product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
RPA2 [p Ser4, p Ser8] Antibody - BSA Free
catalog :
NBP1-23017
quantity :
100 ul
price :
529 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
H1beta234
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 113
Published Application/Species/Sample/DilutionReference
  • western blot; human; fig 2
Sakurikar N, Thompson R, Montano R, Eastman A. A subset of cancer cell lines is acutely sensitive to the Chk1 inhibitor MK-8776 as monotherapy due to CDK2 activation in S phase. Oncotarget. 2016;7:1380-94 pubmed publisher
Elfar G, Aning O, Ngai T, Yeo P, Chan J, Sim S, et al. p53-dependent crosstalk between DNA replication integrity and redox metabolism mediated through a NRF2-PARP1 axis. Nucleic Acids Res. 2024;52:12351-12377 pubmed publisher
Chen L, Gai X, Yu X. Pre-rRNA facilitates the recruitment of RAD51AP1 to DNA double-strand breaks. J Biol Chem. 2024;300:107115 pubmed publisher
Zhang S, Zhao Y, Wang X, Qi C, Tian J, Zou Z. Synergistic lethality between auranofin-induced oxidative DNA damage and ATR inhibition in cancer cells. Life Sci. 2023;332:122131 pubmed publisher
Gao Y, Guitton Sert L, Dessapt J, Coulombe Y, Rodrigue A, Milano L, et al. A CRISPR-Cas9 screen identifies EXO1 as a formaldehyde resistance gene. Nat Commun. 2023;14:381 pubmed publisher
Liao C, Talluri S, Zhao J, Mu S, Kumar S, Shi J, et al. RAD51 Is Implicated in DNA Damage, Chemoresistance and Immune Dysregulation in Solid Tumors. Cancers (Basel). 2022;14: pubmed publisher
de Krijger I, Föhr B, Pérez S, Vincendeau E, Serrat J, Thouin A, et al. MAD2L2 dimerization and TRIP13 control shieldin activity in DNA repair. Nat Commun. 2021;12:5421 pubmed publisher
Niu J, Wang J, Zhang Q, Zou Z, Ding Y. Cinobufagin-induced DNA damage response activates G2/M checkpoint and apoptosis to cause selective cytotoxicity in cancer cells. Cancer Cell Int. 2021;21:446 pubmed publisher
Kumar S, Buon L, Talluri S, Roncador M, Liao C, Zhao J, et al. Integrated genomics and comprehensive validation reveal drivers of genomic evolution in esophageal adenocarcinoma. Commun Biol. 2021;4:617 pubmed publisher
Venkatesan S, Angelova M, Puttick C, Zhai H, Caswell D, Lu W, et al. Induction of APOBEC3 exacerbates DNA replication stress and chromosomal instability in early breast and lung cancer evolution. Cancer Discov. 2021;: pubmed publisher
Shinoda K, Zong D, Callen E, Wu W, Dumitrache L, Belinky F, et al. The dystonia gene THAP1 controls DNA double-strand break repair choice. Mol Cell. 2021;81:2611-2624.e10 pubmed publisher
Li H, Ma L, Bian X, Lv Y, Lin W. FK228 sensitizes radioresistant small cell lung cancer cells to radiation. Clin Epigenetics. 2021;13:41 pubmed publisher
Bian X, Wang X, Zhang Q, Ma L, Cao G, Xu A, et al. The MYC Paralog-PARP1 Axis as a Potential Therapeutic Target in MYC Paralog-Activated Small Cell Lung Cancer. Front Oncol. 2020;10:565820 pubmed publisher
Samanta D, Huang T, Shah R, Yang Y, Pan F, Semenza G. BIRC2 Expression Impairs Anti-Cancer Immunity and Immunotherapy Efficacy. Cell Rep. 2020;32:108073 pubmed publisher
D Anna F, Van Dyck L, Xiong J, Zhao H, Berrens R, Qian J, et al. DNA methylation repels binding of hypoxia-inducible transcription factors to maintain tumor immunotolerance. Genome Biol. 2020;21:182 pubmed publisher
