product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
ASC/TMS1 Antibody - BSA Free
catalog :
NBP1-78977
quantity :
0.1 ml (also 0.025 ml)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
8E10.1D6
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section
more info or order :
citations: 53
Reference
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Ferrara F, Yan X, Pecorelli A, Guiotto A, Colella S, Pasqui A, et al. Combined exposure to UV and PM affect skin oxinflammatory responses and it is prevented by antioxidant mix topical application: Evidences from clinical study. J Cosmet Dermatol. 2024;23:2644-2656 pubmed publisher
Yan X, Fu P, Zhang Y, Ling D, Reynolds L, Hua W, et al. MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise. Molecules. 2024;29: pubmed publisher
Ferrara F, Pecorelli A, Pambianchi E, White S, Choudhary H, Casoni A, et al. Vitamin C compounds mixture prevents skin barrier alterations and inflammatory responses upon real life multi pollutant exposure. Exp Dermatol. 2024;33:e15000 pubmed publisher
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McElwain C, Musumeci A, Manna S, McCarthy F, McCarthy C. L-ergothioneine reduces mitochondrial-driven NLRP3 activation in gestational diabetes mellitus. J Reprod Immunol. 2024;161:104171 pubmed publisher
Ivarsson J, Ferrara F, Vallese A, Guiotto A, Colella S, Pecorelli A, et al. Comparison of Pollutant Effects on Cutaneous Inflammasomes Activation. Int J Mol Sci. 2023;24: pubmed publisher
Quan J, Gao F, Ma T, Ye W, Gao X, Deng M, et al. Toxoplasma gondii Induces Pyroptosis in Human Placental Trophoblast and Amniotic Cells by Inducing ROS Production and Activation of Cathepsin B and NLRP1/NLRP3/NLRC4/AIM2 Inflammasome. Am J Pathol. 2023;193:2047-2065 pubmed publisher
Chen X, Huang L, Tang J, Wu D, An N, Ye Z, et al. Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice by improving the TFEB-mediated autophagy-lysosome pathway. Biomed Pharmacother. 2023;165:115122 pubmed publisher
Ning J, Pei Z, Wang M, Hu H, Chen M, Liu Q, et al. Site-specific Atg13 methylation-mediated autophagy regulates epithelial inflammation in PM2.5-induced pulmonary fibrosis. J Hazard Mater. 2023;457:131791 pubmed publisher
Gratuze M, Schlachetzki J, D Oliveira Albanus R, Jain N, Novotny B, Brase L, et al. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4. Neuron. 2023;111:202-219.e7 pubmed publisher
Li T, Li L, Peng R, Hao H, Zhang H, Gao Y, et al. Abrocitinib Attenuates Microglia-Mediated Neuroinflammation after Traumatic Brain Injury via Inhibiting the JAK1/STAT1/NF-κB Pathway. Cells. 2022;11: pubmed publisher
Ferrara F, Cordone V, Pecorelli A, Benedusi M, Pambianchi E, Guiotto A, et al. Ubiquitination as a key regulatory mechanism for O3-induced cutaneous redox inflammasome activation. Redox Biol. 2022;56:102440 pubmed publisher
Zaninelli T, Fattori V, Saraiva Santos T, Badaró Garcia S, Staurengo Ferrari L, Andrade K, et al. RvD1 disrupts nociceptor neuron and macrophage activation and neuroimmune communication, reducing pain and inflammation in gouty arthritis in mice. Br J Pharmacol. 2022;179:4500-4515 pubmed publisher
Zhang Z, Dang S, Li S, Liu Y, Qi M, Wang N, et al. Glucose Fluctuations Aggravate Myocardial Fibrosis via the Nuclear Factor-κB-Mediated Nucleotide-Binding Oligomerization Domain-Like Receptor Protein 3 Inflammasome Activation. Front Cardiovasc Med. 2022;9:748183 pubmed publisher
Jung E, Suh K, Han J, Kim H, Kang H, Choi W, et al. Amyloid-β activates NLRP3 inflammasomes by affecting microglial immunometabolism through the Syk-AMPK pathway. Aging Cell. 2022;21:e13623 pubmed publisher
Chen X, Wu D, Wu H, Li H, Yang C, Su H, et al. Metformin improves renal injury of MRL/lpr lupus-prone mice via the AMPK/STAT3 pathway. Lupus Sci Med. 2022;9: pubmed publisher
Hosoya T, Uchida S, Shibata S, Tomioka N, Matsumoto K, Hosoyamada M. Xanthine Oxidoreductase Inhibitors Suppress the Onset of Exercise-Induced AKI in High HPRT Activity Urat1-Uox Double Knockout Mice. J Am Soc Nephrol. 2022;33:326-341 pubmed publisher
Lage S, Amaral E, Hilligan K, Laidlaw E, Rupert A, Namasivayan S, et al. Persistent Oxidative Stress and Inflammasome Activation in CD14highCD16- Monocytes From COVID-19 Patients. Front Immunol. 2021;12:799558 pubmed publisher
Zhang C, Wang X, Wang C, He C, Ma Q, Li J, et al. Qingwenzhike Prescription Alleviates Acute Lung Injury Induced by LPS via Inhibiting TLR4/NF-kB Pathway and NLRP3 Inflammasome Activation. Front Pharmacol. 2021;12:790072 pubmed publisher
Pastar I, Sawaya A, Marjanovic J, Burgess J, Strbo N, Rivas K, et al. Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression. J Clin Invest. 2021;131: pubmed publisher
Guo M, Chivero E, Callen S, Buch S. NLRP3 Inflammasome Is Involved in Cocaine-Mediated Potentiation on Behavioral Changes in CX3CR1-Deficient Mice. J Pers Med. 2021;11: pubmed publisher
Borges Rodriguez M, Shields C, Travis O, Tramel R, Baik C, Giachelli C, et al. Platelet Inhibition Prevents NLRP3 Inflammasome Activation and Sepsis-Induced Kidney Injury. Int J Mol Sci. 2021;22: pubmed publisher
Li Z, Xu H, Xu Y, Lu G, Peng Q, Chen J, et al. Morinda officinalis oligosaccharides alleviate depressive-like behaviors in post-stroke rats via suppressing NLRP3 inflammasome to inhibit hippocampal inflammation. CNS Neurosci Ther. 2021;27:1570-1586 pubmed publisher
Dang R, Yang M, Cui C, Wang C, Zhang W, Geng C, et al. Activation of angiotensin-converting enzyme 2/angiotensin (1-7)/mas receptor axis triggers autophagy and suppresses microglia proinflammatory polarization via forkhead box class O1 signaling. Aging Cell. 2021;20:e13480 pubmed publisher
Li X, Zhang X, Xia J, Zhang L, Chen B, Lian G, et al. Macrophage HIF-2α suppresses NLRP3 inflammasome activation and alleviates insulin resistance. Cell Rep. 2021;36:109607 pubmed publisher
Shih H, Chang C, Lai C, Huang C. Therapeutic effect of modulating the NLRP3-regulated transforming growth factor-β signaling pathway on interstitial cystitis/bladder pain syndrome. Biomed Pharmacother. 2021;138:111522 pubmed publisher
Zhang X, Huang W, Tang P, Sun Y, Zhang X, Qiu L, et al. Anti-inflammatory and neuroprotective effects of natural cordycepin in rotenone-induced PD models through inhibiting Drp1-mediated mitochondrial fission. Neurotoxicology. 2021;84:1-13 pubmed publisher
Gordon M, Meagher P, Connelly K. Effect of Empagliflozin and Liraglutide on the Nucleotide-Binding and Oligomerization Domain-Like Receptor Family Pyrin Domain-Containing 3 Inflammasome in a Rodent Model of Type 2 Diabetes Mellitus. Can J Diabetes. 2020;: pubmed publisher
