product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
TNF-alpha Antibody - BSA Free
catalog :
NBP1-19532
quantity :
0.1 mg (also 0.025 mg)
price :
459 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat, dogs, rhesus macaque
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, immunohistochemistry knockout validation
more info or order :
citations: 75
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry knockout validation; mouse; loading ...; fig s1a, s1b
Fu X, Peng J, Wang A, Luo Z. Tumor necrosis factor alpha mediates neuromuscular synapse elimination. Cell Discov. 2020;6:9 pubmed publisher
  • immunohistochemistry; mouse; 1:300; loading ...; fig 3a
Lindfors S, Polianskyte Prause Z, Bouslama R, Lehtonen E, Mannerla M, Nisen H, et al. Adiponectin receptor agonist AdipoRon ameliorates renal inflammation in diet-induced obese mice and endotoxin-treated human glomeruli ex vivo. Diabetologia. 2021;64:1866-1879 pubmed publisher
  • immunohistochemistry; human; 1:100; fig 3
Szylberg Å, Janiczek M, Popiel A, MarszaÅ‚ek A. Expression of COX-2, IL-1β, TNF-α and IL-4 in epithelium of serrated adenoma, adenoma and hyperplastic polyp. Arch Med Sci. 2016;12:172-8 pubmed publisher
  • immunohistochemistry - frozen section; rat; 1:200; fig 6
Vieira Ramos G, Pinheiro C, Messa S, Delfino G, Marqueti R, Salvini T, et al. Cryotherapy Reduces Inflammatory Response Without Altering Muscle Regeneration Process and Extracellular Matrix Remodeling of Rat Muscle. Sci Rep. 2016;6:18525 pubmed publisher
Kawasaki R, Sakata A, Tatsumi K, Mitani S, Takeda M, Kasuda S, et al. β-hydroxybutyrate suppresses pathological changes of blood-induced arthropathy in rats. Sci Rep. 2024;14:29696 pubmed publisher
Riva A, Sahin E, Volpedo G, Petretto A, Lavarello C, Di Sapia R, et al. Identification of an epilepsy-linked gut microbiota signature in a pediatric rat model of acquired epilepsy. Neurobiol Dis. 2024;194:106469 pubmed publisher
Azzam S, Abdel Khalek M, Abdel Rahman A, Osman A, Selim H, Sharif A, et al. Revealing how phenytoin triggers liver damage and the potential protective effects of Balanites Aegyptiaca fruit extracts: Exploring Nrf2/MAPK/ Beclin-1 signaling pathways. Biomed Pharmacother. 2023;165:115265 pubmed publisher
Ohkawa Y, Kanto N, Nakano M, Fujinawa R, Kizuka Y, Johnson E, et al. Involvement of langerin in the protective function of a keratan sulfate-based disaccharide in an emphysema mouse model. J Biol Chem. 2023;:105052 pubmed publisher
Chen X, Huang L, Tang J, Wu D, An N, Ye Z, et al. Asiatic acid alleviates cisplatin-induced renal fibrosis in tumor-bearing mice by improving the TFEB-mediated autophagy-lysosome pathway. Biomed Pharmacother. 2023;165:115122 pubmed publisher
Yeh J, Kuo C, Shih P, Hsu J, I Chen P, Huang Y. Xanthine derivative KMUP-1 ameliorates retinopathy. Biomed Pharmacother. 2023;165:115109 pubmed publisher
Wei F, Tuong Z, Omer M, Ngo C, Asiatico J, Kinzel M, et al. A novel multifunctional radioprotective strategy using P7C3 as a countermeasure against ionizing radiation-induced bone loss. Bone Res. 2023;11:34 pubmed publisher
Vos S, Aaron R, Weng M, Daw J, Rodriguez Rivera E, Subauste C. CD40 Upregulation in the Retina of Patients With Diabetic Retinopathy: Association With TRAF2/TRAF6 Upregulation and Inflammatory Molecule Expression. Invest Ophthalmol Vis Sci. 2023;64:17 pubmed publisher
Alam A, Singh T, Kayhanian S, Tjerkaski J, Garcia N, Carpenter K, et al. Modeling the Inflammatory Response of Traumatic Brain Injury Using Human Induced Pluripotent Stem Cell Derived Microglia. J Neurotrauma. 2023;40:2164-2173 pubmed publisher
