Caspase-1 Antibody | Novus Biologicals NBP1-45433 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Caspase-1 Antibody

catalog :

NBP1-45433

quantity :

0.1 mg (also 20 ug)

price :

479 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

13A9

reactivity :

human, mouse, rat

application :

western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section

citations: 61

Published Application/Species/Sample/Dilution	Reference
western blot; rat; 1:1000; fig 8a	Liang H, Matei N, McBride D, Xu Y, Zhou Z, Tang J, et al. TGR5 activation attenuates neuroinflammation via Pellino3 inhibition of caspase-8/NLRP3 after middle cerebral artery occlusion in rats. J Neuroinflammation. 2021;18:40 pubmed publisher
western blot; mouse; 1:100; loading ...; fig 6a	Rumfield C, Hyseni I, McBride J, Walker D, Fang R. Activation of ASC Inflammasome Driven by Toll-Like Receptor 4 Contributes to Host Immunity against Rickettsial Infection. Infect Immun. 2020;88: pubmed publisher
western blot; rat; 1:500; loading ...; fig 7a	Yu J, Wang W, Matei N, Li X, Pang J, Mo J, et al. Ezetimibe Attenuates Oxidative Stress and Neuroinflammation via the AMPK/Nrf2/TXNIP Pathway after MCAO in Rats. Oxid Med Cell Longev. 2020;2020:4717258 pubmed publisher
western blot; rat; 1:500; loading ...; fig 5c	Zhou K, Enkhjargal B, Xie Z, Sun C, Wu L, Malaguit J, et al. Dihydrolipoic Acid Inhibits Lysosomal Rupture and NLRP3 Through Lysosome-Associated Membrane Protein-1/Calcium/Calmodulin-Dependent Protein Kinase II/TAK1 Pathways After Subarachnoid Hemorrhage in Rat. Stroke. 2018;49:175-183 pubmed publisher
	Wang Y, Sadike D, Huang B, Li P, Wu Q, Jiang N, et al. Regulatory T cells alleviate myelin loss and cognitive dysfunction by regulating neuroinflammation and microglial pyroptosis via TLR4/MyD88/NF-κB pathway in LPC-induced demyelination. J Neuroinflammation. 2023;20:41 pubmed publisher
	Montoya T, S xe1 nchez Hidalgo M, Castej xf3 n M, Vazqu xe9 z Rom xe1 n M, de Sotomayor M, Ortega Vidal J, et al. Oleocanthal supplemented diet improves renal damage and endothelial dysfunction in pristane-induced systemic lupus erythematosus in mice. Food Res Int. 2023;163:112140 pubmed publisher
	Xiao Q, Kang Z, Liu C, Tang B. Panax notoginseng Saponins Attenuate Cerebral Ischemia-Reperfusion Injury via Mitophagy-Induced Inhibition of NLRP3 Inflammasome in Rats. Front Biosci (Landmark Ed). 2022;27:300 pubmed publisher
	Babaei F, Mirzababaei M, Dargahi L, Shahsavari Z, Nassiri Asl M, Karima S. Preventive Effect of Saccharomyces boulardii on Memory Impairment Induced by Lipopolysaccharide in Rats. ACS Chem Neurosci. 2022;13:3180-3187 pubmed publisher
	Eggelbusch M, Shi A, Broeksma B, V xe1 zquez Cruz M, Soares M, de Wit G, et al. The NLRP3 inflammasome contributes to inflammation-induced morphological and metabolic alterations in skeletal muscle. J Cachexia Sarcopenia Muscle. 2022;13:3048-3061 pubmed publisher
	Ke Q, Shi C, Lv Y, Wang L, Luo J, Jiang L, et al. SGLT2 inhibitor counteracts NLRP3 inflammasome via tubular metabolite itaconate in fibrosis kidney. FASEB J. 2022;36:e22078 pubmed publisher
	Li M, Lu H, Wang X, Duan C, Zhu X, Zhang Y, et al. Pyruvate kinase M2 (PKM2) interacts with activating transcription factor 2 (ATF2) to bridge glycolysis and pyroptosis in microglia. Mol Immunol. 2021;140:250-266 pubmed publisher
	Fan X, Zhang J, Dai Y, Shan K, Xu J. Blockage of P2X7R suppresses Th1/Th17-mediated immune responses and corneal allograft rejection via inhibiting NLRP3 inflammasome activation. Exp Eye Res. 2021;212:108792 pubmed publisher
	Lu Y, Nanayakkara G, Sun Y, Liu L, Xu K, Drummer C, et al. Procaspase-1 patrolled to the nucleus of proatherogenic lipid LPC-activated human aortic endothelial cells induces ROS promoter CYP1B1 and strong inflammation. Redox Biol. 2021;47:102142 pubmed publisher
	Yin K, Zhou X, Jiang W, Wang L, Dai Z, Tang B. Jiangzhi Ligan Decoction Inhibits GSDMD-Mediated Canonical/Noncanonical Pyroptosis Pathways and Alleviates High-Fat Diet-Induced Nonalcoholic Fatty Liver Disease. Dis Markers. 2021;2021:9963534 pubmed publisher
	Liu X, Liu H, Lu X, Zhao S. N-acetylcysteine alleviates ocular surface damage in STZ-induced diabetic mice by inhibiting the ROS/NLRP3/Caspase-1/IL-1β signaling pathway. Exp Eye Res. 2021;209:108654 pubmed publisher
	Zhou K, Enkhjargal B, Mo J, Zhang T, Zhu Q, Wu P, et al. Dihydrolipoic acid enhances autophagy and alleviates neurological deficits after subarachnoid hemorrhage in rats. Exp Neurol. 2021;342:113752 pubmed publisher
	Jiang S, Zhang H, Li X, Yi B, Huang L, Hu Z, et al. Vitamin D/VDR attenuate cisplatin-induced AKI by down-regulating NLRP3/Caspase-1/GSDMD pyroptosis pathway. J Steroid Biochem Mol Biol. 2021;206:105789 pubmed publisher
	Li L, Zou Y, Liu B, Yang R, Yang J, Sun M, et al. Contribution of the P2X4 Receptor in Rat Hippocampus to the Comorbidity of Chronic Pain and Depression. ACS Chem Neurosci. 2020;11:4387-4397 pubmed publisher
	Zhang Q, Wang J, Huang F, Yao Y, Xu L. Leptin induces NAFLD progression through infiltrated CD8+ T lymphocytes mediating pyroptotic-like cell death of hepatocytes and macrophages. Dig Liver Dis. 2020;: pubmed publisher
	Lim J, Lee H, Jung Y, Kim J, Chae C, Kim S, et al. Ethanol-activated CaMKII signaling induces neuronal apoptosis through Drp1-mediated excessive mitochondrial fission and JNK1-dependent NLRP3 inflammasome activation. Cell Commun Signal. 2020;18:123 pubmed publisher
	Wang C, Jia Q, Sun C, Jing C. Calcium sensing receptor contribute to early brain injury through the CaMKII/NLRP3 pathway after subarachnoid hemorrhage in mice. Biochem Biophys Res Commun. 2020;530:651-657 pubmed publisher
	Verma V, Kumar P, Gupta S, Yadav S, Dhanda R, Thorlacius H, et al. α-Hemolysin of uropathogenic E. coli regulates NLRP3 inflammasome activation and mitochondrial dysfunction in THP-1 macrophages. Sci Rep. 2020;10:12653 pubmed publisher
	Shi Y, Shi X, Liang J, Luo J, Ba J, Chen J, et al. Aggravated MRSA pneumonia secondary to influenza A virus infection is derived from decreased expression of IL-1β. J Med Virol. 2020;: pubmed publisher
	Saber S, Abd El Kader E, Sharaf H, El Shamy R, El Saeed B, Mostafa A, et al. Celastrol augments sensitivity of NLRP3 to CP-456773 by modulating HSP-90 and inducing autophagy in dextran sodium sulphate-induced colitis in rats. Toxicol Appl Pharmacol. 2020;400:115075 pubmed publisher
	Liu G, Baird A, Parsons M, Fan K, Skerrett Byrne D, Nair P, et al. Platelet activating factor receptor acts to limit colitis-induced liver inflammation. FASEB J. 2020;34:7718-7732 pubmed publisher
	Kim H, Seo J, Lee S, Ha K, Choi B, Shin Y, et al. AIM2 inflammasome contributes to brain injury and chronic post-stroke cognitive impairment in mice. Brain Behav Immun. 2020;87:765-776 pubmed publisher
	Wei H, Bu R, Yang Q, Jia J, Li T, Wang Q, et al. Exendin-4 Protects against Hyperglycemia-Induced Cardiomyocyte Pyroptosis via the AMPK-TXNIP Pathway. J Diabetes Res. 2019;2019:8905917 pubmed publisher
	Verma V, Gupta S, Kumar P, Yadav S, Dhanda R, Gaind R, et al. Involvement of NLRP3 and NLRC4 Inflammasome in Uropathogenic E. coli Mediated Urinary Tract Infections. Front Microbiol. 2019;10:2020 pubmed publisher
	Zhao S, Zhou Y, Fan Y, Gong Y, Yang J, Yang R, et al. Involvement of purinergic 2X4 receptor in glycoprotein 120-induced pyroptosis in dorsal root ganglia. J Neurochem. 2019;: pubmed publisher
	Liu B, Mao X, Huang D, Li F, Dong N. Novel role of NLRP3-inflammasome in regulation of lipogenesis in fasting-induced hepatic steatosis. Diabetes Metab Syndr Obes. 2019;12:801-811 pubmed publisher
	Mohammed S, Torres Luquis O, Walls E, Lloyd F. Lymph-circulating tumor cells show distinct properties to blood-circulating tumor cells and are efficient metastatic precursors. Mol Oncol. 2019;13:1400-1418 pubmed publisher
	Zhao K, Li X, Chen X, Zhu Q, Yin F, Ruan Q, et al. Inhibition of miR-140-3p or miR-155-5p by antagomir treatment sensitize chordoma cells to chemotherapy drug treatment by increasing PTEN expression. Eur J Pharmacol. 2019;854:298-306 pubmed publisher
	Liu G, Mateer S, Hsu A, Goggins B, Tay H, Mathe A, et al. Platelet activating factor receptor regulates colitis-induced pulmonary inflammation through the NLRP3 inflammasome. Mucosal Immunol. 2019;: pubmed publisher
	Hlavac N, VandeVord P. Astrocyte Mechano-Activation by High-Rate Overpressure Involves Alterations in Structural and Junctional Proteins. Front Neurol. 2019;10:99 pubmed publisher
	Ren W, Hou J, Yang C, Wang H, Wu S, Wu Y, et al. Extracellular vesicles secreted by hypoxia pre-challenged mesenchymal stem cells promote non-small cell lung cancer cell growth and mobility as well as macrophage M2 polarization via miR-21-5p delivery. J Exp Clin Cancer Res. 2019;38:62 pubmed publisher
	Chiba Y, He B, Yoshizaki K, Rhodes C, Ishijima M, Bleck C, et al. The transcription factor AmeloD stimulates epithelial cell motility essential for tooth morphology. J Biol Chem. 2019;294:3406-3418 pubmed publisher
	Lopes de Oliveira G, Alarcón de la Lastra C, Rosillo M, Castejon Martinez M, Sanchez Hidalgo M, Rolim Medeiros J, et al. Preventive effect of bergenin against the development of TNBS-induced acute colitis in rats is associated with inflammatory mediators inhibition and NLRP3/ASC inflammasome signaling pathways. Chem Biol Interact. 2019;297:25-33 pubmed publisher
	Che C, Li C, Lin J, Zhang J, Jiang N, Yuan K, et al. Wnt5a contributes to dectin-1 and LOX-1 induced host inflammatory response signature in Aspergillus fumigatus keratitis. Cell Signal. 2018;52:103-111 pubmed publisher
	Park S, Kim H, Kim K, Roh S. Sonic hedgehog signalling regulates the self-renewal and proliferation of skin-derived precursor cells in mice. Cell Prolif. 2018;51:e12500 pubmed publisher
	Chen N, Ou Z, Zhang W, Zhu X, Li P, Gong J. Cathepsin B regulates non-canonical NLRP3 inflammasome pathway by modulating activation of caspase-11 in Kupffer cells. Cell Prolif. 2018;51:e12487 pubmed publisher
	Mandal P, Feng Y, Lyons J, Berger S, Otani S, DeLaney A, et al. Caspase-8 Collaborates with Caspase-11 to Drive Tissue Damage and Execution of Endotoxic Shock. Immunity. 2018;49:42-55.e6 pubmed publisher
	Chen C, Melo E, Jakob P, Friedlein A, Elsässer B, Goettig P, et al. N-Terminomics identifies HtrA1 cleavage of thrombospondin-1 with generation of a proangiogenic fragment in the polarized retinal pigment epithelial cell model of age-related macular degeneration. Matrix Biol. 2018;70:84-101 pubmed publisher
	Melo E, Oertle P, Trepp C, Meistermann H, Burgoyne T, Sborgi L, et al. HtrA1 Mediated Intracellular Effects on Tubulin Using a Polarized RPE Disease Model. EBioMedicine. 2018;27:258-274 pubmed publisher
	Hu Q, Zhang T, Yi L, Zhou X, Mi M. Dihydromyricetin inhibits NLRP3 inflammasome-dependent pyroptosis by activating the Nrf2 signaling pathway in vascular endothelial cells. Biofactors. 2018;44:123-136 pubmed publisher
	Chen M, Zhu X, Ran L, Lang H, Yi L, Mi M. Trimethylamine-N-Oxide Induces Vascular Inflammation by Activating the NLRP3 Inflammasome Through the SIRT3-SOD2-mtROS Signaling Pathway. J Am Heart Assoc. 2017;6: pubmed publisher
	Farjood F, Vargis E. Physical disruption of cell-cell contact induces VEGF expression in RPE cells. Mol Vis. 2017;23:431-446 pubmed
	Lee H, Lee S, Kim N, Park K, Choi B, Shin Y, et al. Low-level light emitting diode (LED) therapy suppresses inflammasome-mediated brain damage in experimental ischemic stroke. J Biophotonics. 2017;10:1502-1513 pubmed publisher
	Lin C, Chao H, Li Z, Xu X, Liu Y, Bao Z, et al. Omega-3 fatty acids regulate NLRP3 inflammasome activation and prevent behavior deficits after traumatic brain injury. Exp Neurol. 2017;290:115-122 pubmed publisher
	Koeppen A, Becker A, Feustel P, Gelman B, Mazurkiewicz J. The significance of intercalated discs in the pathogenesis of Friedreich cardiomyopathy. J Neurol Sci. 2016;367:171-6 pubmed publisher
	Draganov D, Gopalakrishna Pillai S, Chen Y, Zuckerman N, Moeller S, Wang C, et al. Modulation of P2X4/P2X7/Pannexin-1 sensitivity to extracellular ATP via Ivermectin induces a non-apoptotic and inflammatory form of cancer cell death. Sci Rep. 2015;5:16222 pubmed publisher
	Michelhaugh S, Guastella A, Varadarajan K, Klinger N, Parajuli P, Ahmad A, et al. Development of patient-derived xenograft models from a spontaneously immortal low-grade meningioma cell line, KCI-MENG1. J Transl Med. 2015;13:227 pubmed publisher
	Chow A, Ng L, Lam C, Wong S, Wan T, Cheng N, et al. The Enhanced metastatic potential of hepatocellular carcinoma (HCC) cells with sorafenib resistance. PLoS ONE. 2013;8:e78675 pubmed publisher
	Maeda M, Johnson E, Mandal S, Lawson K, Keim S, Svoboda R, et al. Expression of inappropriate cadherins by epithelial tumor cells promotes endocytosis and degradation of E-cadherin via competition for p120(ctn). Oncogene. 2006;25:4595-604 pubmed
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product information