Verma V, Kumar P, Gupta S, Yadav S, Dhanda R, Thorlacius H, et al. α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages. Sci Rep. 2020;10:12653 pubmed publisher
Cornelius D, Travis O, Tramel R, Borges Rodriguez M, Baik C, Greer M, et al. NLRP3 inflammasome inhibition attenuates sepsis-induced platelet activation and prevents multi-organ injury in cecal-ligation puncture. PLoS ONE. 2020;15:e0234039 pubmed publisher
Pérez Martínez P, Rojas Espinosa O, Hernández Chávez V, Arce Paredes P, Estrada Parra S. Anti-inflammatory effect of omega unsaturated fatty acids and dialysable leucocyte extracts on collagen-induced arthritis in DBA/1 mice. Int J Exp Pathol. 2020;101:55-64 pubmed publisher
Shin N, Shin H, Yi Y, Beom J, Lee W, Lee C, et al. p66shc siRNA-Encapsulated PLGA Nanoparticles Ameliorate Neuropathic Pain Following Spinal Nerve Ligation. Polymers (Basel). 2020;12: pubmed publisher
Dang S, Zhang Z, LI K, Zheng J, Qian L, Liu X, et al. Blockade of β-adrenergic signaling suppresses inflammasome and alleviates cardiac fibrosis. Ann Transl Med. 2020;8:127 pubmed publisher
Kariya S, Okano M, Zhao P, Maeda Y, Kataoka Y, Higaki T, et al. Role of Macrophage Migration Inhibitory Factor in NLRP3 Inflammasome Expression in Otitis Media. Otol Neurotol. 2020;41:364-370 pubmed publisher
Verma V, Gupta S, Kumar P, Yadav S, Dhanda R, Gaind R, et al. Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections. Front Microbiol. 2019;10:2020 pubmed publisher
Lage S, Dominical V, Wong C, Sereti I. Evaluation of Canonical Inflammasome Activation in Human Monocytes by Imaging Flow Cytometry. Front Immunol. 2019;10:1284 pubmed publisher
Cornelius D, Baik C, Travis O, White D, Young C, Austin Pierce W, et al. NLRP3 inflammasome activation in platelets in response to sepsis. Physiol Rep. 2019;7:e14073 pubmed publisher
Wang X, Pan J, Liu H, Zhang M, Liu D, Lu L, et al. AIM2 gene silencing attenuates diabetic cardiomyopathy in type 2 diabetic rat model. Life Sci. 2019;221:249-258 pubmed publisher
Kariya S, Okano M, Zhao P, Maeda Y, Kataoka Y, Higaki T, et al. NLRP3 inflammasome expression in lipopolysaccharide-induced otitis media. Acta Otolaryngol. 2018;138:1061-1065 pubmed publisher
Zhou L, Su X, Li B, Chu C, Sun H, Zhang N, et al. PM2.5 exposure impairs sperm quality through testicular damage dependent on NALP3 inflammasome and miR-183/96/182 cluster targeting FOXO1 in mouse. Ecotoxicol Environ Saf. 2019;169:551-563 pubmed publisher
Han H, Chou C, Li R, Liu J, Zhang L, Zhu W, et al. Chalcomoracin is a potent anticancer agent acting through triggering Oxidative stress via a mitophagy- and paraptosis-dependent mechanism. Sci Rep. 2018;8:9566 pubmed publisher
Cohen T, Boland M, Boland B, Takahashi V, Tovchigrechko A, Lee Y, et al. S. aureus Evades Macrophage Killing through NLRP3-Dependent Effects on Mitochondrial Trafficking. Cell Rep. 2018;22:2431-2441 pubmed publisher
Piao Y, Gwon D, Kang D, Hwang T, Shin N, Kwon H, et al. TLR4-mediated autophagic impairment contributes to neuropathic pain in chronic constriction injury mice. Mol Brain. 2018;11:11 pubmed publisher
Kim M, Hwang J, Yun C, Lee Y, Choi Y. Delivery of exogenous mitochondria via centrifugation enhances cellular metabolic function. Sci Rep. 2018;8:3330 pubmed publisher
