product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal SCD Antibody
catalog :
NBP1-26393F
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-26393F
Product Name :
Rabbit Polyclonal SCD Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
delta(9)-desaturase, Delta(9)-desaturase, Delta-9 desaturase, delta-9-desaturase, EC 1.14.19.1, FADS5, Fatty acid desaturase, MSTP008, predicted protein of HQ0998, SCD1, SCDOS, Stearoyl-CoA desaturase, stearoyl-CoA desaturase (delta-9-desaturase), stearoyl-CoA desaturase opposite strand, acyl-CoA desaturase
Background :
SCD (stearoyl-CoA desaturase, or SCD1) is the terminal component of liver microsomal stearyl-CoA desaturase system, that utilizes O2 and electrons from reduced cytochrome b5 to catalyze the insertion of a double bond into a range of fatty acyl-CoA substrates including palmitoyl-CoA and stearoyl-CoA (de novo synthesis of monounsaturated fats from saturated fatty acids). SCD1 promoter region is bound by a wide array of transcription factors, including SREBP-1 and PPAR-alpha and the expression of SREBP-1 as well as SCD1 is upregulated by PI3K/mTOR signaling. Moreover, SCD1 transcription is hormonally upregulated by insulin and growth factors, but inhibited by estrogen and leptin. Oleate (an 18:1 fatty acid) is the major monounsaturated fatty acid of membrane phospholipids, triglycerides, cholesteryl esters, wax esters and alkyl-1,2-diacylglycerol. The ratio of unsaturated to saturated fatty acids is one of the factors influencing membrane fluidity; its alteration is important in a number of diseases, such as cancer, diabetes, obesity, and neurological, vascular and heart disease. This ratio, referred to as Desaturation Index, can be analyzed for multiple fatty acids in plasma and represents a potential biomarker of SCD inhibition.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
Synthetic peptide made to an internal portion of human SCD (within residues 50-100). [Swiss-Prot# O00767]
Localization :
endoplasmic reticulum membrane.
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human
Storage :
Store at 4C in the dark.
Swissprot Human :
O00767
TMW :
41 kDa
Uses :
This SCD antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~41 kDa.
Research Area :
Cancer, Diabetes Research, Lipid and Metabolism, Signal Transduction, Stem Cell Markers
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.