product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Serpin E1/PAI-1 Antibody - BSA Free
catalog :
NBP1-19773
quantity :
0.1 mg (also 0.025 mg)
price :
409 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
clone name :
59A426
reactivity :
human, mouse, rat
application :
western blot, ELISA, immunohistochemistry, immunocytochemistry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 66
Reference
Samarkina A, Youssef M, Ostano P, Ghosh S, Ma M, Tassone B, et al. Androgen receptor is a determinant of melanoma targeted drug resistance. Nat Commun. 2023;14:6498 pubmed publisher
Qu F, Brough S, Michno W, MADUBATA C, Hartmann G, Puno A, et al. Crosstalk between small-cell lung cancer cells and astrocytes mimics brain development to promote brain metastasis. Nat Cell Biol. 2023;25:1506-1519 pubmed publisher
Wang X, Guo L, Huang J, Jiang S, Li N, Mu H, et al. Plasminogen Activator Inhibitor-1 Potentiates Neutrophil Infiltration and Tissue Injury in Colitis. Int J Biol Sci. 2023;19:2132-2149 pubmed publisher
Liu B, Kong Y, Alimi O, Kuss M, Tu H, Hu W, et al. Multifunctional Microgel-Based Cream Hydrogels for Postoperative Abdominal Adhesion Prevention. ACS Nano. 2023;17:3847-3864 pubmed publisher
Ghosh A, Kalousdian A, Shang M, Lux E, Eren M, Keating A, et al. Cardiomyocyte PAI-1 influences the cardiac transcriptome and limits the extent of cardiac fibrosis in response to left ventricular pressure overload. Cell Signal. 2023;104:110555 pubmed publisher
Zhu X, Schrader J, Irizarry B, Smith S, Van Nostrand W. Impact of Aβ40 and Aβ42 Fibrils on the Transcriptome of Primary Astrocytes and Microglia. Biomedicines. 2022;10: pubmed publisher
Bertelli P, Pedrini E, Hughes D, McDonnell S, Pathak V, Peixoto E, et al. Long term high glucose exposure induces premature senescence in retinal endothelial cells. Front Physiol. 2022;13:929118 pubmed publisher
Hasuike Y, Mochizuki H, Nakamori M. Expanded CUG Repeat RNA Induces Premature Senescence in Myotonic Dystrophy Model Cells. Front Genet. 2022;13:865811 pubmed publisher
Gao J, Wen J, Hu D, Liu K, Zhang Y, Zhao X, et al. Bottlebrush inspired injectable hydrogel for rapid prevention of postoperative and recurrent adhesion. Bioact Mater. 2022;16:27-46 pubmed publisher
Hu B, Sai W, Yuan J, Lan H, Qi J, Wang D, et al. PGF2α-FP Receptor Ameliorates Senescence of VSMCs in Vascular Remodeling by Src/PAI-1 Signal Pathway. Oxid Med Cell Longev. 2022;2022:2908261 pubmed publisher
Zhang S, Cao Y, Du J, Liu H, Chen X, Li M, et al. Neutrophil extracellular traps contribute to tissue plasminogen activator resistance in acute ischemic stroke. FASEB J. 2021;35:e21835 pubmed publisher
Chen D, Khan N, Close B, Goel R, Blum B, Tavares A, et al. SARS-CoV-2 Disrupts Proximal Elements in the JAK-STAT Pathway. J Virol. 2021;95:e0086221 pubmed publisher
Sun H, Pratt R, Hodgkinson C, Dzau V. Sequential paracrine mechanisms are necessary for the therapeutic benefits of stem cell therapy. Am J Physiol Cell Physiol. 2020;319:C1141-C1150 pubmed publisher
Lee Y, Kwon S, Lee E, Kim G, Min S, Hong S, et al. Mitochondrial Respiratory Defect Enhances Hepatoma Cell Invasiveness via STAT3/NFE2L1/STX12 Axis. Cancers (Basel). 2020;12: pubmed publisher
Ishiwata S, Iizuka H, Sonoda H, Tsunoda D, Tajika Y, Chikuda H, et al. Upregulated miR-224-5p suppresses osteoblast differentiation by increasing the expression of Pai-1 in the lumbar spine of a rat model of congenital kyphoscoliosis. Mol Cell Biochem. 2020;475:53-62 pubmed publisher
Feoktistova M, Makarov R, Brenji S, Schneider A, Hooiveld G, Luedde T, et al. A20 Promotes Ripoptosome Formation and TNF-Induced Apoptosis via cIAPs Regulation and NIK Stabilization in Keratinocytes. Cells. 2020;9: pubmed publisher
Kimura N, Nakagami G, Minematsu T, Sanada H. Non-invasive detection of local tissue responses to predict pressure ulcer development in mouse models. J Tissue Viability. 2020;29:51-57 pubmed publisher