Liang Y, Liang S, Zhang Y, Deng Y, He Y, Chen Y, et al. Oral Administration of Compound Probiotics Ameliorates HFD-Induced Gut Microbe Dysbiosis and Chronic Metabolic Inflammation via the G Protein-Coupled Receptor 43 in Non-alcoholic Fatty Liver Disease Rats. Probiotics Antimicrob Proteins. 2019;11:175-185 pubmed publisher
Zhang B, Xu D, She L, Wang Z, Yang N, Sun R, et al. Silybin inhibits NLRP3 inflammasome assembly through the NAD+/SIRT2 pathway in mice with nonalcoholic fatty liver disease. FASEB J. 2018;32:757-767 pubmed publisher
Tan W, Song L, Graham M, Schettino A, Navaratnam D, Yarbrough W, et al. Novel Role of the Mitochondrial Protein Fus1 in Protection from Premature Hearing Loss via Regulation of Oxidative Stress and Nutrient and Energy Sensing Pathways in the Inner Ear. Antioxid Redox Signal. 2017;27:489-509 pubmed publisher
Macpherson M, Westbom C, Kogan H, Shukla A. Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro. Histochem Cell Biol. 2017;147:595-604 pubmed publisher
Ko J, Park J, Park Y, Koh H. PPAR-? activation attenuates deltamethrin-induced apoptosis by regulating cytosolic PINK1 and inhibiting mitochondrial dysfunction. Toxicol Lett. 2016;260:8-17 pubmed publisher
Kim S, Cha J, Kang H, Lee J, Lee J, Park J, et al. Corosolic acid ameliorates acute inflammation through inhibition of IRAK-1 phosphorylation in macrophages. BMB Rep. 2016;49:276-81 pubmed
Kariya S, Okano M, Zhao P, Kataoka Y, Yoshinobu J, Maeda Y, et al. Activation of NLRP3 inflammasome in human middle ear cholesteatoma and chronic otitis media. Acta Otolaryngol. 2016;136:136-40 pubmed publisher
Yao X, Carlson D, Sun Y, Ma L, Wolf S, Minei J, et al. Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. PLoS ONE. 2015;10:e0139416 pubmed publisher
product information
master code :
NBP1-78977
SKU :
NBP1-78977
product name :
ASC/TMS1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The ASC/TMS1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to ASC/TMS1. This antibody reacts with human,mouse,rat. The ASC/TMS1 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Immunohistochemistry-Paraffin,Western Blot,Flow Cytometry Control,IF/IHC,Flow Cytometry,Immunoprecipitation,Immunomicroscopy,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Simple Western.
target :
ASC/TMS1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This ASC/TMS1 Antibody was developed against a synthetic peptide made to an N-terminal portion of the human ASC/TMS1 protein (between residues 1-50) [Uniprot: Q9ULZ3]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
gene symbol :
PYCARD
Antibody validation :
Biological Validation
accessionNumbers :
Q9ULZ3
applications :
Immunohistochemistry,Western Blot,Flow Cytometry Control,IF/IHC,Flow Cytometry,Immunoprecipitation,Immunohistochemistry-Paraffin,Immunomicroscopy,Immunocytochemistry/ Immunofluorescence,Flow (Intracellular),Simple Western
USD :
459 USD
alt names :
apoptosis-associated speck-like protein containing a CARD, ASC, CARD5, caspase recruitment domain protein 5, Caspase recruitment domain-containing protein 5, hASC, PYCARD, PYD and CARD domain-containing protein, Target of methylation-induced silencing 1, TMS, TMS1, TMS-1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.