Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody - BSA Free | Novus Biologicals NBP1-06640 product information

product summary

company name :

Novus Biologicals

other brands :

IMGENEX

product type :

antibody

product name :

Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody - BSA Free

catalog :

NBP1-06640

quantity :

0.1 ml (also 0.025 ml)

price :

459 USD

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section

more info or order :

Novus Biologicals product webpage

citations: 13

Reference
Gao Y, Wang N, Jia D. JMJD3 downregulates IL4i1 aggravating lipopolysaccharide-induced acute lung injury via H3K27 and H3K4 demethylation. Environ Toxicol. 2023;38:754-769 pubmed publisher
Gao Y, Wang N, Jia D. H3K27 tri-demethylase JMJD3 inhibits macrophage apoptosis by promoting ADORA2A in lipopolysaccharide-induced acute lung injury. Cell Death Discov. 2022;8:475 pubmed publisher
Ming Chin Lee K, Achuthan A, De Souza D, Lupancu T, Binger K, Lee M, et al. Type I interferon antagonism of the JMJD3-IRF4 pathway modulates macrophage activation and polarization. Cell Rep. 2022;39:110719 pubmed publisher
Wang W, Cho H, Lee J, Lee S. The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development. Nat Commun. 2022;13:958 pubmed publisher
Wu Q, Shichino Y, Abe T, Suetsugu T, Omori A, Kiyonari H, et al. Selective translation of epigenetic modifiers affects the temporal pattern and differentiation of neural stem cells. Nat Commun. 2022;13:470 pubmed publisher
Zhang W, Fu Z, Yin H, Han Q, Fan W, Wang F, et al. Macrophage Polarization Modulated by Porcine Circovirus Type 2 Facilitates Bacterial Coinfection. Front Immunol. 2021;12:688294 pubmed publisher
Nanduri J, Wang N, Wang B, Prabhakar N. Lysine demethylase KDM6B regulates HIF-1α mediated systemic and cellular responses to intermittent hypoxia. Physiol Genomics. 2021;: pubmed publisher
Lu H, Xie Y, Tran L, Lan J, Yang Y, Murugan N, et al. Chemotherapy-induced S100A10 recruits KDM6A to facilitate OCT4-mediated breast cancer stemness. J Clin Invest. 2020;: pubmed publisher
Huang M, Wang Q, Long F, Di Y, Wang J, Zhun Zhu Y, et al. Jmjd3 regulates inflammasome activation and aggravates DSS-induced colitis in mice. FASEB J. 2020;34:4107-4119 pubmed publisher
Luo X, Yang D, Wu W, Long F, Xiao C, Qin M, et al. Critical role of histone demethylase Jumonji domain-containing protein 3 in the regulation of neointima formation following vascular injury. Cardiovasc Res. 2018;114:1894-1906 pubmed publisher
Liu S, Wang X, Pan L, Wu W, Yang D, Qin M, et al. Endogenous hydrogen sulfide regulates histone demethylase JMJD3-mediated inflammatory response in LPS-stimulated macrophages and in a mouse model of LPS-induced septic shock. Biochem Pharmacol. 2018;149:153-162 pubmed publisher
Taube J, Sphyris N, Johnson K, Reisenauer K, Nesbit T, Joseph R, et al. The H3K27me3-demethylase KDM6A is suppressed in breast cancer stem-like cells, and enables the resolution of bivalency during the mesenchymal-epithelial transition. Oncotarget. 2017;8:65548-65565 pubmed publisher
Luo T, Dunphy P, McBride J. Ehrlichia chaffeensis Tandem Repeat Effector Targets Differentially Influence Infection. Front Cell Infect Microbiol. 2017;7:178 pubmed publisher

image

image 1 :

Western Blot: Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody [NBP1-06640] - KDM6A protein levels are decreased following EMT and upregulated during MET. MCF10A cells, treated as described, were analyzed by immunoblotting for Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 and vimentin (Vim). COX IV was used as a loading control. Image collected and cropped by CiteAb from the following publication (http://www.oncotarget.com/fulltext/19214), licensed under a CC-BY licence.

product information

brand :

Novus Biologicals, a Bio-Techne brand

catalog number base :

NBP1-06640

SKU :

NBP1-06640

product name :

Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody - BSA Free

description :

The Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody - BSA Free from Novus Biologicals is a rabbit polyclonal antibody to Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3. This antibody reacts with human,mouse. The Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3 Antibody - BSA Free has been validated for the following applications: Immunohistochemistry,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence.

target :

Lysine (K)-specific Demethylase 6B/KDM6B/JMJD3

unit size :

0.1 ml (also 0.025 ml)

category :

Primary Antibodies

buffer :

PBS (pH 7.4)

clonality :

Polyclonal

concentration :

1.0 mg/ml

conjugate :

Unconjugated

host :

Rabbit

immunogen :

Synthetic peptide made to an internal portion of the mouse JMJD3 protein (within residues 600-650). [Swiss-Prot# Q5NCY0]

isotype :

IgG

purity :

Immunogen affinity purified

species :

Human,Mouse

storage :

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.

gene symbol :

KDM6B

Antibody validation :

Biological Validation

applications :

Immunohistochemistry,IF/IHC,Flow Cytometry,Western Blot,Immunohistochemistry-Paraffin,Immunocytochemistry/ Immunofluorescence

USD :

449

USD 2025 :

459 USD

alt names :

EC 1.14.11, EC 1.14.11.-, JmjC domain-containing protein 3, JMJD3lysine-specific demethylase 6B, jumonji domain containing 3, histone lysine demethylase, Jumonji domain-containing protein 3, KIAA0346jumonji domain containing 3, lysine (K)-specific demethylase 6B, Lysine demethylase 6B

more info or order :

Novus Biologicals product webpage