product summary
Loading...
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Ferroportin/SLC40A1 Antibody - BSA Free
catalog :
NBP1-21502
quantity :
0.1 ml (also 0.025 ml)
price :
479 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
DyLight 650
clone name :
5B12
reactivity :
human, mouse, rat, bovine
application :
western blot, immunohistochemistry, immunocytochemistry, neutralization, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation, immunohistochemistry knockout validation
more info or order :
citations: 169
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; 1:100; loading ...; fig s1a
  • western blot knockout validation; mouse; loading ...; fig 1c
Mohammad G, Matakidou A, Robbins P, Lakhal Littleton S. The kidney hepcidin/ferroportin axis controls iron reabsorption and determines the magnitude of kidney and systemic iron overload. Kidney Int. 2021;100:559-569 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1c
Ashok A, Chaudhary S, Wise A, Rana N, McDonald D, Kritikos A, et al. Release of Iron-Loaded Ferritin in Sodium Iodate-Induced Model of Age Related Macular Degeneration: An In-Vitro and In-Vivo Study. Antioxidants (Basel). 2021;10: pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 1d, s1d
Bao W, Pang P, Zhou X, Hu F, Xiong W, Chen K, et al. Loss of ferroportin induces memory impairment by promoting ferroptosis in Alzheimer's disease. Cell Death Differ. 2021;28:1548-1562 pubmed publisher
  • western blot; mouse; loading ...; fig s1e
Singh K, Leu J, Barnoud T, Vonteddu P, Gnanapradeepan K, Lin C, et al. African-centric TP53 variant increases iron accumulation and bacterial pathogenesis but improves response to malaria toxin. Nat Commun. 2020;11:473 pubmed publisher
  • western blot; human; 1:300; loading ...; fig 3s5c
Pulos Holmes M, Srole D, Juarez M, Lee A, McSwiggen D, Ingolia N, et al. Repression of ferritin light chain translation by human eIF3. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 2a
Geng S, Zhang Y, Lee C, Li L. Novel reprogramming of neutrophils modulates inflammation resolution during atherosclerosis. Sci Adv. 2019;5:eaav2309 pubmed publisher
  • immunohistochemistry; bovine; loading ...; fig 1b
Ashok A, Karmakar S, Chandel R, Ravikumar R, Dalal S, Kong Q, et al. Prion protein modulates iron transport in the anterior segment: Implications for ocular iron homeostasis and prion transmission. Exp Eye Res. 2018;175:1-13 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
  • western blot; human; loading ...; fig 1a
Zhang D, Wu J, Shah B, Greutélaers K, Ghosh M, Ollivierre H, et al. Erythrocytic ferroportin reduces intracellular iron accumulation, hemolysis, and malaria risk. Science. 2018;359:1520-1523 pubmed publisher
  • western blot; mouse; fig 2
Gasperini L, Meneghetti E, Legname G, Benetti F. In Absence of the Cellular Prion Protein, Alterations in Copper Metabolism and Copper-Dependent Oxidase Activity Affect Iron Distribution. Front Neurosci. 2016;10:437 pubmed
  • immunohistochemistry; human; 1:500; loading ...; fig 3b
Ng O. Iron, microbiota and colorectal cancer. Wien Med Wochenschr. 2016;166:431-436 pubmed
Abboud E, Chrayteh D, Boussetta N, Dalle H, Malerba M, Wu T, et al. Skin hepcidin initiates psoriasiform skin inflammation via Fe-driven hyperproliferation and neutrophil recruitment. Nat Commun. 2024;15:6718 pubmed publisher
Rosenblum S, Bailey D, Kosman D. Calcium and IL-6 regulate the anterograde trafficking and plasma membrane residence of the iron exporter ferroportin to modulate iron efflux. J Biol Chem. 2024;300:107348 pubmed publisher
Liu Z, Wang H, Zhang Z, Ma Y, Jing Q, Zhang S, et al. Fam96a is essential for the host control of Toxoplasma gondii infection by fine-tuning macrophage polarization via an iron-dependent mechanism. PLoS Negl Trop Dis. 2024;18:e0012163 pubmed publisher
Yang W, Li M, Ding J, Li J, Wu G, Liu B, et al. High-altitude hypoxia exposure inhibits erythrophagocytosis by inducing macrophage ferroptosis in the spleen. elife. 2024;12: pubmed publisher
Sun Y, Tang L, Kan X, Tan L, Song C, Qiu X, et al. Oncolytic Newcastle disease virus induced degradation of YAP through E3 ubiquitin ligase PRKN to exacerbate ferroptosis in tumor cells. J Virol. 2024;98:e0189723 pubmed publisher
Soofi A, Li V, Beamish J, Abdrabh S, Hamad M, Das N, et al. Renal-specific loss of ferroportin disrupts iron homeostasis and attenuates recovery from acute kidney injury. Am J Physiol Renal Physiol. 2024;326:F178-F188 pubmed publisher
Kang D, Park S, Song K, Bae S, Lee J, Jang K, et al. Anticancer Effects of 6-Gingerol through Downregulating Iron Transport and PD-L1 Expression in Non-Small Cell Lung Cancer Cells. Cells. 2023;12: pubmed publisher
Yang W, Li J, Hu J, Yuan X, Ding J, Jiang H, et al. Hypobaric hypoxia induces iron mobilization from liver and spleen and increases serum iron via activation of ghrelin/GHSR1a/MAPK signalling pathway in mice. Sci Rep. 2023;13:20254 pubmed publisher
Deng G, Wu C, Li Y, Shi H, Zhong W, Hong M, et al. Caveolin-1 is critical for hepatic iron storage capacity in the development of nonalcoholic fatty liver disease. Mil Med Res. 2023;10:53 pubmed publisher
Peng R, Liu X, Wang C, Li F, Li T, Li L, et al. Iron overload enhances TBI-induced cardiac dysfunction by promoting ferroptosis and cardiac inflammation. Biochem Biophys Res Commun. 2023;682:46-55 pubmed publisher
Pokrajac N, Tokarew N, Gurdita A, Ortín Martínez A, Wallace V. Meningeal macrophages inhibit chemokine signaling in pre-tumor cells to suppress mouse medulloblastoma initiation. Dev Cell. 2023;58:2015-2031.e8 pubmed publisher
Yamada K, Tazaki A, Ushio Watanabe N, Usui Y, Takeda A, Matsunaga M, et al. Retinal ferroptosis as a critical mechanism for the induction of retinochoroiditis during ocular toxoplasmosis. Redox Biol. 2023;67:102890 pubmed publisher
Li Q, Xu T, Zha X, Feng X, Zhang F, Luo J. Buddlejasaponin IVb ameliorates ferroptosis of dopaminergic neuron by suppressing IRP2-mediated iron overload in Parkinson's disease. J Ethnopharmacol. 2023;319:117196 pubmed publisher
Ma S, Li C, Yan C, Liu N, Jiang G, Yang H, et al. Melatonin alleviates early brain injury by inhibiting the NRF2-mediated ferroptosis pathway after subarachnoid hemorrhage. Free Radic Biol Med. 2023;208:555-570 pubmed publisher
Kaur H, Minchella P, Alvarez Carbonell D, Purandare N, Nagampalli V, Blankenberg D, et al. Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells. Int J Mol Sci. 2023;24: pubmed publisher
Liu W, Zhang S, Li Q, Wu Y, Jia X, Feng W, et al. Lactate modulates iron metabolism by binding soluble adenylyl cyclase. Cell Metab. 2023;35:1597-1612.e6 pubmed publisher
Tamiya H, Urushihara N, Shizuma K, Ogawa H, Nakai S, Wakamatsu T, et al. SHARPIN Enhances Ferroptosis in Synovial Sarcoma Cells via NF-κB- and PRMT5-Mediated PGC1α Reduction. Cancers (Basel). 2023;15: pubmed publisher
Sun F, Cui L, Qian J, Li M, Chen L, Chen C, et al. Decidual Stromal Cell Ferroptosis Associated with Abnormal Iron Metabolism Is Implicated in the Pathogenesis of Recurrent Pregnancy Loss. Int J Mol Sci. 2023;24: pubmed publisher
Qin Y, Bai D, Tang M, Zhang M, Zhao L, Li J, et al. Ketogenic diet alleviates brain iron deposition and cognitive dysfunction via Nrf2-mediated ferroptosis pathway in APP/PS1 mouse. Brain Res. 2023;1812:148404 pubmed publisher
Shi L, Tao Z, Zheng L, Yang J, Hu X, Scott K, et al. FoxO1 regulates adipose transdifferentiation and iron influx by mediating Tgfβ1 signaling pathway. Redox Biol. 2023;63:102727 pubmed publisher
Mukhopadhyay S, Encarnaci xf3 n Rosado J, Lin E, Sohn A, Zhang H, Mancias J, et al. Autophagy supports mitochondrial metabolism through the regulation of iron homeostasis in pancreatic cancer. Sci Adv. 2023;9:eadf9284 pubmed publisher
Principe P, Mukosera G, Gray Hutto N, Tugung A, Gheorghe C, Blood A. Nitric Oxide Affects Heme Oxygenase-1, Hepcidin, and Transferrin Receptor Expression in the Placenta. Int J Mol Sci. 2023;24: pubmed publisher
Bao X, Luo X, Bai X, Lv Y, Weng X, Zhang S, et al. Cigarette tar mediates macrophage ferroptosis in atherosclerosis through the hepcidin/FPN/SLC7A11 signaling pathway. Free Radic Biol Med. 2023;201:76-88 pubmed publisher
Tan X, Zhang T, Ding X, Zhao X, Liu Q, Xia Z, et al. Iron overload facilitates neonatal hypoxic-ischemic brain damage via SLC7A11-mediated ferroptosis. J Neurosci Res. 2023;101:1107-1124 pubmed publisher
Nagpal A, Needham K, Lane D, Ayton S, Redvers R, John M, et al. Integrin αvβ3 Is a Master Regulator of Resistance to TKI-Induced Ferroptosis in HER2-Positive Breast Cancer. Cancers (Basel). 2023;15: pubmed publisher
Xie J, Lv H, Liu X, Xia Z, Li J, Hong E, et al. Nox4-and Tf/TfR-mediated peroxidation and iron overload exacerbate neuronal ferroptosis after intracerebral hemorrhage: Involvement of EAAT3 dysfunction. Free Radic Biol Med. 2023;199:67-80 pubmed publisher
Zhao J, Jia Y, Mahmut D, Deik A, Jeanfavre S, Clish C, et al. Human hematopoietic stem cell vulnerability to ferroptosis. Cell. 2023;186:732-747.e16 pubmed publisher
Santhakumar S, Athiyarath R, Cherian A, Abraham V, George B, Lipi x144 ski P, et al. Impact of maternal iron deficiency anemia on fetal iron status and placental iron transporters in human pregnancy. Blood Cells Mol Dis. 2023;99:102727 pubmed publisher
Han Y, Luo Z, Yue Z, Miao L, Xv M, Chang S, et al. The tendency of anemia of inflammation in periodontal diseases. Clin Sci (Lond). 2023;137:251-264 pubmed publisher
Masoumi Z, Hansson L, Hansson E, Ahlm E, Mezey E, Erlandsson L, et al. Assessing erythroferrone and iron homeostasis in preeclamptic and normotensive pregnancies: A retrospective study. Placenta. 2023;133:10-18 pubmed publisher
Zhang Y, Dong P, Liu N, Yang J, Wang H, Geng Q. TRIM6 Reduces Ferroptosis and Chemosensitivity by Targeting SLC1A5 in Lung Cancer. Oxid Med Cell Longev. 2023;2023:9808100 pubmed publisher
Hu C, Jiang H, Yang Y, Wang G, Ji Q, Jia Z, et al. DL-3-n-butylphthalide alleviates motor disturbance by suppressing ferroptosis in a rat model of Parkinson's disease. Neural Regen Res. 2023;18:194-199 pubmed publisher
Chen X, Song X, Li J, Zhang R, Yu C, Zhou Z, et al. Identification of HPCAL1 as a specific autophagy receptor involved in ferroptosis. Autophagy. 2023;19:54-74 pubmed publisher
BELVIN B, Lewis J. Ferroportin depletes iron needed for cell cycle progression in head and neck squamous cell carcinoma. Front Oncol. 2022;12:1025434 pubmed publisher
Joffin N, Gliniak C, Funcke J, Paschoal V, Crewe C, Chen S, et al. Adipose tissue macrophages exert systemic metabolic control by manipulating local iron concentrations. Nat Metab. 2022;4:1474-1494 pubmed publisher
Wang H, Dou M, Li J, Cao P, Li J, Guo T, et al. Expression patterns and correlation analyses of muscle-specific genes in the process of sheep myoblast differentiation. In Vitro Cell Dev Biol Anim. 2022;58:798-809 pubmed publisher
Song Y, Yang N, Si H, Liu T, Wang H, Geng H, et al. Iron overload impairs renal function and is associated with vascular calcification in rat aorta. Biometals. 2022;35:1325-1339 pubmed publisher
Suh D, Lee W, Yeo W, Kyung B, Jung K, Seo H, et al. A Novel Muscle Atrophy Mechanism: Myocyte Degeneration Due to Intracellular Iron Deprivation. Cells. 2022;11: pubmed publisher
Li L, Wang K, Jia R, Xie J, Ma L, Hao Z, et al. Ferroportin-dependent ferroptosis induced by ellagic acid retards liver fibrosis by impairing the SNARE complexes formation. Redox Biol. 2022;56:102435 pubmed publisher
Wang L, Zhao G, Wang X, Liu X, Li Y, Qiu L, et al. Glycochenodeoxycholate Affects Iron Homeostasis via Up-Regulating Hepcidin Expression. Nutrients. 2022;14: pubmed publisher
Doan L, Chu L, Huang Z, Nguyen A, Lee C, Huang C, et al. Virofree, an Herbal Medicine-Based Formula, Interrupts the Viral Infection of Delta and Omicron Variants of SARS-CoV-2. Front Pharmacol. 2022;13:905197 pubmed publisher
Yuan B, Zhao X, Shen J, Chen S, Huang H, Zhou X, et al. Activation of SIRT1 Alleviates Ferroptosis in the Early Brain Injury after Subarachnoid Hemorrhage. Oxid Med Cell Longev. 2022;2022:9069825 pubmed publisher
Wang D, Zhang S, Ge X, Yin Z, Li M, Guo M, et al. Mesenchymal stromal cell treatment attenuates repetitive mild traumatic brain injury-induced persistent cognitive deficits via suppressing ferroptosis. J Neuroinflammation. 2022;19:185 pubmed publisher
Santana Codina N, Del Rey M, Kapner K, Zhang H, Gikandi A, Malcolm C, et al. NCOA4-Mediated Ferritinophagy Is a Pancreatic Cancer Dependency via Maintenance of Iron Bioavailability for Iron-Sulfur Cluster Proteins. Cancer Discov. 2022;12:2180-2197 pubmed publisher
Zhang H, Jamieson K, Grenier J, Nikhanj A, Tang Z, Wang F, et al. Myocardial Iron Deficiency and Mitochondrial Dysfunction in Advanced Heart Failure in Humans. J Am Heart Assoc. 2022;11:e022853 pubmed publisher
Lee W, Lee H, Hur J, Lee G, Won J, Kim E, et al. PPARδ Activation Mitigates 6-OHDA-Induced Neuronal Damage by Regulating Intracellular Iron Levels. Antioxidants (Basel). 2022;11: pubmed publisher
Wang C, Zhang W, Xu W, Liu Z, Huang K. AMP-activated protein kinase α1 phosphorylates PHD2 to maintain systemic iron homeostasis. Clin Transl Med. 2022;12:e854 pubmed publisher
V xe1 squez Trincado C, Dunn J, Han J, Hymms B, Tamaroff J, Patel M, et al. Frataxin deficiency lowers lean mass and triggers the integrated stress response in skeletal muscle. JCI Insight. 2022;7: pubmed publisher
Toe Q, Issitt T, Mahomed A, Almaghlougth F, Bahree I, Sturge C, et al. Human pulmonary artery endothelial cells upregulate ACE2 expression in response to iron-regulatory elements: Potential implications for SARS-CoV-2 infection. Pulm Circ. 2022;12:e12068 pubmed publisher
Jiang H, Zhang X, Yang W, Li M, Wang G, Luo Q. Ferrostatin-1 Ameliorates Liver Dysfunction via Reducing Iron in Thioacetamide-induced Acute Liver Injury in Mice. Front Pharmacol. 2022;13:869794 pubmed publisher
Park W, Choi B, Kim Y, Kim Y, Park M, Kim D, et al. Melatonin Regulates Iron Homeostasis by Inducing Hepcidin Expression in Hepatocytes. Int J Mol Sci. 2022;23: pubmed publisher
Zhang X, Song T, Zhao M, Tao X, Zhang B, Sun C, et al. Sirtuin 2 Alleviates Chronic Neuropathic Pain by Suppressing Ferroptosis in Rats. Front Pharmacol. 2022;13:827016 pubmed publisher
Soliman S, El Labbad E, Abu Qiyas A, Fayed B, Hamoda A, Al Rawi A, et al. Novel Secreted Peptides From Rhizopus arrhizus var. delemar With Immunomodulatory Effects That Enhance Fungal Pathogenesis. Front Microbiol. 2022;13:863133 pubmed publisher
