product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PD-L1 Antibody - BSA Free
catalog :
NBP1-76769
quantity :
0.1 mg (also 0.025 mg)
price :
499 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight680
clone name :
6H12
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 37
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; fig 6
Zhang J, Qi J, Wei H, Lei Y, Yu H, Liu N, et al. TGFβ1 in Cancer-Associated Fibroblasts Is Associated With Progression and Radiosensitivity in Small-Cell Lung Cancer. Front Cell Dev Biol. 2021;9:667645 pubmed publisher
  • western blot; human; fig 4g
Mondal T, Shivange G, Tihagam R, Lyerly E, Battista M, Talwar D, et al. Unexpected PD-L1 immune evasion mechanism in TNBC, ovarian, and other solid tumors by DR5 agonist antibodies. EMBO Mol Med. 2021;13:e12716 pubmed publisher
Zhong Y, Li M, Han L, Tai Y, Cao S, Li J, et al. Galangin inhibits programmed cell death-ligand 1 expression by suppressing STAT3 and MYC and enhances T cell tumor-killing activity. Phytomedicine. 2023;116:154877 pubmed publisher
Chen M, Hung M, Pan C, Huang S, Jan C, Li Y, et al. Pemetrexed combined with dual immune checkpoint blockade enhances cytotoxic T lymphocytes against lung cancer. Cancer Sci. 2023;114:2761-2773 pubmed publisher
Caron J, Han X, Lary C, Sathyanarayana P, Remick S, Ernstoff M, et al. Targeting the secreted RGDKGE collagen fragment reduces PD‑L1 by a proteasome‑dependent mechanism and inhibits tumor growth. Oncol Rep. 2023;49: pubmed publisher
Dong M, Qian M, Ruan Z. CUL3/SPOP complex prevents immune escape and enhances chemotherapy sensitivity of ovarian cancer cells through degradation of PD-L1 protein. J Immunother Cancer. 2022;10: pubmed publisher
Luo Z, Liao T, Zhang Y, Zheng H, Sun Q, Han F, et al. Ex vivo anchored PD-L1 functionally prevent in vivo renal allograft rejection. Bioeng Transl Med. 2022;7:e10316 pubmed publisher
Riondato F, Colitti B, Rosati S, Sini F, Martini V. A method to test antibody cross-reactivity toward animal antigens for flow cytometry. Cytometry A. 2022;: pubmed publisher
Sakuma K, Kii T, Takahashi H, Suzuki S, Yoshikawa K, Ogawa T, et al. An In Vivo Study of Local Administration of Low-dose Anti-PD-1 Antibody Using an Oral Cancer Cell Line. Anticancer Res. 2022;42:4293-4303 pubmed publisher
Yang W, Han B, Chen Y, Geng F. SAAL1, a novel oncogene, is associated with prognosis and immunotherapy in multiple types of cancer. Aging (Albany NY). 2022;14:6316-6337 pubmed publisher
Dong G, Huang X, Chen R, Wu L, Jiang S, Chen S. Increased PD-L1 Restricts Liver Injury in Nonalcoholic Fatty Liver Disease. Oxid Med Cell Longev. 2022;2022:5954437 pubmed publisher
Xia W, Zhang S, Duan H, Wang C, Qian S, Shen H. The combination therapy of Everolimus and anti-PD-1 improves the antitumor effect by regulating CD8+ T cells in bladder cancer. Med Oncol. 2022;39:37 pubmed publisher
Chakrabarti J, Koh V, Steele N, Hawkins J, Ito Y, Merchant J, et al. Disruption of Her2-Induced PD-L1 Inhibits Tumor Cell Immune Evasion in Patient-Derived Gastric Cancer Organoids. Cancers (Basel). 2021;13: pubmed publisher
Jin Y, Zuo H, Li M, Zhang Z, Xing Y, Wang J, et al. Anti-Tumor Effects of Carrimycin and Monomeric Isovalerylspiramycin I on Hepatocellular Carcinoma in Vitro and in Vivo. Front Pharmacol. 2021;12:774231 pubmed publisher
Ravindran Menon D, Li Y, Yamauchi T, Osborne D, Vaddi P, Wempe M, et al. EGCG Inhibits Tumor Growth in Melanoma by Targeting JAK-STAT Signaling and Its Downstream PD-L1/PD-L2-PD1 Axis in Tumors and Enhancing Cytotoxic T-Cell Responses. Pharmaceuticals (Basel). 2021;14: pubmed publisher
Koikawa K, Kibe S, Suizu F, Sekino N, Kim N, Manz T, et al. Targeting Pin1 renders pancreatic cancer eradicable by synergizing with immunochemotherapy. Cell. 2021;184:4753-4771.e27 pubmed publisher
Sun T, Li M, Zhang Z, Wang J, Xing Y, Ri M, et al. Usnic acid suppresses cervical cancer cell proliferation by inhibiting PD-L1 expression and enhancing T-lymphocyte tumor-killing activity. Phytother Res. 2021;35:3916-3935 pubmed publisher
Liu X, Xing Y, Li M, Zhang Z, Wang J, Ri M, et al. Licochalcone A inhibits proliferation and promotes apoptosis of colon cancer cell by targeting programmed cell death-ligand 1 via the NF-κB and Ras/Raf/MEK pathways. J Ethnopharmacol. 2021;273:113989 pubmed publisher
Holokai L, Chakrabarti J, Lundy J, Croagh D, Adhikary P, Richards S, et al. Murine- and Human-Derived Autologous Organoid/Immune Cell Co-Cultures as Pre-Clinical Models of Pancreatic Ductal Adenocarcinoma. Cancers (Basel). 2020;12: pubmed publisher
Yang A, Li M, Zhang Z, Wang J, Xing Y, Ri M, et al. Erianin regulates programmed cell death ligand 1 expression and enhances cytotoxic T lymphocyte activity. J Ethnopharmacol. 2021;273:113598 pubmed publisher
Zhou J, Wu Z, Hu J, Yang D, Chen X, Wang Q, et al. High-throughput single-EV liquid biopsy: Rapid, simultaneous, and multiplexed detection of nucleic acids, proteins, and their combinations. Sci Adv. 2020;6: pubmed publisher
Tsutaho A, Hashimoto A, Hashimoto S, Hata S, Kachi S, Hirano S, et al. High expression of AMAP1, an ARF6 effector, is associated with elevated levels of PD-L1 and fibrosis of pancreatic cancer. Cell Commun Signal. 2020;18:101 pubmed publisher
Li Z, Zhang C, Du J, Zhao J, Shi M, Jin M, et al. Adipocytes promote tumor progression and induce PD-L1 expression via TNF-α/IL-6 signaling. Cancer Cell Int. 2020;20:179 pubmed publisher
Liu C, Ma Z, Cai Z, Zhang F, Liu C, Chen T, et al. Identification of primordial germ cell-like cells as liver metastasis initiating cells in mouse tumour models. Cell Discov. 2020;6:15 pubmed publisher
Yang Q, Peng J, Shi K, Xiao Y, Liu Q, Han R, et al. Rationally designed peptide-conjugated gold/platinum nanosystem with active tumor-targeting for enhancing tumor photothermal-immunotherapy. J Control Release. 2019;308:29-43 pubmed publisher
Wang X, Wu W, Gao J, Li Z, Dong B, Lin X, et al. Autophagy inhibition enhances PD-L1 expression in gastric cancer. J Exp Clin Cancer Res. 2019;38:140 pubmed publisher
Holokai L, Chakrabarti J, Broda T, Chang J, Hawkins J, Sundaram N, et al. Increased Programmed Death-Ligand 1 is an Early Epithelial Cell Response to Helicobacter pylori Infection. PLoS Pathog. 2019;15:e1007468 pubmed publisher
Chakrabarti J, Holokai L, Syu L, Steele N, Chang J, Wang J, et al. Hedgehog signaling induces PD-L1 expression and tumor cell proliferation in gastric cancer. Oncotarget. 2018;9:37439-37457 pubmed publisher
Xing Y, Mi C, Wang Z, Zhang Z, Li M, Zuo H, et al. Fraxinellone has anticancer activity in vivo by inhibiting programmed cell death-ligand 1 expression by reducing hypoxia-inducible factor-1α and STAT3. Pharmacol Res. 2018;135:166-180 pubmed publisher
Maisel K, Merrilees M, Atochina Vasserman E, Lian L, Obraztsova K, Rue R, et al. Immune Checkpoint Ligand PD-L1 is Upregulated in Pulmonary Lymphangioleiomyomatosis (LAM). Am J Respir Cell Mol Biol. 2018;: pubmed publisher
Zhang P, Liu J, Li W, Li S, Han X. Lactoferricin B reverses cisplatin resistance in head and neck squamous cell carcinoma cells through targeting PD-L1. Cancer Med. 2018;: pubmed publisher
He H, Zhou Y, Zhou Y, Zhuang J, He X, Wang S, et al. Dexmedetomidine mitigates microglia-mediated neuroinflammation through up-regulation of programmed cell death protein 1 in a rat spinal cord injury model. J Neurotrauma. 2018;: pubmed publisher
Sun J, Lian M, Ma H, Wang R, Ma Z, Wang H, et al. Competing endogenous RNA network analysis of CD274, IL‑10 and FOXP3 co‑expression in laryngeal squamous cell carcinoma. Mol Med Rep. 2018;17:3859-3869 pubmed publisher
D Arrigo P, Russo M, Rea A, Tufano M, Guadagno E, Del Basso De Caro M, et al. A regulatory role for the co-chaperone FKBP51s in PD-L1 expression in glioma. Oncotarget. 2017;8:68291-68304 pubmed publisher
Gravelle P, Burroni B, Péricart S, Rossi C, Bezombes C, Tosolini M, et al. Mechanisms of PD-1/PD-L1 expression and prognostic relevance in non-Hodgkin lymphoma: a summary of immunohistochemical studies. Oncotarget. 2017;8:44960-44975 pubmed publisher
Bronchud M, Tresserra F, Xu W, Warren S, Cusidó M, Zantop B, et al. Placental immune editing switch (PIES): learning about immunomodulatory pathways from a unique case report. Oncotarget. 2016;7:83817-83827 pubmed publisher
Aguilar L, Shirley L, Chung V, Marsh C, Walker J, Coyle W, et al. Gene-mediated cytotoxic immunotherapy as adjuvant to surgery or chemoradiation for pancreatic adenocarcinoma. Cancer Immunol Immunother. 2015;64:727-36 pubmed publisher
product information
master code :
NBP1-76769
SKU :
NBP1-76769
product name :
PD-L1 Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The PD-L1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to PD-L1. This antibody reacts with human,mouse,rat. The PD-L1 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry-Paraffin,Immunohistochemistry,Immunoprecipitation,Western Blot,IF/IHC,IHC-F,Immunohistochemistry Whole-Mount,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,ELISA,Immunohistochemistry-Frozen,Dual RNAscope ISH-IHC.
target :
PD-L1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Antibody was raised against a 17 amino acid synthetic peptide from near the center of human PD-L1. The immunogen is located within amino acids 60-110 of PD-L1.
isotype :
IgG
purity :
Peptide affinity purified
species :
Human,Mouse,Rat
specificity :
PD-L1 antibody has no cross-reactivity to PD-L2
theoretical molecular weight :
37 kDa
gene symbol :
CD274
Antibody validation :
Independent Anitbodies
accessionNumbers :
NP_054862
applications :
Immunohistochemistry,Immunoprecipitation,Western Blot,IF/IHC,IHC-F,Immunohistochemistry-Paraffin,Immunohistochemistry Whole-Mount,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Flow Cytometry,ELISA,Immunohistochemistry-Frozen,Dual RNAscope ISH-IHC
USD :
499 USD
alt names :
Avelumab, B7-H, B7-H1, B7H1PDCD1L1, CD274 antigenMGC142294, CD274 molecule, PDCD1LG1MGC142296, PD-L1, PD-L1B7 homolog 1, PDL1PDCD1 ligand 1, programmed cell death 1 ligand 1, Programmed death ligand 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.