A20/TNFAIP3 Antibody (59A426) - BSA Free | Novus Biologicals NBP1-77533 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

A20/TNFAIP3 Antibody (59A426) - BSA Free

catalog :

NBP1-77533

quantity :

0.1 mg (also 0.025 mg)

price :

489 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

59A426

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 42

Published Application/Species/Sample/Dilution	Reference
western blot; human	Reihill J, Malcomson B, Bertelsen A, Cheung S, Czerwiec A, Barsden R, et al. Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells. Br J Pharmacol. 2016;173:778-89 pubmed publisher
western blot; mouse	Perez C, Jukica A, Listopad J, Anders K, KÃ¼hl A, Loddenkemper C, et al. Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts. Int J Cancer. 2015;137:359-71 pubmed publisher
western blot; mouse	De A, Dainichi T, RATHINAM C, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-?B signaling. EMBO Rep. 2014;15:775-83 pubmed publisher
	Wang Y, Liu T, Shen C, Lin S, Hung C, Hsu L, et al. K48/K63-linked polyubiquitination of ATG9A by TRAF6 E3 ligase regulates oxidative stress-induced autophagy. Cell Rep. 2022;38:110354 pubmed publisher
	Tran V, Ju H. Fluorescence Based on Surface Plasmon Coupled Emission for Ultrahigh Sensitivity Immunoassay of Cardiac Troponin I. Biomedicines. 2021;9: pubmed publisher
	Feoktistova M, Makarov R, Brenji S, Schneider A, Hooiveld G, Luedde T, et al. A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes. Cells. 2020;9: pubmed publisher
	Ma J, Xiao Y, Tian B, Chen S, Zhang B, Wu J, et al. Genome-wide analyses of long non-coding RNA expression profiles and functional network analysis in esophageal squamous cell carcinoma. Sci Rep. 2019;9:9162 pubmed publisher
	Lim M, Maubach G, Sokolova O, Feige M, Diezko R, Buchbinder J, et al. Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017;24:1621-1631 pubmed publisher
	Lai T, Wu S, Tsai M, Chuang E, Chuang L, Hsu L, et al. Transcription of Tnfaip3 is regulated by NF-?B and p38 via C/EBP? in activated macrophages. PLoS ONE. 2013;8:e73153 pubmed publisher
	Svingerud T, Solstad T, Sun B, Nyrud M, Kileng y, Greiner Tollersrud L, et al. Atlantic salmon type I IFN subtypes show differences in antiviral activity and cell-dependent expression: evidence for high IFNb/IFNc-producing cells in fish lymphoid tissues. J Immunol. 2012;189:5912-23 pubmed publisher
	Karube K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, et al. Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood. 2011;118:3195-204 pubmed publisher
	Gerlach B, Cordier S, Schmukle A, Emmerich C, Rieser E, Haas T, et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 2011;471:591-6 pubmed publisher
	Hövelmeyer N, Reissig S, Xuan N, Adams Quack P, Lukas D, Nikolaev A, et al. A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol. 2011;41:595-601 pubmed publisher
	Adrianto I, Wen F, Templeton A, Wiley G, King J, Lessard C, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011;43:253-8 pubmed publisher
	Imbeault M, Ouellet M, Giguère K, Bertin J, Bélanger D, Martin G, et al. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol. 2011;85:2189-200 pubmed publisher
	Malinverni C, Unterreiner A, Staal J, Demeyer A, Galaup M, Luyten M, et al. Cleavage by MALT1 induces cytosolic release of A20. Biochem Biophys Res Commun. 2010;400:543-7 pubmed publisher
	Frenzel L, Claus R, Plume N, Schwamb J, Konermann C, Pallasch C, et al. Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus. Int J Cancer. 2011;128:2495-500 pubmed publisher
	Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, et al. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Res. 2010;70:5829-39 pubmed publisher
	Hjelmeland A, Wu Q, Wickman S, Eyler C, Heddleston J, Shi Q, et al. Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol. 2010;8:e1000319 pubmed publisher
	Hailfinger S, Lenz G, Ngo V, Posvitz Fejfar A, Rebeaud F, Guzzardi M, et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:19946-51 pubmed publisher
	Metellus P, Coulibaly B, Nanni I, Fina F, Eudes N, Giorgi R, et al. Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. Cancer. 2009;115:4783-94 pubmed publisher
	Honma K, Tsuzuki S, Nakagawa M, Tagawa H, Nakamura S, Morishima Y, et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood. 2009;114:2467-75 pubmed publisher
	Duwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, et al. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol. 2009;182:7718-28 pubmed publisher
	Schmitz R, Hansmann M, Bohle V, Martin Subero J, Hartmann S, Mechtersheimer G, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med. 2009;206:981-9 pubmed publisher
	Verhelst K, Verstrepen L, Coornaert B, Carpentier I, Beyaert R. Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation. Methods Mol Biol. 2009;517:205-15 pubmed publisher
	Breckpot K, Aerts Toegaert C, Heirman C, Peeters U, Beyaert R, Aerts J, et al. Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine. J Immunol. 2009;182:860-70 pubmed
	Li L, Soetandyo N, Wang Q, Ye Y. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim Biophys Acta. 2009;1793:346-53 pubmed publisher
	Werner S, Kearns J, Zadorozhnaya V, Lynch C, O Dea E, Boldin M, et al. Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev. 2008;22:2093-101 pubmed publisher
	Li L, Hailey D, Soetandyo N, Li W, Lippincott Schwartz J, Shu H, et al. Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling. Biochim Biophys Acta. 2008;1783:1140-9 pubmed publisher
	Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 2008;9:263-71 pubmed publisher
	Chevillard G, Derjuga A, Devost D, Zingg H, Blank V. Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction. 2007;134:811-22 pubmed
	Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, et al. Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain. Biochim Biophys Acta. 2008;1783:826-37 pubmed
	Zhang B, Guan C, Chen W, Zhang P, Yan M, Shi J, et al. A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation. Chin Med J (Engl). 2007;120:1830-5 pubmed
	Yokota S, Okabayashi T, Yokosawa N, Fujii N. Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. FASEB J. 2008;22:74-83 pubmed
	Hutti J, Turk B, Asara J, Ma A, Cantley L, Abbott D. IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol. 2007;27:7451-61 pubmed
	Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P. Toll-like receptor 3 expressed by melanoma cells as a target for therapy?. Clin Cancer Res. 2007;13:4565-74 pubmed
	Wang Y, Li L, Han K, Zhai Z, Shu H. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 2004;576:86-90 pubmed
	Ke B, Shen X, Lassman C, Gao F, Busuttil R, Kupiec Weglinski J. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Am J Transplant. 2003;3:1076-82 pubmed
	Yang K, Arcaroli J, Kupfner J, Pitts T, Park J, Strasshiem D, et al. Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell Signal. 2003;15:225-33 pubmed
	Ke B, Shen X, Zhai Y, Gao F, Busuttil R, Volk H, et al. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002;13:1845-57 pubmed
	Wu W, Xu Z, Chang K. The promyelocytic leukemia protein represses A20-mediated transcription. J Biol Chem. 2002;277:31734-9 pubmed
	Kupfner J, Arcaroli J, Yum H, Nadler S, Yang K, Abraham E. Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis. J Immunol. 2001;167:7044-51 pubmed

