product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
GAP-43 Antibody - BSA Free
catalog :
NBP1-41123
quantity :
0.1 ml (also 0.025 ml)
price :
409 USD
clonality :
polyclonal
host :
domestic sheep
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs
application :
western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 77
Published Application/Species/Sample/DilutionReference
  • western blot; rat; 1:2000; loading ...; fig 4c
Van de Bittner G, Riley M, Cao L, Ehses J, Herrick S, Ricq E, et al. Nasal neuron PET imaging quantifies neuron generation and degeneration. J Clin Invest. 2017;127:681-694 pubmed publisher
Ferreira A, Chambel S, Avelino A, Cruz C. Spinal Cord Injury Causes Marked Tissue Rearrangement in the Urethra-Experimental Study in the Rat. Int J Mol Sci. 2022;23: pubmed publisher
Li L, Huang W, Hsueh Y, Yamauchi K, Olivares N, Davila R, et al. Intramuscular delivery of neural crest stem cell spheroids enhances neuromuscular regeneration after denervation injury. Stem Cell Res Ther. 2022;13:205 pubmed publisher
Jeong M, Ocwieja K, Han D, Wackym P, Zhang Y, Brown A, et al. Direct SARS-CoV-2 infection of the human inner ear may underlie COVID-19-associated audiovestibular dysfunction. Commun Med (Lond). 2021;1:44 pubmed publisher
Yazdani A, Howidi B, Shi M, Tugarinov N, Khoja Z, Wintermark P. Sildenafil improves hippocampal brain injuries and restores neuronal development after neonatal hypoxia-ischemia in male rat pups. Sci Rep. 2021;11:22046 pubmed publisher
Kong G, Zhou L, Serger E, Palmisano I, De Virgiliis F, Hutson T, et al. AMPK controls the axonal regenerative ability of dorsal root ganglia sensory neurons after spinal cord injury. Nat Metab. 2020;2:918-933 pubmed publisher
Cohrs G, Drucks B, Synowitz M, Held Feindt J, Knerlich Lukoschus F. Expression Patterns of Hypoxia-Inducible Factors, Proinflammatory, and Neuroprotective Cytokines in Neuroepithelial Tissues of Lumbar Spinal Lipomas-A Pilot Study. World Neurosurg. 2020;141:e633-e644 pubmed publisher
Kiesswetter E, Sieber C, Volkert D. Protein intake in older people : Why, how much and how?. Z Gerontol Geriatr. 2020;53:285-289 pubmed publisher
Peng W, de Bruijn H, ten Hagen T, van Dam G, Roodenburg J, Berg K, et al. Targeted Photodynamic Therapy of Human Head and Neck Squamous Cell Carcinoma with Anti-epidermal Growth Factor Receptor Antibody Cetuximab and Photosensitizer IR700DX in the Mouse Skin-fold Window Chamber Model. Photochem Photobiol. 2020;96:708-717 pubmed publisher
Liu L, Zhang L, Zhao J, Guo X, Luo Y, Hu W, et al. Tumor Necrosis Factor Receptor-Associated Protein 1 Protects against Mitochondrial Injury by Preventing High Glucose-Induced mPTP Opening in Diabetes. Oxid Med Cell Longev. 2020;2020:6431517 pubmed publisher
Lucia K, Wu Y, Garcia J, Barlier A, Buchfelder M, Saeger W, et al. Hypoxia and the hypoxia inducible factor 1α activate protein kinase A by repressing RII beta subunit transcription. Oncogene. 2020;39:3367-3380 pubmed publisher
Andrade F, Nguyen N, Warri A, Hilakivi Clarke L. Reversal of increased mammary tumorigenesis by valproic acid and hydralazine in offspring of dams fed high fat diet during pregnancy. Sci Rep. 2019;9:20271 pubmed publisher
Chao A, Chen C, Wu M, Hou B, Yang D. Roles of Id1/HIF-1 and CDK5/HIF-1 in cell cycle reentry induced by amyloid-beta peptide in post-mitotic cortical neuron. Biochim Biophys Acta Mol Cell Res. 2020;1867:118628 pubmed publisher
Zhao L, Zhao J, Gao R, Tian Y, Zhang Y, Tang W, et al. Intrabody against prolyl hydroxylase 2 ameliorates acetaminophen-induced acute liver injury in mice via concomitant promotion of angiogenesis and redox homeostasis. Biomed Pharmacother. 2020;123:109783 pubmed publisher
Carrasco Pozo C, Tan K, Rodriguez T, Avery V. The Molecular Effects of Sulforaphane and Capsaicin on Metabolism upon Androgen and Tip60 Activation of Androgen Receptor. Int J Mol Sci. 2019;20: pubmed publisher
Osawa T, Shimamura T, Saito K, Hasegawa Y, Ishii N, Nishida M, et al. Phosphoethanolamine Accumulation Protects Cancer Cells under Glutamine Starvation through Downregulation of PCYT2. Cell Rep. 2019;29:89-103.e7 pubmed publisher
Zhao L, Liu Z, Yang F, Zhang Y, Xue Y, Miao H, et al. Intrabody against prolyl hydroxylase 2 promotes angiogenesis by stabilizing hypoxia-inducible factor-1α. Sci Rep. 2019;9:11861 pubmed publisher
Oyama Y, Bartman C, Bonney S, Lee J, Walker L, Han J, et al. Intense Light-Mediated Circadian Cardioprotection via Transcriptional Reprogramming of the Endothelium. Cell Rep. 2019;28:1471-1484.e11 pubmed publisher
Mallikarjuna P, Raviprakash T, Aripaka K, Ljungberg B, Landström M. Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma. Cell Cycle. 2019;18:2141-2156 pubmed publisher
Masterson J, Biette K, Hammer J, Nguyen N, Capocelli K, Saeedi B, et al. Epithelial HIF-1α/claudin-1 axis regulates barrier dysfunction in eosinophilic esophagitis. J Clin Invest. 2019;129:3224-3235 pubmed publisher
Kaushik D, Bhattacharya A, Mirzaei R, Rawji K, Ahn Y, Rho J, et al. Enhanced glycolytic metabolism supports transmigration of brain-infiltrating macrophages in multiple sclerosis. J Clin Invest. 2019;129:3277-3292 pubmed publisher
Yang Y, Li M, Xu G, Feng L, Zhang E, Chen J, et al. Nogo-B Receptor Directs Mitochondria-Associated Membranes to Regulate Vascular Smooth Muscle Cell Proliferation. Int J Mol Sci. 2019;20: pubmed publisher
Tumova S, Kerimi A, Williamson G. Long term treatment with quercetin in contrast to the sulfate and glucuronide conjugates affects HIF1α stability and Nrf2 signaling in endothelial cells and leads to changes in glucose metabolism. Free Radic Biol Med. 2019;137:158-168 pubmed publisher
Harms M, Li Q, Lee S, Zhang C, Kull B, Hallen S, et al. Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes. Cell Rep. 2019;27:213-225.e5 pubmed publisher
Fu H, Ding X, Zhang W, Kang Y. Profiling of nuclear copper-binding proteins under hypoxic condition. Biometals. 2019;32:329-341 pubmed publisher
Wu Z, Zhang W, Kang Y. Copper affects the binding of HIF-1α to the critical motifs of its target genes. Metallomics. 2019;11:429-438 pubmed publisher
Cheng Y, Sun M, Chen L, Li Y, Lin L, Yao B, et al. Ten-Eleven Translocation Proteins Modulate the Response to Environmental Stress in Mice. Cell Rep. 2018;25:3194-3203.e4 pubmed publisher
Lambertini E, Penolazzi L, Angelozzi M, Bergamin L, Manferdini C, Vieceli Dalla Sega F, et al. Hypoxia Preconditioning of Human MSCs: a Direct Evidence of HIF-1α and Collagen Type XV Correlation. Cell Physiol Biochem. 2018;51:2237-2249 pubmed publisher
Fuhrmann D, Wittig I, Brüne B. TMEM126B deficiency reduces mitochondrial SDH oxidation by LPS, attenuating HIF-1α stabilization and IL-1β expression. Redox Biol. 2019;20:204-216 pubmed publisher
Yang L, Chen M, Zhang J, Ren D, Hu B. Hypoxia Delays Oligodendrocyte Progenitor Cell Migration and Myelin Formation by Suppressing Bmp2b Signaling in Larval Zebrafish. Front Cell Neurosci. 2018;12:348 pubmed publisher
Cohrs G, Drucks B, Sürie J, Vokuhl C, Synowitz M, Held Feindt J, et al. Expression profiles of pro-inflammatory and pro-apoptotic mediators in secondary tethered cord syndrome after myelomeningocele repair surgery. Childs Nerv Syst. 2019;35:315-328 pubmed publisher
Stoyanoff T, Rodriguez J, Todaro J, Colavita J, Torres A, Aguirre M. Erythropoietin attenuates LPS-induced microvascular damage in a murine model of septic acute kidney injury. Biomed Pharmacother. 2018;107:1046-1055 pubmed publisher
Ronellenfitsch M, Zeiner P, Mittelbronn M, Urban H, Pietsch T, Reuter D, et al. Akt and mTORC1 signaling as predictive biomarkers for the EGFR antibody nimotuzumab in glioblastoma. Acta Neuropathol Commun. 2018;6:81 pubmed publisher
Zheng J, Zhang M, Weng H. Induction of the mitochondrial NDUFA4L2 protein by HIF-1a regulates heart regeneration by promoting the survival of cardiac stem cell. Biochem Biophys Res Commun. 2018;503:2226-2233 pubmed publisher
Chhipa R, Fan Q, Anderson J, Muraleedharan R, Huang Y, Ciraolo G, et al. AMP kinase promotes glioblastoma bioenergetics and tumour growth. Nat Cell Biol. 2018;20:823-835 pubmed publisher
Peruzzotti Jametti L, Bernstock J, Vicario N, Costa A, Kwok C, Leonardi T, et al. Macrophage-Derived Extracellular Succinate Licenses Neural Stem Cells to Suppress Chronic Neuroinflammation. Cell Stem Cell. 2018;22:355-368.e13 pubmed publisher
Dopeso H, Jiao H, Cuesta A, Henze A, Jurida L, Kracht M, et al. PHD3 Controls Lung Cancer Metastasis and Resistance to EGFR Inhibitors through TGFα. Cancer Res. 2018;78:1805-1819 pubmed publisher
Eriksson J, Wanka C, Burger M, Urban H, Hartel I, von Renesse J, et al. Suppression of oxidative phosphorylation confers resistance against bevacizumab in experimental glioma. J Neurochem. 2017;: pubmed publisher
McClendon J, Jansing N, Redente E, Gandjeva A, Ito Y, Colgan S, et al. Hypoxia-Inducible Factor 1? Signaling Promotes Repair of the Alveolar Epithelium after Acute Lung Injury. Am J Pathol. 2017;187:1772-1786 pubmed publisher
Li D, Du Y, Yuan X, Han X, Dong Z, Chen X, et al. Hepatic hypoxia-inducible factors inhibit PPAR? expression to exacerbate acetaminophen induced oxidative stress and hepatotoxicity. Free Radic Biol Med. 2017;110:102-116 pubmed publisher
Zhang X, Liu L, Liu J, Cheng Z, Wang Z, Shi C, et al. Endothelial cells co-cultured with renal carcinoma cells significantly reduce RECK expression under chemical hypoxia. Cell Biol Int. 2017;41:922-927 pubmed publisher
Mimura I, Hirakawa Y, Kanki Y, Kushida N, Nakaki R, Suzuki Y, et al. Novel lnc RNA regulated by HIF-1 inhibits apoptotic cell death in the renal tubular epithelial cells under hypoxia. Physiol Rep. 2017;5: pubmed publisher
Kaplan A, Morquette B, Kroner A, Leong S, Madwar C, Sanz R, et al. Small-Molecule Stabilization of 14-3-3 Protein-Protein Interactions Stimulates Axon Regeneration. Neuron. 2017;93:1082-1093.e5 pubmed publisher
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell W, Tan A, et al. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017;6:e287 pubmed publisher
Hou F, Li W, Shi Q, Li H, Liu S, Zong S, et al. Yi Ai Fang, a traditional Chinese herbal formula, impacts the vasculogenic mimicry formation of human colorectal cancer through HIF-1? and epithelial mesenchymal transition. BMC Complement Altern Med. 2016;16:428 pubmed
Kushida N, Nomura S, Mimura I, Fujita T, Yamamoto S, Nangaku M, et al. Hypoxia-Inducible Factor-1? Activates the Transforming Growth Factor-?/SMAD3 Pathway in Kidney Tubular Epithelial Cells. Am J Nephrol. 2016;44:276-285 pubmed
Campillo N, Jorba I, Schaedel L, Casals B, Gozal D, Farre R, et al. A Novel Chip for Cyclic Stretch and Intermittent Hypoxia Cell Exposures Mimicking Obstructive Sleep Apnea. Front Physiol. 2016;7:319 pubmed publisher
Sullivan A, Peet D, Whitelaw M. MAGED1 is a novel regulator of a select subset of bHLH PAS transcription factors. FEBS J. 2016;283:3488-502 pubmed publisher
Kowitzke B, Cohrs G, Leuschner I, Koch A, Synowitz M, Mehdorn H, et al. Cellular Profiles and Molecular Mediators of Lesion Cascades in the Placode in Human Open Spinal Neural Tube Defects. J Neuropathol Exp Neurol. 2016;75:827-42 pubmed publisher
Hoang N, Kadonosono T, Kuchimaru T, Kizaka Kondoh S. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model. Cancer Sci. 2016;107:1151-8 pubmed publisher
Salvi V, Vermi W, Gianello V, Lonardi S, Gagliostro V, Naldini A, et al. Dendritic cell-derived VEGF-A plays a role in inflammatory angiogenesis of human secondary lymphoid organs and is driven by the coordinated activation of multiple transcription factors. Oncotarget. 2016;7:39256-39269 pubmed publisher
Mammadzada P, Gudmundsson J, Kvanta A, André H. Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis. Acta Ophthalmol. 2016;94:805-814 pubmed publisher
Spitzbarth I, Lempp C, Kegler K, Ulrich R, Kalkuhl A, Deschl U, et al. Immunohistochemical and transcriptome analyses indicate complex breakdown of axonal transport mechanisms in canine distemper leukoencephalitis. Brain Behav. 2016;6:e00472 pubmed publisher
Jang J, Ko M, Yun J, Kim M, Kim J, Park H, et al. Nitric Oxide Produced by Macrophages Inhibits Adipocyte Differentiation and Promotes Profibrogenic Responses in Preadipocytes to Induce Adipose Tissue Fibrosis. Diabetes. 2016;65:2516-28 pubmed publisher
Semba H, Takeda N, Isagawa T, Sugiura Y, Honda K, Wake M, et al. HIF-1?-PDK1 axis-induced active glycolysis plays an essential role in macrophage migratory capacity. Nat Commun. 2016;7:11635 pubmed publisher
Takahashi N, Davy P, Gardner L, Mathews J, Yamazaki Y, Allsopp R. Hypoxia Inducible Factor 1 Alpha Is Expressed in Germ Cells throughout the Murine Life Cycle. PLoS ONE. 2016;11:e0154309 pubmed publisher
Joyal J, Sun Y, Gantner M, Shao Z, Evans L, Saba N, et al. Retinal lipid and glucose metabolism dictates angiogenesis through the lipid sensor Ffar1. Nat Med. 2016;22:439-45 pubmed publisher
Mori H, Yao Y, Learman B, Kurozumi K, Ishida J, Ramakrishnan S, et al. Induction of WNT11 by hypoxia and hypoxia-inducible factor-1α regulates cell proliferation, migration and invasion. Sci Rep. 2016;6:21520 pubmed publisher
Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, et al. The LINK-A lncRNA activates normoxic HIF1? signalling in triple-negative breast cancer. Nat Cell Biol. 2016;18:213-24 pubmed publisher
Song M, Liu T, Shi C, Zhang X, Chen X. Bioconjugated Manganese Dioxide Nanoparticles Enhance Chemotherapy Response by Priming Tumor-Associated Macrophages toward M1-like Phenotype and Attenuating Tumor Hypoxia. ACS Nano. 2016;10:633-647 pubmed publisher
de Jong O, van Balkom B, Gremmels H, Verhaar M. Exosomes from hypoxic endothelial cells have increased collagen crosslinking activity through up-regulation of lysyl oxidase-like 2. J Cell Mol Med. 2016;20:342-50 pubmed publisher
Cheng S, Xing W, Pourteymoor S, Schulte J, Mohan S. Conditional Deletion of Prolyl Hydroxylase Domain-Containing Protein 2 (Phd2) Gene Reveals Its Essential Role in Chondrocyte Function and Endochondral Bone Formation. Endocrinology. 2016;157:127-40 pubmed publisher
Highet A, Khoda S, Buckberry S, Leemaqz S, Bianco Miotto T, Harrington E, et al. Hypoxia induced HIF-1/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion. Eur J Cell Biol. 2015;94:589-602 pubmed publisher
André H, Tunik S, Aronsson M, Kvanta A. Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model. Invest Ophthalmol Vis Sci. 2015;56:6591-604 pubmed publisher
Chen P, Weng J, Hsu P, Shew J, Huang Y, Lee W. NPGPx modulates CPEB2-controlled HIF-1α RNA translation in response to oxidative stress. Nucleic Acids Res. 2015;43:9393-404 pubmed publisher
Chen X, Liu J, He B, Li Y, Liu S, Wu B, et al. Vascular endothelial growth factor (VEGF) regulation by hypoxia inducible factor-1 alpha (HIF1A) starts and peaks during endometrial breakdown, not repair, in a mouse menstrual-like model. Hum Reprod. 2015;30:2160-70 pubmed publisher
Park I, Chung P, Ahn J. Enhancement of Ischemic Wound Healing by Spheroid Grafting of Human Adipose-Derived Stem Cells Treated with Low-Level Light Irradiation. PLoS ONE. 2015;10:e0122776 pubmed publisher
Wang J, Ding N, Li Y, Cheng H, Wang D, Yang Q, et al. Insulin-like growth factor binding protein 5 (IGFBP5) functions as a tumor suppressor in human melanoma cells. Oncotarget. 2015;6:20636-49 pubmed
Zhang J, Han C, Dai H, Hou J, Dong Y, Cui X, et al. Hypoxia-Inducible Factor-2α Limits Natural Killer T Cell Cytotoxicity in Renal Ischemia/Reperfusion Injury. J Am Soc Nephrol. 2016;27:92-106 pubmed publisher
Forristal C, Brown A, Helwani F, Winkler I, Nowlan B, Barbier V, et al. Hypoxia inducible factor (HIF)-2α accelerates disease progression in mouse models of leukemia and lymphoma but is not a poor prognosis factor in human AML. Leukemia. 2015;29:2075-85 pubmed publisher
Saeedi B, Kao D, Kitzenberg D, Dobrinskikh E, Schwisow K, Masterson J, et al. HIF-dependent regulation of claudin-1 is central to intestinal epithelial tight junction integrity. Mol Biol Cell. 2015;26:2252-62 pubmed publisher
Koh H, Chang C, Jeon S, Yoon H, Ahn Y, Kim H, et al. The HIF-1/glial TIM-3 axis controls inflammation-associated brain damage under hypoxia. Nat Commun. 2015;6:6340 pubmed publisher
García L, Leimgruber C, Uribe Echevarría E, Acosta P, Brahamian J, Polack F, et al. Protective phenotypes of club cells and alveolar macrophages are favored as part of endotoxin-mediated prevention of asthma. Exp Biol Med (Maywood). 2015;240:904-16 pubmed publisher
Hung Y, Chang S, Huang C, Yin J, Hwang C, Yang L, et al. Inhibitor of Differentiation-1 and Hypoxia-Inducible Factor-1 Mediate Sonic Hedgehog Induction by Amyloid Beta-Peptide in Rat Cortical Neurons. Mol Neurobiol. 2016;53:793-809 pubmed publisher
Sun K, Chen M, Tu M, Wang I, Chang S, Li C. MicroRNA-20a regulates autophagy related protein-ATG16L1 in hypoxia-induced osteoclast differentiation. Bone. 2015;73:145-53 pubmed publisher
Khamaisi M, Toukan H, Axelrod J, Rosenberger C, Skarzinski G, Shina A, et al. Endothelin-converting enzyme is a plausible target gene for hypoxia-inducible factor. Kidney Int. 2015;87:761-70 pubmed publisher
Obama T, Takayanagi T, Kobayashi T, Bourne A, Elliott K, Charbonneau M, et al. Vascular induction of a disintegrin and metalloprotease 17 by angiotensin II through hypoxia inducible factor 1?. Am J Hypertens. 2015;28:10-4 pubmed publisher
product information
master code :
NBP1-41123
SKU :
NBP1-41123
product name :
GAP-43 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The GAP-43 Antibody - BSA Free from Novus is a sheep polyclonal antibody to GAP-43. This antibody reacts with canine,feline,hamster,human,mouse,primate,rat. The GAP-43 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Frozen,IF/IHC,Immunohistochemistry-Paraffin,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry.
target :
GAP-43
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Sheep
immunogen :
GAP-43 from rat brain [Uniprot: P07936]
isotype :
IgG
purity :
Protein G purified
species :
Canine,Feline,Hamster,Human,Mouse,Primate,Rat
theoretical molecular weight :
45 kDa
gene symbol :
GAP43
Antibody validation :
Biological Validation
applications :
IF/IHC,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunoblotting,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry
USD :
409 USD
alt names :
Axonal membrane protein GAP-43, B-50, calmodulin-binding protein P-57, growth associated protein 43, Growth-associated protein 43, nerve growth-related peptide GAP43, Neural phosphoprotein B-50, neuromodulin, neuron growth-associated protein 43, PP46, protein F1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.