FIH-1/HIF-1AN Antibody (162c) | Novus Biologicals NBP1-30333 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

FIH-1/HIF-1AN Antibody (162c)

catalog :

NBP1-30333

quantity :

0.1 ml (also 0.025 ml)

price :

379 USD

clonality :

monoclonal

host :

mouse

conjugate :

nonconjugated

clone name :

162c

reactivity :

human

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 18

Published Application/Species/Sample/Dilution	Reference
western blot; human	Wollenick K, Hu J, Kristiansen G, Schraml P, Rehrauer H, Berchner Pfannschmidt U, et al. Synthetic transactivation screening reveals ETV4 as broad coactivator of hypoxia-inducible factor signaling. Nucleic Acids Res. 2012;40:1928-43 pubmed publisher
western blot; human	Khan M, Bhattacharyya T, Andrikopoulos P, Esteban M, Barod R, Connor T, et al. Factor inhibiting HIF (FIH-1) promotes renal cancer cell survival by protecting cells from HIF-1?-mediated apoptosis. Br J Cancer. 2011;104:1151-9 pubmed publisher
immunohistochemistry - paraffin section; human	Yan M, Rayoo M, Takano E, Thorne H, Fox S. BRCA1 tumours correlate with a HIF-1alpha phenotype and have a poor prognosis through modulation of hydroxylase enzyme profile expression. Br J Cancer. 2009;101:1168-74 pubmed publisher
western blot; human	Cockman M, Lancaster D, Stolze I, Hewitson K, McDonough M, Coleman M, et al. Posttranslational hydroxylation of ankyrin repeats in IkappaB proteins by the hypoxia-inducible factor (HIF) asparaginyl hydroxylase, factor inhibiting HIF (FIH). Proc Natl Acad Sci U S A. 2006;103:14767-72 pubmed
immunohistochemistry - paraffin section; human	Soilleux E, Turley H, Tian Y, Pugh C, Gatter K, Harris A. Use of novel monoclonal antibodies to determine the expression and distribution of the hypoxia regulatory factors PHD-1, PHD-2, PHD-3 and FIH in normal and neoplastic human tissues. Histopathology. 2005;47:602-10 pubmed
immunocytochemistry; human western blot; human	Stolze I, Tian Y, Appelhoff R, Turley H, Wykoff C, Gleadle J, et al. Genetic analysis of the role of the asparaginyl hydroxylase factor inhibiting hypoxia-inducible factor (FIH) in regulating hypoxia-inducible factor (HIF) transcriptional target genes [corrected]. J Biol Chem. 2004;279:42719-25 pubmed
	Beel S, Kolloch L, Apken L, Jürgens L, Bolle A, Sudhof N, et al. κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis. Nat Commun. 2020;11:3409 pubmed publisher
	Krishnan A, Katsumi T, Guicciardi M, Azad A, Ozturk N, Trussoni C, et al. Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Receptor Deficiency Promotes the Ductular Reaction, Macrophage Accumulation, and Hepatic Fibrosis in the Abcb4-/- Mouse. Am J Pathol. 2020;190:1284-1297 pubmed publisher
	Pickel C, Günter J, Ruiz Serrano A, Spielmann P, Fabrizio J, Wolski W, et al. Oxygen-dependent bond formation with FIH regulates the activity of the client protein OTUB1. Redox Biol. 2019;26:101265 pubmed publisher
	Tam P, Yiu R, Lendahl U, Andersson E. Cholangiopathies - Towards a molecular understanding. EBioMedicine. 2018;35:381-393 pubmed publisher
	Ma M, Hua S, Li G, Wang S, Cheng X, He S, et al. Prolyl hydroxylase domain protein 3 and asparaginyl hydroxylase factor inhibiting HIF-1 levels are predictive of tumoral behavior and prognosis in hepatocellular carcinoma. Oncotarget. 2017;8:12983-13002 pubmed publisher
	Mysore V, Szablowski J, Dervan P, FROST P. A DNA-binding Molecule Targeting the Adaptive Hypoxic Response in Multiple Myeloma Has Potent Antitumor Activity. Mol Cancer Res. 2016;14:253-66 pubmed publisher
	Lu X, Zhou Y, Zhang L, Ji H, Li L, Shi Y, et al. Loss of Dicer1 impairs hepatocyte survival and leads to chronic inflammation and progenitor cell activation. World J Gastroenterol. 2015;21:6591-603 pubmed publisher
	Bird T, Lu W, Boulter L, Gordon Keylock S, Ridgway R, Williams M, et al. Bone marrow injection stimulates hepatic ductular reactions in the absence of injury via macrophage-mediated TWEAK signaling. Proc Natl Acad Sci U S A. 2013;110:6542-7 pubmed publisher
	Dorrell C, Erker L, Schug J, Kopp J, Canaday P, Fox A, et al. Prospective isolation of a bipotential clonogenic liver progenitor cell in adult mice. Genes Dev. 2011;25:1193-203 pubmed publisher
	Dorrell C, Grompe M, Pan F, Zhong Y, Canaday P, Shultz L, et al. Isolation of mouse pancreatic alpha, beta, duct and acinar populations with cell surface markers. Mol Cell Endocrinol. 2011;339:144-50 pubmed publisher
	Lu L, Li Y, Kim S, Bossuyt W, Liu P, Qiu Q, et al. Hippo signaling is a potent in vivo growth and tumor suppressor pathway in the mammalian liver. Proc Natl Acad Sci U S A. 2010;107:1437-42 pubmed publisher
	Dorrell C, Erker L, Lanxon Cookson K, Abraham S, Victoroff T, Ro S, et al. Surface markers for the murine oval cell response. Hepatology. 2008;48:1282-91 pubmed publisher

product information

brand :

Novus

master code :

NBP1-30333

SKU :

NBP1-30333

product name :

FIH-1/HIF-1AN Antibody (162c)

description :

The FIH-1/HIF-1AN Antibody (162c) from Novus Biologicals is a mouse monoclonal antibody to FIH-1/HIF-1AN. This antibody reacts with human. The FIH-1/HIF-1AN Antibody (162c) has been validated for the following applications: Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin.

target :

FIH-1/HIF-1AN

category :

Primary Antibodies

sizes available :

0.1 ml (also 0.025 ml)

buffer :

Tris-Glycine and 0.15M NaCl

clonality :

Monoclonal

clone :

162c

concentration :

1 mg/ml

conjugate :

Unconjugated

host :

Mouse

immunogen :

Full length human Factor Inhibiting HIF-1 protein [Swiss-Prot# Q9NWT6]

isotype :

IgG1

purity :

Protein G purified

species :

Human

theoretical molecular weight :

40 kDa

gene symbol :

HIF1AN

accessionNumbers :

Q9NWT6

applications :

Western Blot, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunohistochemistry-Paraffin

USD :

356

USD 2023 :

379 USD

alt names :

DKFZp762F1811, EC 1.14.11.16, factor inhibiting HIF1, Factor inhibiting HIF-1, FIH1FIH-1, FLJ20615, FLJ22027, hypoxia inducible factor 1, alpha subunit inhibitor, hypoxia-inducible factor 1-alpha inhibitor, Hypoxia-inducible factor asparagine hydroxylase, peptide-aspartate beta-dioxygenase

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage