product summary
request information :
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Rabbit Polyclonal Fer Antibody
catalog :
NBP1-20089F
quantity :
0.1 ml
price :
309.00 USD
clonality :
polyclonal
host :
rabbit
conjugate :
FITC
reactivity :
human, mouse, dog
application :
western blot
more info or order :
Novus Biologicals product webpage
product information
Catalog Number :
NBP1-20089F
Product Name :
Rabbit Polyclonal Fer Antibody
List Price :
309.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
EC 2.7.10, EC 2.7.10.2, fer (fps/fes related) tyrosine kinase, p94-Fer, Proto-oncogene c-Fer, TYK3phosphoprotein NCP94, Tyrosine kinase 3, tyrosine-protein kinase Fer
Background :
FER (Feline sarcoma related) is a ubiquitously expressed non-receptor protein tyrosine kinase with about 94-kD size that acts downstream of cell surface receptors for growth factors and plays a key role in regulating actin cytoskeleton, microtubule assembly, lamellipodia formation, cell adhesion, cell migration and chemotaxis. It acts downstream of EGFR, KIT, FCER1, PDGFRA/PDGFRB receptor etc and phosphorylates CTTN, CTNND1, PTK2/FAK1, GAB1, PECAM1, PTPN11, JUP, PTPN1 and STAT3. Similar to other tyrosine kinases, FER has a central Src-homology 2 (SH2) domain involved in binding to phosphotyrosine-containing peptide sequences and a highly conserved C-terminal kinase domain, whereas it is different by an NH2-terminal FER/ClP4 homology and adjacent coiled-coil domains. FER is expressed ubiquitously in human tissues and higher FER levels are observed in cancer cells compared with adjacent normal cells e.g. renal cell carcinoma.
Buffer :
50mM sodium borate
Clonality :
Polyclonal
Conjugate :
FITC
Application Summary :
Western Blot
Host :
Rabbit
Immunogen :
Synthetic peptide made to an internal portion of human FER (within residues 400-450). [Swiss-Prot# P16591]
Localization :
Cytoplasm
Preservative :
No Preservative
Purity :
Immunogen affinity purified
CrossReactivity :
Human. Predicted to react with mouse and canine based on 100% sequence homology.
Storage :
Store at 4C in the dark.
Swissprot Human :
P16591
TMW :
94 kDa
Uses :
This FER antibody is useful for Immunocytochemistry/Immunofluorescence and Western blot, where a band is seen ~94 kDa. In ICC/IF cytoplasmic staining was observed.
Research Area :
Protein Kinase
more info or order :
Novus Biologicals product webpage
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com
3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.