Merchut Maya J, Maya Mendoza A, Fornara O, Rahbar A, Bröchner C, Sehested A, et al. Cancer cell stemness, responses to experimental genotoxic treatments, cytomegalovirus protein expression and DNA replication stress in pediatric medulloblastomas. Cell Cycle. 2020;19:727-741 pubmed publisher
Wang H, Zhang S, Song L, Qu M, Zou Z. Synergistic lethality between PARP-trapping and alantolactone-induced oxidative DNA damage in homologous recombination-proficient cancer cells. Oncogene. 2020;39:2905-2920 pubmed publisher
Fagan Solis K, Simpson D, Kumar R, Martelotto L, Mose L, Rashid N, et al. A P53-Independent DNA Damage Response Suppresses Oncogenic Proliferation and Genome Instability. Cell Rep. 2020;30:1385-1399.e7 pubmed publisher
Olcina M, Balanis N, Kim R, Aksoy B, Kodysh J, Thompson M, et al. Mutations in an Innate Immunity Pathway Are Associated with Poor Overall Survival Outcomes and Hypoxic Signaling in Cancer. Cell Rep. 2018;25:3721-3732.e6 pubmed publisher
Warren N, Eastman A. Inhibition of checkpoint kinase 1 following gemcitabine-mediated S phase arrest results in CDC7- and CDK2-dependent replication catastrophe. J Biol Chem. 2019;294:1763-1778 pubmed publisher
Samanta D, Park Y, Ni X, Li H, Zahnow C, Gabrielson E, et al. Chemotherapy induces enrichment of CD47+/CD73+/PDL1+ immune evasive triple-negative breast cancer cells. Proc Natl Acad Sci U S A. 2018;115:E1239-E1248 pubmed publisher
Simonetta M, de Krijger I, Serrat J, Moatti N, Fortunato D, Hoekman L, et al. H4K20me2 distinguishes pre-replicative from post-replicative chromatin to appropriately direct DNA repair pathway choice by 53BP1-RIF1-MAD2L2. Cell Cycle. 2017;:1-29 pubmed publisher
Lu H, Chen I, Shimoda L, Park Y, Zhang C, Tran L, et al. Chemotherapy-Induced Ca2+ Release Stimulates Breast Cancer Stem Cell Enrichment. Cell Rep. 2017;18:1946-1957 pubmed publisher
Ju J, Godet I, Ye I, Byun J, Jayatilaka H, Lee S, et al. Hypoxia Selectively Enhances Integrin ?5?1 Receptor Expression in Breast Cancer to Promote Metastasis. Mol Cancer Res. 2017;15:723-734 pubmed publisher
Qu J, Sun W, Zhong J, Lv H, Zhu M, Xu J, et al. Phosphoglycerate mutase 1 regulates dNTP pool and promotes homologous recombination repair in cancer cells. J Cell Biol. 2017;216:409-424 pubmed publisher
Murakami A, Wang L, Kalhorn S, Schraml P, Rathmell W, Tan A, et al. Context-dependent role for chromatin remodeling component PBRM1/BAF180 in clear cell renal cell carcinoma. Oncogenesis. 2017;6:e287 pubmed publisher
Taylor S, Bagnall J, Mason D, Levy R, Fernig D, See V. Differential sub-nuclear distribution of hypoxia-inducible factors (HIF)-1 and -2 alpha impacts on their stability and mobility. Open Biol. 2016;6: pubmed
Thienpont B, Steinbacher J, Zhao H, D Anna F, Kuchnio A, Ploumakis A, et al. Tumour hypoxia causes DNA hypermethylation by reducing TET activity. Nature. 2016;537:63-68 pubmed publisher
Li S, Heller J, Bostick J, Lee A, Schjerven H, Kastner P, et al. Ikaros Inhibits Group 3 Innate Lymphoid Cell Development and Function by Suppressing the Aryl Hydrocarbon Receptor Pathway. Immunity. 2016;45:185-97 pubmed publisher
Luo W, Chen I, Chen Y, Alkam D, Wang Y, Semenza G. PRDX2 and PRDX4 are negative regulators of hypoxia-inducible factors under conditions of prolonged hypoxia. Oncotarget. 2016;7:6379-97 pubmed publisher
