This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
Mouse Monoclonal FANCC Antibody
catalog :
NBP1-18974
quantity :
0.1 ml
price :
309.00 USD
clonality :
monoclonal
host :
mouse
reactivity :
human
application :
western blot, immunocytochemistry, immunoprecipitation
citations: 7
Heinrich M, Silvey K, Stone S, Zigler A, Griffith D, Montalto M, et al. Posttranscriptional cell cycle-dependent regulation of human FANCC expression. Blood. 2000;95:3970-7 pubmed
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Hoatlin M, Zhi Y, Ball H, Silvey K, Melnick A, Stone S, et al. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood. 1999;94:3737-47 pubmed
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Xie Y, de Winter J, Waisfisz Q, Nieuwint A, Scheper R, Arwert F, et al. Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells. Br J Haematol. 2000;111:1057-64 pubmed
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product information
Catalog Number :
NBP1-18974
Product Name :
Mouse Monoclonal FANCC Antibody
List Price :
309.00 USD
Product Type :
Primary Antibodies
Package Size :
0.1 ml
AltNames :
FA3, FACCProtein FACC, FACFanconi anemia group C protein, Fanconi anemia, complementation group C, FLJ14675
Background :
FANCC (Fanconi anemia group C protein) is a DNA repair protein which implicates in post-replication DNA repair or a cell cycle checkpoint function. FANCC also involves in the interstrand DNA cross-link repair as well as the maintenance of chromosome stability/integrity. FANCC participates in the multisubunit FA complex (FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9, FANCM and HSP70) which is not found in FA patients. Upon IFNG induction, FANCC facilitate STAT1 activation via recruitement of STAT1 to IFNGR1. FANCC interacts with ZBTB32 (upon IFNG induction), CDK1, STAT1 etc and FANCC-EIF2AK2 interactions leads to augmented EIF2AK2 activation and cell death. FANCC is expressed ubiquitously and the major form is nuclear while the minor form is cytoplasmic. Defects in FANCC are the cause of Fanconi anemia complementation group C (FANCC), disorder affecting all bone marrow elements and resulting in anemia, leukopenia and thrombopenia.
Buffer :
PBS
Clonality :
Monoclonal
Clone :
8F3
Concentration :
1.9 mg/ml
Application Summary :
Western Blot, Immunocytochemistry/Immunofluorescence, Immunoprecipitation
Host :
Mouse
Immunogen :
A synthetic peptide made to a region of the C-terminus of human FANCC (within residues 450-558) [Swiss-Prot# Q00597].
Isotype :
IgG2b
Localization :
Nucleus. Cytoplasm. Note= The major form is nuclear. The minor form is cytoplasmic.
Preservative :
No Preservative
Purity :
Protein A purified
CrossReactivity :
Human
Storage :
Store at -20C. Avoid freeze-thaw cycles.
Swissprot Human :
Q00597
TMW :
63 kDa
Uses :
This FANCC antibody is useful for Immunocytochemistry/Immunofluorescence, Immunoprecipitation and Western blot where a band is seen ~63 kDa.
Research Area :
Breast Cancer, Cancer, DNA Repair, Genes Sensitive to DNA Damaging Agents
References Product :
MAGRON A Carreau M. Implication de la voie de signalisation de Fanconi dans la regulation du cycle cellulaire via stathmine, un nouveau partenaire de FANCC. Thesis. 2015 (ICC/IF, IP, WB, Human) Huang F, Ben Aissa M, Magron A et al. The Fanconi Anemia Group C Protein Interacts with Uncoordinated 5A and Delays Apoptosis. PLoS ONE 3/28/2014 [PMID: 24676280] (IP, WB, ICC/IF, Human) Huard CC, Tremblay CS, Magron A, Carreau M. The Fanconi anemia pathway has a dual function in Dickkopf-1 transcriptional repression. Proc. Natl. Acad. Sci. U.S.A. 2014 Feb 12 [PMID: 24469828] (IP, ICC/IF, WB, Human) Huard C, Tremblay CS, Helsper K et al. Fanconi anemia proteins interact with CtBP1 and modulate the expression of the Wnt antagonist Dickkopf-1. Blood 2013 Jan 9 [PMID: 23303816] Xie, X et al. Aberrant Fanconi anaemia protein profiles in acute myeloid leukaemia cells. Br J Haematol;111(4):1057-64. 2000 Dec. [PMID: 11167740] (IP, WB, Human) Tremblay CS, Huang FF, Habi O, Huard CC, Godin C, Levesque G, Carreau M. HES1 is a novel interactor of the Fanconi anemia core complex. Blood. 112(5):2062-70. Epub 2008 Jun 11. Erratum in: Blood. 2009 Oct 29;114(18):3974. 2008 Sep 1. [PMID: 18550849] (IP, WB, ICC/IF, Human) Hoatlin, M E et al. A novel BTB/POZ transcriptional repressor protein interacts with the Fanconi anemia group C protein and PLZF. Blood;94(11):3737-47. 1999 Dec 1. [PMID: 10572087] (WB, Human) Heinrich, MC et al. Posttranscriptional cell cycle-dependent regulation of human FANCC expression. Blood;95(12):3970-7. 2000 Jun 15. [PMID: 10845936] (WB, ICC/IF, Human)
company information
Novus Biologicals
8100 Southpark Way, A-8
Littleton, CO 80120
Littleton, CO 80120
novus@novusbio.com
www.novusbio.com3037301950
headquarters: USA
The mission of Novus Biologicals, LLC is to accelerate scientific discovery by developing and marketing unique products in the forefront of science. Novus Biologicals was organized to provide the biological research community with a mechanism for commercializing unique biological materials. We also focus on continually monitoring scientific trends and supply materials to serve these trends. By making these products widely available to institutional and commercial researchers, Novus Biologicals plays an important role in furthering biological research. All of Novus Biologicals products are supplied with detailed technical information and ongoing support. By serving niche and emerging markets, Novus Biologicals has become specialists in markets and has formed and will continue to form ongoing partnerships with our customers.
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