product information

master code :

NBP1-77533

SKU :

NBP1-77533

product name :

A20/TNFAIP3 Antibody (59A426) - BSA Free

unit size :

0.1 mg (also 0.025 mg)

description :

The A20/TNFAIP3 Antibody (59A426) - BSA Free from Novus is a mouse monoclonal antibody to A20/TNFAIP3. This antibody reacts with human,mouse,rat. The A20/TNFAIP3 Antibody (59A426) - BSA Free has been validated for the following applications: Western Blot,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Flow (Intracellular),Simple Western,CyTOF-ready.

target :

A20/TNFAIP3

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

59A426

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Full length recombinant human A20/TNFAIP3 Antibody (59A426). The epitope has been mapped to the C-terminal portion of A20 (amino acids 440-790)

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Human,Mouse,Rat

gene symbol :

TNFAIP3

accessionNumbers :

P21580

applications :

Western Blot,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,Flow (Intracellular),Simple Western,CyTOF-ready

USD :

489 USD

alt names :

A20TNFA1P2, EC 3.4.19.12, EC 6.3.2.-, MGC104522, MGC138687, OTU domain-containing protein 7C, OTUD7CMGC138688, Putative DNA-binding protein A20, TNF alpha-induced protein 3, tumor necrosis factor alpha-induced protein 3, tumor necrosis factor inducible protein A20, tumor necrosis factor, alpha-induced protein 3, Zinc finger protein A20

storage :

Store at -20C. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage