product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TIM-1/KIM-1/HAVCR Antibody - BSA Free
catalog :
NBP1-76701
quantity :
0.1 mg (also 0.025 mg)
price :
479 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
MECA-79
reactivity :
human, mouse
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 41
Published Application/Species/Sample/DilutionReference
  • western blot knockout validation; human; loading ...; fig 3c
Yang C, Zhang Y, Zeng X, Chen H, Chen Y, Yang D, et al. Kidney injury molecule-1 is a potential receptor for SARS-CoV-2. J Mol Cell Biol. 2021;13:185-196 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 9c
Sun M, Li J, Mao L, Wu J, Deng Z, He M, et al. p53 Deacetylation Alleviates Sepsis-Induced Acute Kidney Injury by Promoting Autophagy. Front Immunol. 2021;12:685523 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 1b
Zheng H, Zhang Y, Li L, Zhang R, Luo Z, Yang Z, et al. Depletion of Toll-Like Receptor-9 Attenuates Renal Tubulointerstitial Fibrosis After Ischemia-Reperfusion Injury. Front Cell Dev Biol. 2021;9:641527 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2c
Qing X, Chinenov Y, Redecha P, Madaio M, Roelofs J, FARBER G, et al. iRhom2 promotes lupus nephritis through TNF-? and EGFR signaling. J Clin Invest. 2018;128:1397-1412 pubmed publisher
Wu T, Zhu W, Duan R, Sun J, Bao S, Chen K, et al. Magnetic vagus nerve stimulation ameliorates contrast-induced acute kidney injury by circulating plasma exosomal miR-365-3p. J Nanobiotechnology. 2024;22:666 pubmed publisher
Zhong D, Chen J, Qiao R, Song C, Hao C, Zou Y, et al. Genetic or pharmacologic blockade of mPGES-2 attenuates renal lipotoxicity and diabetic kidney disease by targeting Rev-Erbα/FABP5 signaling. Cell Rep. 2024;43:114075 pubmed publisher
Bae C, Kim Y, Kwon Y. CU06-1004 alleviates oxidative stress and inflammation on folic acid-induced acute kidney injury in mice. J Pharmacol Sci. 2024;154:77-85 pubmed publisher
An S, Yao Y, Wu J, Hu H, Wu J, Sun M, et al. Gut-derived 4-hydroxyphenylacetic acid attenuates sepsis-induced acute kidney injury by upregulating ARC to inhibit necroptosis. Biochim Biophys Acta Mol Basis Dis. 2024;1870:166876 pubmed publisher
xc7 omakl x131 S, xd6 zdemir S, G xfc lo x11f lu M. Chrysin attenuates paclitaxel-induced hepatorenal toxicity in rats by suppressing oxidative damage, inflammation, and apoptosis. Life Sci. 2023;332:122096 pubmed publisher
Micha x142 ek K, Oberska P, Murawski M, Schwarz T, Tomaszewska E, Muszy x144 ski S, et al. Kidney morphology and renal expression of aquaporins 2, 3 and 4 during cerulein - Induced chronic pancreatitis in pigs. Adv Med Sci. 2023;68:306-313 pubmed publisher
Yang C, Chen Y, Sung P, CHIANG J, Chen C, Li Y, et al. Repeated administration of adipose-derived mesenchymal stem cells added on beneficial effects of empagliflozin on protecting renal function in diabetic kidney disease rat. Biomed J. 2023;:100613 pubmed publisher
Ban K, Nam G, Kim D, Oh Y, Jun H. Prevention of LPS-Induced Acute Kidney Injury in Mice by Bavachin and Its Potential Mechanisms. Antioxidants (Basel). 2022;11: pubmed publisher
Kansakar U, Gambardella J, Varzideh F, Avvisato R, Jankauskas S, Mone P, et al. miR-142 Targets TIM-1 in Human Endothelial Cells: Potential Implications for Stroke, COVID-19, Zika, Ebola, Dengue, and Other Viral Infections. Int J Mol Sci. 2022;23: pubmed publisher
Freitas F, Attwell D. Pericyte-mediated constriction of renal capillaries evokes no-reflow and kidney injury following ischaemia. elife. 2022;11: pubmed publisher
Zheng X, Narayanan S, Xu C, Eliasson Angelstig S, Gr xfc nler J, Zhao A, et al. Repression of hypoxia-inducible factor-1 contributes to increased mitochondrial reactive oxygen species production in diabetes. elife. 2022;11: pubmed publisher
Liu H, Li X, Liu J, Cui S, Liu H, Hu B, et al. miR-6869-5p Transported by Plasma Extracellular Vesicles Mediates Renal Tubule Injury and Renin-Angiotensin System Activation in Obesity. Front Med (Lausanne). 2021;8:725598 pubmed publisher
Han S, Lin F, Ruan Y, Zhao S, Yuan R, Ning J, et al. miR-132-3p promotes the cisplatin-induced apoptosis and inflammatory response of renal tubular epithelial cells by targeting SIRT1 via the NF-κB pathway. Int Immunopharmacol. 2021;99:108022 pubmed publisher
Ali A, Shibu M, Kuo C, Lo J, Chen R, Day C, et al. CHIP-overexpressing Wharton's jelly-derived mesenchymal stem cells attenuate hyperglycemia-induced oxidative stress-mediated kidney injuries in diabetic rats. Free Radic Biol Med. 2021;173:70-80 pubmed publisher
Zhang Q, Wang L, Wu M, Liu X, Zhu Y, Zhu J, et al. Humanized anti‑TLR4 monoclonal antibody ameliorates lipopolysaccharide‑related acute kidney injury by inhibiting TLR4/NF‑κB signaling. Mol Med Rep. 2021;24: pubmed publisher
Li X, Zhao J, Kasinath V, Uehara M, Jiang L, Banouni N, et al. Lymph node fibroblastic reticular cells deposit fibrosis-associated collagen following organ transplantation. J Clin Invest. 2020;130:4182-4194 pubmed publisher
He B, Johansson Percival A, Backhouse J, Li J, Lee G, Hamzah J, et al. Remodeling of Metastatic Vasculature Reduces Lung Colonization and Sensitizes Overt Metastases to Immunotherapy. Cell Rep. 2020;30:714-724.e5 pubmed publisher
Kang H, Lim J, Noh K, Park D, Cho H, Susztak K, et al. Effective reconstruction of functional organotypic kidney spheroid for in vitro nephrotoxicity studies. Sci Rep. 2019;9:17610 pubmed publisher
Samodelov S, Visentin M, Gai Z, Häusler S, Kullak Ublick G. Renal glycosuria as a novel early sign of colistin-induced kidney damage in mice. Antimicrob Agents Chemother. 2019;: pubmed publisher
Matsubara S, Seki M, Suzuki S, Komori T, Takamori M. Tertiary lymphoid organs in the inflammatory myopathy associated with PD-1 inhibitors. J Immunother Cancer. 2019;7:256 pubmed publisher
Uehara M, Li X, Sheikhi A, Zandi N, Walker B, Saleh B, et al. Anti-IL-6 eluting immunomodulatory biomaterials prolong skin allograft survival. Sci Rep. 2019;9:6535 pubmed publisher
Bahmani B, Uehara M, Ordikhani F, Li X, Jiang L, Banouni N, et al. Ectopic high endothelial venules in pancreatic ductal adenocarcinoma: A unique site for targeted delivery. EBioMedicine. 2018;38:79-88 pubmed publisher
Yao Z, Qiao Y, Li X, Chen J, Ding J, Bai L, et al. Exosomes Exploit the Virus Entry Machinery and Pathway To Transmit Alpha Interferon-Induced Antiviral Activity. J Virol. 2018;92: pubmed publisher
Bahmani B, Uehara M, Jiang L, Ordikhani F, Banouni N, Ichimura T, et al. Targeted delivery of immune therapeutics to lymph nodes prolongs cardiac allograft survival. J Clin Invest. 2018;128:4770-4786 pubmed publisher
Song M, Yang Y, Yi Z, Zhang Z, Shen X, Hu G, et al. Sema 3A as a biomarker of the activated mTOR pathway during hexavalent chromium-induced acute kidney injury. Toxicol Lett. 2018;299:226-235 pubmed publisher
Sharma M, Naura A, Singla S. Modulatory effect of 4-phenyl butyric acid on hyperoxaluria-induced renal injury and inflammation. Mol Cell Biochem. 2019;451:185-196 pubmed publisher
Trudu M, Schaeffer C, Riba M, Ikehata M, Brambilla P, Messa P, et al. Early involvement of cellular stress and inflammatory signals in the pathogenesis of tubulointerstitial kidney disease due to UMOD mutations. Sci Rep. 2017;7:7383 pubmed publisher
Morrison M, Yakala G, Liang W, Wielinga P, Salic K, van Koppen A, et al. Protective effect of rosiglitazone on kidney function in high-fat challenged human-CRP transgenic mice: a possible role for adiponectin and miR-21?. Sci Rep. 2017;7:2915 pubmed publisher
Weber H, Tsurkan M, Magno V, Freudenberg U, Werner C. Heparin-based hydrogels induce human renal tubulogenesis in vitro. Acta Biomater. 2017;57:59-69 pubmed publisher
Pei L, Solis G, Nguyen M, Kamat N, Magenheimer L, Zhuo M, et al. Paracellular epithelial sodium transport maximizes energy efficiency in the kidney. J Clin Invest. 2016;126:2509-18 pubmed publisher
Tang W, Wang Z, Kennedy D, Wu Y, Buffa J, Agatisa Boyle B, et al. Gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway contributes to both development of renal insufficiency and mortality risk in chronic kidney disease. Circ Res. 2015;116:448-55 pubmed publisher
Hautz T, Zelger B, Nasr I, Mundinger G, Barth R, Rodriguez E, et al. Lymphoid neogenesis in skin of human hand, nonhuman primate, and rat vascularized composite allografts. Transpl Int. 2014;27:966-76 pubmed publisher
Hirakawa J, Tsuboi K, Sato K, Kobayashi M, Watanabe S, Takakura A, et al. Novel anti-carbohydrate antibodies reveal the cooperative function of sulfated N- and O-glycans in lymphocyte homing. J Biol Chem. 2010;285:40864-78 pubmed publisher
Burke S, Dong H, Hazan A, Croy B. Aberrant endometrial features of pregnancy in diabetic NOD mice. Diabetes. 2007;56:2919-26 pubmed
Drayton D, Ying X, Lee J, Lesslauer W, Ruddle N. Ectopic LT alpha beta directs lymphoid organ neogenesis with concomitant expression of peripheral node addressin and a HEV-restricted sulfotransferase. J Exp Med. 2003;197:1153-63 pubmed
Samulowitz U, Kuhn A, Brachtendorf G, Nawroth R, Braun A, Bankfalvi A, et al. Human endomucin: distribution pattern, expression on high endothelial venules, and decoration with the MECA-79 epitope. Am J Pathol. 2002;160:1669-81 pubmed
Csencsits K, Jutila M, Pascual D. Nasal-associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site. J Immunol. 1999;163:1382-9 pubmed
product information
master code :
NBP1-76701
SKU :
NBP1-76701
product name :
TIM-1/KIM-1/HAVCR Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The TIM-1/KIM-1/HAVCR Antibody - BSA Free from Novus is a rabbit polyclonal antibody to TIM-1/KIM-1/HAVCR. This antibody reacts with human,mouse,porcine,rat. The TIM-1/KIM-1/HAVCR Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Western Blot,Simple Western,IF/IHC,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry/ Immunofluorescence,ELISA,Knockdown Validated.
target :
TIM-1/KIM-1/HAVCR
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Antibody was raised against a peptide corresponding to 16 amino acids near the amino terminus of human TIM-1. The immunogen is located within amino acids 50 - 100 of TIM-1. Amino Acid Squence: TNGTHVTYRKDTRYKL
isotype :
IgG
purity :
Peptide affinity purified
species :
Human,Mouse,Porcine,Rat
specificity :
Human TIM-1/KIM-1/HAVCR has 5 isoforms, including isoform a precursor (364aa, 39kD), isoform a (364aa, 39kD), isoform b precursor (401aa, 44kD), isoform b (359aa, 39kD), and isoform c (359aa, 39kD)
theoretical molecular weight :
44 kDa
gene symbol :
HAVCR1
Antibody validation :
Independent Anitbodies
accessionNumbers :
Q96D42
applications :
Western Blot,Simple Western,IF/IHC,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Immunocytochemistry/ Immunofluorescence,ELISA,Knockdown Validated
USD :
479 USD
alt names :
HAVCR-1, HAVCRT cell immunoglobin domain and mucin domain protein 1, hepatitis A virus cellular receptor 1, Kidney injury molecule 1, KIM1, KIM-1, T-cell immunoglobulin and mucin domain-containing protein 1, TIM-1TIM, TIM1TIMD-1, TIMD1T-cell membrane protein 1
storage :
Store at 4C.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.