product summary
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company name :
Novus Biologicals
other brands :
IMGENEX
product type :
antibody
product name :
PGC1 alpha Antibody - BSA Free
catalog :
NBP1-04676
quantity :
0.1 ml (also 0.025 ml)
price :
429 USD
clonality :
polyclonal
host :
domestic rabbit
conjugate :
nonconjugated
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 171
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; human; 1:1000; fig 4a
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  • western blot; mouse; 1:3000; loading ...; fig 7a
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Sun X, Dong S, Kato H, Kong J, Ito Y, Hirofuji Y, et al. Mitochondrial Calcium-Triggered Oxidative Stress and Developmental Defects in Dopaminergic Neurons Differentiated from Deciduous Teeth-Derived Dental Pulp Stem Cells with MFF Insufficiency. Antioxidants (Basel). 2022;11: pubmed publisher
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Wang X, Zhang X, Cao K, Zeng M, Fu X, Zheng A, et al. Cardiac disruption of SDHAF4-mediated mitochondrial complex II assembly promotes dilated cardiomyopathy. Nat Commun. 2022;13:3947 pubmed publisher
Han B, Zhao H, Gong X, Sun J, Chi S, Liu T, et al. Upregulation of PGC-1α Attenuates Oxygen-Glucose Deprivation-Induced Hippocampal Neuronal Injury. Neural Plast. 2022;2022:9682999 pubmed publisher
Yang X, Zhang M, Xie B, Peng Z, Manning J, Zimmerman R, et al. Myocardial brain-derived neurotrophic factor regulates cardiac bioenergetics through the transcription factor Yin Yang 1. Cardiovasc Res. 2022;: pubmed publisher
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Jiang Q, Ji A, Li D, Shi L, Gao M, Lv N, et al. Mitochondria damage in ambient particulate matter induced cardiotoxicity: Roles of PPAR alpha/PGC-1 alpha signaling. Environ Pollut. 2021;288:117792 pubmed publisher
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Huang X, Pan L, Zuo Z, Li M, Zeng L, Li R, et al. LINC00842 inactivates transcription co-regulator PGC-1α to promote pancreatic cancer malignancy through metabolic remodelling. Nat Commun. 2021;12:3830 pubmed publisher
Wang G, Yang Y, Ma H, Shi L, Jia W, Hao X, et al. LncRNA FENDRR Inhibits ox-LDL Induced Mitochondrial Energy Metabolism Disorder in Aortic Endothelial Cells via miR-18a-5p/PGC-1α Signaling Pathway. Front Endocrinol (Lausanne). 2021;12:622665 pubmed publisher
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Mukherjee D, Chander V, Bandyopadhyay A. PARIS-DJ-1 Interaction Regulates Mitochondrial Functions in Cardiomyocytes which is Critically Important in Cardiac Hypertrophy. Mol Cell Biol. 2020;: pubmed publisher
Subramani J, Kundumani Sridharan V, Das K. Thioredoxin protects mitochondrial structure, function and biogenesis in myocardial ischemia-reperfusion via redox-dependent activation of AKT-CREB- PGC1α pathway in aged mice. Aging (Albany NY). 2020;12:19809-19827 pubmed publisher
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Zheng J, Akbari M, Schirmer C, Reynaert M, Loyens A, Lefebvre B, et al. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy. Acta Neuropathol Commun. 2020;8:25 pubmed publisher
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Kim J, Ko H, Wang H, Lee H, Yun M, Kang E. Effect of dapagliflozin, a sodium-glucose co-transporter-2 inhibitor, on gluconeogenesis in proximal renal tubules. Diabetes Obes Metab. 2020;22:373-382 pubmed publisher
Kalvala A, Yerra V, Kumar A. LONP1 induction by SRT1720 attenuates mitochondrial dysfunction against high glucose induced neurotoxicity in PC12 cells. Toxicol In Vitro. 2020;62:104695 pubmed publisher
Yin J, Nielsen M, Carcione T, Li S, Shi J. Apolipoprotein E regulates mitochondrial function through the PGC-1α-sirtuin 3 pathway. Aging (Albany NY). 2019;11:11148-11156 pubmed publisher
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Suzuki J. Effects of exercise training with short-duration intermittent hypoxia on endurance performance and muscle metabolism in well-trained mice. Physiol Rep. 2019;7:e14182 pubmed publisher
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image
image 1 :
Novus Biologicals NBP1-04676 image 1
Knockout Validated: PGC1 alpha Antibody [NBP1-04676] - Western blot shows lysates of A431 human squamous carcinoma parental cell line and PGC1 alpha knockout (KO) A431 cell line. PVDF membrane was probed with 1:1000 of Rabbit Polyclonal PGC1 alpha Antibody (Catalog # NBP1-04676) followed by HRP-conjugated Anti-Rabbit IgG Secondary Antibody (Catalog #HAF008). Specific band was detected for PGC1 alpha at approximately 105 kDa (as indicated) in the parental A431 cell line, but is not detectable in the knockout A431 cell line. This experiment was conducted under reducing conditions.
product information
brand :
Novus
master code :
NBP1-04676
SKU :
NBP1-04676
product name :
PGC1 alpha Antibody - BSA Free
description :
The PGC1 alpha Antibody - BSA Free from Novus is a rabbit polyclonal antibody to PGC1 alpha. This antibody reacts with human, mouse, rat, porcine, goat, hamster, sheep, squirrel. The PGC1 alpha Antibody - BSA Free has been validated for the following applications: Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated, Knockdown Validated.
target :
PGC1 alpha
category :
Primary Antibodies
sizes available :
0.1 ml (also 0.025 ml)
buffer :
PBS
clonality :
Polyclonal
concentration :
1.0 mg/ml
conjugate :
Unconjugated
host :
Rabbit
immunogen :
This PGC1 alpha Antibody was developed against a recombinant protein made to an internal portion of the human PGC-1 alpha protein (within residues 400-550). [Swiss-Prot# Q9UBK2].
isotype :
IgG
purity :
Immunogen affinity purified
species :
Human, Mouse, Rat, Porcine, Goat, Hamster, Sheep, Squirrel
theoretical molecular weight :
91 kDa
gene symbol :
PPARGC1A
images :
https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0020.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0020.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NBP1-04676-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NBP1-04676-img0022.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NBP1-04676-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NBP1-04676-img0011.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-Cytometry-NBP1-04676-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-Cytometry-NBP1-04676-img0021.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1 alpha Antibody - BSA Free-Western Blot-NBP1-04676-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1 alpha Antibody - BSA Free-Western Blot-NBP1-04676-img0023.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0012.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Western-Blot-NBP1-04676-img0013.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NBP1-04676-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunocytochemistry-Immunofluorescence-NBP1-04676-img0010.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NBP1-04676-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Immunohistochemistry-Paraffin-NBP1-04676-img0008.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-(Intracellular)-NBP1-04676-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-(Intracellular)-NBP1-04676-img0014.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-(Intracellular)-NBP1-04676-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Flow-(Intracellular)-NBP1-04676-img0016.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Knockout-Validated-NBP1-04676-img0019.jpg, https://aeroglobalimagesprod.blob.core.windows.net/images/datasheets/PGC1-alpha-Antibody---BSA-Free-Knockout-Validated-NBP1-04676-img0019.jpg
accessionNumbers :
Q9UBK2
applications :
Western Blot, Chromatin Immunoprecipitation, Flow Cytometry, Immunohistochemistry, Immunocytochemistry/Immunofluorescence, Immunoprecipitation, Immunohistochemistry-Paraffin, Immunohistochemistry-Frozen, Flow (Intracellular), Knockout Validated, Knockdown Validated
USD :
429 USD
alt names :
LEM6, Ligand effect modulator 6, ligand effect modulator-6, L-PGC-1alpha, peroxisome proliferative activated receptor, gamma, coactivator 1, alpha, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a, peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT, peroxisome proliferator-activated receptor gamma coactivator 1-alpha, peroxisome proliferator-activated receptor gamma, coactivator 1 alpha, PGC1, PGC-1(alpha), PGC1A, PGC-1-alpha, PGC1APGC-1(alpha), PGC1peroxisome proliferative activated receptor, gamma, coactivator 1, PGC-1v, PPAR gamma coactivator variant form, PPAR gamma coactivator-1, PPARgamma coactivator 1alpha, PPAR-gamma coactivator 1-alpha, PPARGC1, PPARGC-1-alpha
storage :
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
more info or order :
company information
Novus Biologicals
10771 E Easter Ave
Centennial, CO 80112
novus@novusbio.com
https://www.novusbio.com
3037301950
headquarters: USA
Novus Biologicals licenses, manufactures, and markets antibodies to over 20,000 unique targets to support a wide array of research areas. Novus is built on honesty, collaboration and strong relationships and continues to provide quality tools that accelerate research. Every product is backed by our 100% guarantee.