Lgr5/GPR49 Antibody - BSA Free | Novus Biologicals NBP1-28904 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Lgr5/GPR49 Antibody - BSA Free

catalog :

NBP1-28904

quantity :

0.1 ml (also 0.025 ml)

price :

479 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

clone name :

2G10

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

more info or order :

Novus Biologicals product webpage

citations: 28

Reference
Yen L, Nelli R, Twu N, Mora D xed az J, Castillo G, Sitthicharoenchai P, et al. Development and characterization of segment-specific enteroids from the pig small intestine in Matrigel and transwell inserts: insights into susceptibility to porcine epidemic diarrhea Virus. Front Immunol. 2024;15:1451154 pubmed publisher
Zhang R, Zhang X, Zhang W, Cui W, Xiao Y, Liu L, et al. Sohlh2 Regulates the Stemness and Differentiation of Colon Cancer Stem Cells by Downregulating LncRNA-H19 Transcription. Mol Cancer Res. 2023;21:115-126 pubmed publisher
Zhang R, Liu L, Wang F, Zhao W, Liu K, Yu H, et al. AKAP8L enhances the stemness and chemoresistance of gastric cancer cells by stabilizing SCD1 mRNA. Cell Death Dis. 2022;13:1041 pubmed publisher
Lee J, Kim J, Cho H, Jo S, Jang Y. JIB-04, a Pan-Inhibitor of Histone Demethylases, Targets Histone-Lysine-Demethylase-Dependent AKT Pathway, Leading to Cell Cycle Arrest and Inhibition of Cancer Stem-Like Cell Properties in Hepatocellular Carcinoma Cells. Int J Mol Sci. 2022;23: pubmed publisher
Akbari S, Kunter I, Azbazdar Y, Ozhan G, Atabey N, Firtina Karagonlar Z, et al. LGR5/R-Spo1/Wnt3a axis promotes stemness and aggressive phenotype in hepatoblast-like hepatocellular carcinoma cell lines. Cell Signal. 2021;82:109972 pubmed publisher
Di W, Lv Y, Xia F, Sheng Y, Liu J, Ding G. Improvement of intestinal stem cells and barrier function via energy restriction in middle-aged C57BL/6 mice. Nutr Res. 2020;81:47-57 pubmed publisher
von Erlach T, Saxton S, Shi Y, Minahan D, Reker D, Javid F, et al. Robotically handled whole-tissue culture system for the screening of oral drug formulations. Nat Biomed Eng. 2020;4:544-559 pubmed publisher
Khanna A, Thoms J, Stringer B, Chung S, Ensbey K, Jue T, et al. Constitutive CHK1 Expression Drives a pSTAT3-CIP2A Circuit that Promotes Glioblastoma Cell Survival and Growth. Mol Cancer Res. 2020;18:709-722 pubmed publisher
Xie Y, Ding F, Di W, Lv Y, Xia F, Sheng Y, et al. Impact of a high‑fat diet on intestinal stem cells and epithelial barrier function in middle‑aged female mice. Mol Med Rep. 2020;21:1133-1144 pubmed publisher
Endicott S, Boynton D, Beckmann L, Miller R. Long-lived mice with reduced growth hormone signaling have a constitutive upregulation of hepatic chaperone-mediated autophagy. Autophagy. 2020;:1-14 pubmed publisher
Li W, Zhang H, Yang L, Wang Y. Cancerous inhibitor of protein phosphatase 2A regulates cisplatin resistance in ovarian cancer. Oncol Lett. 2019;17:1211-1216 pubmed publisher
Liu C, Hsu C, Huang T, Lee C, Chen J, Yang S, et al. ER stress-related ATF6 upregulates CIP2A and contributes to poor prognosis of colon cancer. Mol Oncol. 2018;12:1706-1717 pubmed publisher
Kim M, Cho H, Yoon H, Ahn Y, Park E, Jin Y, et al. JIB-04, A Small Molecule Histone Demethylase Inhibitor, Selectively Targets Colorectal Cancer Stem Cells by Inhibiting the Wnt/β-Catenin Signaling Pathway. Sci Rep. 2018;8:6611 pubmed publisher
Zhao S, Gao X, Zang S, Li Y, Feng X, Yuan X. MicroRNA-383-5p acts as a prognostic marker and inhibitor of cell proliferation in lung adenocarcinoma by cancerous inhibitor of protein phosphatase 2A. Oncol Lett. 2017;14:3573-3579 pubmed publisher
Wang X, Gao P, Wang M, Liu J, Lin J, Zhang S, et al. Feedback between E2F1 and CIP2A regulated by human papillomavirus E7 in cervical cancer: implications for prognosis. Am J Transl Res. 2017;9:2327-2339 pubmed
Cervelló I, Gil Sanchis C, Santamaria X, Faus A, Vallvé Juanico J, Díaz Gimeno P, et al. Leucine-rich repeat-containing G-protein-coupled receptor 5-positive cells in the endometrial stem cell niche. Fertil Steril. 2017;107:510-519.e3 pubmed publisher
Khanna A, Rane J, Kivinummi K, Urbanucci A, Helenius M, Tolonen T, et al. CIP2A is a candidate therapeutic target in clinically challenging prostate cancer cell populations. Oncotarget. 2015;6:19661-70 pubmed
Shaikh L, Zhou J, Teo A, Garg S, Neogi S, Figg N, et al. LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. J Clin Endocrinol Metab. 2015;100:E836-44 pubmed publisher
Jung K, Saif L. Porcine epidemic diarrhea virus infection: Etiology, epidemiology, pathogenesis and immunoprophylaxis. Vet J. 2015;204:134-43 pubmed publisher
Chao T, Wang C, Chen Y, Lai C, Chang F, Tsai Y, et al. Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A. Oncotarget. 2015;6:2164-79 pubmed
Jung H, Phillips B, Chan E. miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3?. Mol Cancer. 2014;13:80 pubmed publisher
Zhai M, Cong L, Han Y, Tu G. CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion. Tumour Biol. 2014;35:1123-8 pubmed publisher
Jung H, Patel R, Phillips B, Wang H, Cohen D, Reinhold W, et al. Tumor suppressor miR-375 regulates MYC expression via repression of CIP2A coding sequence through multiple miRNA-mRNA interactions. Mol Biol Cell. 2013;24:1638-48, S1-7 pubmed publisher
Lee J, Jeong H, Park E, Hwang J, Huang B, Bae E, et al. CIP2A facilitates apoptotic resistance of fibroblast-like synoviocytes in rheumatoid arthritis independent of c-Myc expression. Rheumatol Int. 2013;33:2241-8 pubmed publisher
Ma L, Wen Z, Liu Z, Hu Z, Ma J, Chen X, et al. Overexpression and small molecule-triggered downregulation of CIP2A in lung cancer. PLoS ONE. 2011;6:e20159 pubmed publisher
Lee J, Park E, Hwang J, Oh J, Kim H, Bae E, et al. CIP2A expression is associated with synovial hyperplasia and invasive function of fibroblast-like synoviocytes in rheumatoid arthritis. Rheumatol Int. 2012;32:2023-30 pubmed publisher
Wang J, Li W, Li L, Yu X, Jia J, Chen C. CIP2A is over-expressed in acute myeloid leukaemia and associated with HL60 cells proliferation and differentiation. Int J Lab Hematol. 2011;33:290-8 pubmed publisher
Li W, Ge Z, Liu C, Liu Z, Bjorkholm M, Jia J, et al. CIP2A is overexpressed in gastric cancer and its depletion leads to impaired clonogenicity, senescence, or differentiation of tumor cells. Clin Cancer Res. 2008;14:3722-8 pubmed publisher

product information

master code :

NBP1-28904

SKU :

NBP1-28904

product name :

Lgr5/GPR49 Antibody - BSA Free

unit size :

0.1 ml (also 0.025 ml)

description :

The Lgr5/GPR49 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Lgr5/GPR49. This antibody reacts with human,mouse,porcine. The Lgr5/GPR49 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence.

target :

Lgr5/GPR49

category :

Primary Antibodies

buffer :

PBS

clonality :

Polyclonal

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Synthetic peptide made to an internal portion of the human GPR49/LGR5 protein (within residues 650-700). [Swiss-Prot: O75473]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse,Porcine

gene symbol :

LGR5

accessionNumbers :

O75473

applications :

Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry,Immunocytochemistry/ Immunofluorescence

USD :

479 USD

alt names :

FEX, G protein-coupled receptor 49, GPR49G-protein coupled receptor HG38, GPR67, G-protein coupled receptor 49, G-protein coupled receptor 67, GRP49, HG38, leucine-rich repeat containing G protein-coupled receptor 5, leucine-rich repeat-containing G protein-coupled receptor 5, leucine-rich repeat-containing G-protein coupled receptor 5, MGC117008, orphan G protein-coupled receptor HG38

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

more info or order :

Novus Biologicals product webpage