LAG-3 Antibody (L4-PL33) - BSA Free | Novus Biologicals NBP1-97657 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

LAG-3 Antibody (L4-PL33) - BSA Free

catalog :

NBP1-97657

quantity :

50 ug (also 25 ug, 100 ug)

price :

379 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

L4-PL33

reactivity :

human

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, neutralization, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

citations: 26

Reference
Li K, Tandurella J, Gai J, Zhu Q, Lim S, Thomas D, et al. Multi-omic analyses of changes in the tumor microenvironment of pancreatic adenocarcinoma following neoadjuvant treatment with anti-PD-1 therapy. Cancer Cell. 2022;40:1374-1391.e7 pubmed publisher
Rappold P, Vuong L, Leibold J, Chakiryan N, Curry M, Kuo F, et al. A Targetable Myeloid Inflammatory State Governs Disease Recurrence in Clear-Cell Renal Cell Carcinoma. Cancer Discov. 2022;12:2308-2329 pubmed publisher
El Halabi L, Adam J, Gravelle P, Marty V, Danu A, Lazarovici J, et al. Expression of the Immune Checkpoint Regulators LAG-3 and TIM-3 in Classical Hodgkin Lymphoma. Clin Lymphoma Myeloma Leuk. 2021;21:257-266.e3 pubmed publisher
Dummer R, Lebbe C, Atkinson V, Mandala M, Nathan P, Arance A, et al. Combined PD-1, BRAF and MEK inhibition in advanced BRAF-mutant melanoma: safety run-in and biomarker cohorts of COMBI-i. Nat Med. 2020;26:1557-1563 pubmed publisher
Harper J, Gordon S, Chan C, Wang H, Lindemuth E, Galardi C, et al. CTLA-4 and PD-1 dual blockade induces SIV reactivation without control of rebound after antiretroviral therapy interruption. Nat Med. 2020;26:519-528 pubmed publisher
Xie D, Geng L, Xiong K, Zhao T, Wang S, Xue J, et al. Cold-Inducible RNA-Binding Protein Prevents an Excessive Heart Rate Response to Stress by Targeting Phosphodiesterase. Circ Res. 2020;126:1706-1720 pubmed publisher
Chung Y, Luo A, Park K, Loonat A, Lakhal Littleton S, Robbins P, et al. Iron-deficiency anemia reduces cardiac contraction by downregulating RyR2 channels and suppressing SERCA pump activity. JCI Insight. 2019;4: pubmed publisher
Péricart S, Tosolini M, Gravelle P, Rossi C, Traverse Glehen A, Amara N, et al. Profiling Immune Escape in Hodgkin's and Diffuse large B-Cell Lymphomas Using the Transcriptome and Immunostaining. Cancers (Basel). 2018;10: pubmed publisher
Wang J, Ti Y, Wang Y, Guo G, Jiang H, Chang M, et al. LAG-3 Represents a Marker of CD4+ T Cells with Regulatory Activity in Patients with Bone Fracture. Immunol Invest. 2018;47:492-503 pubmed publisher
Sabins N, Chornoguz O, Leander K, Kaplan F, Carter R, Kinder M, et al. TIM-3 Engagement Promotes Effector Memory T Cell Differentiation of Human Antigen-Specific CD8 T Cells by Activating mTORC1. J Immunol. 2017;199:4091-4102 pubmed publisher
Ma Q, Huang D, Zhang H, Wang S, Chen X. Function and regulation of LAG3 on CD4+CD25- T cells in non-small cell lung cancer. Exp Cell Res. 2017;360:358-364 pubmed publisher
Schroeder M, Ali M, Hulikova A, Supuran C, Clarke K, Vaughan Jones R, et al. Extramitochondrial domain rich in carbonic anhydrase activity improves myocardial energetics. Proc Natl Acad Sci U S A. 2013;110:E958-67 pubmed publisher
Klug D, Boulé S, Wissocque L, Montaigne D, Marechal X, Hassoun S, et al. Right ventricular pacing with mechanical dyssynchrony causes apoptosis interruptus and calcium mishandling. Can J Cardiol. 2013;29:510-8 pubmed publisher
Garcia Perez C, Hajnoczky G, Csordás G. Physical coupling supports the local Ca2+ transfer between sarcoplasmic reticulum subdomains and the mitochondria in heart muscle. J Biol Chem. 2008;283:32771-80 pubmed publisher
Casati C, Camisaschi C, Novellino L, Mazzocchi A, Triebel F, Rivoltini L, et al. Human lymphocyte activation gene-3 molecules expressed by activated T cells deliver costimulation signal for dendritic cell activation. J Immunol. 2008;180:3782-8 pubmed
Anyatonwu G, Estrada M, Tian X, Somlo S, Ehrlich B. Regulation of ryanodine receptor-dependent calcium signaling by polycystin-2. Proc Natl Acad Sci U S A. 2007;104:6454-9 pubmed
Prasad A, Ma H, Sumbilla C, Lee D, Klein M, Inesi G. Phenylephrine hypertrophy, Ca2+-ATPase (SERCA2), and Ca2+ signaling in neonatal rat cardiac myocytes. Am J Physiol Cell Physiol. 2007;292:C2269-75 pubmed
Triebel F, Hacene K, Pichon M. A soluble lymphocyte activation gene-3 (sLAG-3) protein as a prognostic factor in human breast cancer expressing estrogen or progesterone receptors. Cancer Lett. 2006;235:147-53 pubmed
Macon Lemaitre L, Triebel F. The negative regulatory function of the lymphocyte-activation gene-3 co-receptor (CD223) on human T cells. Immunology. 2005;115:170-8 pubmed
Di Carlo E, Cappello P, Sorrentino C, D Antuono T, Pellicciotta A, Giovarelli M, et al. Immunological mechanisms elicited at the tumour site by lymphocyte activation gene-3 (LAG-3) versus IL-12: sharing a common Th1 anti-tumour immune pathway. J Pathol. 2005;205:82-91 pubmed
Khan S, Lee K, Minhas K, Gonzalez D, Raju S, Tejani A, et al. Neuronal nitric oxide synthase negatively regulates xanthine oxidoreductase inhibition of cardiac excitation-contraction coupling. Proc Natl Acad Sci U S A. 2004;101:15944-8 pubmed
Krizaj D, Liu X, Copenhagen D. Expression of calcium transporters in the retina of the tiger salamander (Ambystoma tigrinum). J Comp Neurol. 2004;475:463-80 pubmed
Spragg D, Leclercq C, Loghmani M, Faris O, Tunin R, Disilvestre D, et al. Regional alterations in protein expression in the dyssynchronous failing heart. Circulation. 2003;108:929-32 pubmed
Tupling A, Asahi M, MacLennan D. Sarcolipin overexpression in rat slow twitch muscle inhibits sarcoplasmic reticulum Ca2+ uptake and impairs contractile function. J Biol Chem. 2002;277:44740-6 pubmed
Asahi M, Kurzydlowski K, Tada M, MacLennan D. Sarcolipin inhibits polymerization of phospholamban to induce superinhibition of sarco(endo)plasmic reticulum Ca2+-ATPases (SERCAs). J Biol Chem. 2002;277:26725-8 pubmed
Demeure C, Wolfers J, Martin Garcia N, Gaulard P, Triebel F. T Lymphocytes infiltrating various tumour types express the MHC class II ligand lymphocyte activation gene-3 (LAG-3): role of LAG-3/MHC class II interactions in cell-cell contacts. Eur J Cancer. 2001;37:1709-18 pubmed

