product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal FIH-1/HIF-1AN Antibody
catalog :
NBP1-30333B
quantity :
0.1 ml
price :
299.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
biotin
reactivity :
human
application :
western blot, immunohistochemistry, immunohistochemistry - paraffin section
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-30333B
Product Name :
Mouse Monoclonal FIH-1/HIF-1AN Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
DKFZp762F1811, EC 1.14.11.16, factor inhibiting HIF1, Factor inhibiting HIF-1, FIH1FIH-1, FLJ20615, FLJ22027, hypoxia inducible factor 1, alpha subunit inhibitor, hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase
Background :
Factor Inhibiting HIF1 (FIH) protein facilitates repression of HIF-1 transcriptional activity by binding to VHL, which acts as a transcriptional corepressor. VHL inhibits HIF-1 alpha transactivation function by recruiting histone deacetylases. Involvement of VHL in association with FIH provides a unifying mechanism for the modulation of HIF-1 alpha protein stabilization and transcriptional activation in response to changes in cellular oxygen concentration.
Buffer :
PBS
Clonality :
Monoclonal
Clone :
162c
Conjugate :
Biotin
Application Summary :
Western Blot, Immunohistochemistry, Immunohistochemistry-Paraffin
Host :
Mouse
Immunogen :
Full length human Factor Inhibiting HIF-1 protein [Swiss-Prot# Q9NWT6]
Isotype :
IgG1
Localization :
Nuclear
Preservative :
No Preservative
Purity :
Protein G purified
CrossReactivity :
Human
Storage :
Store at 4C in the dark.
Swissprot Human :
Q9NWT6
TMW :
40 kDa
Uses :
This Factor Inhibiting HIF-1 antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry paraffin embedded sections and Western blot analysis where a band can be seen at 40 kDa. Prior to immunostaining paraffin tissues, antigen retrieval with sodium citrate buffer (pH 6.0) is recommended.
Research Area :
Angiogenesis, Cancer, Chromatin Research, Hypoxia, Transcription Factors and Regulators
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.