Jiang H, Muir R, Gonciarz R, Olshen A, Yeh I, Hann B, et al. Ferrous iron-activatable drug conjugate achieves potent MAPK blockade in KRAS-driven tumors. J Exp Med. 2022;219: pubmed publisher
Fern xe1 ndez Garc xed a V, Gonz xe1 lez Ramos S, Avenda xf1 o Ortiz J, Mart xed n Sanz P, Delgado C, Castrillo A, et al. NOD1 splenic activation confers ferroptosis protection and reduces macrophage recruitment under pro-atherogenic conditions. Biomed Pharmacother. 2022;148:112769 pubmed publisher
Wyart E, Hsu M, Sartori R, Mina E, Rausch V, Pierobon E, et al. Iron supplementation is sufficient to rescue skeletal muscle mass and function in cancer cachexia. EMBO Rep. 2022;23:e53746 pubmed publisher
Sato T, SHAPIRO J, Chang H, Miller R, Ardehali H. Aging is associated with increased brain iron through cortex-derived hepcidin expression. elife. 2022;11: pubmed publisher
Arita A, Kita I, Shinoda S. Internalization and Decrease of Duodenal DMT1 Involved in Transient Suppression of Iron Uptake in Short-Acting Mucosal Block. Biol Trace Elem Res. 2022;200:4795-4806 pubmed publisher
Deng Q, Yang S, Sun L, Huang K, Dong K, Zhu Y, et al. A detrimental role of NLRP6 in host iron metabolism during Salmonella infection. Redox Biol. 2022;49:102217 pubmed publisher
Li D, Liu X, Pi W, Zhang Y, Yu L, Xu C, et al. Fisetin Attenuates Doxorubicin-Induced Cardiomyopathy In Vivo and In Vitro by Inhibiting Ferroptosis Through SIRT1/Nrf2 Signaling Pathway Activation. Front Pharmacol. 2021;12:808480 pubmed publisher
Sp N, Kang D, Jo E, Lee J, Jang K. Iron Metabolism as a Potential Mechanism for Inducing TRAIL-Mediated Extrinsic Apoptosis Using Methylsulfonylmethane in Embryonic Cancer Stem Cells. Cells. 2021;10: pubmed publisher
Sp N, Kang D, Jo E, Lee J, Bae S, Jang K. Pivotal Role of Iron Homeostasis in the Induction of Mitochondrial Apoptosis by 6-Gingerol Through PTEN Regulated PD-L1 Expression in Embryonic Cancer Cells. Front Oncol. 2021;11:781720 pubmed publisher
Kang D, Sp N, Jo E, Lee J, Jang K. New Insights into the Pivotal Role of Iron/Heme Metabolism in TLR4/NF-κB Signaling-Mediated Inflammatory Responses in Human Monocytes. Cells. 2021;10: pubmed publisher
Han M, Böhlke M, Maher T, Kim J. Alcohol exposure increases manganese accumulation in the brain and exacerbates manganese-induced neurotoxicity in mice. Arch Toxicol. 2021;95:3665-3679 pubmed publisher
Liu K, Liu J, Zou B, Li C, Zeh H, Kang R, et al. Trypsin-Mediated Sensitization to Ferroptosis Increases the Severity of Pancreatitis in Mice. Cell Mol Gastroenterol Hepatol. 2021;: pubmed publisher
Vasquez Trincado C, Patel M, Sivaramakrishnan A, Bekeova C, Anderson Pullinger L, Wang N, et al. Adaptation of the heart to Frataxin depletion: Evidence that integrated stress response can predominate over mTORC1 activation. Hum Mol Genet. 2021;: pubmed publisher
Konieczny P, Mukherjee S, Stepniak Konieczna E, Taylor K, Niewiadomska D, Piasecka A, et al. Cyclic mismatch binding ligands interact with disease-associated CGG trinucleotide repeats in RNA and suppress their translation. Nucleic Acids Res. 2021;: pubmed publisher
Wang X, Wang Z, Cao J, Dong Y, Chen Y. Melatonin Alleviates Acute Sleep Deprivation-Induced Memory Loss in Mice by Suppressing Hippocampal Ferroptosis. Front Pharmacol. 2021;12:708645 pubmed publisher
Bailey D, Clark W, Kosman D. The iron chelator, PBT434, modulates transcellular iron trafficking in brain microvascular endothelial cells. PLoS ONE. 2021;16:e0254794 pubmed publisher
Zhao S, Wang X, Zheng X, Liang X, Wang Z, Zhang J, et al. Iron deficiency exacerbates cisplatin- or rhabdomyolysis-induced acute kidney injury through promoting iron-catalyzed oxidative damage. Free Radic Biol Med. 2021;173:81-96 pubmed publisher
Argenziano M, Tortora C, Paola A, Pota E, Martino M, Pinto D, et al. Eltrombopag and its iron chelating properties in pediatric acute myeloid leukemia. Oncotarget. 2021;12:1377-1387 pubmed publisher
Chaudhary S, Ashok A, Wise A, Rana N, McDonald D, Kritikos A, et al. Upregulation of brain hepcidin in prion diseases. Prion. 2021;15:126-137 pubmed publisher
Wei D, Ke Y, Duan P, Zhou L, Wang C, Cao P. MicroRNA-302a-3p induces ferroptosis of non-small cell lung cancer cells via targeting ferroportin. Free Radic Res. 2021;55:821-830 pubmed publisher
Zhang Z, Funcke J, Zi Z, Zhao S, Straub L, Zhu Y, et al. Adipocyte iron levels impinge on a fat-gut crosstalk to regulate intestinal lipid absorption and mediate protection from obesity. Cell Metab. 2021;33:1624-1639.e9 pubmed publisher
Schwartz A, Goyert J, Solanki S, Kerk S, Chen B, Castillo C, et al. Hepcidin sequesters iron to sustain nucleotide metabolism and mitochondrial function in colorectal cancer epithelial cells. Nat Metab. 2021;3:969-982 pubmed publisher
Tang Z, Jiang W, Mao M, Zhao J, Chen J, Cheng N. Deubiquitinase USP35 modulates ferroptosis in lung cancer via targeting ferroportin. Clin Transl Med. 2021;11:e390 pubmed publisher
Asperti M, Bellini S, Grillo E, Gryzik M, Cantamessa L, Ronca R, et al. H-ferritin suppression and pronounced mitochondrial respiration make Hepatocellular Carcinoma cells sensitive to RSL3-induced ferroptosis. Free Radic Biol Med. 2021;169:294-303 pubmed publisher
Lu S, Song Y, Luo R, Li S, Li G, Wang K, et al. Ferroportin-Dependent Iron Homeostasis Protects against Oxidative Stress-Induced Nucleus Pulposus Cell Ferroptosis and Ameliorates Intervertebral Disc Degeneration In Vivo. Oxid Med Cell Longev. 2021;2021:6670497 pubmed publisher
Derbis M, Kul E, Niewiadomska D, Sekrecki M, Piasecka A, Taylor K, et al. Short antisense oligonucleotides alleviate the pleiotropic toxicity of RNA harboring expanded CGG repeats. Nat Commun. 2021;12:1265 pubmed publisher
Petit F, Drecourt A, Dussiot M, Zangarelli C, Hermine O, Munnich A, et al. Defective palmitoylation of transferrin receptor triggers iron overload in Friedreich ataxia fibroblasts. Blood. 2021;137:2090-2102 pubmed publisher
Deng Q, Yang S, Sun L, Dong K, Li Y, Wu S, et al. Salmonella effector SpvB aggravates dysregulation of systemic iron metabolism via modulating the hepcidin-ferroportin axis. Gut Microbes. 2021;13:1-18 pubmed publisher
Li J, Liu J, Xu Y, Wu R, Chen X, Song X, et al. Tumor heterogeneity in autophagy-dependent ferroptosis. Autophagy. 2021;:1-14 pubmed publisher
Li Y, Zeng X, Lu D, Yin M, Shan M, Gao Y. Erastin induces ferroptosis via ferroportin-mediated iron accumulation in endometriosis. Hum Reprod. 2021;36:951-964 pubmed publisher
Fernández Mendívil C, Luengo E, Trigo Alonso P, García Magro N, Negredo P, Lopez M. Protective role of microglial HO-1 blockade in aging: Implication of iron metabolism. Redox Biol. 2021;38:101789 pubmed publisher
Mu M, Qian Z, Yang S, Rong K, Yung W, Ke Y. Therapeutic effect of a histone demethylase inhibitor in Parkinson's disease. Cell Death Dis. 2020;11:927 pubmed publisher
Yamaguchi H, Honda S, Torii S, Shimizu K, Katoh K, Miyake K, et al. Wipi3 is essential for alternative autophagy and its loss causes neurodegeneration. Nat Commun. 2020;11:5311 pubmed publisher
Verma N, Vinik Y, Saroha A, Nair N, Ruppin E, Mills G, et al. Synthetic lethal combination targeting BET uncovered intrinsic susceptibility of TNBC to ferroptosis. Sci Adv. 2020;6: pubmed publisher
Yang G, Qian C, Zhang C, Bao Y, Liu M, Jiang F, et al. Hepcidin attenuates the iron-mediated secondary neuronal injury after intracerebral hemorrhage in rats. Transl Res. 2020;: pubmed publisher
Renassia C, Louis S, Cuvellier S, Boussetta N, Deschemin J, Borderie D, et al. Neutrophils from hereditary hemochromatosis patients are protected from iron excess and are primed. Blood Adv. 2020;4:3853-3863 pubmed publisher
Lin P, Tang H, Wu S, Shaw N, Su C. Saponin Formosanin C-induced Ferritinophagy and Ferroptosis in Human Hepatocellular Carcinoma Cells. Antioxidants (Basel). 2020;9: pubmed publisher
Kim H, Kwon W, Park J, Lee M, Oh Y, Suh S, et al. Hepatic STAMP2 mediates recombinant FGF21-induced improvement of hepatic iron overload in nonalcoholic fatty liver disease. FASEB J. 2020;: pubmed publisher
Pease N, Shephard M, Sertorio M, Waltz S, Vinnedge L. DEK Expression in Breast Cancer Cells Leads to the Alternative Activation of Tumor Associated Macrophages. Cancers (Basel). 2020;12: pubmed publisher
Lee J, You J, Shin D, Roh J. Inhibition of Glutaredoxin 5 predisposes Cisplatin-resistant Head and Neck Cancer Cells to Ferroptosis. Theranostics. 2020;10:7775-7786 pubmed publisher
Tsuji Y. Transmembrane protein western blotting: Impact of sample preparation on detection of SLC11A2 (DMT1) and SLC40A1 (ferroportin). PLoS ONE. 2020;15:e0235563 pubmed publisher
Hazlett H, Hampton T, Aridgides D, Armstrong D, Dessaint J, Mellinger D, et al. Altered iron metabolism in cystic fibrosis macrophages: the impact of CFTR modulators and implications for Pseudomonas aeruginosa survival. Sci Rep. 2020;10:10935 pubmed publisher
Kämmerer L, Mohammad G, Wolna M, Robbins P, Lakhal Littleton S. Fetal liver hepcidin secures iron stores in utero. Blood. 2020;136:1549-1557 pubmed publisher
Li S, Qian Z, Xu G, Zheng J, Wu Y. Hepatocyte growth factor protects PC12 cells against OGD/R-induced injury by reducing iron. Biosci Rep. 2020;40: pubmed publisher
Ashok A, Chaudhary S, Kritikos A, Kang M, McDonald D, Rhee D, et al. TGFβ2-Hepcidin Feed-Forward Loop in the Trabecular Meshwork Implicates Iron in Glaucomatous Pathology. Invest Ophthalmol Vis Sci. 2020;61:24 pubmed publisher
Wang R, Liu X, Wu J, Liu H, Wang W, Chen X, et al. Role of microRNA-122 in microcystin-leucine arginine-induced dysregulation of hepatic iron homeostasis in mice. Environ Toxicol. 2020;35:822-830 pubmed publisher
