Published Application/Species/Sample/Dilution | Reference |
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- western blot; human; loading ...; fig 4
| Girardini M, Maniaci C, Hughes S, Testa A, Ciulli A. Cereblon versus VHL: Hijacking E3 ligases against each other using PROTACs. Bioorg Med Chem. 2019;27:2466-2479 pubmed publisher
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- western blot; human; 1:1000; loading ...; fig 1c
| Jian Y, Gao W, Geng C, Zhou H, Leng Y, Li Y, et al. Arsenic trioxide potentiates sensitivity of multiple myeloma cells to lenalidomide by upregulating cereblon expression levels. Oncol Lett. 2017;14:3243-3248 pubmed publisher
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| Lee S, Kim H, Woo Y, Kim J, Kim H, Park J, et al. UBX-390: A Novel Androgen Receptor Degrader for Therapeutic Intervention in Prostate Cancer. Adv Sci (Weinh). 2024;11:e2400398 pubmed publisher
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| Jiang B, Weinstock D, Donovan K, Sun H, Wolfe A, Amaka S, et al. ITK degradation to block T cell receptor signaling and overcome therapeutic resistance in T cell lymphomas. Cell Chem Biol. 2023;30:383-393.e6 pubmed publisher
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| Mehta S, Buyanbat A, Kai Y, Karayel Ö, Goldman S, Seruggia D, et al. Temporal resolution of gene derepression and proteome changes upon PROTAC-mediated degradation of BCL11A protein in erythroid cells. Cell Chem Biol. 2022;29:1273-1287.e8 pubmed publisher
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| Shen C, Nayak A, Neitzel L, Yang F, Li B, Williams C, et al. The Casein kinase 1α agonist pyrvinium attenuates Wnt-mediated CK1α degradation via interaction with the E3 ubiquitin ligase component Cereblon. J Biol Chem. 2022;298:102227 pubmed publisher
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| Yamamoto T, Nakayama J, Yamamoto Y, Kuroda M, Hattori Y, Ochiya T. SORT1/LAMP2-mediated Extracellular Vesicle Secretion and Cell Adhesion Are Linked to Lenalidomide Resistance in Multiple Myeloma. Blood Adv. 2022;: pubmed publisher
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| Mori T, Verma R, Nakamoto Matsubara R, Siu K, Panaroni C, Fulzele K, et al. Low NCOR2 levels in multiple myeloma patients drive multidrug resistance via MYC upregulation. Blood Cancer J. 2021;11:194 pubmed publisher
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| Wu X, Yang X, Xiong Y, Li R, Ito T, Ahmed T, et al. Distinct CDK6 complexes determine tumor cell response to CDK4/6 inhibitors and degraders. Nat Cancer. 2021;2:429-443 pubmed publisher
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| Shen C, Nayak A, Neitzel L, Adams A, Silver Isenstadt M, Sawyer L, et al. The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling. Nat Commun. 2021;12:5263 pubmed publisher
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| Powell C, Du G, Bushman J, He Z, Zhang T, Fischer E, et al. Selective degradation-inducing probes for studying cereblon (CRBN) biology. RSC Med Chem. 2021;12:1381-1390 pubmed publisher
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| Misiewicz Krzeminska I, de Ramón C, Corchete L, Krzeminski P, Rojas E, Isidro I, et al. Quantitative expression of Ikaros, IRF4, and PSMD10 proteins predicts survival in VRD-treated patients with multiple myeloma. Blood Adv. 2020;4:6023-6033 pubmed publisher
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| Powell C, Du G, Che J, He Z, Donovan K, Yue H, et al. Selective Degradation of GSPT1 by Cereblon Modulators Identified via a Focused Combinatorial Library. ACS Chem Biol. 2020;15:2722-2730 pubmed publisher
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| Martínez Høyer S, Deng Y, Parker J, Jiang J, Mo A, Docking T, et al. Loss of lenalidomide-induced megakaryocytic differentiation leads to therapy resistance in del(5q) myelodysplastic syndrome. Nat Cell Biol. 2020;22:526-533 pubmed publisher
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| Jain P, Ballaré C, Blanco E, Vizan P, Di Croce L. PHF19 mediated regulation of proliferation and invasiveness in prostate cancer cells. elife. 2020;9: pubmed publisher
