DEPTOR/DEPDC6 Antibody - BSA Free | Novus Biologicals NBP1-49674 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

DEPTOR/DEPDC6 Antibody - BSA Free

catalog :

NBP1-49674

quantity :

0.1 ml (also 0.025 ml)

price :

409 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

TL2.1

reactivity :

human, mouse, rat, bovine

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 56

Published Application/Species/Sample/Dilution	Reference
western blot; human; 1:1000; fig s7	Carbonneau M, M Gagné L, Lalonde M, Germain M, Motorina A, Guiot M, et al. The oncometabolite 2-hydroxyglutarate activates the mTOR signalling pathway. Nat Commun. 2016;7:12700 pubmed publisher
	Read T, Cisterna B, Skruber K, Ahmadieh S, Lindamood H, Vitriol J, et al. The actin binding protein profilin 1 is critical for mitochondria function. bioRxiv. 2023;: pubmed publisher
	Colas C, Mouchiroud M, Al Dow M, Kolnohuz A, G xe9 linas Y, Caron A, et al. DEPTOR loss impairs brown adipocyte development in vitro but has limited impacts in mice. Mol Metab. 2023;67:101660 pubmed publisher
	Tan M, Chang Y, Liu X, Li H, Tang Z, Nyati M, et al. The Sag-Shoc2 axis regulates conversion of mPanINs to cystic lesions in Kras pancreatic tumor model. Cell Rep. 2022;41:111837 pubmed publisher
	Ruiz Serrano A, Boyle C, Monn xe9 Rodr xed guez J, G xfc nter J, Jucht A, Pfundstein S, et al. The Deubiquitinase OTUB1 Is a Key Regulator of Energy Metabolism. Int J Mol Sci. 2022;23: pubmed publisher
	De Carvalho F, Muñoz V, Brandao C, Simabuco F, Pavan I, Nakandakari S, et al. Taurine upregulates insulin signaling and mitochondrial metabolism in vitro but not in adipocytes of obese women. Nutrition. 2022;93:111430 pubmed publisher
	Ruiz Serrano A, Monné Rodríguez J, Günter J, Sherman S, Jucht A, Fluechter P, et al. OTUB1 regulates lung development, adult lung tissue homeostasis, and respiratory control. FASEB J. 2021;35:e22039 pubmed publisher
	Serrano Maci xe1 M, Sim xf3 n J, Gonz xe1 lez Rellan M, Azkargorta M, Goikoetxea Usandizaga N, Lopitz Otsoa F, et al. Neddylation inhibition ameliorates steatosis in NAFLD by boosting hepatic fatty acid oxidation via the DEPTOR-mTOR axis. Mol Metab. 2021;53:101275 pubmed publisher
	Gnanapradeepan K, Leu J, Basu S, Barnoud T, Good M, Lee J, et al. Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser. elife. 2020;9: pubmed publisher
	George S, Kiss A, Obaid S, Venegas A, Talapatra T, Wei C, et al. p38δ genetic ablation protects female mice from anthracycline cardiotoxicity. Am J Physiol Heart Circ Physiol. 2020;319:H775-H786 pubmed publisher
	Kim D, Park G, Huuhtanen J, Lundgren S, Khajuria R, Hurtado A, et al. Somatic mTOR mutation in clonally expanded T lymphocytes associated with chronic graft versus host disease. Nat Commun. 2020;11:2246 pubmed publisher
	The E, Yao Q, Zhang P, Zhai Y, Ao L, Fullerton D, et al. Mechanistic Roles of Matrilin-2 and Klotho in Modulating the Inflammatory Activity of Human Aortic Valve Cells. Cells. 2020;9: pubmed publisher
	Ji X, Zhang X, Li H, Sun L, Hou X, Song H, et al. Nfa34810 Facilitates Nocardia farcinica Invasion of Host Cells and Stimulates Tumor Necrosis Factor Alpha Secretion through Activation of the NF-κB and Mitogen-Activated Protein Kinase Pathways via Toll-Like Receptor 4. Infect Immun. 2020;88: pubmed publisher
	Baek M, Ahn C, Cho H, Choi J, Son K, Yoon M. Simulated microgravity inhibits C2C12 myogenesis via phospholipase D2-induced Akt/FOXO1 regulation. Sci Rep. 2019;9:14910 pubmed publisher
	Yao H, Tang H, Zhang Y, Zhang Q, Liu X, Liu Y, et al. DEPTOR inhibits cell proliferation and confers sensitivity to dopamine agonist in pituitary adenoma. Cancer Lett. 2019;459:135-144 pubmed publisher
	Saito N, Araya J, Ito S, Tsubouchi K, Minagawa S, Hara H, et al. Involvement of Lamin B1 Reduction in Accelerated Cellular Senescence during Chronic Obstructive Pulmonary Disease Pathogenesis. J Immunol. 2019;202:1428-1440 pubmed publisher
	Suryawan A, Davis T. Amino Acid- and Insulin-Induced Activation of mTORC1 in Neonatal Piglet Skeletal Muscle Involves Sestin2-GATOR2, Rag A/C-mTOR, and RHEB-mTOR Complex Formation. J Nutr. 2018;148:825-833 pubmed publisher
	Li F, Song R, Ao L, Reece T, Cleveland J, Dong N, et al. ADAMTS5 Deficiency in Calcified Aortic Valves Is Associated With Elevated Pro-Osteogenic Activity in Valvular Interstitial Cells. Arterioscler Thromb Vasc Biol. 2017;37:1339-1351 pubmed publisher
	Caron A, Mouchiroud M, Gautier N, Labbé S, Villot R, Turcotte L, et al. Loss of hepatic DEPTOR alters the metabolic transition to fasting. Mol Metab. 2017;6:447-458 pubmed publisher
	Song H, Yoon M. PLD1 regulates adipogenic differentiation through mTOR - IRS-1 phosphorylation at serine 636/639. Sci Rep. 2016;6:36968 pubmed publisher
	Caron A, Labbé S, Lanfray D, Blanchard P, Villot R, Roy C, et al. Mediobasal hypothalamic overexpression of DEPTOR protects against high-fat diet-induced obesity. Mol Metab. 2016;5:102-112 pubmed publisher
	Caron A, Baraboi E, Laplante M, Richard D. DEP domain-containing mTOR-interacting protein in the rat brain: distribution of expression and potential implication. J Comp Neurol. 2015;523:93-107 pubmed publisher
	KÃ¤bisch R, MejÃas Luque R, Gerhard M, Prinz C. Involvement of Toll-like receptors on Helicobacter pylori-induced immunity. PLoS ONE. 2014;9:e104804 pubmed publisher
	Rojas Bernabé A, Garcia Hernández O, Maldonado Bernal C, Delegado Dominguez J, Ortega E, Gutiérrez Kobeh L, et al. Leishmania mexicana lipophosphoglycan activates ERK and p38 MAP kinase and induces production of proinflammatory cytokines in human macrophages through TLR2 and TLR4. Parasitology. 2014;141:788-800 pubmed publisher
	Klink M, Brzezinska M, Szulc I, Brzostek A, Kielbik M, Sulowska Z, et al. Cholesterol oxidase is indispensable in the pathogenesis of Mycobacterium tuberculosis. PLoS ONE. 2013;8:e73333 pubmed publisher
	Abdi J, Mutis T, Garssen J, Redegeld F. Characterization of the Toll-like receptor expression profile in human multiple myeloma cells. PLoS ONE. 2013;8:e60671 pubmed publisher
	Brzezinska M, Szulc I, Brzostek A, Klink M, Kielbik M, Sulowska Z, et al. The role of 3-ketosteroid 1(2)-dehydrogenase in the pathogenicity of Mycobacterium tuberculosis. BMC Microbiol. 2013;13:43 pubmed publisher
	Harman A, Bye C, Nasr N, Sandgren K, Kim M, Mercier S, et al. Identification of lineage relationships and novel markers of blood and skin human dendritic cells. J Immunol. 2013;190:66-79 pubmed publisher
	Shimizu T, Kida Y, Kuwano K. Cytoadherence-dependent induction of inflammatory responses by Mycoplasma pneumoniae. Immunology. 2011;133:51-61 pubmed publisher
	Dasgupta G, Chentoufi A, You S, Falatoonzadeh P, Urbano L, Akhtarmalik A, et al. Engagement of TLR2 reverses the suppressor function of conjunctiva CD4+CD25+ regulatory T cells and promotes herpes simplex virus epitope-specific CD4+CD25- effector T cell responses. Invest Ophthalmol Vis Sci. 2011;52:3321-33 pubmed publisher
	Melchjorsen J, Rintahaka J, Søby S, Horan K, Poltajainen A, Østergaard L, et al. Early innate recognition of herpes simplex virus in human primary macrophages is mediated via the MDA5/MAVS-dependent and MDA5/MAVS/RNA polymerase III-independent pathways. J Virol. 2010;84:11350-8 pubmed publisher
	Oberg H, Ly T, Ussat S, Meyer T, Kabelitz D, Wesch D. Differential but direct abolishment of human regulatory T cell suppressive capacity by various TLR2 ligands. J Immunol. 2010;184:4733-40 pubmed publisher
	Kasari V, Kurg K, Margus T, Tenson T, Kaldalu N. The Escherichia coli mqsR and ygiT genes encode a new toxin-antitoxin pair. J Bacteriol. 2010;192:2908-19 pubmed publisher
	Ding J, Rapista A, Teleshova N, Mosoyan G, Jarvis G, Klotman M, et al. Neisseria gonorrhoeae enhances HIV-1 infection of primary resting CD4+ T cells through TLR2 activation. J Immunol. 2010;184:2814-24 pubmed publisher
	Rydberg C, Mansson A, Uddman R, Riesbeck K, Cardell L. Toll-like receptor agonists induce inflammation and cell death in a model of head and neck squamous cell carcinomas. Immunology. 2009;128:e600-11 pubmed publisher
	Yang X, Fullerton D, Su X, Ao L, Cleveland J, Meng X. Pro-osteogenic phenotype of human aortic valve interstitial cells is associated with higher levels of Toll-like receptors 2 and 4 and enhanced expression of bone morphogenetic protein 2. J Am Coll Cardiol. 2009;53:491-500 pubmed publisher
	Ji S, Shin J, Kim Y, Oh J, Min B, Choi Y. Toll-like receptor 2 and NALP2 mediate induction of human beta-defensins by fusobacterium nucleatum in gingival epithelial cells. Infect Immun. 2009;77:1044-52 pubmed publisher
	Guzy C, Paclik D, Schirbel A, Sonnenborn U, Wiedenmann B, Sturm A. The probiotic Escherichia coli strain Nissle 1917 induces gammadelta T cell apoptosis via caspase- and FasL-dependent pathways. Int Immunol. 2008;20:829-40 pubmed publisher
	Burgener I, Jungi T. Antibodies specific for human or murine Toll-like receptors detect canine leukocytes by flow cytometry. Vet Immunol Immunopathol. 2008;124:184-91 pubmed publisher
	Prabha C, Rajashree P, Sulochana D. TLR2 and TLR4 expression on the immune cells of tuberculous pleural fluid. Immunol Lett. 2008;117:26-34 pubmed publisher
	Pegu A, Qin S, Fallert Junecko B, Nisato R, Pepper M, Reinhart T. Human lymphatic endothelial cells express multiple functional TLRs. J Immunol. 2008;180:3399-405 pubmed
	Wong C, Cheung P, Ip W, Lam C. Intracellular signaling mechanisms regulating toll-like receptor-mediated activation of eosinophils. Am J Respir Cell Mol Biol. 2007;37:85-96 pubmed
	Menzies B, Kenoyer A. Signal transduction and nuclear responses in Staphylococcus aureus-induced expression of human beta-defensin 3 in skin keratinocytes. Infect Immun. 2006;74:6847-54 pubmed
	Xu S, Koldovsky U, Xu M, Wang D, Fitzpatrick E, Son G, et al. High-avidity antitumor T-cell generation by toll receptor 8-primed, myeloid- derived dendritic cells is mediated by IL-12 production. Surgery. 2006;140:170-8 pubmed
	Shimizu T, Kida Y, Kuwano K. A dipalmitoylated lipoprotein from Mycoplasma pneumoniae activates NF-kappa B through TLR1, TLR2, and TLR6. J Immunol. 2005;175:4641-6 pubmed
	Srivastava M, Srivastava B. Expression of mRNA and proteins for toll-like receptors, associated molecules, defensins and LL-37 by SRIK-NKL, a CD8+ NK/T cell line. Leuk Res. 2005;29:813-20 pubmed
