product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
NLRP3/NALP3 Antibody - BSA Free
catalog :
NBP1-77080
quantity :
0.1 mg (also 0.025 mg)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
14C8
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 99
Reference
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Verma V, Kumar P, Gupta S, Yadav S, Dhanda R, Thorlacius H, et al. α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages. Sci Rep. 2020;10:12653 pubmed publisher
Toyohara T, Roudnicky F, Florido M, Nakano T, Yu H, Katsuki S, et al. Patient hiPSCs Identify Vascular Smooth Muscle Arylacetamide Deacetylase as Protective against Atherosclerosis. Cell Stem Cell. 2020;27:147-157.e7 pubmed publisher
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Geyfman M, Debabov D, Poloso N, Alvandi N. Mechanistic insight into the activity of a sulfone compound dapsone on Propionibacterium (Newly Reclassified as Cutibacterium) Acnes-mediated cytokine production. Exp Dermatol. 2019;28:190-197 pubmed publisher
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Hua X, Yuan X, Li Y, Chen H, Yuan J, Tanumiharjo S, et al. Desiccating stress worsens alkali burn injury by magnifying caspase-8-induced imbalance of NLRP3 and NLRP6. J Allergy Clin Immunol. 2017;140:1172-1176.e3 pubmed publisher
Lee H, Lee S, Kim N, Park K, Choi B, Shin Y, et al. Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke. J Biophotonics. 2017;10:1502-1513 pubmed publisher
Macpherson M, Westbom C, Kogan H, Shukla A. Actin polymerization plays a significant role in asbestos-induced inflammasome activation in mesothelial cells in vitro. Histochem Cell Biol. 2017;147:595-604 pubmed publisher
Zhu W, Cao F, Feng J, Chen H, Wan J, Lu Q, et al. NLRP3 inflammasome activation contributes to long-term behavioral alterations in mice injected with lipopolysaccharide. Neuroscience. 2017;343:77-84 pubmed publisher
Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S. Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes. Toxicol Sci. 2017;155:432-443 pubmed publisher
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Chi W, Chen H, Li F, Zhu Y, Yin W, Zhuo Y. HMGB1 promotes the activation of NLRP3 and caspase-8 inflammasomes via NF-κB pathway in acute glaucoma. J Neuroinflammation. 2015;12:137 pubmed publisher
Castelán F, Xelhuantzi N, Hernández Aragón L, Rodríguez Antolín J, Cuevas E, Martínez Gómez M. Morphometry of paravaginal ganglia from the pelvic plexus: impact of multiparity, primiparity, and pregnancy. Eur J Obstet Gynecol Reprod Biol. 2013;170:286-92 pubmed publisher
Jardel P, Debiais C, Godet J, Irani J, Fromont G. Ductal carcinoma of the prostate shows a different immunophenotype from high grade acinar cancer. Histopathology. 2013;63:57-63 pubmed publisher
López García K, E Cuevas -, Corona Quintanilla D, Jiménez Estrada I, Martinez Gomez M, Castelán F. Effect of multiparity on morphometry and oestrogen receptor expression of pelvic and perineal striated muscles in rabbits: is serum oestradiol relevant?. Eur J Obstet Gynecol Reprod Biol. 2013;169:113-20 pubmed publisher
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Verma M, Miki Y, Abe K, Nagasaki S, Niikawa H, Suzuki S, et al. Co-expression of estrogen receptor beta and aromatase in Japanese lung cancer patients: gender-dependent clinical outcome. Life Sci. 2012;91:800-8 pubmed publisher
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Miki Y, et al. Aromatase in colon carcinoma. Anticancer Res. 2012;32:3069-75 pubmed
Cheng L, Li J, Han Y, Lin J, Niu C, Zhou Z, et al. PES1 promotes breast cancer by differentially regulating ER? and ER?. J Clin Invest. 2012;122:2857-70 pubmed publisher
Karlsson C, Helenius G, Fernandes O, Karlsson M. Oestrogen receptor β in NSCLC - prevalence, proliferative influence, prognostic impact and smoking. APMIS. 2012;120:451-8 pubmed publisher
Tonetti D, Gao W, Escarzaga D, Walters K, Szafran A, Coon J. PKC? and ER? Are Associated with Triple-Negative Breast Cancers in African American and Caucasian Patients. Int J Breast Cancer. 2012;2012:740353 pubmed publisher
Zuguchi M, Miki Y, Onodera Y, Fujishima F, Takeyama D, Okamoto H, et al. Estrogen receptor ? and ? in esophageal squamous cell carcinoma. Cancer Sci. 2012;103:1348-55 pubmed publisher
Sase T, Suzuki T, Miura K, Shiiba K, Sato I, Nakamura Y, et al. Runt-related transcription factor 2 in human colon carcinoma: a potent prognostic factor associated with estrogen receptor. Int J Cancer. 2012;131:2284-93 pubmed publisher
Verma M, Miki Y, Abe K, Niikawa H, Sasano H. Cytoplasmic estrogen receptor ? as a potential marker in human non-small cell lung carcinoma. Expert Opin Ther Targets. 2012;16 Suppl 1:S91-102 pubmed publisher
Navaratnam S, Skliris G, Qing G, Banerji S, Badiani K, Tu D, et al. Differential role of estrogen receptor beta in early versus metastatic non-small cell lung cancer. Horm Cancer. 2012;3:93-100 pubmed publisher
Choijamts B, Jimi S, Kondo T, Naganuma Y, Matsumoto T, Kuroki M, et al. CD133+ cancer stem cell-like cells derived from uterine carcinosarcoma (malignant mixed Müllerian tumor). Stem Cells. 2011;29:1485-95 pubmed publisher
Honma N, Saji S, Hirose M, Horiguchi S, Kuroi K, Hayashi S, et al. Sex steroid hormones in pairs of tumor and serum from breast cancer patients and pathobiological role of androstene-3β, 17β-diol. Cancer Sci. 2011;102:1848-54 pubmed publisher
Mehasseb M, Panchal R, Taylor A, Brown L, Bell S, Habiba M. Estrogen and progesterone receptor isoform distribution through the menstrual cycle in uteri with and without adenomyosis. Fertil Steril. 2011;95:2228-35, 2235.e1 pubmed publisher
Vouk K, Smuc T, Guggenberger C, Ribic Pucelj M, Sinkovec J, Husen B, et al. Novel estrogen-related genes and potential biomarkers of ovarian endometriosis identified by differential expression analysis. J Steroid Biochem Mol Biol. 2011;125:231-42 pubmed publisher
Miki Y, Abe K, Suzuki S, Suzuki T, Sasano H. Suppression of estrogen actions in human lung cancer. Mol Cell Endocrinol. 2011;340:168-74 pubmed publisher
Paruthiyil S, Cvoro A, Tagliaferri M, Cohen I, Shtivelman E, Leitman D. Estrogen receptor ? causes a G2 cell cycle arrest by inhibiting CDK1 activity through the regulation of cyclin B1, GADD45A, and BTG2. Breast Cancer Res Treat. 2011;129:777-84 pubmed publisher
Huang G, Gunter M, Arend R, Li M, Arias Pulido H, Prossnitz E, et al. Co-expression of GPR30 and ERbeta and their association with disease progression in uterine carcinosarcoma. Am J Obstet Gynecol. 2010;203:242.e1-5 pubmed publisher
Vivar O, Zhao X, Saunier E, Griffin C, Mayba O, Tagliaferri M, et al. Estrogen receptor beta binds to and regulates three distinct classes of target genes. J Biol Chem. 2010;285:22059-66 pubmed publisher
Mak P, Leav I, Pursell B, Bae D, Yang X, Taglienti C, et al. ERbeta impedes prostate cancer EMT by destabilizing HIF-1alpha and inhibiting VEGF-mediated snail nuclear localization: implications for Gleason grading. Cancer Cell. 2010;17:319-32 pubmed publisher
Vivar O, Saunier E, Leitman D, Firestone G, Bjeldanes L. Selective activation of estrogen receptor-beta target genes by 3,3'-diindolylmethane. Endocrinology. 2010;151:1662-7 pubmed publisher
Koyama S, Wada Hiraike O, Nakagawa S, Tanikawa M, Hiraike H, Miyamoto Y, et al. Repression of estrogen receptor beta function by putative tumor suppressor DBC1. Biochem Biophys Res Commun. 2010;392:357-62 pubmed publisher
Abe K, Miki Y, Ono K, Mori M, Kakinuma H, Kou Y, et al. Highly concordant coexpression of aromatase and estrogen receptor beta in non-small cell lung cancer. Hum Pathol. 2010;41:190-8 pubmed publisher
Wong M, Dobbins T, Tseung J, Tran N, Lee C, O BRIEN C, et al. Oestrogen receptor beta expression in pleomorphic adenomas of the parotid gland. J Clin Pathol. 2009;62:789-93 pubmed publisher
Raso M, Behrens C, Herynk M, Liu S, Prudkin L, Ozburn N, et al. Immunohistochemical expression of estrogen and progesterone receptors identifies a subset of NSCLCs and correlates with EGFR mutation. Clin Cancer Res. 2009;15:5359-68 pubmed publisher
Maehle B, Collett K, Tretli S, Akslen L, Grotmol T. Estrogen receptor beta--an independent prognostic marker in estrogen receptor alpha and progesterone receptor-positive breast cancer?. APMIS. 2009;117:644-50 pubmed publisher
Chakravarty D, Gupta N, Goda J, Srinivasan R, Patel F, Dhaliwal L. Steroid receptors, HER2/neu and Ki-67, in endometrioid type of endometrial carcinoma: Correlation with conventional histomorphological features of prognosis. Acta Histochem. 2010;112:355-63 pubmed publisher
Miki Y, Suzuki T, Nagasaki S, Hata S, Akahira J, Sasano H. Comparative effects of raloxifene, tamoxifen and estradiol on human osteoblasts in vitro: estrogen receptor dependent or independent pathways of raloxifene. J Steroid Biochem Mol Biol. 2009;113:281-9 pubmed publisher
Huang G, Arend R, Li M, Gunter M, Chiu L, Horwitz S, et al. Tissue microarray analysis of hormonal signaling pathways in uterine carcinosarcoma. Am J Obstet Gynecol. 2009;200:457.e1-5 pubmed publisher
Sato R, Suzuki T, Katayose Y, Miura K, Shiiba K, Tateno H, et al. Steroid sulfatase and estrogen sulfotransferase in colon carcinoma: regulators of intratumoral estrogen concentrations and potent prognostic factors. Cancer Res. 2009;69:914-22 pubmed publisher
Urbanska K, Pannizzo P, Lassak A, Gualco E, Surmacz E, Croul S, et al. Estrogen receptor beta-mediated nuclear interaction between IRS-1 and Rad51 inhibits homologous recombination directed DNA repair in medulloblastoma. J Cell Physiol. 2009;219:392-401 pubmed publisher
Belcher S, Ma X, Le H. Blockade of estrogen receptor signaling inhibits growth and migration of medulloblastoma. Endocrinology. 2009;150:1112-21 pubmed publisher
Chakravarty D, Srinivasan R, Ghosh S, Rajwanshi A, Gopalan S. Estrogen receptor beta (ERbeta) in endometrial simple hyperplasia and endometrioid carcinoma. Appl Immunohistochem Mol Morphol. 2008;16:535-42 pubmed publisher
Setlur S, Mertz K, Hoshida Y, Demichelis F, Lupien M, Perner S, et al. Estrogen-dependent signaling in a molecularly distinct subclass of aggressive prostate cancer. J Natl Cancer Inst. 2008;100:815-25 pubmed publisher
Ohata C, Tadokoro T, Itami S. Expression of estrogen receptor beta in normal skin, melanocytic nevi and malignant melanomas. J Dermatol. 2008;35:215-21 pubmed publisher
Dohi O, Hatori M, Suzuki T, Ono K, Hosaka M, Akahira J, et al. Sex steroid receptors expression and hormone-induced cell proliferation in human osteosarcoma. Cancer Sci. 2008;99:518-23 pubmed
Bukulmez O, Hardy D, Carr B, Word R, Mendelson C. Inflammatory status influences aromatase and steroid receptor expression in endometriosis. Endocrinology. 2008;149:1190-204 pubmed
Caiazza F, Galluzzo P, Lorenzetti S, Marino M. 17Beta-estradiol induces ERbeta up-regulation via p38/MAPK activation in colon cancer cells. Biochem Biophys Res Commun. 2007;359:102-7 pubmed
Gruvberger Saal S, Bendahl P, Saal L, Laakso M, Hegardt C, Edén P, et al. Estrogen receptor beta expression is associated with tamoxifen response in ERalpha-negative breast carcinoma. Clin Cancer Res. 2007;13:1987-94 pubmed