Aswani S, Mohan M, Aparna N, Boban P, Saja K. Oxidized LDL-mediated upregulation of ADAMTS-4 in monocytes/macrophages involves ROS-NF-κB-SIRT-1 pathway. Physiol Int. 2023;110:173-190 pubmed publisher
P xe9 rez Acu xf1 a D, Rhee K, Shin S, Ahn J, Lee J, Lee S. Retina-to-brain spreading of α-synuclein after intravitreal injection of preformed fibrils. Acta Neuropathol Commun. 2023;11:83 pubmed publisher
Abulfadl Y, El Ela Y, Al Khaiyat A, Elkhodary K, Badran M. Cyclophosphamide enfeebles myocardial isometric contraction force via RIP1/RIP3/MLKL/TRPM7-mediated necroptosis. Biomed Pharmacother. 2023;163:114819 pubmed publisher
Salman S, Guermonprez C, Peno Mazzarino L, Lati E, Rousseaud A, Declercq L, et al. Photobiomodulation Controls Keratinocytes Inflammatory Response through Nrf2 and Reduces Langerhans Cells Activation. Antioxidants (Basel). 2023;12: pubmed publisher
Ghebryal L, Noshy M, El Ghor A, Eissa S. Comparative analysis of Acomys cahirinus and Mus musculus responses to genotoxicity, oxidative stress, and inflammation. Sci Rep. 2023;13:3989 pubmed publisher
Khedr L, Eladawy R, Nassar N, Saad M. Canagliflozin attenuates chronic unpredictable mild stress induced neuroinflammation via modulating AMPK/mTOR autophagic signaling. Neuropharmacology. 2023;223:109293 pubmed publisher
Nishad R, Mukhi D, Kethavath S, Raviraj S, Paturi A, Motrapu M, et al. Podocyte derived TNF-α mediates monocyte differentiation and contributes to glomerular injury. FASEB J. 2022;36:e22622 pubmed publisher
Garcia Hernandez M, Rangel Moreno J, García Castañeda M, Kenney H, Paine A, Thullen M, et al. Dendritic cell-specific transmembrane protein is required for synovitis and bone resorption in inflammatory arthritis. Front Immunol. 2022;13:1026574 pubmed publisher
Guo X, Sun Y, Wang Z, Ren B, Xu H, Peng X, et al. The Preventive Effect of A Magnetic Nanoparticle-Modified Root Canal Sealer on Persistent Apical Periodontitis. Int J Mol Sci. 2022;23: pubmed publisher
Kochumon S, Hasan A, Al Rashed F, Sindhu S, Thomas R, Jacob T, et al. Increased Adipose Tissue Expression of IL-23 Associates with Inflammatory Markers in People with High LDL Cholesterol. Cells. 2022;11: pubmed publisher
Hu Q, Yao J, Wu X, Li J, Li G, Tang W, et al. Emodin attenuates severe acute pancreatitis-associated acute lung injury by suppressing pancreatic exosome-mediated alveolar macrophage activation. Acta Pharm Sin B. 2022;12:3986-4003 pubmed publisher
Dafnis I, Mountaki C, Fanarioti E, Mastellos D, Karvelas M, Karathanos V, et al. Temporal Pattern of Neuroinflammation Associated with a Low Glycemic Index Diet in the 5xFAD Mouse Model of Alzheimer's Disease. Mol Neurobiol. 2022;59:7303-7322 pubmed publisher
Chen K, Deng Y, Shang S, Tang L, Li Q, Bai X, et al. Complement factor B inhibitor LNP023 improves lupus nephritis in MRL/lpr mice. Biomed Pharmacother. 2022;153:113433 pubmed publisher
Ibrahim Y, Hammady S, Rifaai R, Waz S, Ibrahim M, Hafez H. Dose-dependent ameliorating effect of lipoxin A4 on gentamicin-induced nephrotoxicity in rats: The role of TNFα, TGF-β, ICAM-1, and JNK signaling. Chem Biol Interact. 2022;366:110139 pubmed publisher
Perdigoto A, Deng S, Du K, Kuchroo M, Burkhardt D, Tong A, et al. Immune cells and their inflammatory mediators modify β cells and cause checkpoint inhibitor-induced diabetes. JCI Insight. 2022;7: pubmed publisher
Chen H, Zhou J, Chen H, Liang J, Xie C, Gu X, et al. Bmi-1-RING1B prevents GATA4-dependent senescence-associated pathological cardiac hypertrophy by promoting autophagic degradation of GATA4. Clin Transl Med. 2022;12:e574 pubmed publisher
Rohlfing A, Kolb K, Sigle M, Ziegler M, Bild A, M xfc nzer P, et al. ACKR3 regulates platelet activation and ischemia-reperfusion tissue injury. Nat Commun. 2022;13:1823 pubmed publisher
Zhang Y, Zhao M, Gao H, Yu G, Zhao Y, Yao F, et al. MAPK signalling-induced phosphorylation and subcellular translocation of PDHE1α promotes tumour immune evasion. Nat Metab. 2022;4:374-388 pubmed publisher
Motawea A, Abd El Hady W, Ahmed El Emam G. The protective impact of adapted trimebutine maleate-loaded nanostructured lipid carriers for alleviating the severity of acute colitis. Drug Deliv. 2022;29:906-924 pubmed publisher
Ma T, Li X, Zhu Y, Yu S, Liu T, Zhang X, et al. Excessive Activation of Notch Signaling in Macrophages Promote Kidney Inflammation, Fibrosis, and Necroptosis. Front Immunol. 2022;13:835879 pubmed publisher
Narouiepour A, Ebrahimzadeh Bideskan A, Rajabzadeh G, Gorji A, Negah S. Neural stem cell therapy in conjunction with curcumin loaded in niosomal nanoparticles enhanced recovery from traumatic brain injury. Sci Rep. 2022;12:3572 pubmed publisher
Alzahrani B, Gaballa M, Tantawy A, Moussa M, Shoulah S, Elshafae S. Blocking Toll-like receptor 9 attenuates bleomycin-induced pulmonary injury. J Pathol Transl Med. 2022;56:81-91 pubmed publisher
Tanyeli A, Guzel Erdogan D, Comaklı S, Polat E, Güler M, Eraslan E, et al. Therapeutic effects of apocynin on ovarian ischemia-reperfusion induced lung injury. Biotech Histochem. 2022;97:536-545 pubmed publisher
Othman M, Mubarak H, Sayed M. Ameliorative role of alpha-lipoic acid in renal cortical structural damage, induced by limb ischemia-reperfusion injury in the rat. Ultrastruct Pathol. 2022;46:110-121 pubmed publisher
Boss M, Ke Y, Bian L, Harrison L, Lee B, Prebble A, et al. Therapeutic Intervention Using a Smad7-Based Tat Protein to Treat Radiation-Induced Oral Mucositis. Int J Radiat Oncol Biol Phys. 2022;112:759-770 pubmed publisher
Zhou J, Hou C, Chen H, Qin Z, Miao Z, Zhao J, et al. P16 I NK 4a Deletion Ameliorates Damage of Intestinal Epithelial Barrier and Microbial Dysbiosis in a Stress-Induced Premature Senescence Model of Bmi-1 Deficiency. Front Cell Dev Biol. 2021;9:671564 pubmed publisher
G xfc ler M, Tanyeli A, Erdo x11f an D, Eraslan E, xc7 omakl x131 S, Polat E, et al. Urapidil alleviates ovarian torsion detorsion injury via regulating oxidative stress, apoptosis, autophagia, and inflammation. Iran J Basic Med Sci. 2021;24:935-942 pubmed publisher
Cheng Y, Chiu Y, Dai Z, Wu B. Loganin Ameliorates Painful Diabetic Neuropathy by Modulating Oxidative Stress, Inflammation and Insulin Sensitivity in Streptozotocin-Nicotinamide-Induced Diabetic Rats. Cells. 2021;10: pubmed publisher
Vendidandala N, Yin T, Nelli G, Pasupuleti V, Nyamathulla S, Mokhtar S. Gallocatechin‑silver nanoparticle impregnated cotton gauze patches enhance wound healing in diabetic rats by suppressing oxidative stress and inflammation via modulating the Nrf2/HO-1 and TLR4/NF-κB pathways. Life Sci. 2021;286:120019 pubmed publisher
Velatooru L, Abe R, Imanishi M, Gi Y, Ko K, Heo K, et al. Disturbed flow-induced FAK K152 SUMOylation initiates the formation of pro-inflammation positive feedback loop by inducing reactive oxygen species production in endothelial cells. Free Radic Biol Med. 2021;177:404-418 pubmed publisher
Choudhary V, Kaddour Djebbar I, Custer V, Uaratanawong R, Chen X, Cohen E, et al. Glycerol Improves Skin Lesion Development in the Imiquimod Mouse Model of Psoriasis: Experimental Confirmation of Anecdotal Reports from Patients with Psoriasis. Int J Mol Sci. 2021;22: pubmed publisher
Yan Y, Liang H, Liu X, Liu L, Chen Y. Topical cationic hairy particles targeting cell free DNA in dermis enhance treatment of psoriasis. Biomaterials. 2021;276:121027 pubmed publisher
Wang M, Feng L, Li Z, Ma K, Chang K, Chen X, et al. Thymosin β4 reverses phenotypic polarization of glial cells and cognitive impairment via negative regulation of NF-κB signaling axis in APP/PS1 mice. J Neuroinflammation. 2021;18:146 pubmed publisher
Zheng C, Sui B, Zhang X, Hu J, Chen J, Liu J, et al. Apoptotic vesicles restore liver macrophage homeostasis to counteract type 2 diabetes. J Extracell Vesicles. 2021;10:e12109 pubmed publisher
Iannucci J, Sen A, Grammas P. Isoform-Specific Effects of Apolipoprotein E on Markers of Inflammation and Toxicity in Brain Glia and Neuronal Cells In Vitro. Curr Issues Mol Biol. 2021;43:215-225 pubmed publisher
Lliberós C, Liew S, Zareie P, La Gruta N, Mansell A, Hutt K. Evaluation of inflammation and follicle depletion during ovarian ageing in mice. Sci Rep. 2021;11:278 pubmed publisher
Wu J, Dou Y, Ladiges W. Adverse Neurological Effects of Short-Term Sleep Deprivation in Aging Mice Are Prevented by SS31 Peptide. Clocks Sleep. 2020;2:325-333 pubmed publisher
El Ayadi A, Wang C, Zhang M, Wetzel M, Prasai A, Finnerty C, et al. Metal chelation reduces skin epithelial inflammation and rescues epithelial cells from toxicity due to thermal injury in a rat model. Burns Trauma. 2020;8:tkaa024 pubmed publisher
Jang J, Yeom M, Ahn S, Oh J, Ji S, Kim T, et al. Acupuncture inhibits neuroinflammation and gut microbial dysbiosis in a mouse model of Parkinson's disease. Brain Behav Immun. 2020;89:641-655 pubmed publisher
Naranjo J, Saldin L, Sobieski E, Quijano L, Hill R, Chan P, et al. Esophageal extracellular matrix hydrogel mitigates metaplastic change in a dog model of Barrett's esophagus. Sci Adv. 2020;6:eaba4526 pubmed publisher
Oh J, Hwang T, Jang J, Park J, Ryu Y, Lee H, et al. Muscovite nanoparticles mitigate neuropathic pain by modulating the inflammatory response and neuroglial activation in the spinal cord. Neural Regen Res. 2020;15:2162-2168 pubmed publisher
Han Y, Lee Y, Jang Y, Kim H, Seo H, Jung T, et al. Aspirin Improves Nonalcoholic Fatty Liver Disease and Atherosclerosis through Regulation of the PPARδ-AMPK-PGC-1α Pathway in Dyslipidemic Conditions. Biomed Res Int. 2020;2020:7806860 pubmed publisher
Wang M, Zong H, Chang K, Han H, Yasir Rizvi M, Iffat Neha S, et al. 5-HT1AR alleviates Aβ-induced cognitive decline and neuroinflammation through crosstalk with NF-κB pathway in mice. Int Immunopharmacol. 2020;82:106354 pubmed publisher
Kurt B, Ozleyen A, Antika G, Yilmaz Y, Tumer T. Multitarget Profiling of a Strigolactone Analogue for Early Events of Alzheimer's Disease: In Vitro Therapeutic Activities against Neuroinflammation. ACS Chem Neurosci. 2020;11:501-507 pubmed publisher
Li S, Jiang L, Yang Y, Cao J, Zhang Q, Zhang J, et al. Siglec1 enhances inflammation through miR-1260-dependent degradation of IκBα in COPD. Exp Mol Pathol. 2020;113:104398 pubmed publisher
Wang J, Liu H, Xie G, Cai W, Xu J. Identification of hub genes and key pathways of dietary advanced glycation end products‑induced non‑alcoholic fatty liver disease by bioinformatics analysis and animal experiments. Mol Med Rep. 2020;21:685-694 pubmed publisher
Li X, Xue Y, Guo H, Deng C, Peng D, Yang H, et al. High hydrostatic pressure induces atrial electrical remodeling through upregulation of inflammatory cytokines. Life Sci. 2020;242:117209 pubmed publisher
Sparks R, Lui A, Bader D, Patel R, Murr M, Guida W, et al. A specific small-molecule inhibitor of protein kinase CδI activity improves metabolic dysfunction in human adipocytes from obese individuals. J Biol Chem. 2019;294:14896-14910 pubmed publisher
