initiated apoptotic signalling pathway in selenite-treated HepG(2) cells: mitochondria serve as the main target. Free Radic Biol Med. 2001;30:9-21 pubmed
Narvaez C, Welsh J. Role of mitochondria and caspases in vitamin D-mediated apoptosis of MCF-7 breast cancer cells. J Biol Chem. 2001;276:9101-7 pubmed
Datta R, Oki E, Endo K, Biedermann V, Ren J, Kufe D. XIAP regulates DNA damage-induced apoptosis downstream of caspase-9 cleavage. J Biol Chem. 2000;275:31733-8 pubmed
Maccarrone M, Lorenzon T, Bari M, Melino G, Finazzi Agro A. Anandamide induces apoptosis in human cells via vanilloid receptors. Evidence for a protective role of cannabinoid receptors. J Biol Chem. 2000;275:31938-45 pubmed
Maeno E, Ishizaki Y, Kanaseki T, Hazama A, Okada Y. Normotonic cell shrinkage because of disordered volume regulation is an early prerequisite to apoptosis. Proc Natl Acad Sci U S A. 2000;97:9487-92 pubmed
Walczak H, Bouchon A, Stahl H, Krammer P. Tumor necrosis factor-related apoptosis-inducing ligand retains its apoptosis-inducing capacity on Bcl-2- or Bcl-xL-overexpressing chemotherapy-resistant tumor cells. Cancer Res. 2000;60:3051-7 pubmed
Dunussi Joannopoulos K, Runyon K, Erickson J, Schaub R, Hawley R, Leonard J. Vaccines with interleukin-12-transduced acute myeloid leukemia cells elicit very potent therapeutic and long-lasting protective immunity. Blood. 1999;94:4263-73 pubmed
Pervaiz S, Seyed M, Hirpara J, Clement M, Loh K. Purified photoproducts of merocyanine 540 trigger cytochrome C release and caspase 8-dependent apoptosis in human leukemia and melanoma cells. Blood. 1999;93:4096-108 pubmed

product information

brand :

Novus

master code :

NBP2-00441

SKU :

NBP2-00441-100ug

product name :

Ly-6G/Ly-6C Antibody (RB6-8C5)

description :

The Ly-6G/Ly-6C Antibody (RB6-8C5) from Novus Biologicals is a rat monoclonal antibody to Ly-6G/Ly-6C. This antibody reacts with mouse. The Ly-6G/Ly-6C Antibody (RB6-8C5) has been validated for the following applications: Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, In vivo assay, CyTOF-ready.

target :

Ly-6G/Ly-6C

category :

Primary Antibodies

unit size :

100 ug (also 25 ug)

buffer :

PBS

clonality :

Monoclonal

clone :

RB6-8C5

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rat

immunogen :

Normal mouse bone marrow.

isotype :

IgG2b Kappa

purity :

Protein A or G purified

species :

Mouse

specificity :

Studies indicate that in the bone marrow and lysed whole blood, the antibody clone RB6-8C5 also reacts with an additional subpopulation of Ly-6C high cells.

gene symbol :

LY6G

catalog number base :

NBP2-00441

applications :

Western Blot, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, In vivo assay, CyTOF-ready

2020 USD :

279

2021 USD :

279 USD

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.