Galluzzo P, Caiazza F, Moreno S, Marino M. Role of ERbeta palmitoylation in the inhibition of human colon cancer cell proliferation. Endocr Relat Cancer. 2007;14:153-67 pubmed
Cvoro A, Paruthiyil S, Jones J, Tzagarakis Foster C, Clegg N, Tatomer D, et al. Selective activation of estrogen receptor-beta transcriptional pathways by an herbal extract. Endocrinology. 2007;148:538-47 pubmed
Al Dhaheri M, Rowan B. Protein kinase A exhibits selective modulation of estradiol-dependent transcription in breast cancer cells that is associated with decreased ligand binding, altered estrogen receptor alpha promoter interaction, and changes in receptor phosphorylation. Mol Endocrinol. 2007;21:439-56 pubmed
Skliris G, Lewis A, Emberley E, Peng B, Weebadda W, Kemp A, et al. Estrogen receptor-beta regulates psoriasin (S100A7) in human breast cancer. Breast Cancer Res Treat. 2007;104:75-85 pubmed
Dietrich W, Haitel A, Holzer G, Huber J, Kolbus A, Tschugguel W. Estrogen receptor-beta is the predominant estrogen receptor subtype in normal human synovia. J Soc Gynecol Investig. 2006;13:512-7 pubmed
Skliris G, Leygue E, Curtis Snell L, Watson P, Murphy L. Expression of oestrogen receptor-beta in oestrogen receptor-alpha negative human breast tumours. Br J Cancer. 2006;95:616-26 pubmed
Savinov A, Remacle A, Golubkov V, Krajewska M, Kennedy S, Duffy M, et al. Matrix metalloproteinase 26 proteolysis of the NH2-terminal domain of the estrogen receptor beta correlates with the survival of breast cancer patients. Cancer Res. 2006;66:2716-24 pubmed
Cvoro A, Tzagarakis Foster C, Tatomer D, Paruthiyil S, Fox M, Leitman D. Distinct roles of unliganded and liganded estrogen receptors in transcriptional repression. Mol Cell. 2006;21:555-64 pubmed
Poola I, Fuqua S, De Witty R, Abraham J, Marshallack J, Liu A. Estrogen receptor alpha-negative breast cancer tissues express significant levels of estrogen-independent transcription factors, ERbeta1 and ERbeta5: potential molecular targets for chemoprevention. Clin Cancer Res. 2005;11:7579-85 pubmed
Schwartz A, Prysak G, Murphy V, Lonardo F, Pass H, Schwartz J, et al. Nuclear estrogen receptor beta in lung cancer: expression and survival differences by sex. Clin Cancer Res. 2005;11:7280-7 pubmed
Poola I, Abraham J, Baldwin K, Saunders A, Bhatnagar R. Estrogen receptors beta4 and beta5 are full length functionally distinct ERbeta isoforms: cloning from human ovary and functional characterization. Endocrine. 2005;27:227-38 pubmed
Zheng F, Wu R, Smith C, O Malley B. Rapid estrogen-induced phosphorylation of the SRC-3 coactivator occurs in an extranuclear complex containing estrogen receptor. Mol Cell Biol. 2005;25:8273-84 pubmed
Ishibashi H, Suzuki T, Suzuki S, Niikawa H, Lu L, Miki Y, et al. Progesterone receptor in non-small cell lung cancer--a potent prognostic factor and possible target for endocrine therapy. Cancer Res. 2005;65:6450-8 pubmed
Helguero L, Faulds M, Gustafsson J, Haldosén L. Estrogen receptors alfa (ERalpha) and beta (ERbeta) differentially regulate proliferation and apoptosis of the normal murine mammary epithelial cell line HC11. Oncogene. 2005;24:6605-16 pubmed
Miki Y, Suzuki T, Tazawa C, Ishizuka M, Semba S, Gorai I, et al. Analysis of gene expression induced by diethylstilbestrol (DES) in human primitive Mullerian duct cells using microarray. Cancer Lett. 2005;220:197-210 pubmed
Jones L, Li M, Halama E, Ma Y, Lubet R, Grubbs C, et al. Promotion of mammary cancer development by tamoxifen in a mouse model of Brca1-mutation-related breast cancer. Oncogene. 2005;24:3554-62 pubmed
Hopp T, Weiss H, Parra I, Cui Y, Osborne C, Fuqua S. Low levels of estrogen receptor beta protein predict resistance to tamoxifen therapy in breast cancer. Clin Cancer Res. 2004;10:7490-9 pubmed
Balfe P, McCann A, McGoldrick A, McAllister K, Kennedy M, Dervan P, et al. Estrogen receptor alpha and beta profiling in human breast cancer. Eur J Surg Oncol. 2004;30:469-74 pubmed
Speirs V, Carder P, Lane S, Dodwell D, Lansdown M, Hanby A. Oestrogen receptor beta: what it means for patients with breast cancer. Lancet Oncol. 2004;5:174-81 pubmed
Paruthiyil S, Parmar H, Kerekatte V, Cunha G, Firestone G, Leitman D. Estrogen receptor beta inhibits human breast cancer cell proliferation and tumor formation by causing a G2 cell cycle arrest. Cancer Res. 2004;64:423-8 pubmed
Tee M, Rogatsky I, Tzagarakis Foster C, Cvoro A, An J, Christy R, et al. Estradiol and selective estrogen receptor modulators differentially regulate target genes with estrogen receptors alpha and beta. Mol Biol Cell. 2004;15:1262-72 pubmed
Tonetti D, Rubenstein R, DeLeon M, Zhao H, Pappas S, Bentrem D, et al. Stable transfection of an estrogen receptor beta cDNA isoform into MDA-MB-231 breast cancer cells. J Steroid Biochem Mol Biol. 2003;87:47-55 pubmed
Skliris G, Munot K, Bell S, Carder P, Lane S, Horgan K, et al. Reduced expression of oestrogen receptor beta in invasive breast cancer and its re-expression using DNA methyl transferase inhibitors in a cell line model. J Pathol. 2003;201:213-20 pubmed
Li X, Hisaoka M, Hashimoto H. Expression of estrogen receptors alpha and beta in soft tissue sarcomas: Immunohistochemical and molecular analysis. Pathol Int. 2003;53:671-9 pubmed
Omoto Y, Eguchi H, Yamamoto Yamaguchi Y, Hayashi S. Estrogen receptor (ER) beta1 and ERbetacx/beta2 inhibit ERalpha function differently in breast cancer cell line MCF7. Oncogene. 2003;22:5011-20 pubmed
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Skliris G, Carder P, Lansdown M, Speirs V. Immunohistochemical detection of ERbeta in breast cancer: towards more detailed receptor profiling?. Br J Cancer. 2001;84:1095-8 pubmed
product information
master code :
NBP1-77080
SKU :
NBP1-77080
product name :
NLRP3/NALP3 Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The NLRP3/NALP3 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to NLRP3/NALP3. This antibody reacts with bacteria - escherichia coli,e. coli,human,mouse. The NLRP3/NALP3 Antibody - BSA Free has been validated for the following applications: IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,SDS-Page,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry.
target :
NLRP3/NALP3
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
NLRP3/NALP3 Antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human NALP3. The immunogen is located within amino acids 120 - 170 of NALP3.
isotype :
IgG
purity :
Immunogen affinity purified
species :
Bacteria - Escherichia coli,E. coli,Human,Mouse
theoretical molecular weight :
110 kDa
gene symbol :
NLRP3
Antibody validation :
Biological Validation
accessionNumbers :
Q96P20
applications :
IF/IHC,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,SDS-Page,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry
USD :
459 USD
alt names :
AII, AII/AVP, Angiotensin/vasopressin receptor AII/AVP-like, AVP, C1orf7, Caterpiller protein 1.1, CLR1.1, Cold autoinflammatory syndrome 1, Cold autoinflammatory syndrome 1 protein, Cryopyrin, Familial cold autoinflammatory syndrome, FCU, Leucine-rich repeat-, and PYD-containing protein 3, Muckle-Wells syndrome, MWS, NACHT, LRR and PYD containing protein 3, NACHT, LRR and PYD domains-containing protein 3, NALP3, NLR family, pyrin domain containing 3, NLRP3, Nucleotide-Binding Oligomerization Domain, Leucine Rich Repeat And Pyrin Domain Containing 3, PYPAF1, PYRIN-containing APAF1-like protein 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.