product information

brand :

Novus

master code :

NBP1-97657

SKU :

NBP1-97657

product name :

LAG-3 Antibody (L4-PL33) - BSA Free

description :

The LAG-3 Antibody (L4-PL33) - BSA Free from Novus is a mouse monoclonal antibody to LAG-3. This antibody reacts with human, primate. The LAG-3 Antibody (L4-PL33) - BSA Free has been validated for the following applications: Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Block/Neutralize.

target :

LAG-3

category :

Primary Antibodies

sizes available :

50 ug (also 25 ug, 100 ug)

buffer :

PBS, 10% glycerol

clonality :

Monoclonal

clone :

L4-PL33

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

This LAG-3 Antibody (L4-PL33) was prepared from synthetic peptide corresponding to 30 aa (GPPAAAPGHPLAPGPHPAAPSSWGPRPRRY) from the first N-terminal D1 domain of human LAG-3 (lymphocyte activation gene-3).

isotype :

IgG1 Kappa

purity :

Protein A or G purified

species :

Human, Primate

specificity :

LAG-3 Antibody (L4-PL33) recognizes the 30 aa extra-loop of the first N-terminal D1 domain of human LAG-3

theoretical molecular weight :

57.5 kDa

gene symbol :

LAG3

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0009.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Western-Blot-NBP1-97657-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Western-Blot-NBP1-97657-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Western-Blot-NBP1-97657-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Western-Blot-NBP1-97657-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Western-Blot-NBP1-97657-img0001.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0006.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Immunohistochemistry-Paraffin-NBP1-97657-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Immunohistochemistry-Paraffin-NBP1-97657-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Immunohistochemistry-Paraffin-NBP1-97657-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Immunohistochemistry-Paraffin-NBP1-97657-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Immunohistochemistry-Paraffin-NBP1-97657-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0005.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0007.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/LAG-3-Antibody-(17B4)-Flow-Cytometry-NBP1-97657-img0007.jpg

applications :

Western Blot, Flow Cytometry, ELISA, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Block/Neutralize

extended description :

Clone L4-PL33 was used by HLDA to establish CD designation.

USD :

379 USD

product details :

Clone L4-PL33 was used by HLDA to establish CD designation.

alt names :

17b4, 17b4 lag3, 17b4 neutralizing, anti human lag3, Anti-LAG-3, CD223, CD223 Antigen, Human LAG3, Human LAG-3, LAG3, LAG-3, LAG-3 17b4, LAG-3 blocking, lymphocyte activating 3, lymphocyte activation gene 3 protein, lymphocyte-activation gene 3, Secreted lymphocyte activation gene 3 protein, sLAG-3

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.