	Cognasse F, Hamzeh H, Chavarin P, Acquart S, Genin C, Garraud O. Evidence of Toll-like receptor molecules on human platelets. Immunol Cell Biol. 2005;83:196-8 pubmed
	Bazzocchi C, Mortarino M, Comazzi S, Bandi C, Franceschi A, Genchi C. Expression and function of Toll-like receptor 2 in canine blood phagocytes. Vet Immunol Immunopathol. 2005;104:15-9 pubmed
	Zhong F, Cao W, Chan E, Tay P, Cahya F, Zhang H, et al. Deviation from major codons in the Toll-like receptor genes is associated with low Toll-like receptor expression. Immunology. 2005;114:83-93 pubmed
	Gibson F, Hong C, Chou H, Yumoto H, Chen J, Lien E, et al. Innate immune recognition of invasive bacteria accelerates atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004;109:2801-6 pubmed
	Mempel M, Voelcker V, Köllisch G, Plank C, Rad R, Gerhard M, et al. Toll-like receptor expression in human keratinocytes: nuclear factor kappaB controlled gene activation by Staphylococcus aureus is toll-like receptor 2 but not toll-like receptor 4 or platelet activating factor receptor dependent. J Invest Dermatol. 2003;121:1389-96 pubmed
	Lotz S, Aga E, Wilde I, van Zandbergen G, Hartung T, Solbach W, et al. Highly purified lipoteichoic acid activates neutrophil granulocytes and delays their spontaneous apoptosis via CD14 and TLR2. J Leukoc Biol. 2004;75:467-77 pubmed
	Medvedev A, Lentschat A, Wahl L, Golenbock D, Vogel S. Dysregulation of LPS-induced Toll-like receptor 4-MyD88 complex formation and IL-1 receptor-associated kinase 1 activation in endotoxin-tolerant cells. J Immunol. 2002;169:5209-16 pubmed
	Flo T, Halaas O, Torp S, Ryan L, Lien E, Dybdahl B, et al. Differential expression of Toll-like receptor 2 in human cells. J Leukoc Biol. 2001;69:474-81 pubmed
	Faure E, Thomas L, Xu H, Medvedev A, Equils O, Arditi M. Bacterial lipopolysaccharide and IFN-gamma induce Toll-like receptor 2 and Toll-like receptor 4 expression in human endothelial cells: role of NF-kappa B activation. J Immunol. 2001;166:2018-24 pubmed
	Flo T, Halaas O, Lien E, Ryan L, Teti G, Golenbock D, et al. Human toll-like receptor 2 mediates monocyte activation by Listeria monocytogenes, but not by group B streptococci or lipopolysaccharide. J Immunol. 2000;164:2064-9 pubmed

product information

master code :

NBP1-49674

SKU :

NBP1-49674

product name :

DEPTOR/DEPDC6 Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The DEPTOR/DEPDC6 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to DEPTOR/DEPDC6. This antibody reacts with bovine,human,mouse,rat. The DEPTOR/DEPDC6 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Knockout Validated.

target :

DEPTOR/DEPDC6

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A genomic peptide made to an internal region of the human DEPTOR protein (within residues 10-200). [Swiss-Prot: Q8TB45]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Bovine,Human,Mouse,Rat

gene symbol :

DEPTOR

Antibody validation :

Knockout/Knockdown

accessionNumbers :

Q8TB45, Q570Y9

applications :

Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Knockout Validated

USD :

409 USD

alt names :

DEP domain containing 6, DEP domain containing mTOR interacting protein, DEP domain containing MTOR-interacting protein, DEP domain-containing mTOR-interacting protein, DEP domain-containing protein 6, DEP.6, DEPDC6FLJ12341, DKFZp564B1778, FLJ12428, FLJ13854

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage