NKX6.1 Antibody - BSA Free | Novus Biologicals NBP1-49672 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

NKX6.1 Antibody - BSA Free

catalog :

NBP1-49672

quantity :

0.1 ml (also 0.025 ml)

price :

479 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

14A231

reactivity :

human, mouse, rat, zebrafish

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 56

Published Application/Species/Sample/Dilution	Reference
immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s1c	Spaeth J, Gupte M, Perelis M, Yang Y, CYPHERT H, Guo S, et al. Defining a Novel Role for the Pdx1 Transcription Factor in Islet β-Cell Maturation and Proliferation During Weaning. Diabetes. 2017;66:2830-2839 pubmed publisher
	Lavecchia A, Mantzouratou P, Cerullo D, Locatelli M, Conti S, Tironi M, et al. Thyroid hormone treatment counteracts cellular phenotypical remodeling in diabetic organs. iScience. 2023;26:107826 pubmed publisher
	Hu X, White K, Olroyd A, Dejesus R, Dominguez A, Dowdle W, et al. Hypoimmune induced pluripotent stem cells survive long term in fully immunocompetent, allogeneic rhesus macaques. Nat Biotechnol. 2023;: pubmed publisher
	McDonald S, Ray P, Bunn R, Fowlkes J, Thrailkill K, Popescu I. Heterogeneity and altered β-cell identity in the TallyHo model of early-onset type 2 diabetes. Acta Histochem. 2022;124:151940 pubmed publisher
	Xi Y, Song B, Ngan I, Solloway M, Humphrey M, Wang Y, et al. Glucagon-receptor-antagonism-mediated β-cell regeneration as an effective anti-diabetic therapy. Cell Rep. 2022;39:110872 pubmed publisher
	Liu T, Sun P, Zou J, Wang L, Wang G, Liu N, et al. Increased frequency of β cells with abnormal NKX6.1 expression in type 2 diabetes but not in subjects with higher risk for type 2 diabetes. BMC Endocr Disord. 2021;21:47 pubmed publisher
	Zhu X, Oguh A, Gingerich M, Soleimanpour S, Stoffers D, Gannon M. Cell Cycle Regulation of the Pdx1 Transcription Factor in Developing Pancreas and Insulin-Producing β Cells. Diabetes. 2021;: pubmed publisher
	Morello F, Borshagovski D, Survila M, Tikker L, Sadik Ogli S, Kirjavainen A, et al. Molecular Fingerprint and Developmental Regulation of the Tegmental GABAergic and Glutamatergic Neurons Derived from the Anterior Hindbrain. Cell Rep. 2020;33:108268 pubmed publisher
	Deng H, Yang F, Ma X, Wang Y, Chen Q, Yuan L. Long-Term Liraglutide Administration Induces Pancreas Neogenesis in Adult T2DM Mice. Cell Transplant. 2020;29:963689720927392 pubmed publisher
	Mahaddalkar P, Scheibner K, Pfluger S, Ansarullah -, Sterr M, Beckenbauer J, et al. Generation of pancreatic β cells from CD177+ anterior definitive endoderm. Nat Biotechnol. 2020;38:1061-1072 pubmed publisher
	Spaeth J, Liu J, Peters D, Guo M, Osipovich A, Mohammadi F, et al. The Pdx1 Bound Swi/Snf Chromatin Remodeling Complex Regulates Pancreatic Progenitor Cell Proliferation and Mature Islet β Cell Function. Diabetes. 2019;: pubmed publisher
	Wilson C, Spaeth J, Karp J, Stocks B, Hoopes E, Stein R, et al. B lymphocytes protect islet β cells in diabetes prone NOD mice treated with imatinib. JCI Insight. 2019;5: pubmed publisher
	Griffiths W, Crick P, Meljon A, Theofilopoulos S, Abdel Khalik J, Yutuc E, et al. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma. Biochim Biophys Acta Mol Cell Biol Lipids. 2019;1864:191-211 pubmed publisher
	Mohan V, Radha V, Nguyen T, Stawiski E, Pahuja K, Goldstein L, et al. Comprehensive genomic analysis identifies pathogenic variants in maturity-onset diabetes of the young (MODY) patients in South India. BMC Med Genet. 2018;19:22 pubmed publisher
	Kropp P, Dunn J, Carboneau B, Stoffers D, Gannon M. Cooperative function of Pdx1 and Oc1 in multipotent pancreatic progenitors impacts postnatal islet maturation and adaptability. Am J Physiol Endocrinol Metab. 2018;314:E308-E321 pubmed publisher
	Todoric J, Antonucci L, Di Caro G, Li N, Wu X, Lytle N, et al. Stress-Activated NRF2-MDM2 Cascade Controls Neoplastic Progression in Pancreas. Cancer Cell. 2017;32:824-839.e8 pubmed publisher
	Cui J, Li Y, Zhu L, Liu D, Songyang Z, Wang H, et al. NLRP4 negatively regulates type I interferon signaling by targeting the kinase TBK1 for degradation via the ubiquitin ligase DTX4. Nat Immunol. 2012;13:387-95 pubmed publisher
	Bakkar N, Ladner K, Canan B, Liyanarachchi S, Bal N, Pant M, et al. IKK? and alternative NF-?B regulate PGC-1? to promote oxidative muscle metabolism. J Cell Biol. 2012;196:497-511 pubmed publisher
	Delhase M, Kim S, Lee H, Naiki Ito A, Chen Y, Ahn E, et al. TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. Proc Natl Acad Sci U S A. 2012;109:E177-86 pubmed publisher
	Harikumar K, Sung B, Pandey M, Guha S, Krishnan S, Aggarwal B. Escin, a pentacyclic triterpene, chemosensitizes human tumor cells through inhibition of nuclear factor-kappaB signaling pathway. Mol Pharmacol. 2010;77:818-27 pubmed publisher
	Huang J, Ren T, Guan H, Jiang Y, Cheng H. HTLV-1 Tax is a critical lipid raft modulator that hijacks IkappaB kinases to the microdomains for persistent activation of NF-kappaB. J Biol Chem. 2009;284:6208-17 pubmed publisher
	Eckmann L, Nebelsiek T, Fingerle A, Dann S, Mages J, Lang R, et al. Opposing functions of IKKbeta during acute and chronic intestinal inflammation. Proc Natl Acad Sci U S A. 2008;105:15058-63 pubmed publisher
	Otipoby K, Sasaki Y, Schmidt Supprian M, Patke A, Gareus R, Pasparakis M, et al. BAFF activates Akt and Erk through BAFF-R in an IKK1-dependent manner in primary mouse B cells. Proc Natl Acad Sci U S A. 2008;105:12435-8 pubmed publisher
	Pandey M, Sung B, Kunnumakkara A, Sethi G, Chaturvedi M, Aggarwal B. Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis. Cancer Res. 2008;68:5370-9 pubmed publisher
	Kasinski A, Du Y, Thomas S, Zhao J, Sun S, Khuri F, et al. Inhibition of IkappaB kinase-nuclear factor-kappaB signaling pathway by 3,5-bis(2-flurobenzylidene)piperidin-4-one (EF24), a novel monoketone analog of curcumin. Mol Pharmacol. 2008;74:654-61 pubmed publisher
	Beraza N, Ludde T, Assmus U, Roskams T, Vander Borght S, Trautwein C. Hepatocyte-specific IKK gamma/NEMO expression determines the degree of liver injury. Gastroenterology. 2007;132:2504-17 pubmed
	Jackson Bernitsas D, Ichikawa H, Takada Y, Myers J, Lin X, Darnay B, et al. Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-kappaB activation and proliferation in human head and neck squamous cell carcinoma. Oncogene. 2007;26:1385-97 pubmed
	Sethi G, Ahn K, Sandur S, Lin X, Chaturvedi M, Aggarwal B. Indirubin enhances tumor necrosis factor-induced apoptosis through modulation of nuclear factor-kappa B signaling pathway. J Biol Chem. 2006;281:23425-35 pubmed
	Ichikawa H, Aggarwal B. Guggulsterone inhibits osteoclastogenesis induced by receptor activator of nuclear factor-kappaB ligand and by tumor cells by suppressing nuclear factor-kappaB activation. Clin Cancer Res. 2006;12:662-8 pubmed
	Vinolo E, Sebban H, Chaffotte A, Israel A, Courtois G, Veron M, et al. A point mutation in NEMO associated with anhidrotic ectodermal dysplasia with immunodeficiency pathology results in destabilization of the oligomer and reduces lipopolysaccharide- and tumor necrosis factor-mediated NF-kappa B activation. J Biol Chem. 2006;281:6334-48 pubmed
	Ichikawa H, Takada Y, Murakami A, Aggarwal B. Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products. J Immunol. 2005;174:7383-92 pubmed
	Ruocco M, Maeda S, Park J, Lawrence T, Hsu L, Cao Y, et al. I{kappa}B kinase (IKK){beta}, but not IKK{alpha}, is a critical mediator of osteoclast survival and is required for inflammation-induced bone loss. J Exp Med. 2005;201:1677-87 pubmed
	Nonaka M, Horie R, Itoh K, Watanabe T, Yamamoto N, Yamaoka S. Aberrant NF-kappaB2/p52 expression in Hodgkin/Reed-Sternberg cells and CD30-transformed rat fibroblasts. Oncogene. 2005;24:3976-86 pubmed
	Panopoulos A, Harraz M, Engelhardt J, Zandi E. Iron-mediated H2O2 production as a mechanism for cell type-specific inhibition of tumor necrosis factor alpha-induced but not interleukin-1beta-induced IkappaB kinase complex/nuclear factor-kappaB activation. J Biol Chem. 2005;280:2912-23 pubmed
	Shishodia S, Aggarwal B. Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis. J Biol Chem. 2004;279:47148-58 pubmed
	Shishodia S, Koul D, Aggarwal B. Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis. J Immunol. 2004;173:2011-22 pubmed
	Takada Y, Fang X, Jamaluddin M, Boyd D, Aggarwal B. Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor. J Biol Chem. 2004;279:39541-54 pubmed
	Chandrasekar B, Vemula K, Surabhi R, Li Weber M, Owen Schaub L, Jensen L, et al. Activation of intrinsic and extrinsic proapoptotic signaling pathways in interleukin-18-mediated human cardiac endothelial cell death. J Biol Chem. 2004;279:20221-33 pubmed
	Takada Y, Singh S, Aggarwal B. Identification of a p65 peptide that selectively inhibits NF-kappa B activation induced by various inflammatory stimuli and its role in down-regulation of NF-kappaB-mediated gene expression and up-regulation of apoptosis. J Biol Chem. 2004;279:15096-104 pubmed
	Takada Y, Aggarwal B. Flavopiridol inhibits NF-kappaB activation induced by various carcinogens and inflammatory agents through inhibition of IkappaBalpha kinase and p65 phosphorylation: abrogation of cyclin D1, cyclooxygenase-2, and matrix metalloprotease-9. J Biol Chem. 2004;279:4750-9 pubmed
	Saito N, Courtois G, Chiba A, Yamamoto N, Nitta T, Hironaka N, et al. Two carboxyl-terminal activation regions of Epstein-Barr virus latent membrane protein 1 activate NF-kappaB through distinct signaling pathways in fibroblast cell lines. J Biol Chem. 2003;278:46565-75 pubmed
	Chen L, Egan L, Li Z, Greten F, Kagnoff M, Karin M. The two faces of IKK and NF-kappaB inhibition: prevention of systemic inflammation but increased local injury following intestinal ischemia-reperfusion. Nat Med. 2003;9:575-81 pubmed
	Majumdar S, Aggarwal B. Adenosine suppresses activation of nuclear factor-kappaB selectively induced by tumor necrosis factor in different cell types. Oncogene. 2003;22:1206-18 pubmed
	Ashikawa K, Majumdar S, Banerjee S, Bharti A, Shishodia S, Aggarwal B. Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation. J Immunol. 2002;169:6490-7 pubmed
	Chinanonwait N, Miura H, Yamamoto N, Yamaoka S. A recessive mutant cell line with a constitutive IkappaB kinase activity. FEBS Lett. 2002;531:553-60 pubmed
	Dejardin E, Droin N, Delhase M, Haas E, Cao Y, Makris C, et al. The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways. Immunity. 2002;17:525-35 pubmed
	Makris C, Roberts J, Karin M. The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation. Mol Cell Biol. 2002;22:6573-81 pubmed
	Anto R, Mukhopadhyay A, Shishodia S, Gairola C, Aggarwal B. Cigarette smoke condensate activates nuclear transcription factor-kappaB through phosphorylation and degradation of IkappaB(alpha): correlation with induction of cyclooxygenase-2. Carcinogenesis. 2002;23:1511-8 pubmed
	Majumdar S, Lamothe B, Aggarwal B. Thalidomide suppresses NF-kappa B activation induced by TNF and H2O2, but not that activated by ceramide, lipopolysaccharides, or phorbol ester. J Immunol. 2002;168:2644-51 pubmed
	Agou F, Ye F, Goffinont S, Courtois G, Yamaoka S, Israel A, et al. NEMO trimerizes through its coiled-coil C-terminal domain. J Biol Chem. 2002;277:17464-75 pubmed
	Cao Y, Bonizzi G, Seagroves T, Greten F, Johnson R, Schmidt E, et al. IKKalpha provides an essential link between RANK signaling and cyclin D1 expression during mammary gland development. Cell. 2001;107:763-75 pubmed
	Majumdar S, Aggarwal B. Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation. J Immunol. 2001;167:2911-20 pubmed
	Miller B, Zandi E. Complete reconstitution of human IkappaB kinase (IKK) complex in yeast. Assessment of its stoichiometry and the role of IKKgamma on the complex activity in the absence of stimulation. J Biol Chem. 2001;276:36320-6 pubmed
	Koul D, Yao Y, Abbruzzese J, Yung W, Reddy S. Tumor suppressor MMAC/PTEN inhibits cytokine-induced NFkappaB activation without interfering with the IkappaB degradation pathway. J Biol Chem. 2001;276:11402-8 pubmed
	Manna S, Mukhopadhyay A, Aggarwal B. Leflunomide suppresses TNF-induced cellular responses: effects on NF-kappa B, activator protein-1, c-Jun N-terminal protein kinase, and apoptosis. J Immunol. 2000;165:5962-9 pubmed
	Manna S, Mukhopadhyay A, Aggarwal B. IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis. J Immunol. 2000;165:4927-34 pubmed

product information

master code :

NBP1-49672

SKU :

NBP1-49672

product name :

NKX6.1 Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The NKX6.1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to NKX6.1. This antibody reacts with human,mouse,rat,fish - danio rerio (zebrafish). The NKX6.1 Antibody - BSA Free has been validated for the following applications: Immunocytochemistry/ Immunofluorescence,IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vitro assay,Immunohistochemistry,Simple Western.

target :

NKX6.1

category :

Primary Antibodies

buffer :

PBS, 30% Glycerol

clonality :

Polyclonal

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

A genomic peptide made to an internal region of the human Nkx6.1 protein (within residues 50-200). [Swiss-Prot P78426]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse,Rat,Fish - Danio rerio (Zebrafish)

gene symbol :

NKX6-1

accessionNumbers :

P78426

applications :

IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,In vitro assay,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry,Simple Western

USD :

479 USD

alt names :

Homeobox protein NK-6 homolog A, NK homeo box, family 6, member A, NK homeobox (Drosophila), family 6, A, NK homeobox, family 6, A, NK6 homeobox 1, NK6 transcription factor homolog A, NK6 transcription factor related, locus 1, NK6 transcription factor related, locus 1 (Drosophila), NKX6.1, NKX6Ahomeobox protein Nkx-6.1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage