product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
ZEB1 Antibody
catalog :
NBP1-05987
quantity :
0.1 ml
price :
429 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, EMSA, chromatin immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 51
Reference
Schuhwerk H, Kleemann J, Gupta P, van Roey R, Armstark I, Kreileder M, et al. The EMT transcription factor ZEB1 governs a fitness-promoting but vulnerable DNA replication stress response. Cell Rep. 2022;41:111819 pubmed publisher
Han B, Jung K, Lee J, Yoon Y, Ko S, Park M, et al. Lidocaine enhances the efficacy of palbociclib in triple-negative breast cancer. Am J Cancer Res. 2022;12:3083-3098 pubmed
Ichikawa M, Endo K, Itoh Y, Osada A, Kimura Y, Ueki K, et al. Ets family proteins regulate the EMT transcription factors Snail and ZEB in cancer cells. FEBS Open Bio. 2022;12:1353-1364 pubmed publisher
Yoshioka H, Suzuki A, Iwaya C, Iwata J. Suppression of microRNA 124-3p and microRNA 340-5p ameliorates retinoic acid-induced cleft palate in mice. Development. 2022;149: pubmed publisher
Choi S, Kim J, Chen C, Wu C, Marco M, Barriga F, et al. KRAS Mutants Upregulate Integrin β4 to Promote Invasion and Metastasis in Colorectal Cancer. Mol Cancer Res. 2022;20:1305-1319 pubmed publisher
Kang E, Jung S, Nam S, Park Y, Seo S, Park K, et al. Tissue miR-200c-3p and circulating miR-1290 as potential prognostic biomarkers for colorectal cancer. Sci Rep. 2022;12:2295 pubmed publisher
Celik M, Celik Z. Role of the Immunohistochemical ZEB1 Expression in Uterine Mesenchymal Neoplasms. Int J Surg Pathol. 2022;:10668969211070180 pubmed publisher
Wang J, Farkas C, Benyoucef A, Carmichael C, Haigh K, Wong N, et al. Interplay between the EMT transcription factors ZEB1 and ZEB2 regulates hematopoietic stem and progenitor cell differentiation and hematopoietic lineage fidelity. PLoS Biol. 2021;19:e3001394 pubmed publisher
Lu J, Cao L, Xu Y, Huang X, Cho S, Ashktorab H, et al. FOXC1 modulates stem-like cell properties and chemoresistance through hedgehog and EMT signaling in gastric adenocarcinoma. Mol Ther. 2021;: pubmed publisher
Kalogirou C, Linxweiler J, Schmucker P, Snaebjornsson M, Schmitz W, Wach S, et al. MiR-205-driven downregulation of cholesterol biosynthesis through SQLE-inhibition identifies therapeutic vulnerability in aggressive prostate cancer. Nat Commun. 2021;12:5066 pubmed publisher
Chen Y, Jiang K, Bai X, Liu M, Lin S, Xu T, et al. ZEB1 Induces Ddr1 Promoter Hypermethylation and Contributes to the Chronic Pain in Spinal Cord in Rats Following Oxaliplatin Treatment. Neurochem Res. 2021;46:2181-2191 pubmed publisher
Wojnarowicz P, Escolano M, Huang Y, Desai B, Chin Y, Shah R, et al. Anti-tumor effects of an ID antagonist with no observed acquired resistance. NPJ Breast Cancer. 2021;7:58 pubmed publisher
Carstens J, Yang S, Correa de Sampaio P, Zheng X, Barua S, McAndrews K, et al. Stabilized epithelial phenotype of cancer cells in primary tumors leads to increased colonization of liver metastasis in pancreatic cancer. Cell Rep. 2021;35:108990 pubmed publisher
Li J, Luco A, Camirand A, St Arnaud R, Kremer R. Vitamin D Regulates CXCL12/CXCR4 and Epithelial-to-Mesenchymal Transition in a Model of Breast Cancer Metastasis to Lung. Endocrinology. 2021;162: pubmed publisher
Pratheeshkumar P, Siraj A, Divya S, Parvathareddy S, Alobaisi K, Al Sobhi S, et al. CHD4 Predicts Aggressiveness in PTC Patients and Promotes Cancer Stemness and EMT in PTC Cells. Int J Mol Sci. 2021;22: pubmed publisher
Neufert C, Heichler C, Brabletz T, Scheibe K, Boonsanay V, Greten F, et al. Inducible mouse models of colon cancer for the analysis of sporadic and inflammation-driven tumor progression and lymph node metastasis. Nat Protoc. 2021;16:61-85 pubmed publisher
Sáenz de Santa María I, Celada L, San José Martínez A, Cubiella T, Chiara M. Blockage of Squamous Cancer Cell Collective Invasion by FAK Inhibition Is Released by CAFs and MMP-2. Cancers (Basel). 2020;12: pubmed publisher
Wilkinson M, Abramova E, Guo C, Gow J, Murray A, Koudelka A, et al. Fatty acid nitroalkenes inhibit the inflammatory response to bleomycin-mediated lung injury. Toxicol Appl Pharmacol. 2020;407:115236 pubmed publisher
Sato K, Hikita H, Myojin Y, Fukumoto K, Murai K, Sakane S, et al. Hyperglycemia enhances pancreatic cancer progression accompanied by elevations in phosphorylated STAT3 and MYC levels. PLoS ONE. 2020;15:e0235573 pubmed publisher
Huang C, Yoon C, Zhou X, Zhou Y, Zhou W, Liu H, et al. ERK1/2-Nanog signaling pathway enhances CD44(+) cancer stem-like cell phenotypes and epithelial-to-mesenchymal transition in head and neck squamous cell carcinomas. Cell Death Dis. 2020;11:266 pubmed publisher
Horn L, Riskin J, Hempel H, Fousek K, Lind H, Hamilton D, et al. Simultaneous inhibition of CXCR1/2, TGF-β, and PD-L1 remodels the tumor and its microenvironment to drive antitumor immunity. J Immunother Cancer. 2020;8: pubmed publisher
Ran J, Yang H, Huang H, Huang H, Xu Z, Zhang W, et al. ZEB1 modulates endometrial receptivity through epithelial-mesenchymal transition in endometrial epithelial cells in vitro. Biochem Biophys Res Commun. 2020;525:699-705 pubmed publisher
Murata M, Ito T, Tanaka Y, Yamamura K, Furue K, Furue M. OVOL2-Mediated ZEB1 Downregulation May Prevent Promotion of Actinic Keratosis to Cutaneous Squamous Cell Carcinoma. J Clin Med. 2020;9: pubmed publisher
Viswanathan K, Siddiqui M, Borczuk A. The diagnostic utility of zinc E-box 1 (ZEB1) transcription factor for identification of pulmonary sarcomatoid carcinoma in cytologic and surgical specimens. J Am Soc Cytopathol. 2020;9:55-61 pubmed publisher
Wu R, Chen Z, Zhou W, Li Y, Huang Z, Lin D, et al. High expression of ZEB1 in endometriosis and its role in 17β-estradiol-induced epithelial-mesenchymal transition. Int J Clin Exp Pathol. 2018;11:4744-4758 pubmed
Miro C, Di Cicco E, Ambrosio R, Mancino G, Di Girolamo D, Cicatiello A, et al. Thyroid hormone induces progression and invasiveness of squamous cell carcinomas by promoting a ZEB-1/E-cadherin switch. Nat Commun. 2019;10:5410 pubmed publisher
Osada A, Endo K, Kimura Y, Sakamoto K, Nakamura R, Sakamoto K, et al. Addiction of mesenchymal phenotypes on the FGF/FGFR axis in oral squamous cell carcinoma cells. PLoS ONE. 2019;14:e0217451 pubmed publisher
Hah Y, Cho H, Jo S, Park Y, Heo E, Yoon T. Nicotinamide N‑methyltransferase induces the proliferation and invasion of squamous cell carcinoma cells. Oncol Rep. 2019;42:1805-1814 pubmed publisher
Yoon C, Till J, Cho S, Chang K, Lin J, Huang C, et al. KRAS activation in gastric adenocarcinoma stimulates epithelial-to-mesenchymal transition to cancer stem-like cells and promotes metastasis. Mol Cancer Res. 2019;: pubmed publisher
Sippel T, Johnson A, Li H, Hanson D, Nguyen T, Bullock B, et al. Activation of PPARγ in Myeloid Cells Promotes Progression of Epithelial Lung Tumors Through TGF-β1. Mol Cancer Res. 2019;: pubmed publisher
Ordonez L, Hay T, McEwen R, Polanska U, Hughes A, Delpuech O, et al. Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours. Oncotarget. 2019;10:2586-2606 pubmed publisher
Rios A, Capaldo B, Vaillant F, Pal B, van Ineveld R, Dawson C, et al. Intraclonal Plasticity in Mammary Tumors Revealed through Large-Scale Single-Cell Resolution 3D Imaging. Cancer Cell. 2019;35:618-632.e6 pubmed publisher
Katsuno Y, Meyer D, Zhang Z, Shokat K, Akhurst R, Miyazono K, et al. Chronic TGF-β exposure drives stabilized EMT, tumor stemness, and cancer drug resistance with vulnerability to bitopic mTOR inhibition. Sci Signal. 2019;12: pubmed publisher
Fujiwara S, Saiki Y, Ishizawa K, Fukushige S, Yamanaka M, Sato M, et al. Expression of SNAIL in accompanying PanIN is a key prognostic indicator in pancreatic ductal adenocarcinomas. Cancer Med. 2019;8:1671-1678 pubmed publisher
Jia D, Augert A, Kim D, Eastwood E, Wu N, Ibrahim A, et al. Crebbp Loss Drives Small Cell Lung Cancer and Increases Sensitivity to HDAC Inhibition. Cancer Discov. 2018;8:1422-1437 pubmed publisher
Knaack H, Lenk L, Philipp L, Miarka L, Rahn S, Viol F, et al. Liver metastasis of pancreatic cancer: the hepatic microenvironment impacts differentiation and self-renewal capacity of pancreatic ductal epithelial cells. Oncotarget. 2018;9:31771-31786 pubmed publisher
Chen Y, LeBleu V, Carstens J, Sugimoto H, Zheng X, Malasi S, et al. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. EMBO Mol Med. 2018;10: pubmed publisher
Weng C, Chen L, Lin Y, Shih J, Lin Y, Tseng R, et al. Epithelial-mesenchymal transition (EMT) beyond EGFR mutations per se is a common mechanism for acquired resistance to EGFR TKI. Oncogene. 2019;38:455-468 pubmed publisher
Cho S, Yoon C, Lee J, Chang K, Lin J, Kim Y, et al. KMT2C Mutations in Diffuse-Type Gastric Adenocarcinoma Promote Epithelial-to-Mesenchymal Transition. Clin Cancer Res. 2018;24:6556-6569 pubmed publisher
Suzuki K, Kawataki T, Endo K, Miyazawa K, Kinouchi H, Saitoh M. Expression of ZEBs in gliomas is associated with invasive properties and histopathological grade. Oncol Lett. 2018;16:1758-1764 pubmed publisher
Chang K, Yoon C, Yi B, Tap W, Simon M, Yoon S. Platelet-derived growth factor receptor-α and -β promote cancer stem cell phenotypes in sarcomas. Oncogenesis. 2018;7:47 pubmed publisher
Maturi V, Enroth S, Heldin C, Moustakas A. Genome-wide binding of transcription factor ZEB1 in triple-negative breast cancer cells. J Cell Physiol. 2018;233:7113-7127 pubmed publisher
Maturi V, Morén A, Enroth S, Heldin C, Moustakas A. Genomewide binding of transcription factor Snail1 in triple-negative breast cancer cells. Mol Oncol. 2018;12:1153-1174 pubmed publisher
Acharya K, Nettles S, Sellers K, Im D, Harling M, Pattanayak C, et al. The Progestin Receptor Interactome in the Female Mouse Hypothalamus: Interactions with Synaptic Proteins Are Isoform Specific and Ligand Dependent. Eneuro. 2017;4: pubmed publisher
Lutz G, Jurak I, Kim E, Kim J, Hackenberg M, Leader A, et al. Viral Ubiquitin Ligase Stimulates Selective Host MicroRNA Expression by Targeting ZEB Transcriptional Repressors. Viruses. 2017;9: pubmed publisher
Liang X, Yuan X, Yu J, Wu Y, Li K, Sun C, et al. Histone Chaperone ASF1A Predicts Poor Outcomes for Patients With Gastrointestinal Cancer and Drives Cancer Progression by Stimulating Transcription of β-Catenin Target Genes. EBioMedicine. 2017;21:104-116 pubmed publisher
Katsura A, Tamura Y, Hokari S, Harada M, Morikawa M, Sakurai T, et al. ZEB1-regulated inflammatory phenotype in breast cancer cells. Mol Oncol. 2017;11:1241-1262 pubmed publisher
Kim Y, Choi Y, Lee J, Soh E, Kim J, Park T. Senescent tumor cells lead the collective invasion in thyroid cancer. Nat Commun. 2017;8:15208 pubmed publisher
Yoon C, Cho S, Chang K, Park D, Ryeom S, Yoon S. Role of Rac1 Pathway in Epithelial-to-Mesenchymal Transition and Cancer Stem-like Cell Phenotypes in Gastric Adenocarcinoma. Mol Cancer Res. 2017;15:1106-1116 pubmed publisher
Wang Y, Xu X, Yu S, Jeong K, Zhou Z, Han L, et al. Systematic characterization of A-to-I RNA editing hotspots in microRNAs across human cancers. Genome Res. 2017;27:1112-1125 pubmed publisher
Sinh N, Endo K, Miyazawa K, Saitoh M. Ets1 and ESE1 reciprocally regulate expression of ZEB1/ZEB2, dependent on ERK1/2 activity, in breast cancer cells. Cancer Sci. 2017;108:952-960 pubmed publisher
image
image 1 :
Novus Biologicals NBP1-05987 image 1
Immunohistochemistry: ZEB1 Antibody [NBP1-05987] - Immunohistochemical staining results of EMT regulators in HG-PanIN: SNAIL, SLUG, TWIST1, and ZEB1. We categorized and defined three grades: grade 0, <10% positive staining; grade 1, 10%-50% positive; grade 2, 50%< positive Image collected and cropped by CiteAb from the following publication (https://onlinelibrary.wiley.com/doi/abs/10.1002/cam4.2016) licensed under a CC-BY licence.
product information
brand :
Novus
master code :
NBP1-05987
SKU :
NBP1-05987
product name :
ZEB1 Antibody
description :
The ZEB1 Antibody from Novus is a rabbit polyclonal antibody to ZEB1. This antibody reacts with human, mouse, rat. The ZEB1 Antibody has been validated for the following applications: Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Gel Super Shift Assays, Microarray, Chromatin Immunoprecipitation (ChIP), Single Cell Western, Knockdown Validated.
target :
ZEB1
category :
Primary Antibodies
sizes available :
0.1 ml
buffer :
TBS and 0.1% BSA
clonality :
Polyclonal
concentration :
0.2 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
The immunogen recognized by this antibody maps to a region between residue 1074 and 1124 of human zinc finger E-box binding homeobox 1 using the numbering given in entry NP_110378.3
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat
gene symbol :
ZEB1
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Immunohistochemistry-NBP1-05987-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Western-Blot-NBP1-05987-img0017.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Immunohistochemistry-Paraffin-NBP1-05987-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Western-Blot-NBP1-05987-img0003.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Immunohistochemistry-Paraffin-NBP1-05987-img0004.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Immunohistochemistry-Paraffin-NBP1-05987-img0018.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/ZEB1-Antibody-Immunoprecipitation-NBP1-05987-img0013.jpg
accessionNumbers :
P37275
applications :
Western Blot, Simple Western, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Gel Super Shift Assays, Microarray, Chromatin Immunoprecipitation (ChIP), Single Cell Western, Knockdown Validated
USD :
429 USD
alt names :
AREB6MGC133261, delta-crystallin enhancer binding factor 1, DELTAEF1, FECD6, Negative regulator of IL2, NIL2A, NIL-2-A, NIL-2-A zinc finger protein, posterior polymorphous corneal dystrophy 3, PPCD3, TCF-8, TCF8BZP, Transcription factor 8, transcription factor 8 (represses interleukin 2 expression), ZEB, Zfhep, ZFHX1A, zinc finger E-box binding homeobox 1, zinc finger E-box-binding homeobox 1, zinc finger homeodomain enhancer-binding protein
storage :
Store at 4C. Do not freeze.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.