Mallikarjuna P, Raviprakash T, Aripaka K, Ljungberg B, Landström M. Interactions between TGF-β type I receptor and hypoxia-inducible factor-α mediates a synergistic crosstalk leading to poor prognosis for patients with clear cell renal cell carcinoma. Cell Cycle. 2019;18:2141-2156 pubmed publisher
Ma J, Xiao Y, Tian B, Chen S, Zhang B, Wu J, et al. Genome-wide analyses of long non-coding RNA expression profiles and functional network analysis in esophageal squamous cell carcinoma. Sci Rep. 2019;9:9162 pubmed publisher
Larocca T, Mariani A, Watkins L, Link C. TDP-43 knockdown causes innate immune activation via protein kinase R in astrocytes. Neurobiol Dis. 2019;:104514 pubmed publisher
Delfarah A, Parrish S, Junge J, Yang J, Seo F, Li S, et al. Inhibition of nucleotide synthesis promotes replicative senescence of human mammary epithelial cells. J Biol Chem. 2019;294:10564-10578 pubmed publisher
Zhong Y, Zhang Y, Xu J, Zhou J, Liu J, Ye M, et al. Low-Intensity Focused Ultrasound-Responsive Phase-Transitional Nanoparticles for Thrombolysis without Vascular Damage: A Synergistic Nonpharmaceutical Strategy. ACS Nano. 2019;13:3387-3403 pubmed publisher
Cheng Q, Tong F, Shen Y, He C, Wang C, Ding F. Achyranthes bidentata polypeptide k improves long-term neurological outcomes through reducing downstream microvascular thrombosis in experimental ischemic stroke. Brain Res. 2019;1706:166-176 pubmed publisher
Priyadarshini R, Hussain M, Attri P, Kaur E, Tripathi V, Priya S, et al. BLM Potentiates c-Jun Degradation and Alters Its Function as an Oncogenic Transcription Factor. Cell Rep. 2018;24:947-961.e7 pubmed publisher
Hiebert P, WIETECHA M, Cangkrama M, Haertel E, Mavrogonatou E, Stumpe M, et al. Nrf2-Mediated Fibroblast Reprogramming Drives Cellular Senescence by Targeting the Matrisome. Dev Cell. 2018;46:145-161.e10 pubmed publisher
Mallikarjuna P, Sitaram R, Landström M, Ljungberg B. VHL status regulates transforming growth factor-β signaling pathways in renal cell carcinoma. Oncotarget. 2018;9:16297-16310 pubmed publisher
Lim M, Maubach G, Sokolova O, Feige M, Diezko R, Buchbinder J, et al. Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017;24:1621-1631 pubmed publisher
Gerenu G, Martisova E, Ferrero H, Carracedo M, Rantamäki T, Ramirez M, et al. Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits. Biochim Biophys Acta Mol Basis Dis. 2017;1863:991-1001 pubmed publisher
Sitaram R, Mallikarjuna P, Landström M, Ljungberg B. Transforming growth factor-β promotes aggressiveness and invasion of clear cell renal cell carcinoma. Oncotarget. 2016;7:35917-35931 pubmed publisher
Reihill J, Malcomson B, Bertelsen A, Cheung S, Czerwiec A, Barsden R, et al. Induction of the inflammatory regulator A20 by gibberellic acid in airway epithelial cells. Br J Pharmacol. 2016;173:778-89 pubmed publisher
Perez C, Jukica A, Listopad J, Anders K, Kühl A, Loddenkemper C, et al. Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts. Int J Cancer. 2015;137:359-71 pubmed publisher
De A, Dainichi T, RATHINAM C, Ghosh S. The deubiquitinase activity of A20 is dispensable for NF-?B signaling. EMBO Rep. 2014;15:775-83 pubmed publisher
Lai T, Wu S, Tsai M, Chuang E, Chuang L, Hsu L, et al. Transcription of Tnfaip3 is regulated by NF-?B and p38 via C/EBP? in activated macrophages. PLoS ONE. 2013;8:e73153 pubmed publisher
Svingerud T, Solstad T, Sun B, Nyrud M, Kileng y, Greiner Tollersrud L, et al. Atlantic salmon type I IFN subtypes show differences in antiviral activity and cell-dependent expression: evidence for high IFNb/IFNc-producing cells in fish lymphoid tissues. J Immunol. 2012;189:5912-23 pubmed publisher
Karube K, Nakagawa M, Tsuzuki S, Takeuchi I, Honma K, Nakashima Y, et al. Identification of FOXO3 and PRDM1 as tumor-suppressor gene candidates in NK-cell neoplasms by genomic and functional analyses. Blood. 2011;118:3195-204 pubmed publisher
Gerlach B, Cordier S, Schmukle A, Emmerich C, Rieser E, Haas T, et al. Linear ubiquitination prevents inflammation and regulates immune signalling. Nature. 2011;471:591-6 pubmed publisher
Hövelmeyer N, Reissig S, Xuan N, Adams Quack P, Lukas D, Nikolaev A, et al. A20 deficiency in B cells enhances B-cell proliferation and results in the development of autoantibodies. Eur J Immunol. 2011;41:595-601 pubmed publisher
Adrianto I, Wen F, Templeton A, Wiley G, King J, Lessard C, et al. Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus. Nat Genet. 2011;43:253-8 pubmed publisher
Imbeault M, Ouellet M, Giguère K, Bertin J, Bélanger D, Martin G, et al. Acquisition of host-derived CD40L by HIV-1 in vivo and its functional consequences in the B-cell compartment. J Virol. 2011;85:2189-200 pubmed publisher
Malinverni C, Unterreiner A, Staal J, Demeyer A, Galaup M, Luyten M, et al. Cleavage by MALT1 induces cytosolic release of A20. Biochem Biophys Res Commun. 2010;400:543-7 pubmed publisher
Frenzel L, Claus R, Plume N, Schwamb J, Konermann C, Pallasch C, et al. Sustained NF-kappaB activity in chronic lymphocytic leukemia is independent of genetic and epigenetic alterations in the TNFAIP3 (A20) locus. Int J Cancer. 2011;128:2495-500 pubmed publisher
Harada Y, Kanehira M, Fujisawa Y, Takata R, Shuin T, Miki T, et al. Cell-permeable peptide DEPDC1-ZNF224 interferes with transcriptional repression and oncogenicity in bladder cancer cells. Cancer Res. 2010;70:5829-39 pubmed publisher
Hjelmeland A, Wu Q, Wickman S, Eyler C, Heddleston J, Shi Q, et al. Targeting A20 decreases glioma stem cell survival and tumor growth. PLoS Biol. 2010;8:e1000319 pubmed publisher
Hailfinger S, Lenz G, Ngo V, Posvitz Fejfar A, Rebeaud F, Guzzardi M, et al. Essential role of MALT1 protease activity in activated B cell-like diffuse large B-cell lymphoma. Proc Natl Acad Sci U S A. 2009;106:19946-51 pubmed publisher
Metellus P, Coulibaly B, Nanni I, Fina F, Eudes N, Giorgi R, et al. Prognostic impact of O6-methylguanine-DNA methyltransferase silencing in patients with recurrent glioblastoma multiforme who undergo surgery and carmustine wafer implantation: a prospective patient cohort. Cancer. 2009;115:4783-94 pubmed publisher
Honma K, Tsuzuki S, Nakagawa M, Tagawa H, Nakamura S, Morishima Y, et al. TNFAIP3/A20 functions as a novel tumor suppressor gene in several subtypes of non-Hodgkin lymphomas. Blood. 2009;114:2467-75 pubmed publisher
Duwel M, Welteke V, Oeckinghaus A, Baens M, Kloo B, Ferch U, et al. A20 negatively regulates T cell receptor signaling to NF-kappaB by cleaving Malt1 ubiquitin chains. J Immunol. 2009;182:7718-28 pubmed publisher
Schmitz R, Hansmann M, Bohle V, Martin Subero J, Hartmann S, Mechtersheimer G, et al. TNFAIP3 (A20) is a tumor suppressor gene in Hodgkin lymphoma and primary mediastinal B cell lymphoma. J Exp Med. 2009;206:981-9 pubmed publisher
Verhelst K, Verstrepen L, Coornaert B, Carpentier I, Beyaert R. Cellular expression of A20 and ABIN-3 in response to Toll-like receptor-4 stimulation. Methods Mol Biol. 2009;517:205-15 pubmed publisher
Breckpot K, Aerts Toegaert C, Heirman C, Peeters U, Beyaert R, Aerts J, et al. Attenuated expression of A20 markedly increases the efficacy of double-stranded RNA-activated dendritic cells as an anti-cancer vaccine. J Immunol. 2009;182:860-70 pubmed
Li L, Soetandyo N, Wang Q, Ye Y. The zinc finger protein A20 targets TRAF2 to the lysosomes for degradation. Biochim Biophys Acta. 2009;1793:346-53 pubmed publisher
Werner S, Kearns J, Zadorozhnaya V, Lynch C, O Dea E, Boldin M, et al. Encoding NF-kappaB temporal control in response to TNF: distinct roles for the negative regulators IkappaBalpha and A20. Genes Dev. 2008;22:2093-101 pubmed publisher
Li L, Hailey D, Soetandyo N, Li W, Lippincott Schwartz J, Shu H, et al. Localization of A20 to a lysosome-associated compartment and its role in NFkappaB signaling. Biochim Biophys Acta. 2008;1783:1140-9 pubmed publisher
Coornaert B, Baens M, Heyninck K, Bekaert T, Haegman M, Staal J, et al. T cell antigen receptor stimulation induces MALT1 paracaspase-mediated cleavage of the NF-kappaB inhibitor A20. Nat Immunol. 2008;9:263-71 pubmed publisher
Chevillard G, Derjuga A, Devost D, Zingg H, Blank V. Identification of interleukin-1beta regulated genes in uterine smooth muscle cells. Reproduction. 2007;134:811-22 pubmed
Bohgaki M, Tsukiyama T, Nakajima A, Maruyama S, Watanabe M, Koike T, et al. Involvement of Ymer in suppression of NF-kappaB activation by regulated interaction with lysine-63-linked polyubiquitin chain. Biochim Biophys Acta. 2008;1783:826-37 pubmed
Zhang B, Guan C, Chen W, Zhang P, Yan M, Shi J, et al. A20 inhibits human salivary adenoid cystic carcinoma cells invasion via blocking nuclear factor-kappaB activation. Chin Med J (Engl). 2007;120:1830-5 pubmed
Yokota S, Okabayashi T, Yokosawa N, Fujii N. Measles virus P protein suppresses Toll-like receptor signal through up-regulation of ubiquitin-modifying enzyme A20. FASEB J. 2008;22:74-83 pubmed
Hutti J, Turk B, Asara J, Ma A, Cantley L, Abbott D. IkappaB kinase beta phosphorylates the K63 deubiquitinase A20 to cause feedback inhibition of the NF-kappaB pathway. Mol Cell Biol. 2007;27:7451-61 pubmed
Salaun B, Lebecque S, Matikainen S, Rimoldi D, Romero P. Toll-like receptor 3 expressed by melanoma cells as a target for therapy?. Clin Cancer Res. 2007;13:4565-74 pubmed
Wang Y, Li L, Han K, Zhai Z, Shu H. A20 is a potent inhibitor of TLR3- and Sendai virus-induced activation of NF-kappaB and ISRE and IFN-beta promoter. FEBS Lett. 2004;576:86-90 pubmed
Ke B, Shen X, Lassman C, Gao F, Busuttil R, Kupiec Weglinski J. Cytoprotective and antiapoptotic effects of IL-13 in hepatic cold ischemia/reperfusion injury are heme oxygenase-1 dependent. Am J Transplant. 2003;3:1076-82 pubmed
Yang K, Arcaroli J, Kupfner J, Pitts T, Park J, Strasshiem D, et al. Involvement of phosphatidylinositol 3-kinase gamma in neutrophil apoptosis. Cell Signal. 2003;15:225-33 pubmed
Ke B, Shen X, Zhai Y, Gao F, Busuttil R, Volk H, et al. Heme oxygenase 1 mediates the immunomodulatory and antiapoptotic effects of interleukin 13 gene therapy in vivo and in vitro. Hum Gene Ther. 2002;13:1845-57 pubmed
Wu W, Xu Z, Chang K. The promyelocytic leukemia protein represses A20-mediated transcription. J Biol Chem. 2002;277:31734-9 pubmed
Kupfner J, Arcaroli J, Yum H, Nadler S, Yang K, Abraham E. Role of NF-kappaB in endotoxemia-induced alterations of lung neutrophil apoptosis. J Immunol. 2001;167:7044-51 pubmed
product information
master code :
NBP1-19773
SKU :
NBP1-19773
product name :
Serpin E1/PAI-1 Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The Serpin E1/PAI-1 Antibody - BSA Free from Novus is a rabbit polyclonal antibody to Serpin E1/PAI-1. This antibody reacts with human,mouse,rat. The Serpin E1/PAI-1 Antibody - BSA Free has been validated for the following applications: Western Blot,IF/IHC,ELISA,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence.
target :
Serpin E1/PAI-1
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal portion of the human PAI1/Serpine 1 protein (between residues 300-400) [UniProt P05121]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human,Mouse,Rat
specificity :
PAI-1 (N315) pAb detects endogenous levels of PAI-1 protein
theoretical molecular weight :
45 kDa
gene symbol :
SERPINE1
Antibody validation :
Biological Validation
accessionNumbers :
P05121
applications :
Western Blot,IF/IHC,ELISA,Immunohistochemistry,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunocytochemistry/ Immunofluorescence
USD :
409 USD
alt names :
Endothelial plasminogen activator inhibitor, PAI1PAI-1, PAISerpin E1, PLANH1plasminogen activator inhibitor 1, serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogenactivator inhibitor type 1), member 1, serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitortype 1), member 1
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.