Altuntas S, Rossin F, Marsella C, D Eletto M, Diaz Hidalgo L, Farrace M, et al. The transglutaminase type 2 and pyruvate kinase isoenzyme M2 interplay in autophagy regulation. Oncotarget. 2015;6:44941-54 pubmed publisher
Frey J, Stonko D, Faugere M, Riddle R. Hypoxia-inducible factor-1α restricts the anabolic actions of parathyroid hormone. Bone Res. 2014;2:14005 pubmed publisher
Xiang L, Gilkes D, Hu H, Luo W, Bullen J, Liang H, et al. HIF-1α and TAZ serve as reciprocal co-activators in human breast cancer cells. Oncotarget. 2015;6:11768-78 pubmed
Xiang L, Gilkes D, Hu H, Takano N, Luo W, Lu H, et al. Hypoxia-inducible factor 1 mediates TAZ expression and nuclear localization to induce the breast cancer stem cell phenotype. Oncotarget. 2014;5:12509-27 pubmed
Kim K, Kim D, Park J, Jung H, Cho Y, Kim H, et al. NNC 55-0396, a T-type Ca2+ channel inhibitor, inhibits angiogenesis via suppression of hypoxia-inducible factor-1α signal transduction. J Mol Med (Berl). 2015;93:499-509 pubmed publisher
Su E, Xin H, Yin P, Dyson M, Coon J, Farrow K, et al. Impaired fetoplacental angiogenesis in growth-restricted fetuses with abnormal umbilical artery doppler velocimetry is mediated by aryl hydrocarbon receptor nuclear translocator (ARNT). J Clin Endocrinol Metab. 2015;100:E30-40 pubmed publisher
Hu H, Takano N, Xiang L, Gilkes D, Luo W, Semenza G. Hypoxia-inducible factors enhance glutamate signaling in cancer cells. Oncotarget. 2014;5:8853-68 pubmed
Rossin F, D Eletto M, Falasca L, Sepe S, Cocco S, Fimia G, et al. Transglutaminase 2 ablation leads to mitophagy impairment associated with a metabolic shift towards aerobic glycolysis. Cell Death Differ. 2015;22:408-18 pubmed publisher
Peng Y, Yuan G, Khan S, Nanduri J, Makarenko V, Reddy V, et al. Regulation of hypoxia-inducible factor-? isoforms and redox state by carotid body neural activity in rats. J Physiol. 2014;592:3841-58 pubmed publisher
Wang T, Gilkes D, Takano N, Xiang L, Luo W, Bishop C, et al. Hypoxia-inducible factors and RAB22A mediate formation of microvesicles that stimulate breast cancer invasion and metastasis. Proc Natl Acad Sci U S A. 2014;111:E3234-42 pubmed publisher
Chaturvedi P, Gilkes D, Takano N, Semenza G. Hypoxia-inducible factor-dependent signaling between triple-negative breast cancer cells and mesenchymal stem cells promotes macrophage recruitment. Proc Natl Acad Sci U S A. 2014;111:E2120-9 pubmed publisher
Zhang J, Ma W. Nerve growth factor regulates the expression of vascular endothelial growth factor in human HaCaT keratinocytes via PI3K/mTOR pathway. Genet Mol Res. 2014;13:9324-35 pubmed publisher
Sena J, Wang L, Pawlus M, Hu C. HIFs enhance the transcriptional activation and splicing of adrenomedullin. Mol Cancer Res. 2014;12:728-41 pubmed publisher
Suzuki K, Nishi K, Takabuchi S, Kai S, Matsuyama T, Kurosawa S, et al. Differential roles of prostaglandin E-type receptors in activation of hypoxia-inducible factor 1 by prostaglandin E1 in vascular-derived cells under non-hypoxic conditions. Peerj. 2013;1:e220 pubmed publisher
Takano N, Peng Y, Kumar G, Luo W, Hu H, Shimoda L, et al. Hypoxia-inducible factors regulate human and rat cystathionine ?-synthase gene expression. Biochem J. 2014;458:203-11 pubmed publisher
Gilkes D, Xiang L, Lee S, Chaturvedi P, Hubbi M, Wirtz D, et al. Hypoxia-inducible factors mediate coordinated RhoA-ROCK1 expression and signaling in breast cancer cells. Proc Natl Acad Sci U S A. 2014;111:E384-93 pubmed publisher
Xiang L, Gilkes D, Chaturvedi P, Luo W, Hu H, Takano N, et al. Ganetespib blocks HIF-1 activity and inhibits tumor growth, vascularization, stem cell maintenance, invasion, and metastasis in orthotopic mouse models of triple-negative breast cancer. J Mol Med (Berl). 2014;92:151-64 pubmed publisher
Cai Z, Luo W, Zhan H, Semenza G. Hypoxia-inducible factor 1 is required for remote ischemic preconditioning of the heart. Proc Natl Acad Sci U S A. 2013;110:17462-7 pubmed publisher
Sena J, Wang L, Hu C. BRG1 and BRM chromatin-remodeling complexes regulate the hypoxia response by acting as coactivators for a subset of hypoxia-inducible transcription factor target genes. Mol Cell Biol. 2013;33:3849-63 pubmed publisher
Yuan G, Peng Y, Reddy V, Makarenko V, Nanduri J, Khan S, et al. Mutual antagonism between hypoxia-inducible factors 1? and 2? regulates oxygen sensing and cardio-respiratory homeostasis. Proc Natl Acad Sci U S A. 2013;110:E1788-96 pubmed publisher
Pawlus M, Wang L, Hu C. STAT3 and HIF1? cooperatively activate HIF1 target genes in MDA-MB-231 and RCC4 cells. Oncogene. 2014;33:1670-9 pubmed publisher
Balamurugan K, Sharan S, Klarmann K, Zhang Y, Coppola V, Summers G, et al. FBXW7α attenuates inflammatory signalling by downregulating C/EBPδ and its target gene Tlr4. Nat Commun. 2013;4:1662 pubmed publisher
Storti P, Bolzoni M, Donofrio G, Airoldi I, Guasco D, Toscani D, et al. Hypoxia-inducible factor (HIF)-1? suppression in myeloma cells blocks tumoral growth in vivo inhibiting angiogenesis and bone destruction. Leukemia. 2013;27:1697-706 pubmed publisher
Chaturvedi P, Gilkes D, Wong C, Luo W, Zhang H, Wei H, et al. Hypoxia-inducible factor-dependent breast cancer-mesenchymal stem cell bidirectional signaling promotes metastasis. J Clin Invest. 2013;123:189-205 pubmed publisher
Luo W, Chang R, Zhong J, Pandey A, Semenza G. Histone demethylase JMJD2C is a coactivator for hypoxia-inducible factor 1 that is required for breast cancer progression. Proc Natl Acad Sci U S A. 2012;109:E3367-76 pubmed publisher
Autheman D, Sheldon R, Chaudhuri N, von Arx S, Siegenthaler C, Ferriero D, et al. Glutathione peroxidase overexpression causes aberrant ERK activation in neonatal mouse cortex after hypoxic preconditioning. Pediatr Res. 2012;72:568-75 pubmed publisher
Pawlus M, Wang L, Ware K, Hu C. Upstream stimulatory factor 2 and hypoxia-inducible factor 2? (HIF2?) cooperatively activate HIF2 target genes during hypoxia. Mol Cell Biol. 2012;32:4595-610 pubmed publisher
Krishnamachary B, Penet M, Nimmagadda S, Mironchik Y, Raman V, Solaiyappan M, et al. Hypoxia regulates CD44 and its variant isoforms through HIF-1? in triple negative breast cancer. PLoS ONE. 2012;7:e44078 pubmed publisher
Chiabrando D, Fiorito V, Marro S, Silengo L, Altruda F, Tolosano E. Cell-specific regulation of Ferroportin transcription following experimentally-induced acute anemia in mice. Blood Cells Mol Dis. 2013;50:25-30 pubmed publisher
Zhang D, Li J, Zhang M, Gao G, Zuo Z, Yu Y, et al. The requirement of c-Jun N-terminal kinase 2 in regulation of hypoxia-inducing factor-1? mRNA stability. J Biol Chem. 2012;287:34361-71 pubmed publisher
Singh A, Mukhopadhyay C, Biswas S, Singh V, Mukhopadhyay C. Intracellular pathogen Leishmania donovani activates hypoxia inducible factor-1 by dual mechanism for survival advantage within macrophage. PLoS ONE. 2012;7:e38489 pubmed publisher
Uniacke J, Holterman C, Lachance G, Franovic A, Jacob M, Fabian M, et al. An oxygen-regulated switch in the protein synthesis machinery. Nature. 2012;486:126-9 pubmed publisher
Kaira K, Nakagawa K, Ohde Y, Okumura T, Takahashi T, Murakami H, et al. Depolarized MUC1 expression is closely associated with hypoxic markers and poor outcome in resected non-small cell lung cancer. Int J Surg Pathol. 2012;20:223-32 pubmed publisher
Zhou L, Yang H. The von Hippel-Lindau tumor suppressor protein promotes c-Cbl-independent poly-ubiquitylation and degradation of the activated EGFR. PLoS ONE. 2011;6:e23936 pubmed publisher
Wong C, Gilkes D, Zhang H, Chen J, Wei H, Chaturvedi P, et al. Hypoxia-inducible factor 1 is a master regulator of breast cancer metastatic niche formation. Proc Natl Acad Sci U S A. 2011;108:16369-74 pubmed publisher
Luo W, Hu H, Chang R, Zhong J, Knabel M, O Meally R, et al. Pyruvate kinase M2 is a PHD3-stimulated coactivator for hypoxia-inducible factor 1. Cell. 2011;145:732-44 pubmed publisher
Lin Q, Cong X, Yun Z. Differential hypoxic regulation of hypoxia-inducible factors 1alpha and 2alpha. Mol Cancer Res. 2011;9:757-65 pubmed publisher
Tamama K, Kawasaki H, Kerpedjieva S, Guan J, Ganju R, Sen C. Differential roles of hypoxia inducible factor subunits in multipotential stromal cells under hypoxic condition. J Cell Biochem. 2011;112:804-17 pubmed publisher
Peng Y, Nanduri J, Khan S, Yuan G, Wang N, Kinsman B, et al. Hypoxia-inducible factor 2? (HIF-2?) heterozygous-null mice exhibit exaggerated carotid body sensitivity to hypoxia, breathing instability, and hypertension. Proc Natl Acad Sci U S A. 2011;108:3065-70 pubmed publisher
Lunde I, Anton S, Bruusgaard J, Rana Z, Ellefsen S, Gundersen K. Hypoxia inducible factor 1 links fast-patterned muscle activity and fast muscle phenotype in rats. J Physiol. 2011;589:1443-54 pubmed publisher
Terzuoli E, Puppo M, Rapisarda A, Uranchimeg B, Cao L, Burger A, et al. Aminoflavone, a ligand of the aryl hydrocarbon receptor, inhibits HIF-1alpha expression in an AhR-independent fashion. Cancer Res. 2010;70:6837-48 pubmed publisher
Amir S, Wang R, Simons J, Mabjeesh N. SEPT9_v1 up-regulates hypoxia-inducible factor 1 by preventing its RACK1-mediated degradation. J Biol Chem. 2009;284:11142-51 pubmed publisher
Kransler K, McGarrigle B, Swartz D, Olson J. Lung development in the Holtzman rat is adversely affected by gestational exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Toxicol Sci. 2009;107:498-511 pubmed publisher
Lysiak J, Kirby J, Tremblay J, Woodson R, Reardon M, Palmer L, et al. Hypoxia-inducible factor-1alpha is constitutively expressed in murine Leydig cells and regulates 3beta-hydroxysteroid dehydrogenase type 1 promoter activity. J Androl. 2009;30:146-56 pubmed publisher
Aminova L, Siddiq A, Ratan R. Antioxidants, HIF prolyl hydroxylase inhibitors or short interfering RNAs to BNIP3 or PUMA, can prevent prodeath effects of the transcriptional activator, HIF-1alpha, in a mouse hippocampal neuronal line. Antioxid Redox Signal. 2008;10:1989-98 pubmed publisher
Puppo M, Battaglia F, Ottaviano C, Delfino S, Ribatti D, Varesio L, et al. Topotecan inhibits vascular endothelial growth factor production and angiogenic activity induced by hypoxia in human neuroblastoma by targeting hypoxia-inducible factor-1alpha and -2alpha. Mol Cancer Ther. 2008;7:1974-84 pubmed publisher
Lauzier M, Robitaille G, Chan D, Giaccia A, Richard D. (2R)-[(4-Biphenylylsulfonyl)amino]-N-hydroxy-3-phenylpropionamide (BiPS), a matrix metalloprotease inhibitor, is a novel and potent activator of hypoxia-inducible factors. Mol Pharmacol. 2008;74:282-8 pubmed publisher
Engebretsen B, Irwin D, Valdez M, O Donovan M, Tucker A, van Patot M. Acute hypobaric hypoxia (5486 m) induces greater pulmonary HIF-1 activation in hilltop compared to madison rats. High Alt Med Biol. 2007;8:312-21 pubmed
Baek J, Liu Y, McDonald K, Wesley J, Zhang H, Semenza G. Spermidine/spermine N(1)-acetyltransferase-1 binds to hypoxia-inducible factor-1alpha (HIF-1alpha) and RACK1 and promotes ubiquitination and degradation of HIF-1alpha. J Biol Chem. 2007;282:33358-66 pubmed
Cheng G, Shao Z, Chaudhari B, Agrawal D. Involvement of chloride channels in TGF-beta1-induced apoptosis of human bronchial epithelial cells. Am J Physiol Lung Cell Mol Physiol. 2007;293:L1339-47 pubmed
Hu C, Sataur A, Wang L, Chen H, Simon M. The N-terminal transactivation domain confers target gene specificity of hypoxia-inducible factors HIF-1alpha and HIF-2alpha. Mol Biol Cell. 2007;18:4528-42 pubmed
Baek J, Liu Y, McDonald K, Wesley J, Hubbi M, Byun H, et al. Spermidine/spermine-N1-acetyltransferase 2 is an essential component of the ubiquitin ligase complex that regulates hypoxia-inducible factor 1alpha. J Biol Chem. 2007;282:23572-80 pubmed
Zhang H, Gao P, Fukuda R, Kumar G, Krishnamachary B, Zeller K, et al. HIF-1 inhibits mitochondrial biogenesis and cellular respiration in VHL-deficient renal cell carcinoma by repression of C-MYC activity. Cancer Cell. 2007;11:407-20 pubmed
Shimojo N, Jesmin S, Zaedi S, Otsuki T, Maeda S, Yamaguchi N, et al. Contributory role of VEGF overexpression in endothelin-1-induced cardiomyocyte hypertrophy. Am J Physiol Heart Circ Physiol. 2007;293:H474-81 pubmed
Asikainen T, Chang L, Coalson J, Schneider B, Waleh N, Ikegami M, et al. Improved lung growth and function through hypoxia-inducible factor in primate chronic lung disease of prematurity. FASEB J. 2006;20:1698-700 pubmed
Slomiany M, Rosenzweig S. Hypoxia-inducible factor-1-dependent and -independent regulation of insulin-like growth factor-1-stimulated vascular endothelial growth factor secretion. J Pharmacol Exp Ther. 2006;318:666-75 pubmed
Nakamura K, Martin K, Jackson J, Beppu K, Woo C, Thiele C. Brain-derived neurotrophic factor activation of TrkB induces vascular endothelial growth factor expression via hypoxia-inducible factor-1alpha in neuroblastoma cells. Cancer Res. 2006;66:4249-55 pubmed
Hu C, Iyer S, Sataur A, Covello K, Chodosh L, Simon M. Differential regulation of the transcriptional activities of hypoxia-inducible factor 1 alpha (HIF-1alpha) and HIF-2alpha in stem cells. Mol Cell Biol. 2006;26:3514-26 pubmed
Okuyama H, Krishnamachary B, Zhou Y, Nagasawa H, Bosch Marce M, Semenza G. Expression of vascular endothelial growth factor receptor 1 in bone marrow-derived mesenchymal cells is dependent on hypoxia-inducible factor 1. J Biol Chem. 2006;281:15554-63 pubmed
Hui A, Bauer A, Striet J, Schnell P, Czyzyk Krzeska M. Calcium signaling stimulates translation of HIF-alpha during hypoxia. FASEB J. 2006;20:466-75 pubmed
Oda T, Hirota K, Nishi K, Takabuchi S, Oda S, Yamada H, et al. Activation of hypoxia-inducible factor 1 during macrophage differentiation. Am J Physiol Cell Physiol. 2006;291:C104-13 pubmed
Amir S, Wang R, Matzkin H, Simons J, Mabjeesh N. MSF-A interacts with hypoxia-inducible factor-1alpha and augments hypoxia-inducible factor transcriptional activation to affect tumorigenicity and angiogenesis. Cancer Res. 2006;66:856-66 pubmed
Schultz K, Fanburg B, Beasley D. Hypoxia and hypoxia-inducible factor-1alpha promote growth factor-induced proliferation of human vascular smooth muscle cells. Am J Physiol Heart Circ Physiol. 2006;290:H2528-34 pubmed
Hirota K, Fukuda R, Takabuchi S, Kizaka Kondoh S, Adachi T, Fukuda K, et al. Induction of hypoxia-inducible factor 1 activity by muscarinic acetylcholine receptor signaling. J Biol Chem. 2004;279:41521-8 pubmed
Slomiany M, Rosenzweig S. IGF-1-induced VEGF and IGFBP-3 secretion correlates with increased HIF-1 alpha expression and activity in retinal pigment epithelial cell line D407. Invest Ophthalmol Vis Sci. 2004;45:2838-47 pubmed
Arsham A, Plas D, Thompson C, Simon M. Akt and hypoxia-inducible factor-1 independently enhance tumor growth and angiogenesis. Cancer Res. 2004;64:3500-7 pubmed
Slomiany M, Rosenzweig S. Autocrine effects of IGF-I-induced VEGF and IGFBP-3 secretion in retinal pigment epithelial cell line ARPE-19. Am J Physiol Cell Physiol. 2004;287:C746-53 pubmed
Tissot van Patot M, Bendrick Peart J, Beckey V, Serkova N, Zwerdlinger L. Greater vascularity, lowered HIF-1/DNA binding, and elevated GSH as markers of adaptation to in vivo chronic hypoxia. Am J Physiol Lung Cell Mol Physiol. 2004;287:L525-32 pubmed
Rapisarda A, Uranchimeg B, Sordet O, Pommier Y, Shoemaker R, Melillo G. Topoisomerase I-mediated inhibition of hypoxia-inducible factor 1: mechanism and therapeutic implications. Cancer Res. 2004;64:1475-82 pubmed
Alam H, Maizels E, Park Y, Ghaey S, Feiger Z, Chandel N, et al. Follicle-stimulating hormone activation of hypoxia-inducible factor-1 by the phosphatidylinositol 3-kinase/AKT/Ras homolog enriched in brain (Rheb)/mammalian target of rapamycin (mTOR) pathway is necessary for induction of select protein markers of f. J Biol Chem. 2004;279:19431-40 pubmed
Hu C, Wang L, Chodosh L, Keith B, Simon M. Differential roles of hypoxia-inducible factor 1alpha (HIF-1alpha) and HIF-2alpha in hypoxic gene regulation. Mol Cell Biol. 2003;23:9361-74 pubmed
Fukuda R, Kelly B, Semenza G. Vascular endothelial growth factor gene expression in colon cancer cells exposed to prostaglandin E2 is mediated by hypoxia-inducible factor 1. Cancer Res. 2003;63:2330-4 pubmed
Mabjeesh N, Escuin D, LaVallee T, Pribluda V, Swartz G, Johnson M, et al. 2ME2 inhibits tumor growth and angiogenesis by disrupting microtubules and dysregulating HIF. Cancer Cell. 2003;3:363-75 pubmed
Mabjeesh N, Willard M, Harris W, Sun H, Wang R, Zhong H, et al. Dibenzoylmethane, a natural dietary compound, induces HIF-1 alpha and increases expression of VEGF. Biochem Biophys Res Commun. 2003;303:279-86 pubmed
Elvert G, Kappel A, Heidenreich R, Englmeier U, Lanz S, Acker T, et al. Cooperative interaction of hypoxia-inducible factor-2alpha (HIF-2alpha ) and Ets-1 in the transcriptional activation of vascular endothelial growth factor receptor-2 (Flk-1). J Biol Chem. 2003;278:7520-30 pubmed
Volm M, Koomagi R, Mattern J, Efferth T. Protein expression profiles indicative for drug resistance of non-small cell lung cancer. Br J Cancer. 2002;87:251-7 pubmed
Rapisarda A, Uranchimeg B, Scudiero D, Selby M, Sausville E, Shoemaker R, et al. Identification of small molecule inhibitors of hypoxia-inducible factor 1 transcriptional activation pathway. Cancer Res. 2002;62:4316-24 pubmed
Fukuda R, Hirota K, Fan F, Jung Y, Ellis L, Semenza G. Insulin-like growth factor 1 induces hypoxia-inducible factor 1-mediated vascular endothelial growth factor expression, which is dependent on MAP kinase and phosphatidylinositol 3-kinase signaling in colon cancer cells. J Biol Chem. 2002;277:38205-11 pubmed
Bernaudin M, Tang Y, Reilly M, Petit E, Sharp F. Brain genomic response following hypoxia and re-oxygenation in the neonatal rat. Identification of genes that might contribute to hypoxia-induced ischemic tolerance. J Biol Chem. 2002;277:39728-38 pubmed
Mabjeesh N, Post D, Willard M, Kaur B, Van Meir E, Simons J, et al. Geldanamycin induces degradation of hypoxia-inducible factor 1alpha protein via the proteosome pathway in prostate cancer cells. Cancer Res. 2002;62:2478-82 pubmed
Zhong H, Hanrahan C, van der Poel H, Simons J. Hypoxia-inducible factor 1alpha and 1beta proteins share common signaling pathways in human prostate cancer cells. Biochem Biophys Res Commun. 2001;284:352-6 pubmed
Tendler D, Bao C, Wang T, Huang E, Ratovitski E, Pardoll D, et al. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 2001;61:3682-8 pubmed
Zagzag D, Zhong H, Scalzitti J, Laughner E, Simons J, Semenza G. Expression of hypoxia-inducible factor 1alpha in brain tumors: association with angiogenesis, invasion, and progression. Cancer. 2000;88:2606-18 pubmed
product information
master code :
NBP1-23017
SKU :
NBP1-23017
product name :
RPA2 [p Ser4, p Ser8] Antibody - BSA Free
unit size :
100 ul
description :
The RPA2 [p Ser4, p Ser8] Antibody - BSA Free from Novus is a rabbit polyclonal antibody to RPA2. This antibody reacts with human,mouse. The RPA2 [p Ser4, p Ser8] Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Immunoprecipitation,Western Blot,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry-Paraffin,Simple Western.
target :
RPA2
category :
Primary Antibodies
buffer :
Tris-Citrate/Phosphate (pH 7.0 - 8.0)
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
Immunogen was a dually phosphorylated synthetic peptide, which represented a portion of human replication protein A2, 32 kDa surrounding phosphorylated serines that corresponded to positions 4 and 8 using the numbering given in entry NP_002937.1 (GeneID
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse
gene symbol :
RPA2
Antibody validation :
Independent Anitbodies
accessionNumbers :
NP_002937.1
applications :
Immunohistochemistry,Immunoprecipitation,Western Blot,Knockdown Validated,Immunocytochemistry/ Immunofluorescence,Immunohistochemistry-Paraffin,Simple Western
USD :
529 USD
alt names :
REPA2, Replication factor A protein 2, replication protein A 32 kDa subunit, Replication protein A 34 kDa subunit, replication protein A2 (32kD), replication protein A2, 32kDa, RF-A protein 2, RP-A p32, RP-A p34, RPA32, RPA34
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.