Smad3 [p Ser423, p Ser425] Antibody - BSA Free | Novus Biologicals NBP1-77836 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Smad3 [p Ser423, p Ser425] Antibody - BSA Free

catalog :

NBP1-77836

quantity :

0.1 mg (also 0.025 mg)

price :

539 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

194C1439

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 17

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:3000; loading ...; fig 7e western blot; mouse; 1:2000; loading ...; fig 4a	Mehta N, Li R, Zhang D, Soomro A, He J, Zhang I, et al. miR299a-5p promotes renal fibrosis by suppressing the antifibrotic actions of follistatin. Sci Rep. 2021;11:88 pubmed publisher
	Letson J, Furuta S. Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast. bioRxiv. 2023;: pubmed publisher
	Soomro A, Khajehei M, Li R, O Neil K, Zhang D, Gao B, et al. A therapeutic target for CKD: activin A facilitates TGFβ1 profibrotic signaling. Cell Mol Biol Lett. 2023;28:10 pubmed publisher
	Cuevas R, Wong R, Joolharzadeh P, Moorhead W, Chu C, Callahan J, et al. Ecto-5'-nucleotidase (Nt5e/CD73)-mediated adenosine signaling attenuates TGFβ-2 induced elastin and cellular contraction. Am J Physiol Cell Physiol. 2023;324:C327-C338 pubmed publisher
	Mukhi D, Kolligundla L, Maruvada S, Nishad R, Pasupulati A. Growth hormone induces transforming growth factor-β1 in podocytes: Implications in podocytopathy and proteinuria. Biochim Biophys Acta Mol Cell Res. 2023;1870:119391 pubmed publisher
	Smith S, Chu D, Qu T, Aggleton J, Schneider R. Species-specific sensitivity to TGFβ signaling and changes to the Mmp13 promoter underlie avian jaw development and evolution. elife. 2022;11: pubmed publisher
	Zheng X, Fernando V, Sharma V, Walia Y, Letson J, Furuta S. Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem Pharmacol. 2020;176:113887 pubmed publisher
	Sorkin M, Huber A, HWANG C, Carson W, Menon R, Li J, et al. Regulation of heterotopic ossification by monocytes in a mouse model of aberrant wound healing. Nat Commun. 2020;11:722 pubmed publisher
	Ren G, Zheng X, Bommarito M, Metzger S, Walia Y, Letson J, et al. Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ. Sci Rep. 2019;9:6688 pubmed publisher
	Mega Tiber P, Kocyigit Sevinc S, Kilinc O, Orun O. Biological effects of whole Z.Officinale extract on chronic myeloid leukemia cell line K562. Gene. 2019;692:217-222 pubmed publisher
	Dou X, Li S, Hu L, Ding L, Ma Y, Ma W, et al. Glutathione disulfide sensitizes hepatocytes to TNFα-mediated cytotoxicity via IKK-β S-glutathionylation: a potential mechanism underlying non-alcoholic fatty liver disease. Exp Mol Med. 2018;50:7 pubmed publisher
	Melão A, Spit M, Cardoso B, Barata J. Optimal interleukin-7 receptor-mediated signaling, cell cycle progression and viability of T-cell acute lymphoblastic leukemia cells rely on casein kinase 2 activity. Haematologica. 2016;101:1368-1379 pubmed
	Rogers K, Moreno S, Smith L, Husson H, Bukanov N, Ledbetter S, et al. Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD. Physiol Rep. 2016;4: pubmed publisher
	Kamal A, Sreekanth K, Kumar P, Shankaraiah N, Balakishan G, Ramaiah M, et al. Synthesis and potential cytotoxic activity of new phenanthrylphenol-pyrrolobenzodiazepines. Eur J Med Chem. 2010;45:2173-81 pubmed publisher
	Ko C, Shen S, Chen Y. Hydroxylation at C4' or C6 is essential for apoptosis-inducing activity of flavanone through activation of the caspase-3 cascade and production of reactive oxygen species. Free Radic Biol Med. 2004;36:897-910 pubmed
	Chen Y, Shen S, Lin H. Rutinoside at C7 attenuates the apoptosis-inducing activity of flavonoids. Biochem Pharmacol. 2003;66:1139-50 pubmed
	Chen Y, Shen S, Lee W, Hsu F, Lin H, Ko C, et al. Emodin induces apoptosis in human promyeloleukemic HL-60 cells accompanied by activation of caspase 3 cascade but independent of reactive oxygen species production. Biochem Pharmacol. 2002;64:1713-24 pubmed

product information

master code :

NBP1-77836

SKU :

NBP1-77836

product name :

Smad3 [p Ser423, p Ser425] Antibody - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The Smad3 [p Ser423, p Ser425] Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Smad3. This antibody reacts with human,mouse. The Smad3 [p Ser423, p Ser425] Antibody - BSA Free has been validated for the following applications: ELISA,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Single Cell Western.

target :

Smad3

category :

Primary Antibodies

buffer :

0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

clonality :

Polyclonal

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Smad3 [p Ser423, p Ser425] Antibody was prepared from whole rabbit serum produced by repeated immunizations with a dual phosphorylated synthetic peptide corresponding to a c-terminal region with Serine 423 and Serine 425 of human Smad3 protein. (Uniprot: P84022)

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse

specificity :

This affinity-purified antibody is directed against the phosphorylated form of human Smad3 protein at the pS423 and pS425 residues

gene symbol :

SMAD3

Antibody validation :

Biological Validation

accessionNumbers :

NC_000015.9, P84022, P84022, P84022, P84022

applications :

ELISA,Western Blot,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunohistochemistry,Immunohistochemistry-Paraffin,Single Cell Western

USD :

539 USD

alt names :

DKFZp586N0721, DKFZp686J10186, hMAD-3, hSMAD3, HsT17436, JV15-2MGC60396, MAD homolog 3, mad protein homolog, MAD, mothers against decapentaplegic homolog 3, MAD, mothers against decapentaplegic homolog 3 (Drosophila), Mad3, MADH3mad homolog JV15-2, mothers against decapentaplegic homolog 3, Mothers against DPP homolog 3, pSMAD, SMA- and MAD-related protein 3, SMAD 3, SMAD family member 3HSPC193, SMAD, mothers against DPP homolog 3, SMAD, mothers against DPP homolog 3 (Drosophila), Smad3

storage :

Store at -20C short term. Aliquot and store at -80C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage