SREBP2 Antibody (1D2) - BSA Free | Novus Biologicals NBP1-54446 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

SREBP2 Antibody (1D2) - BSA Free

catalog :

NBP1-54446

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

1D2

reactivity :

human, mouse, chicken

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 35

Published Application/Species/Sample/Dilution	Reference
western blot; human; loading ...; fig 5g	Tanton H, Sewastianik T, Seo H, Remillard D, Pierre R, Bala P, et al. A novel β-catenin/BCL9 complex inhibitor blocks oncogenic Wnt signaling and disrupts cholesterol homeostasis in colorectal cancer. Sci Adv. 2022;8:eabm3108 pubmed publisher
western blot; human; fig 2d	Gu Q, Yang X, Lv J, Zhang J, Xia B, Kim J, et al. AIBP-mediated cholesterol efflux instructs hematopoietic stem and progenitor cell fate. Science. 2019;363:1085-1088 pubmed publisher
	Chen F, Matsuda A, Budinger G, Sporn P, Casalino Matsuda S. Hypercapnia increases ACE2 expression and pseudo-SARS-CoV-2 entry in bronchial epithelial cells by augmenting cellular cholesterol. Front Immunol. 2023;14:1251120 pubmed publisher
	Fowler J, Boutagy N, Zhang R, Horikami D, Whalen M, Romanoski C, et al. SREBP2 regulates the endothelial response to cytokines via direct transcriptional activation of KLF6. J Lipid Res. 2023;64:100411 pubmed publisher
	Soundararajan A, Wang T, Sundararajan R, Wijeratne A, Mosley A, Harvey F, et al. Multiomics analysis reveals the mechanical stress-dependent changes in trabecular meshwork cytoskeletal-extracellular matrix interactions. Front Cell Dev Biol. 2022;10:874828 pubmed publisher
	Ghaffari S, Jang E, Naderinabi F, Sanwal R, Khosraviani N, Wang C, et al. Endothelial HMGB1 Is a Critical Regulator of LDL Transcytosis via an SREBP2-SR-BI Axis. Arterioscler Thromb Vasc Biol. 2021;41:200-216 pubmed publisher
	Yang R, Zhao Y, Gu Y, Yang Y, Gao X, Yuan Y, et al. Isocitrate dehydrogenase 1 mutation enhances 24(S)-hydroxycholesterol production and alters cholesterol homeostasis in glioma. Oncogene. 2020;: pubmed publisher
	Park K, Hwang C, Yun H, Yeo I, Choi D, Park P, et al. Prevention of multiple system atrophy using human bone marrow-derived mesenchymal stem cells by reducing polyamine and cholesterol-induced neural damages. Stem Cell Res Ther. 2020;11:63 pubmed publisher
	Arda Pirincci P, Sacan O, Ozal Coskun C, Aykol Celik G, Karabulut Bulan O, Yanardag R, et al. Galectin-1 exhibits a protective effect against hepatotoxicity induced by dextran sulfate sodium in mice. Hum Exp Toxicol. 2020;39:423-432 pubmed publisher
	Dileepan M, Rastle Simpson S, Greenberg Y, Wijesinghe D, Kumar N, Yang J, et al. Effect Of Dual sEH/COX-2 Inhibition on Allergen-Induced Airway Inflammation. Front Pharmacol. 2019;10:1118 pubmed publisher
	Ham H, Han S, Yun J, Yeo I, Ham Y, Kim S, et al. Bee venom phospholipase A2 ameliorates amyloidogenesis and neuroinflammation through inhibition of signal transducer and activator of transcription-3 pathway in Tg2576 mice. Transl Neurodegener. 2019;8:26 pubmed publisher
	Choi J, Yun J, Hwang C, Lee H, Kim H, Chun H, et al. (E)-2-methoxy-4-(3-(4-methoxyphenyl) prop-1-en-1-yl) Phenol Ameliorates MPTP-Induced Dopaminergic Neurodegeneration by Inhibiting the STAT3 Pathway. Int J Mol Sci. 2019;20: pubmed publisher
	Gericke A, Wolff I, Musayeva A, Zadeh J, Manicam C, Pfeiffer N, et al. Retinal arteriole reactivity in mice lacking the endothelial nitric oxide synthase (eNOS) gene. Exp Eye Res. 2019;181:150-156 pubmed publisher
	Fong L, Jing R, Smalley K, Wang Z, Taccioli C, Fan S, et al. Human-like hyperplastic prostate with low ZIP1 induced solely by Zn deficiency in rats. Proc Natl Acad Sci U S A. 2018;115:E11091-E11100 pubmed publisher
	Suyama K, Sakai D, Hirayama N, Nakamura Y, Matsushita E, Terayama H, et al. Effects of interleukin-17A in nucleus pulposus cells and its small-molecule inhibitors for intervertebral disc disease. J Cell Mol Med. 2018;22:5539-5551 pubmed publisher
	Boisvert N, Holterman C, Thibodeau J, Nasrallah R, Kamto E, Comin C, et al. Hyperfiltration in ubiquitin C-terminal hydrolase L1-deleted mice. Clin Sci (Lond). 2018;132:1453-1470 pubmed publisher
	Jung Y, Son D, Lee H, Kim D, Song M, Ham Y, et al. Loss of Parkin reduces inflammatory arthritis by inhibiting p53 degradation. Redox Biol. 2017;12:666-673 pubmed publisher
	Grimmig T, Matthes N, Hoeland K, Tripathi S, Chandraker A, Grimm M, et al. TLR7 and TLR8 expression increases tumor cell proliferation and promotes chemoresistance in human pancreatic cancer. Int J Oncol. 2015;47:857-66 pubmed publisher
	Torricelli F, Mandato V, Farnetti E, Abrate M, Casali B, Ciarlini G, et al. Polymorphisms in cyclooxygenase-2 gene in endometrial cancer patients. Tumour Biol. 2015;36:7423-30 pubmed publisher
	Abdel Daim M, Farouk S, Madkour F, Azab S. Anti-inflammatory and immunomodulatory effects of Spirulina platensis in comparison to Dunaliella salina in acetic acid-induced rat experimental colitis. Immunopharmacol Immunotoxicol. 2015;37:126-39 pubmed publisher
	Yuan C, Smith W. A cyclooxygenase-2-dependent prostaglandin E2 biosynthetic system in the Golgi apparatus. J Biol Chem. 2015;290:5606-20 pubmed publisher
	Du X, Kazim A, Dawes I, Brown A, Yang H. The AAA ATPase VPS4/SKD1 regulates endosomal cholesterol trafficking independently of ESCRT-III. Traffic. 2013;14:107-19 pubmed publisher
	Du X, Kazim A, Brown A, Yang H. An essential role of Hrs/Vps27 in endosomal cholesterol trafficking. Cell Rep. 2012;1:29-35 pubmed publisher
	Luu W, Sharpe L, Stevenson J, Brown A. Akt acutely activates the cholesterogenic transcription factor SREBP-2. Biochim Biophys Acta. 2012;1823:458-64 pubmed publisher
	Song B, DeBose Boyd R. Insig-dependent ubiquitination and degradation of 3-hydroxy-3-methylglutaryl coenzyme a reductase stimulated by delta- and gamma-tocotrienols. J Biol Chem. 2006;281:25054-61 pubmed
	Song B, Javitt N, DeBose Boyd R. Insig-mediated degradation of HMG CoA reductase stimulated by lanosterol, an intermediate in the synthesis of cholesterol. Cell Metab. 2005;1:179-89 pubmed
	Sun L, Li L, Goldstein J, Brown M. Insig required for sterol-mediated inhibition of Scap/SREBP binding to COPII proteins in vitro. J Biol Chem. 2005;280:26483-90 pubmed publisher
	Adams C, Reitz J, De Brabander J, Feramisco J, Li L, Brown M, et al. Cholesterol and 25-hydroxycholesterol inhibit activation of SREBPs by different mechanisms, both involving SCAP and Insigs. J Biol Chem. 2004;279:52772-80 pubmed
	Zhang Y, Hillgartner F. Starvation and feeding a high-carbohydrate, low-fat diet regulate the expression sterol regulatory element-binding protein-1 in chickens. J Nutr. 2004;134:2205-10 pubmed
	Demoulin J, Ericsson J, Kallin A, Rorsman C, Ronnstrand L, Heldin C. Platelet-derived growth factor stimulates membrane lipid synthesis through activation of phosphatidylinositol 3-kinase and sterol regulatory element-binding proteins. J Biol Chem. 2004;279:35392-402 pubmed
	Sever N, Yang T, Brown M, Goldstein J, DeBose Boyd R. Accelerated degradation of HMG CoA reductase mediated by binding of insig-1 to its sterol-sensing domain. Mol Cell. 2003;11:25-33 pubmed
	Janowski B. The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP. Proc Natl Acad Sci U S A. 2002;99:12675-80 pubmed
	Yabe D, Brown M, Goldstein J. Insig-2, a second endoplasmic reticulum protein that binds SCAP and blocks export of sterol regulatory element-binding proteins. Proc Natl Acad Sci U S A. 2002;99:12753-8 pubmed publisher
	Yin L, Zhang Y, Hillgartner F. Sterol regulatory element-binding protein-1 interacts with the nuclear thyroid hormone receptor to enhance acetyl-CoA carboxylase-alpha transcription in hepatocytes. J Biol Chem. 2002;277:19554-65 pubmed
	Janowski B, Shan B, Russell D. The hypocholesterolemic agent LY295427 reverses suppression of sterol regulatory element-binding protein processing mediated by oxysterols. J Biol Chem. 2001;276:45408-16 pubmed