Corbett B, Luz S, Arner J, Pearson Leary J, Sengupta A, Taylor D, et al. Sphingosine-1-phosphate receptor 3 in the medial prefrontal cortex promotes stress resilience by reducing inflammatory processes. Nat Commun. 2019;10:3146 pubmed publisher
Gu X, Peng C, Lin S, Qin Z, Liang J, Chen H, et al. P16INK4a played a critical role in exacerbating acute tubular necrosis in acute kidney injury. Am J Transl Res. 2019;11:3850-3861 pubmed
Riggin C, Chen M, Gordon J, Schultz S, Soslowsky L, Khoury V. Ultrasound-Guided Dry Needling of the Healthy Rat Supraspinatus Tendon Elicits Early Healing Without Causing Permanent Damage. J Orthop Res. 2019;37:2035-2042 pubmed publisher
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Xing J, Lu J, Li J. Role of TNF-α in Regulating the Exercise Pressor Reflex in Rats With Femoral Artery Occlusion. Front Physiol. 2018;9:1461 pubmed publisher
Park S, Rhee J, Kim S, Kang J, Kwak J, Son Y, et al. BATF regulates collagen-induced arthritis by regulating T helper cell differentiation. Arthritis Res Ther. 2018;20:161 pubmed publisher
Hoshikawa H, Kamitori K, Indo K, Mori T, Kamata M, Takahashi T, et al. Combined treatment with D-allose, docetaxel and radiation inhibits the tumor growth in an in vivo model of head and neck cancer. Oncol Lett. 2018;15:3422-3428 pubmed publisher
Özdemir S, Altun S, Arslan H. Imidacloprid exposure cause the histopathological changes, activation of TNF-α, iNOS, 8-OHdG biomarkers, and alteration of caspase 3, iNOS, CYP1A, MT1 gene expression levels in common carp (Cyprinus carpio L.). Toxicol Rep. 2018;5:125-133 pubmed publisher
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Huegel J, Choi D, Nuss C, Minnig M, Tucker J, Kuntz A, et al. Effects of pulsed electromagnetic field therapy at different frequencies and durations on rotator cuff tendon-to-bone healing in a rat model. J Shoulder Elbow Surg. 2018;27:553-560 pubmed publisher
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Xu Y, Romero R, Miller D, Kadam L, Mial T, Plazyo O, et al. An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment. J Immunol. 2016;196:2476-2491 pubmed publisher
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product information
master code :
NBP1-19532
SKU :
NBP1-19532
product name :
TNF-alpha Antibody - BSA Free
unit size :
0.1 mg (also 0.025 mg)
description :
The TNF-alpha Antibody - BSA Free from Novus is a rabbit polyclonal antibody to TNF-alpha. This antibody reacts with canine,fish,human,mouse,primate - macaca mulatta (rhesus macaque),rat. The TNF-alpha Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating.
target :
TNF-alpha
category :
Primary Antibodies
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
A synthetic peptide made to an internal portion of the human TNF alpha protein (between residues 100-200) [Uniprot: P01375]
isotype :
IgG
purity :
Immunogen affinity purified
species :
Canine,Fish,Human,Mouse,Primate - Macaca mulatta (Rhesus Macaque),Rat
gene symbol :
TNF
accessionNumbers :
P01375
applications :
Immunohistochemistry,Immunocytochemistry/ Immunofluorescence,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunohistochemistry-Frozen,Immunohistochemistry Free-Floating
USD :
459 USD
alt names :
APC1 protein, Cachectin, DIF, TNF, monocyte-derived, TNF-a, TNF-alphacachectin, TNFATNF, macrophage-derived, TNFSF2TNF superfamily, member 2, tumor necrosis factor, tumor necrosis factor (TNF superfamily, member 2), tumor necrosis factor alpha, Tumor necrosis factor ligand superfamily member 2, tumor necrosis factor-alpha
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.