brand :

Novus

master code :

NBP1-45433

SKU :

NBP1-45433

product name :

Caspase-1 Antibody

description :

The Caspase-1 Antibody from Novus is a rabbit polyclonal antibody to Caspase-1. This antibody reacts with human, mouse, rat, e. coli. The Caspase-1 Antibody has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockdown Validated.

target :

Caspase-1

category :

Primary Antibodies

sizes available :

0.1 mg (also 20 ug)

buffer :

PBS (pH 7.2), 0.5 mM EDTA, 0.5% BSA, 30% glycerol

clonality :

Polyclonal

concentration :

0.5 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Caspase-1 Antibody was developed against a synthetic peptide surrounding amino acid 132 of human caspase-1 (NP_150636).

isotype :

IgG

purity :

Affinity purified

species :

Human, Mouse, Rat, E. coli

specificity :

Caspase-1 Antibody recognizes the 45 kDa procaspase-1 and the 20 kDa cleaved product

gene symbol :

CASP1

images :

https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0002.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0002.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/Caspase-1-Antibody-Western-Blot-NBP1-45433-img0002.jpg

accessionNumbers :

NP_150636

applications :

Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Knockdown Validated

USD :

479 USD

alt names :

CASP1, CASP-1, CASP1 nirs variant 1, caspase 1, apoptosis-related cysteine peptidase, caspase-1, Caspase-1 subunit p10, Caspase-1 subunit p20, EC 3.4.22.36, EC:3.4.22.36, ICE, IL-1 beta-converting enzyme, IL1BC, IL-1BC, IL1BCE, IL1B-convertase, interleukin 1, beta, convertase, interleukin 1-B converting enzyme, Interleukin-1 beta convertase, Interleukin-1 beta-converting enzyme, p45

storage :

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.