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| de Wispelaere M, Du G, Donovan K, Zhang T, Eleuteri N, Yuan J, et al. Small molecule degraders of the hepatitis C virus protease reduce susceptibility to resistance mutations. Nat Commun. 2019;10:3468 pubmed publisher
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| Kumar R, Evans T. Activation-Induced Cytidine Deaminase Regulates Fibroblast Growth Factor/Extracellular Signal-Regulated Kinases Signaling to Achieve the Naïve Pluripotent State During Reprogramming. Stem Cells. 2019;37:1003-1017 pubmed publisher
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| Zoppi V, Hughes S, Maniaci C, Testa A, Gmaschitz T, Wieshofer C, et al. Iterative design and optimization of initially inactive Proteolysis Targeting Chimeras (PROTACs) identify VZ185 as a potent, fast and selective von Hippel-Lindau (VHL)-based dual degrader probe of BRD9 and BRD7. J Med Chem. 2018;: pubmed publisher
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| Sievers Q, Petzold G, Bunker R, Renneville A, Słabicki M, Liddicoat B, et al. Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN. Science. 2018;362: pubmed publisher
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| Yen Y, Hsieh W, Tsai Y, Lü Y, Liau E, Hsu H, et al. Dlk1-Dio3 locus-derived lncRNAs perpetuate postmitotic motor neuron cell fate and subtype identity. elife. 2018;7: pubmed publisher
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| Donovan K, An J, Nowak R, Yuan J, Fink E, Berry B, et al. Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. elife. 2018;7: pubmed publisher
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| Perino M, van Mierlo G, Karemaker I, van Genesen S, Vermeulen M, Marks H, et al. MTF2 recruits Polycomb Repressive Complex 2 by helical-shape-selective DNA binding. Nat Genet. 2018;50:1002-1010 pubmed publisher
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| Olson C, Jiang B, Erb M, Liang Y, Doctor Z, Zhang Z, et al. Pharmacological perturbation of CDK9 using selective CDK9 inhibition or degradation. Nat Chem Biol. 2017;: pubmed publisher
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| Schneider E, Staffas A, Röhner L, Malmberg E, Ashouri A, Krowiorz K, et al. Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia. Haematologica. 2018;103:246-255 pubmed publisher
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| Huang H, Dobrovolsky D, Paulk J, Yang G, Weisberg E, Doctor Z, et al. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. Cell Chem Biol. 2018;25:88-99.e6 pubmed publisher
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| Basu M, Zhu J, Lahaye S, Majumdar U, Jiao K, Han Z, et al. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. JCI Insight. 2017;2: pubmed publisher
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| Qu Y, Yang Q, Liu J, Shi B, Ji M, Li G, et al. c-Myc is Required for BRAFV600E-Induced Epigenetic Silencing by H3K27me3 in Tumorigenesis. Theranostics. 2017;7:2092-2107 pubmed publisher
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| An J, Ponthier C, Sack R, Seebacher J, Stadler M, Donovan K, et al. pSILAC mass spectrometry reveals ZFP91 as IMiD-dependent substrate of the CRL4CRBN ubiquitin ligase. Nat Commun. 2017;8:15398 pubmed publisher
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| Jin H, Oda H, Chen P, Yang C, Zhou X, Kang S, et al. Differential Sensitivity of Target Genes to Translational Repression by miR-17~92. PLoS Genet. 2017;13:e1006623 pubmed publisher
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| Fantini D, Huang S, Asara J, Bagchi S, Raychaudhuri P. Chromatin association of XRCC5/6 in the absence of DNA damage depends on the XPE gene product DDB2. Mol Biol Cell. 2017;28:192-200 pubmed publisher
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| Cooper S, Grijzenhout A, Underwood E, Ancelin K, Zhang T, Nesterova T, et al. Jarid2 binds mono-ubiquitylated H2A lysine 119 to mediate crosstalk between Polycomb complexes PRC1 and PRC2. Nat Commun. 2016;7:13661 pubmed publisher
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| Yoon S, Foley J, Baker J. HEB associates with PRC2 and SMAD2/3 to regulate developmental fates. Nat Commun. 2015;6:6546 pubmed publisher
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