Sheng Y, Chen Y, Qian Z, Zheng J, Liu Y. Cyclophosphamide induces a significant increase in iron content in the liver and spleen of mice. Hum Exp Toxicol. 2020;39:973-983 pubmed publisher
Chen X, Li D, Sun H, Wang W, Wu H, Kong W, et al. Relieving ferroptosis may partially reverse neurodegeneration of the auditory cortex. FEBS J. 2020;: pubmed publisher
Schnetz M, Meier J, Rehwald C, Mertens C, Urbschat A, Tomat E, et al. The Disturbed Iron Phenotype of Tumor Cells and Macrophages in Renal Cell Carcinoma Influences Tumor Growth. Cancers (Basel). 2020;12: pubmed publisher
Mesquita G, Silva T, Gomes A, Oliveira P, Alves M, Fernandes R, et al. H-Ferritin is essential for macrophages' capacity to store or detoxify exogenously added iron. Sci Rep. 2020;10:3061 pubmed publisher
Neves J, Gomes A, Costa D, Barroso C, Vaulont S, Cordeiro da Silva A, et al. A role for hepcidin in the anemia caused by Trypanosoma brucei infection. Haematologica. 2020;: pubmed publisher
Yasumura S, Naito Y, Okuno K, Sawada H, Asakura M, Masuyama T, et al. Effects of Heterozygous TfR1 (Transferrin Receptor 1) Deletion in Pathogenesis of Renal Fibrosis in Mice. Hypertension. 2020;75:413-421 pubmed publisher
Chen Y, Qian Z, Sheng Y, Zheng J, Liu Y. Angiotensin II down-regulates transferrin receptor 1 and ferroportin 1 expression in Neuro-2a cells via activation of type-1 receptor. Neurosci Lett. 2020;716:134684 pubmed publisher
Ashok A, Chaudhary S, McDonald D, Kritikos A, Bhargava D, Singh N. Local synthesis of hepcidin in the anterior segment of the eye: A novel observation with physiological and pathological implications. Exp Eye Res. 2020;190:107890 pubmed publisher
Villalpando Rodriguez G, Blankstein A, Konzelman C, Gibson S. Lysosomal Destabilizing Drug Siramesine and the Dual Tyrosine Kinase Inhibitor Lapatinib Induce a Synergistic Ferroptosis through Reduced Heme Oxygenase-1 (HO-1) Levels. Oxid Med Cell Longev. 2019;2019:9561281 pubmed publisher
Nobuta H, Yang N, Ng Y, Marro S, Sabeur K, Chavali M, et al. Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation. Cell Stem Cell. 2019;25:531-541.e6 pubmed publisher
Thompson K, Wessling Resnick M. ZIP14 is degraded in response to manganese exposure. Biometals. 2019;32:829-843 pubmed publisher
Okuno K, Naito Y, Yasumura S, Sawada H, Asakura M, Masuyama T, et al. Haploinsufficiency of Transferrin Receptor 1 Impairs Angiogenesis with Reduced Mitochondrial Complex I in Mice with Limb Ischemia. Sci Rep. 2019;9:13658 pubmed publisher
Nagpal A, Redvers R, Ling X, Ayton S, Fuentes M, Tavancheh E, et al. Neoadjuvant neratinib promotes ferroptosis and inhibits brain metastasis in a novel syngeneic model of spontaneous HER2+ve breast cancer metastasis. Breast Cancer Res. 2019;21:94 pubmed publisher
Poli M, Anower E Khuda F, Asperti M, Ruzzenenti P, Gryzik M, Denardo A, et al. Hepatic heparan sulfate is a master regulator of hepcidin expression and iron homeostasis in human hepatocytes and mice. J Biol Chem. 2019;294:13292-13303 pubmed publisher
Scindia Y, Wlazlo E, Leeds J, Loi V, Ledesma J, Cechova S, et al. Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury. Front Pharmacol. 2019;10:615 pubmed publisher
Pandur E, Tamási K, Pap R, Varga E, Miseta A, Sipos K. Fractalkine Induces Hepcidin Expression of BV-2 Microglia and Causes Iron Accumulation in SH-SY5Y Cells. Cell Mol Neurobiol. 2019;: pubmed publisher
Lakhal Littleton S, Crosby A, Frise M, Mohammad G, Carr C, Loick P, et al. Intracellular iron deficiency in pulmonary arterial smooth muscle cells induces pulmonary arterial hypertension in mice. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Sohoni S, Ghosh P, Wang T, Kalainayakan S, Vidal C, Dey S, et al. Elevated Heme Synthesis and Uptake Underpin Intensified Oxidative Metabolism and Tumorigenic Functions in Non-Small Cell Lung Cancer Cells. Cancer Res. 2019;79:2511-2525 pubmed publisher
Kalainayakan S, Ghosh P, Dey S, FitzGerald K, Sohoni S, Konduri P, et al. Cyclopamine tartrate, a modulator of hedgehog signaling and mitochondrial respiration, effectively arrests lung tumor growth and progression. Sci Rep. 2019;9:1405 pubmed publisher
Katsura Y, Ohara T, Noma K, Ninomiya T, Kashima H, Kato T, et al. A Novel Combination Cancer Therapy with Iron Chelator Targeting Cancer Stem Cells via Suppressing Stemness. Cancers (Basel). 2019;11: pubmed publisher
Ji P, Lonnerdal B, Kim K, Jinno C. Iron Oversupplementation Causes Hippocampal Iron Overloading and Impairs Social Novelty Recognition in Nursing Piglets. J Nutr. 2019;149:398-405 pubmed publisher
Zhang M, Zhao P, Yung W, Sheng Y, Ke Y, Qian Z. Tissue iron is negatively correlated with TERC or TERT mRNA expression: A heterochronic parabiosis study in mice. Aging (Albany NY). 2018;10:3834-3850 pubmed publisher
Miyazawa M, Bogdan A, Tsuji Y. Perturbation of Iron Metabolism by Cisplatin through Inhibition of Iron Regulatory Protein 2. Cell Chem Biol. 2019;26:85-97.e4 pubmed publisher
Silva J, Rodrigues S, Sampaio Marques B, Gomes P, Neves Carvalho A, Dioli C, et al. Dysregulation of autophagy and stress granule-related proteins in stress-driven Tau pathology. Cell Death Differ. 2018;: pubmed publisher
Schwartz A, Das N, Ramakrishnan S, Jain C, Jurkovic M, Wu J, et al. Hepatic hepcidin/intestinal HIF-2α axis maintains iron absorption during iron deficiency and overload. J Clin Invest. 2019;129:336-348 pubmed publisher
Shin D, Kim E, Lee J, Roh J. Nrf2 inhibition reverses resistance to GPX4 inhibitor-induced ferroptosis in head and neck cancer. Free Radic Biol Med. 2018;129:454-462 pubmed publisher
Samba Mondonga M, Calvé A, Mallette F, Santos M. MyD88 Regulates the Expression of SMAD4 and the Iron Regulatory Hormone Hepcidin. Front Cell Dev Biol. 2018;6:105 pubmed publisher
Ramakrishnan L, Pedersen S, Toe Q, West L, Mumby S, Casbolt H, et al. The Hepcidin/Ferroportin axis modulates proliferation of pulmonary artery smooth muscle cells. Sci Rep. 2018;8:12972 pubmed publisher
Sajja R, Kaisar M, Vijay V, Desai V, Prasad S, Cucullo L. In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity. Sci Rep. 2018;8:12708 pubmed publisher
Ma J, Zhang F, Zhou G, Bao Y, Shen Y, Qian Z. Different Characteristics of Hepcidin Expression in IL-6+/+ and IL-6-/- Neurons and Astrocytes Treated with Lipopolysaccharides. Neurochem Res. 2018;43:1624-1630 pubmed publisher
Kaisar M, Sivandzade F, Bhalerao A, Cucullo L. Conventional and electronic cigarettes dysregulate the expression of iron transporters and detoxifying enzymes at the brain vascular endothelium: In vivo evidence of a gender-specific cellular response to chronic cigarette smoke exposure. Neurosci Lett. 2018;682:1-9 pubmed publisher
Lim D, Kim K, Jeong J, Marques O, Kim H, Song M, et al. The hepcidin-ferroportin axis controls the iron content of Salmonella-containing vacuoles in macrophages. Nat Commun. 2018;9:2091 pubmed publisher
Blanchette Farra N, Kita D, Konstorum A, Tesfay L, Lemler D, Hegde P, et al. Contribution of three-dimensional architecture and tumor-associated fibroblasts to hepcidin regulation in breast cancer. Oncogene. 2018;37:4013-4032 pubmed publisher
Broide E, Reifen R, Matalon S, Berkovich Z, Shirin H, Moshe M. Expression of Duodenal Iron Transporter Proteins in Diabetic Patients with and without Iron Deficiency Anemia. J Diabetes Res. 2018;2018:7494821 pubmed publisher
Puy V, Darwiche W, Trudel S, Gomila C, Lony C, Puy L, et al. Predominant role of microglia in brain iron retention in Sanfilippo syndrome, a pediatric neurodegenerative disease. Glia. 2018;66:1709-1723 pubmed publisher
McCarthy R, Sosa J, Gardeck A, Baez A, Lee C, Wessling Resnick M. Inflammation-induced iron transport and metabolism by brain microglia. J Biol Chem. 2018;293:7853-7863 pubmed publisher
Mertens C, Mora J, Oren B, Grein S, Winslow S, Scholich K, et al. Macrophage-derived lipocalin-2 transports iron in the tumor microenvironment. Oncoimmunology. 2018;7:e1408751 pubmed publisher
Zhabyeyev P, Das S, Basu R, Shen M, Patel V, Kassiri Z, et al. TIMP3 deficiency exacerbates iron overload-mediated cardiomyopathy and liver disease. Am J Physiol Heart Circ Physiol. 2018;314:H978-H990 pubmed publisher
Raggi C, Gammella E, Correnti M, Buratti P, Forti E, Andersen J, et al. Dysregulation of Iron Metabolism in Cholangiocarcinoma Stem-like Cells. Sci Rep. 2017;7:17667 pubmed publisher
Zhang F, Hou H, Yin Z, Chang L, Li F, Chen Y, et al. Impairment of Hepcidin Upregulation by Lipopolysaccharide in the Interleukin-6 Knockout Mouse Brain. Front Mol Neurosci. 2017;10:367 pubmed publisher
Baba Y, Higa J, Shimada B, Horiuchi K, Suhara T, Kobayashi M, et al. Protective effects of the mechanistic target of rapamycin against excess iron and ferroptosis in cardiomyocytes. Am J Physiol Heart Circ Physiol. 2018;314:H659-H668 pubmed publisher
Neves J, Ramos M, Moreira A, Silva T, Gomes M, Rodrigues P. Hamp1 but not Hamp2 regulates ferroportin in fish with two functionally distinct hepcidin types. Sci Rep. 2017;7:14793 pubmed publisher
Zhang W, Lv T, Huang J, Ou X. Type 4B hereditary hemochromatosis associated with a novel mutation in the SLC40A1 gene: A case report and a review of the literature. Medicine (Baltimore). 2017;96:e8064 pubmed publisher
Masaldan S, Clatworthy S, Gamell C, Meggyesy P, Rigopoulos A, Haupt S, et al. Iron accumulation in senescent cells is coupled with impaired ferritinophagy and inhibition of ferroptosis. Redox Biol. 2018;14:100-115 pubmed publisher
Pasricha S, Lim P, Duarte T, Casu C, Oosterhuis D, Mleczko Sanecka K, et al. Hepcidin is regulated by promoter-associated histone acetylation and HDAC3. Nat Commun. 2017;8:403 pubmed publisher
Dietrich P, Johnson I, Alli S, Dragatsis I. Elimination of huntingtin in the adult mouse leads to progressive behavioral deficits, bilateral thalamic calcification, and altered brain iron homeostasis. PLoS Genet. 2017;13:e1006846 pubmed publisher
Basuli D, Tesfay L, Deng Z, Paul B, Yamamoto Y, Ning G, et al. Iron addiction: a novel therapeutic target in ovarian cancer. Oncogene. 2017;36:4089-4099 pubmed publisher
Fader K, Nault R, Kirby M, Markous G, Matthews J, Zacharewski T. Convergence of hepcidin deficiency, systemic iron overloading, heme accumulation, and REV-ERBα/β activation in aryl hydrocarbon receptor-elicited hepatotoxicity. Toxicol Appl Pharmacol. 2017;321:1-17 pubmed publisher
Mertens C, Akam E, Rehwald C, Brüne B, Tomat E, Jung M. Intracellular Iron Chelation Modulates the Macrophage Iron Phenotype with Consequences on Tumor Progression. PLoS ONE. 2016;11:e0166164 pubmed publisher
Zhang Y, Li F, Guo Y, Jiang L, Ma J, Ke Y, et al. (Z)-ligustilide increases ferroportin1 expression and ferritin content in ischemic SH-SY5Y cells. Eur J Pharmacol. 2016;792:48-53 pubmed publisher
Asperti M, Stuemler T, Poli M, Gryzik M, Lifshitz L, Meyron Holtz E, et al. Heparanase Overexpression Reduces Hepcidin Expression, Affects Iron Homeostasis and Alters the Response to Inflammation. PLoS ONE. 2016;11:e0164183 pubmed publisher
Kim D, Kim Y, Jung Y, Kim K, Jeong J, Lee Y, et al. Orphan nuclear receptor SHP regulates iron metabolism through inhibition of BMP6-mediated hepcidin expression. Sci Rep. 2016;6:34630 pubmed publisher
Marques O, Porto G, Rêma A, Faria F, Cruz Paula A, Gomez Lazaro M, et al. Local iron homeostasis in the breast ductal carcinoma microenvironment. BMC Cancer. 2016;16:187 pubmed publisher
Theurl M, Song D, Clark E, Sterling J, Grieco S, Altamura S, et al. Mice with hepcidin-resistant ferroportin accumulate iron in the retina. FASEB J. 2016;30:813-23 pubmed publisher
Mori M, Ito F, Shi L, Wang Y, Ishida C, Hattori Y, et al. Ovarian endometriosis-associated stromal cells reveal persistently high affinity for iron. Redox Biol. 2015;6:578-586 pubmed publisher
Bose C, Megyesi J, Shah S, Hiatt K, Hall K, Karaduta O, et al. Evidence Suggesting a Role of Iron in a Mouse Model of Nephrogenic Systemic Fibrosis. PLoS ONE. 2015;10:e0136563 pubmed publisher
Tesfay L, Clausen K, Kim J, Hegde P, Wang X, Miller L, et al. Hepcidin regulation in prostate and its disruption in prostate cancer. Cancer Res. 2015;75:2254-63 pubmed publisher
Gammella E, Díaz V, Recalcati S, Buratti P, Samaja M, Dey S, et al. Erythropoietin's inhibiting impact on hepcidin expression occurs indirectly. Am J Physiol Regul Integr Comp Physiol. 2015;308:R330-5 pubmed publisher
Katz O, Reifen R, Lerner A. β-Carotene can reverse dysregulation of iron protein in an in vitro model of inflammation. Immunol Res. 2015;61:70-8 pubmed publisher
Jeong S, Lee J, Finley L, Schmidt P, Fleming M, Haigis M. SIRT3 regulates cellular iron metabolism and cancer growth by repressing iron regulatory protein 1. Oncogene. 2015;34:2115-24 pubmed publisher
product information
master code :
NBP1-21502
SKU :
NBP1-21502
product name :
Ferroportin/SLC40A1 Antibody - BSA Free
unit size :
0.1 ml (also 0.025 ml)
description :
The Ferroportin/SLC40A1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Ferroportin/SLC40A1. This antibody reacts with bovine,human,mouse,porcine,rat. The Ferroportin/SLC40A1 Antibody - BSA Free has been validated for the following applications: Western Blot,Immunohistochemistry,In vivo assay,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Knockdown Validated,Flow (Intracellular).
target :
Ferroportin/SLC40A1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This Ferroportin/SLC40A1 Antibody was developed against a synthetic peptide made to an internal portion of human Ferroportin 1 (within residues 250-300). [Swiss-Prot: Q9NP59]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Bovine,Human,Mouse,Porcine,Rat
theoretical molecular weight :
62.5 kDa
gene symbol :
SLC40A1
accessionNumbers :
Q9NP59
applications :
Immunohistochemistry,Western Blot,In vivo assay,Block/Neutralize,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunofluorescence,Knockdown Validated,Flow (Intracellular)
USD :
479 USD
alt names :
Ferroportin-1, FPN1, FPN1IREG1ferroportin 1, HFE4, HFE4ferroportin-1, IREG1, iron regulated gene 1, Iron-regulated transporter 1, member 3, MST079, MSTP079, MTP1, putative ferroportin 1 variant IIIB, SLC11A3, SLC11A3iron regulated gene 1, solute carrier family 11 (proton-coupled divalent metal ion transporters), solute carrier family 11 (proton-coupled divalent metal ion transporters), member 3, solute carrier family 40 (iron-regulated transporter), member 1, solute carrier family 40 member 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.