product information

master code :

NBP1-54446

SKU :

NBP1-54446

product name :

SREBP2 Antibody (1D2) - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The SREBP2 Antibody (1D2) - BSA Free from Novus is a mouse monoclonal antibody to SREBP2. This antibody reacts with avian - chicken,chicken,human,mouse. The SREBP2 Antibody (1D2) - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,Immunoprecipitation,Immunohistochemistry-Paraffin,In vivo assay,Chromatin Immunoprecipitation (ChIP),ELISA,Gel Super Shift Assays,Immunocytochemistry/ Immunofluorescence.

target :

SREBP2

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

1D2

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Human SREBP2 protein (amino acids 48-403). [UniProt# Q12772]

isotype :

IgG1 Kappa

purity :

Protein G purified

species :

Avian - Chicken,Chicken,Human,Mouse

specificity :

Recognizes the precursor and mature forms of human SREBP2

gene symbol :

SREBF2

accessionNumbers :

Q12772

applications :

Immunohistochemistry,Immunoprecipitation,Western Blot,Immunohistochemistry-Paraffin,In vivo assay,Chromatin Immunoprecipitation (ChIP),ELISA,Gel Super Shift Assays,Immunocytochemistry/ Immunofluorescence

USD :

409 USD

alt names :

BHLHD2, bHLHd2sterol regulatory element-binding protein 2, Class D basic helix-loop-helix protein 2, SREBP2, SREBP2SREBP-2, sterol regulatory element binding transcription factor 2, Sterol regulatory element-binding transcription factor 2

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage