BRCA1 Antibody (17F8) - Azide and BSA Free | Novus Biologicals NBP1-41185 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

BRCA1 Antibody (17F8) - Azide and BSA Free

catalog :

NBP1-41185

quantity :

100 ul

price :

469 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

17F8

reactivity :

human, mouse

application :

western blot, ELISA, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 12

Reference
Wang S, Chang C, Huang J, Zeng S, Zhang X, Hung M, et al. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024;134: pubmed publisher
Manchana T, Tantbirojn P, Pohthipornthawat N. BRCA immunohistochemistry for screening of BRCA mutation in epithelial ovarian cancer patients. Gynecol Oncol Rep. 2020;33:100582 pubmed publisher
Zheng X, Fernando V, Sharma V, Walia Y, Letson J, Furuta S. Correction of arginine metabolism with sepiapterin-the precursor of nitric oxide synthase cofactor BH4-induces immunostimulatory-shift of breast cancer. Biochem Pharmacol. 2020;176:113887 pubmed publisher
Rogers K, Moreno S, Smith L, Husson H, Bukanov N, Ledbetter S, et al. Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD. Physiol Rep. 2016;4: pubmed publisher
Bosviel R, Dumollard E, Dechelotte P, Bignon Y, Bernard Gallon D. Can soy phytoestrogens decrease DNA methylation in BRCA1 and BRCA2 oncosuppressor genes in breast cancer?. OMICS. 2012;16:235-44 pubmed publisher
Vardi A, Bosviel R, Rabiau N, Adjakly M, Satih S, Dechelotte P, et al. Soy phytoestrogens modify DNA methylation of GSTP1, RASSF1A, EPH2 and BRCA1 promoter in prostate cancer cells. In Vivo. 2010;24:393-400 pubmed
Bernard Gallon D, Dechelotte P, Le Corre L, Chalabi N, Vissac Sabatier C, Bignon Y. Differential expressions of BRCA1 and BRCA2 in infantile gynecomastia. Anticancer Res. 2004;24:321-4 pubmed
Ongusaha P, Ouchi T, Kim K, Nytko E, Kwak J, Duda R, et al. BRCA1 shifts p53-mediated cellular outcomes towards irreversible growth arrest. Oncogene. 2003;22:3749-58 pubmed
Bernard Gallon D, Dechelotte P, Vissac C, Aunoble B, Cravello L, Malpuech G, et al. BRCA1 and BRCA2 protein expressions in an ovotestis of a 46, XX true hermaphrodite. Breast Cancer Res. 2001;3:61-5 pubmed
Lu M, Arrick B. Transactivation of the p21 promoter by BRCA1 splice variants in mammary epithelial cells: evidence for both common and distinct activities of wildtype and mutant forms. Oncogene. 2000;19:6351-60 pubmed
de Toledo S, Azzam E, Dahlberg W, Gooding T, Little J. ATM complexes with HDM2 and promotes its rapid phosphorylation in a p53-independent manner in normal and tumor human cells exposed to ionizing radiation. Oncogene. 2000;19:6185-93 pubmed
Arizti P, Fang L, Park I, Yin Y, Solomon E, Ouchi T, et al. Tumor suppressor p53 is required to modulate BRCA1 expression. Mol Cell Biol. 2000;20:7450-9 pubmed

product information

master code :

NBP1-41185

SKU :

NBP1-41185

product name :

BRCA1 Antibody (17F8) - Azide and BSA Free

unit size :

100 ul

description :

The BRCA1 Antibody (17F8) - Azide and BSA Free from Novus is a mouse monoclonal antibody to BRCA1. This antibody reacts with human,mouse. The BRCA1 Antibody (17F8) - Azide and BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Knockout Validated,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry,Immunoprecipitation,Chromatin Immunoprecipitation (ChIP).

target :

BRCA1

category :

Primary Antibodies

buffer :

PBS

clonality :

Monoclonal

clone :

17F8

conjugate :

Unconjugated

host :

Mouse

immunogen :

Protein fragment expressed in E. coli corresponding to amino acids 762-1315.

isotype :

IgG1

purity :

Protein G purified

species :

Human,Mouse

specificity :

This antibody does not recognize the delta exon 11 splice variant of BRCA1

theoretical molecular weight :

208 kDa

gene symbol :

BRCA1

Antibody validation :

Knockout/Knockdown

applications :

Western Blot,Immunohistochemistry-Paraffin,Knockout Validated,Immunocytochemistry/ Immunofluorescence,ELISA,Immunohistochemistry,Immunoprecipitation,Chromatin Immunoprecipitation (ChIP)

USD :

469 USD

alt names :

BRCAI, breast and ovarian cancer susceptibility protein 1, breast and ovarian cancer sususceptibility protein, breast cancer 1, early onset, breast cancer type 1 susceptibility protein, EC 6.3.2, EC 6.3.2.-, IRIS, PNCA4, PSCP, subunit 1

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage