product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Borealin Antibody
catalog :
NBP1-22832B
quantity :
0.1 ml
price :
299.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
biotin
reactivity :
human, mouse, rat
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-22832B
Product Name :
Rabbit Polyclonal Borealin Antibody
List Price :
299.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
cell division cycle associated 8, Cell division cycle-associated protein 8, Dasra B, DasraB, dasra-B, Dasra-B, FLJ10468, FLJ12042, hDasra-B, MESRGP, PESCRG3, Pluripotent embryonic stem cell-related gene 3 protein, BOR, borealin, BOREALIN
Background :
Borealin, or CDCA8, is a component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. In the complex, it may be required to direct the CPC to centromeric DNA. Borealin has been shown to interact with Aurora B and survivin (BIRC5). Knockdown of Borealin by small interfering RNA resulted in severe chromosome misalignment at metaphase and accumulation of multiple interphase nuclei. Borealin is also related to the proliferation of human embryonic stem (hES) cells and is highly expressed in mouse undifferentiated ES cells.
Buffer :
PBS
Clonality :
Polyclonal
Conjugate :
Biotin
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
Synthetic peptide made to an internal portion of human Borealin (within residues 200-250). [Swiss-Prot# Q53HL2]
Localization :
Nucleus, nucleolus. Cytoplasm. Centromere. Note: Localizes on chromosome arms and inner centromeres from prophase through metaphase and then transferring to the spindle midzone and midbody from anaphase through cytokinesis.
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human. Immunogen sequence has 92% identity with mouse and rat proteins.
Storage :
Store at 4C in the dark.
Swissprot Human :
Q53HL2
TMW :
38 kDa
Uses :
This Borealin antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen ~38 kDa.
Research Area :
Cell Biology, Cell Cycle and Replication, Chromatin Research, Core ESC Like Genes, Mitotic Regulators, Stem Cell Markers, Zinc Finger
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.